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However, recent studies have shown that the\n                      <jats:italic>homB<\/jats:italic>\n                      gene is one of the virulence genes that affects the severity of the clinical results of this bacterium.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>\n                      The main purpose of this study was to investigate the relationship between the presence of\n                      <jats:italic>homB<\/jats:italic>\n                      gene in\n                      <jats:italic>H. pylori<\/jats:italic>\n                      and the progression of its infection to peptic ulcer and gastric cancer. In the present study, we conducted a systematic search to collect all articles related to the effect of\n                      <jats:italic>homB<\/jats:italic>\n                      -positive strains on clinical outcomes. Finally, 12 eligible studies according to our criteria were included in this meta-analysis and the effect of\n                      <jats:italic>homB<\/jats:italic>\n                      gene on gastric ulcer and gastric cancer diseases was evaluated by summary odds ratio (OR).\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>\n                      Current results showed that the\n                      <jats:italic>homB<\/jats:italic>\n                      -positive strains significantly increase the risk of peptic ulcer (OR 1.36; 1.07\u20131.72 with 95% CIs), especially in western countries (OR 1.61; 1.20\u20132.14 with 95% CIs). Moreover, we observed a positive association between the\n                      <jats:italic>homB<\/jats:italic>\n                      gene and risk of gastric cancer (OR 2.16; 1.37\u20133.40 with 95% CIs). In addition, based on subgroup analysis, it was found that the presence of this gene in\n                      <jats:italic>H. pylori<\/jats:italic>\n                      strains increases the risk of gastric cancer in the Asian population (OR 3.71; 1.85\u20137.45 with 95% CIs).\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions<\/jats:title>\n                    <jats:p>\n                      Overall, in the present study we found that\n                      <jats:italic>homB<\/jats:italic>\n                      gene is responsible for the progressing of primary infection to severe complications, in particular peptic ulcer in western countries and gastric cancer in Asian countries.\n                    <\/jats:p>\n                  <\/jats:sec>","DOI":"10.1186\/s12876-021-01764-y","type":"journal-article","created":{"date-parts":[[2021,4,20]],"date-time":"2021-04-20T07:09:37Z","timestamp":1618902577000},"update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":20,"title":["Correlation between the geographical origin of Helicobacter pylori homB-positive strains and their clinical outcomes: a systematic review and meta-analysis"],"prefix":"10.1186","volume":"21","author":[{"given":"Masoud","family":"Keikha","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mohsen","family":"Karbalaei","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2021,4,20]]},"reference":[{"issue":"8390","key":"1764_CR1","doi-asserted-by":"publisher","first-page":"1311","DOI":"10.1016\/S0140-6736(84)91816-6","volume":"323","author":"B Marshall","year":"1984","unstructured":"Marshall B, Warren JR. 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