{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,1,16]],"date-time":"2026-01-16T10:07:17Z","timestamp":1768558037361,"version":"3.49.0"},"reference-count":13,"publisher":"Springer Science and Business Media LLC","issue":"1","license":[{"start":{"date-parts":[[2021,11,24]],"date-time":"2021-11-24T00:00:00Z","timestamp":1637712000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0"},{"start":{"date-parts":[[2021,11,24]],"date-time":"2021-11-24T00:00:00Z","timestamp":1637712000000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0"}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["BMC Gastroenterol"],"published-print":{"date-parts":[[2021,12]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec>\n                <jats:title>Background<\/jats:title>\n                <jats:p>IgG4-related disease mainly manifests as organomegaly and is accompanied by tissue fibrosis (Mimori, Mod Rheumatol 29(2):213, 2019) which is frequently confused with tumour (Dawei et al., J Gastroenterol Hepatol 29(12):1375\u20138, 2020). There are few reports with of IgG4-related disease with the first clinical manifestation involving the stomach.<\/jats:p>\n              <\/jats:sec><jats:sec>\n                <jats:title>Case presentation<\/jats:title>\n                <jats:p>We present the case of 46-year-old male patient with a \u201cstomach tumour\u201d as the first manifestation of IgG4-related disease. Gastroscopy showed a mass in the stomach, however, the pathology result was chronic inflammation with IgG4 positivity. CT scans of abdomen showed that the stomach wall was thick, the head of the pancreas was swollen, and retroperitoneal fibrosis was severe.The serum IgG4 level was 75\u00a0g\/L (normal range 0.03\u20132.01\u00a0g\/L).After treatment with methylprednisolone for one month, the symptoms were greatly relieved.<\/jats:p>\n              <\/jats:sec><jats:sec>\n                <jats:title>Conclusions<\/jats:title>\n                <jats:p>To reduce the suffering of patients and relieve their financial burden, we should consider the possibility of IgG4-related disease when the initial manifestation is a stomach mass.<\/jats:p>\n              <\/jats:sec>","DOI":"10.1186\/s12876-021-02013-y","type":"journal-article","created":{"date-parts":[[2021,11,24]],"date-time":"2021-11-24T11:02:59Z","timestamp":1637751779000},"update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":4,"title":["\u201cStomach mass\u201d as the first manifestation of IgG4-related disease: a case report"],"prefix":"10.1186","volume":"21","author":[{"given":"Fulong","family":"Zhang","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-2098-2497","authenticated-orcid":false,"given":"Jing","family":"Xu","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yuandong","family":"Zhu","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Qianneng","family":"Wu","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Xincheng","family":"Xie","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yan","family":"Shi","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"297","published-online":{"date-parts":[[2021,11,24]]},"reference":[{"key":"2013_CR1","doi-asserted-by":"publisher","first-page":"21","DOI":"10.3109\/s10165-011-0571-z","volume":"22","author":"H Umehara","year":"2011","unstructured":"Umehara H, et al. Comprehensive diagnostic criteria for IgG4-related disease (IgG4-RD). Mod Rheumatol. 2011;22:21\u201330.","journal-title":"Mod Rheumatol"},{"key":"2013_CR2","doi-asserted-by":"publisher","first-page":"e55","DOI":"10.1016\/S2665-9913(19)30017-7","volume":"1","author":"W Zhang","year":"2019","unstructured":"Zhang W, Stone JH. Management of IgG4-related disease. Lancet Rheumatol. 2019;1:e55\u201365.","journal-title":"Lancet Rheumatol"},{"issue":"3","key":"2013_CR3","doi-asserted-by":"publisher","first-page":"1207","DOI":"10.1007\/s40744-021-00326-8","volume":"8","author":"Y Liu","year":"2021","unstructured":"Liu Y, Jiangnan Fu, Ning X, et al. Malignancy risk of immunoglobin G4-related disease: evidence from a large cohort multicenter retrospective study. Rheumatol Ther. 2021;8(3):1207\u201321. https:\/\/doi.org\/10.1007\/s40744-021-00326-8.","journal-title":"Rheumatol Ther"},{"issue":"3","key":"2013_CR4","doi-asserted-by":"publisher","first-page":"406","DOI":"10.1136\/annrheumdis-2018-214603","volume":"78","author":"ZS Wallace","year":"2019","unstructured":"Wallace ZS, Zhang Y, Perugino CA, et al. Clinical phenotypes of IgG4-related disease: an analysis of two international cross-sectional cohorts. Ann Rheum Dis. 2019;78(3):406\u201312. https:\/\/doi.org\/10.1136\/annrheumdis-2018-214603.","journal-title":"Ann Rheum Dis"},{"issue":"16","key":"2013_CR5","doi-asserted-by":"publisher","first-page":"1031","DOI":"10.1007\/S11605-010-1172-4","volume":"14","author":"J Lopes","year":"2010","unstructured":"Lopes J, Hochwald SN, Lancia N, et al. Autoimmune esophagitis: IgG4-related tumor of the esophagus. J Gastrointest Surg. 2010;14(16):1031\u20134. https:\/\/doi.org\/10.1007\/S11605-010-1172-4.","journal-title":"J Gastrointest Surg"},{"issue":"4","key":"2013_CR6","doi-asserted-by":"publisher","first-page":"295","DOI":"10.14740\/jocmrl845w","volume":"6","author":"M Dumas-campagna","year":"2014","unstructured":"Dumas-campagna M, Bouchard S, Soucy G, et al. IgG4-related esophageal disease presenting as esophagitis dissecans superficialis with chronic stricture. J Clin Med Res. 2014;6(4):295\u20138. https:\/\/doi.org\/10.14740\/jocmrl845w.","journal-title":"J Clin Med Res"},{"issue":"4","key":"2013_CR7","doi-asserted-by":"publisher","first-page":"437","DOI":"10.1007\/a13244-018-0618-1","volume":"9","author":"C Tang","year":"2018","unstructured":"Tang C, Sivarasan N, Griffin N. Abdominal manifestations of IgG4-related disease: a pictorial review. Insights Imaging. 2018;9(4):437\u201348. https:\/\/doi.org\/10.1007\/a13244-018-0618-1.","journal-title":"Insights Imaging"},{"issue":"3","key":"2013_CR8","doi-asserted-by":"publisher","first-page":"795","DOI":"10.2169\/naika.101.795","volume":"101","author":"Research Committee to establish diagnostic criteria and development of treatment for systemic IgG4-related disease; Research Committee to establish a new clinical entity, IgG4-related multi-organ lymphoproliferativesydrome(IgG4 4-MOLPS)","year":"2012","unstructured":"Research Committee to establish diagnostic criteria and development of treatment for systemic IgG4-related disease; Research Committee to establish a new clinical entity, IgG4-related multi-organ lymphoproliferativesydrome(IgG4 4-MOLPS). Comprehensive diagnostic criteria for IgG4-related disease (IgG4-RD), 2011. Research Program of Intractable Disease provided by the Ministry of Health, Labor, and Welfare of Japan [Article in Japanese]. Nippon Naika Gakkai Zasshi. 2012;101(3):795\u2013804.","journal-title":"Nippon Naika Gakkai Zasshi"},{"issue":"12","key":"2013_CR9","first-page":"735","volume":"20","author":"Z Songbai","year":"2015","unstructured":"Songbai Z, Xiaowen Li, Li X, et al. Clinical analysis of IgG4-related gastropathy. Chin J Gastroenterol. 2015;20(12):735\u20139.","journal-title":"Chin J Gastroenterol"},{"issue":"11","key":"2013_CR10","doi-asserted-by":"publisher","first-page":"1607","DOI":"10.1136\/gutjnl-2012-302886","volume":"62","author":"PA Hart","year":"2013","unstructured":"Hart PA, Topazian MD, Witzig TE, et al. Treatment of relapsing autoimmune pancreatitis with immunomodulators and rituximab:the Mayo clinic experience. 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World J Gastroenterol. 2021;27(25):3825\u201336. https:\/\/doi.org\/10.3748\/wjg.v27.i25.3825.","journal-title":"World J Gastroenterol"}],"container-title":["BMC Gastroenterology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1186\/s12876-021-02013-y.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/article\/10.1186\/s12876-021-02013-y\/fulltext.html","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1186\/s12876-021-02013-y.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2021,11,24]],"date-time":"2021-11-24T11:06:26Z","timestamp":1637751986000},"score":1,"resource":{"primary":{"URL":"https:\/\/bmcgastroenterol.biomedcentral.com\/articles\/10.1186\/s12876-021-02013-y"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2021,11,24]]},"references-count":13,"journal-issue":{"issue":"1","published-print":{"date-parts":[[2021,12]]}},"alternative-id":["2013"],"URL":"https:\/\/doi.org\/10.1186\/s12876-021-02013-y","relation":{},"ISSN":["1471-230X"],"issn-type":[{"value":"1471-230X","type":"electronic"}],"subject":[],"published":{"date-parts":[[2021,11,24]]},"assertion":[{"value":"22 May 2021","order":1,"name":"received","label":"Received","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"3 November 2021","order":2,"name":"accepted","label":"Accepted","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"24 November 2021","order":3,"name":"first_online","label":"First Online","group":{"name":"ArticleHistory","label":"Article History"}},{"order":1,"name":"Ethics","group":{"name":"EthicsHeading","label":"Declarations"}},{"value":"The study protocol conformed to the ethical guidelines of the Declaration of Helsinki and was approved by the ethics review committee of HangZhou XiXi Hospital (202105111003000112851). Written informed consent was obtained from the patient and from all individual participants included in the study. Neither the transplant donor nor the recipient was from a vulnerable population.","order":2,"name":"Ethics","group":{"name":"EthicsHeading","label":"Ethics approval and consent to participate"}},{"value":"Written informed consent was obtained from the patient for publication of this Case report and any accompanying images. A copy of the written consent is available for review by the Editor of this journal.","order":3,"name":"Ethics","group":{"name":"EthicsHeading","label":"Consent for publication"}},{"value":"The authors declare that they have no competing interests.","order":4,"name":"Ethics","group":{"name":"EthicsHeading","label":"Competing interests"}}],"article-number":"442"}}