{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,1,15]],"date-time":"2026-01-15T13:09:51Z","timestamp":1768482591662,"version":"3.49.0"},"reference-count":8,"publisher":"Springer Science and Business Media LLC","issue":"1","license":[{"start":{"date-parts":[[2021,7,29]],"date-time":"2021-07-29T00:00:00Z","timestamp":1627516800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0"},{"start":{"date-parts":[[2021,7,29]],"date-time":"2021-07-29T00:00:00Z","timestamp":1627516800000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0"}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["BMC Gastroenterol"],"published-print":{"date-parts":[[2021,12]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec>\n                <jats:title>Background<\/jats:title>\n                <jats:p>Fenofibrate\u00a0is commonly used in the treatment of dyslipidemia. Fenofibrate is related to mild aminotransferase elevations and in some cases severe chronic injury such as fibrosis or cirrhosis, resulting in liver transplantation or death. The latency of disease has been reported to range between weeks to years.<\/jats:p>\n              <\/jats:sec><jats:sec>\n                <jats:title>Case presentation<\/jats:title>\n                <jats:p>A 63\u00a0years old male with hypertriglyceridemia developed symptoms of fatigue and anorexia 48\u00a0h after taking fenofibrate for the first time. The patient\u2019s aminotransferase level was more than 10 times ULN. Immediately, fenofibrate was discontinued and aminotransferase level returned to normal 23\u00a0days later. To assess causality between the drug and liver damage, the standardized Roussel Uclaf Causality Assessment Method (RUCAM) was used. The patient's RUCAM score was 7, which fell in the group of \u201cprobable\u201d. Eight months later, follow-up examination suggested the liver function was normal.<\/jats:p>\n              <\/jats:sec><jats:sec>\n                <jats:title>Conclusions<\/jats:title>\n                <jats:p>Weakness, fatigue and abnormal liver function during fenofibrate therapy should be closely monitored and trigger prompt withdrawal if these symptoms occur.<\/jats:p>\n              <\/jats:sec>","DOI":"10.1186\/s12876-021-01874-7","type":"journal-article","created":{"date-parts":[[2021,7,29]],"date-time":"2021-07-29T12:04:02Z","timestamp":1627560242000},"update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":12,"title":["Liver injury caused by fenofibrate within 48\u00a0h after first administration: a case report"],"prefix":"10.1186","volume":"21","author":[{"given":"Yu","family":"He","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-5616-3042","authenticated-orcid":false,"given":"Ming-zhao","family":"Qin","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yi-wen","family":"Chen","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"297","published-online":{"date-parts":[[2021,7,29]]},"reference":[{"issue":"12","key":"1874_CR1","doi-asserted-by":"publisher","first-page":"3596","DOI":"10.1007\/s10620-017-4812-7","volume":"62","author":"J Ahmad","year":"2017","unstructured":"Ahmad J, et al. Identification and characterization of fenofibrate-induced liver injury. Dig Dis Sci. 2017;62(12):3596\u2013604.","journal-title":"Dig Dis Sci"},{"issue":"5","key":"1874_CR2","first-page":"245","volume":"67","author":"CY Ho","year":"2004","unstructured":"Ho CY, et al. Fenofibrate-induced acute cholestatic hepatitis. J Chin Med Assoc. 2004;67(5):245\u20137.","journal-title":"J Chin Med Assoc"},{"issue":"1","key":"1874_CR3","doi-asserted-by":"publisher","first-page":"65","DOI":"10.1016\/S0248-8663(89)80119-5","volume":"10","author":"J Rigal","year":"1989","unstructured":"Rigal J, et al. Severe mixed hepatitis caused by fenofibrate? A review of the literature apropos of a case. Rev Med Interne. 1989;10(1):65\u20137.","journal-title":"Rev Med Interne"},{"issue":"11","key":"1874_CR4","doi-asserted-by":"publisher","first-page":"1331","DOI":"10.1016\/0895-4356(93)90102-7","volume":"46","author":"C Benichou","year":"1993","unstructured":"Benichou C, Danan G, Flahault A. 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Gastroenterol Clin Biol. 1996;12(20):1137\u20138.","journal-title":"Gastroenterol Clin Biol"},{"issue":"2","key":"1874_CR7","doi-asserted-by":"publisher","first-page":"312","DOI":"10.1007\/s10620-005-1600-6","volume":"50","author":"F Ahmed","year":"2005","unstructured":"Ahmed F, et al. Fenofibrate-induced cirrhosis. Dig Dis Sci. 2005;50(2):312\u20133.","journal-title":"Dig Dis Sci"},{"issue":"5","key":"1874_CR8","doi-asserted-by":"publisher","first-page":"1078","DOI":"10.1053\/j.gastro.2016.12.016","volume":"152","author":"P Nicoletti","year":"2017","unstructured":"Nicoletti P, et al. Association of liver injury from specific drugs, or groups of drugs, with polymorphisms in HLA and other genes in a genome-wide association study. Gastroenterology. 2017;152(5):1078\u201389.","journal-title":"Gastroenterology"}],"container-title":["BMC Gastroenterology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1186\/s12876-021-01874-7.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/article\/10.1186\/s12876-021-01874-7\/fulltext.html","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1186\/s12876-021-01874-7.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2021,7,29]],"date-time":"2021-07-29T12:11:09Z","timestamp":1627560669000},"score":1,"resource":{"primary":{"URL":"https:\/\/bmcgastroenterol.biomedcentral.com\/articles\/10.1186\/s12876-021-01874-7"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2021,7,29]]},"references-count":8,"journal-issue":{"issue":"1","published-print":{"date-parts":[[2021,12]]}},"alternative-id":["1874"],"URL":"https:\/\/doi.org\/10.1186\/s12876-021-01874-7","relation":{},"ISSN":["1471-230X"],"issn-type":[{"value":"1471-230X","type":"electronic"}],"subject":[],"published":{"date-parts":[[2021,7,29]]},"assertion":[{"value":"4 February 2021","order":1,"name":"received","label":"Received","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"30 June 2021","order":2,"name":"accepted","label":"Accepted","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"29 July 2021","order":3,"name":"first_online","label":"First Online","group":{"name":"ArticleHistory","label":"Article History"}},{"order":1,"name":"Ethics","group":{"name":"EthicsHeading","label":"Declarations"}},{"value":"Ethics Committee of Beijing Tongren Hospital, Capital Medical University, TRECKY2020-122.","order":2,"name":"Ethics","group":{"name":"EthicsHeading","label":"Ethics approval and consent to participate"}},{"value":"The patient gave written consent form for his personal and clinical details to be published in this study.","order":3,"name":"Ethics","group":{"name":"EthicsHeading","label":"Consent for publication"}},{"value":"The authors declare that they have no competing interests.","order":4,"name":"Ethics","group":{"name":"EthicsHeading","label":"Competing interests"}}],"article-number":"298"}}