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This study aimed to investigate the association between adherence to a GFD, FI, and HRQOL in individuals with CD.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>This cross-sectional study included 97 adults (mean age: 34 \u00b1 9\u00a0years) diagnosed with CD. The participants were on a GFD for more than 6\u00a0months. Sociodemographic characteristics and medical history were assessed. Adherence to a GFD, FI, and HRQOL were assessed using validated questionnaires.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Most participants (73%) adhered to a GFD, and 62% were experiencing FI. Individuals with CD faced difficulty in accessing GF foods due to the high cost (90%) and limited availability (79%). The mean overall HRQOL score was 60. Scores on the physical and mental health domains were 69 and 47, respectively. Adherence to a GFD was significantly associated with FI (<jats:italic>P<\/jats:italic>\u2009=\u20090.02), while there was no association between adherence to a GFD and HRQOL measures (<jats:italic>P<\/jats:italic>\u2009&gt;\u20090.05). Participants facing FI had lower scores in emotional well-being and mental health domains, and overall HRQOL (<jats:italic>P<\/jats:italic>\u2009&lt;\u20090.05).<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>The findings of the present study demonstrate that FI influences adherence to a GFD, and that FI is associated with HRQOL in terms of both emotional well-being and mental health.<\/jats:p><\/jats:sec>","DOI":"10.1186\/s12876-021-01908-0","type":"journal-article","created":{"date-parts":[[2021,8,25]],"date-time":"2021-08-25T13:04:13Z","timestamp":1629896653000},"update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":46,"title":["The influence of a gluten-free diet on health-related quality of life in individuals with celiac disease"],"prefix":"10.1186","volume":"21","author":[{"given":"Fahdah F.","family":"Al-sunaid","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Maha M.","family":"Al-homidi","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Rawan M.","family":"Al-qahtani","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Reema A.","family":"Al-ashwal","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ghada A.","family":"Mudhish","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mahitab A.","family":"Hanbazaza","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Abeer S.","family":"Al-zaben","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2021,8,25]]},"reference":[{"key":"1908_CR1","doi-asserted-by":"publisher","first-page":"1731","DOI":"10.1056\/NEJMra071600","volume":"357","author":"PH Green","year":"2007","unstructured":"Green PH, Cellier C. 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