{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,15]],"date-time":"2026-10-15T16:15:14Z","timestamp":1792080914226,"version":"4.4.0"},"reference-count":12,"publisher":"Springer Science and Business Media LLC","issue":"1","license":[{"start":{"date-parts":[[2021,8,5]],"date-time":"2021-08-05T00:00:00Z","timestamp":1628121600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0"},{"start":{"date-parts":[[2021,8,5]],"date-time":"2021-08-05T00:00:00Z","timestamp":1628121600000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0"}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["BMC Gastroenterol"],"published-print":{"date-parts":[[2021,12]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec>\n                <jats:title>Background<\/jats:title>\n                <jats:p>Gastrointestinal bleeding caused by gastrointestinal tract involvement in patients with Klippel\u2013Trenaunay syndrome (KTS) is extremely rare and often overlooked.<\/jats:p>\n                <jats:p>Case presentation<\/jats:p>\n                <jats:p>A 9-year-old girl who presented with chronic gastrointestinal bleeding was admitted to our hospital. Laboratory examinations revealed microcytic\u00a0hypochromic\u00a0anemia and a positive fecal occult blood test. Computed tomography (CT) of the lower limbs combined with physical examination confirmed KTS. The pelvic CT showed concentric thickening of the sigmoid colon and rectum, with progressive enhancement after the administration of a contrast agent. Colonoscopy demonstrated vascular malformations of the sigmoid colon and rectum. The patient was finally diagnosed with KTS with gastrointestinal tract involvement. The patient improved after receiving conservative treatment.<\/jats:p>\n              <\/jats:sec><jats:sec>\n                <jats:title>Conclusions<\/jats:title>\n                <jats:p>A suspicion of gastrointestinal tract involvement as an etiology for gastrointestinal bleeding should not be overlooked in patients with KTS. Endoscopy and imaging modalities can synergistically help diagnose this condition.<\/jats:p>\n              <\/jats:sec>","DOI":"10.1186\/s12876-021-01891-6","type":"journal-article","created":{"date-parts":[[2021,8,5]],"date-time":"2021-08-05T09:03:15Z","timestamp":1628154195000},"update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":9,"title":["Gastrointestinal bleeding with Klippel\u2013Trenaunay syndrome: a case report"],"prefix":"10.1186","volume":"21","author":[{"given":"Lin","family":"Han","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shifeng","family":"Chen","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-2439-3326","authenticated-orcid":false,"given":"Shengping","family":"Jiang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2021,8,5]]},"reference":[{"issue":"5","key":"1891_CR1","doi-asserted-by":"publisher","first-page":"457","DOI":"10.1302\/1863-2548.13.190065","volume":"13","author":"JJ Schoch","year":"2019","unstructured":"Schoch JJ, Nguyen H, Schoch BS, Anderson KR, Stans AA, Driscoll D, Tollefson M. Orthopaedic diagnoses in patients with Klippel\u2013Trenaunay syndrome. J Child Orthop. 2019;13(5):457\u201362.","journal-title":"J Child Orthop"},{"issue":"1","key":"1891_CR2","doi-asserted-by":"publisher","first-page":"e161","DOI":"10.14309\/crj.2016.134","volume":"3","author":"EP Tetangco","year":"2016","unstructured":"Tetangco EP, Arshad HMS, Silva R. Klippel\u2013Trenaunay syndrome of the rectosigmoid colon presenting as severe anemia. ACG Case Reports Journal. 2016;3(1):e161.","journal-title":"ACG Case Reports Journal"},{"issue":"6","key":"1891_CR3","doi-asserted-by":"publisher","first-page":"747","DOI":"10.1097\/MOP.0000000000000812","volume":"31","author":"A Martinez-Lopez","year":"2019","unstructured":"Martinez-Lopez A, Salvador-Rodriguez L, Montero-Vilchez T, Molina-Leyva A, Tercedor-Sanchez J, Arias-Santiago S. Vascular malformations syndromes: an update. 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Vesical hemangioma in a patient with Klippel\u2013Trenaunay\u2013Weber syndrome. J Pediatr. 2019;208:293-293.e292.","journal-title":"J Pediatr"},{"issue":"7","key":"1891_CR9","doi-asserted-by":"publisher","first-page":"518","DOI":"10.1016\/S2468-1253(18)30140-7","volume":"3","author":"A Sepulveda","year":"2018","unstructured":"Sepulveda A, Soriano H, Espino A. Gastrointestinal tract involvement in Klippel\u2013Tr\u00e9naunay syndrome. Lancet Gastroenterol Hepatol. 2018;3(7):518.","journal-title":"Lancet Gastroenterol Hepatol"},{"issue":"S 01","key":"1891_CR10","doi-asserted-by":"publisher","first-page":"355","DOI":"10.1055\/s-0042-119038","volume":"48","author":"S Barbeiro","year":"2016","unstructured":"Barbeiro S, Br\u00e1sio R, Atalaia-Martins C, Marcos P, Gon\u00e7alves C, Alves P, Rama N. Klippel\u2013Trenaunay syndrome: endoscopic findings. 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