{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,1,6]],"date-time":"2026-01-06T13:33:39Z","timestamp":1767706419803},"reference-count":17,"publisher":"Springer Science and Business Media LLC","issue":"1","license":[{"start":{"date-parts":[[2021,5,19]],"date-time":"2021-05-19T00:00:00Z","timestamp":1621382400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0"},{"start":{"date-parts":[[2021,5,19]],"date-time":"2021-05-19T00:00:00Z","timestamp":1621382400000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0"}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["BMC Gastroenterol"],"published-print":{"date-parts":[[2021,12]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec>\n                <jats:title>Background<\/jats:title>\n                <jats:p>Percutaneous transhepatic gallbladder drainage (PTGBD) is recommended for acute cholecystitis patients at high risk for surgical treatment. However, there is no evidence about the best timing of surgery after PTGBD. Here, we retrospectively investigated the influence of the interval between PTGBD and surgery on perioperative outcomes and examined the optimal timing of surgery after PTGBD.<\/jats:p>\n              <\/jats:sec><jats:sec>\n                <jats:title>Methods<\/jats:title>\n                <jats:p>\n  We performed a retrospective analysis of 22 patients who underwent cholecystectomy after PTGBD from January 2008 to August 2019. We examined perioperative factors between patients with an interval of \u2264\u20097 days between PTGBD and cholecystectomy (\u2264\u20097-day group; n\u2009=\u200912) and those with an interval of \u2265\u20098 days (\u2265\u20098-day group; n\u2009=\u200910). Moreover, we also examined perioperative factors between patients with an interval of \u2264\u200914 days from PTGBD to cholecystectomy (\u2264\u200914-day group; n\u2009=\u200910) and those with an interval of \u2265\u200915 days (\u2265\u200915-day group; n\u2009=\u200912).<\/jats:p>\n              <\/jats:sec><jats:sec>\n                <jats:title>Results<\/jats:title>\n                <jats:p>Of the 22 patients, 9 had Grade I cholecystitis, 12 had Grade II cholecystitis, and 2 had Grade III cholecystitis. Nine patients had high-grade cholecystitis before PTGBD and 13 had a poor general condition. We examined perioperative factors between patients with an interval of \u2264\u20097 days between PTGBD and cholecystectomy (\u2264\u20097-day group; n\u2009=\u200912) and those with an interval of \u2265\u20098 days (\u2265\u20098-day group; n\u2009=\u200910). The C-reactive protein (CRP) level before surgery was significantly higher (12.70\u2009\u00b1\u20091.95\u00a0mg\/dL vs. 1.13\u2009\u00b1\u20092.13\u00a0mg\/dL, <jats:italic>p<\/jats:italic>\u2009=\u20090.0007) and the total hospitalization was shorter (17.6\u2009\u00b1\u20098.0 days vs. 54.1\u2009\u00b1\u20098.8 days, <jats:italic>p<\/jats:italic>\u2009=\u20090.0060) in the \u2264\u20097-day group than in the \u2265\u20098-day group. We also examined perioperative factors between patients with an interval of \u2264\u200914 days from PTGBD to cholecystectomy (\u2264\u200914-day group; n\u2009=\u200914) and those with an interval of \u2265\u200915 days (\u2265\u200915-day group; n\u2009=\u20098). The CRP level before surgery was significantly higher (11.13\u2009\u00b1\u20092.00\u00a0mg\/dL vs. 0.99\u2009\u00b1\u20092.64\u00a0mg\/dL, <jats:italic>p<\/jats:italic>\u2009=\u20090.0062) and the total hospitalization was shorter (19.5\u2009\u00b1\u20097.2 days vs. 59.9\u2009\u00b1\u20099.5 days, <jats:italic>p<\/jats:italic>\u2009=\u20090.0029) in the \u2264\u200914-day group than in the \u2265\u200915-day group. However, there were no significant differences between the \u2264\u200914-day group and the \u2265\u200915-day group in the levels of hepatic enzymes before surgery, adhesion grade, amount of bleeding during surgery, operative duration, frequency of surgical complications, or length of hospitalization after surgery.<\/jats:p>\n              <\/jats:sec><jats:sec>\n                <jats:title>Conclusions<\/jats:title>\n                <jats:p>The interval between PTGBD and surgery has little influence on perioperative outcomes.<\/jats:p>\n              <\/jats:sec>","DOI":"10.1186\/s12876-021-01810-9","type":"journal-article","created":{"date-parts":[[2021,5,19]],"date-time":"2021-05-19T08:02:49Z","timestamp":1621411369000},"update-policy":"http:\/\/dx.doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":6,"title":["The influence of the interval between percutaneous transhepatic gallbladder drainage and cholecystectomy on perioperative outcomes: a retrospective study"],"prefix":"10.1186","volume":"21","author":[{"given":"Koichi","family":"Kimura","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Eisuke","family":"Adachi","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Sachie","family":"Omori","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ayako","family":"Toyohara","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Takahiro","family":"Higashi","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Kippei","family":"Ohgaki","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Shuhei","family":"Ito","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Shin-ichiro","family":"Maehara","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Toshihiko","family":"Nakamura","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yoichi","family":"Ikeda","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yoshihiko","family":"Maehara","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"297","published-online":{"date-parts":[[2021,5,19]]},"reference":[{"key":"1810_CR1","doi-asserted-by":"publisher","first-page":"319","DOI":"10.1002\/jhbp.450","volume":"24","author":"M Yokoe","year":"2017","unstructured":"Yokoe M, Takada T, Hwang TL, Endo I, Akazawa K, Miura F, et al. 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The protocol followed the 1975 Declaration of Helsinki.  Informed consent was obtained from participants.","order":2,"name":"Ethics","group":{"name":"EthicsHeading","label":"Ethics approval and consent to participate"}},{"value":"Not applicable.","order":3,"name":"Ethics","group":{"name":"EthicsHeading","label":"Consent for publication"}},{"value":"The authors declare that they have no competing interests.","order":4,"name":"Ethics","group":{"name":"EthicsHeading","label":"Competing interests"}}],"article-number":"226"}}