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Patients with malignancies frequently present with activated coagulation pathways, which might potentially related to tumor progression and prognosis. The purpose of the study was to investigate the clinical significance of preoperative serum fibrinogen levels and platelet counts in GBC patients.<\/jats:p>\n              <\/jats:sec><jats:sec>\n                <jats:title>Methods<\/jats:title>\n                <jats:p>\n  The preoperative fasting serum fibrinogen levels and platelet counts of 58 patients with GBC were measured by AUV2700 automatic biochemical analyzer, as well as 60 patients with cholesterol polyps and 60 healthy volunteers. Kaplan\u2013Meier survival analysis was applied to show the correction between fibrinogen levels and outcome after surgery.<\/jats:p>\n              <\/jats:sec><jats:sec>\n                <jats:title>Results<\/jats:title>\n                <jats:p>The fibrinogen levels of patients with GBC were significantly higher than healthy gallbladder and cholesterol polyp of gallbladder (p\u2009&lt;\u20090.001 and p\u2009&lt;\u20090.001, respectively). In GBC, fibrinogen levels were associated with tumor depth (p\u2009=\u20090.001), lymph node metastasis (p\u2009=\u20090.002), distant metastasis (p\u2009&lt;\u20090.001) and Tumor Node Metastasis (TNM) stage (p\u2009&lt;\u20090.001). The levels in TNM stage IV disease were significantly higher than stage III or stage I\u2009+\u2009II disease (p\u2009=\u20090.048 and p\u2009&lt;\u20090.001, respectively), and in TNM stage III disease were significantly higher than stage I\u2009+\u2009II disease (p\u2009=\u20090.002). Furthermore, the overall survival was better in low fibrinogen level group than in high fibrinogen level group (p\u2009&lt;\u20090.001). However, thrombocytosis was not significantly associated with overall survivals (p\u2009&gt;\u20090.05) in multivariate analysis.<\/jats:p>\n              <\/jats:sec><jats:sec>\n                <jats:title>Conclusions<\/jats:title>\n                <jats:p>The preoperative serum fibrinogen levels and platelet counts might be reliable biomarkers for the occurance of disease, tumor depth, lymph node metastasis, distant metastasis and advanced TNM stage in patients with GBC. The serum fibrinogen levels might be a prognostic factor to predict outcome for GBC patients suffering from surgery treatment. Anticoagulation therapy might be considered to control cancer progression in future studies.<\/jats:p>\n              <\/jats:sec>","DOI":"10.1186\/s12876-021-01943-x","type":"journal-article","created":{"date-parts":[[2021,10,7]],"date-time":"2021-10-07T10:23:19Z","timestamp":1633602199000},"update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":11,"title":["The clinical significance of preoperative serum fibrinogen levels and platelet counts in patients with gallbladder carcinoma"],"prefix":"10.1186","volume":"21","author":[{"given":"Peng","family":"Cao","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lei","family":"Jiang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Liang-Yi","family":"Zhou","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yan-Ling","family":"Chen","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2021,10,7]]},"reference":[{"issue":"16","key":"1943_CR1","first-page":"8359","volume":"24","author":"X Wang","year":"2020","unstructured":"Wang X, Lin YK, Lu ZL, Li J. 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The protocol of this study was approved by the Ethics Committee of Affiliated Union Hospital of Fujian Medical University (No. 2021KY031).  and the informed consent was signed by all participants.  We confirm that all methods are carried out in accordance with the relevant guidelines and regulations of the ethics committee. This was a retrospective study conducted at the Affiliated Union Hospital of Fujian Medical University, from October 2008 to October 2017. 58 participants were enrolled in the study.","order":2,"name":"Ethics","group":{"name":"EthicsHeading","label":"Ethics approval and consent to participate"}},{"value":"Not applicable.","order":3,"name":"Ethics","group":{"name":"EthicsHeading","label":"Consent for publication"}},{"value":"The authors declare that they have no competing interests.","order":4,"name":"Ethics","group":{"name":"EthicsHeading","label":"Competing interests"}}],"article-number":"366"}}