{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,19]],"date-time":"2026-05-19T17:18:14Z","timestamp":1779211094443,"version":"3.51.4"},"reference-count":88,"publisher":"Springer Science and Business Media LLC","issue":"1","license":[{"start":{"date-parts":[[2021,12,1]],"date-time":"2021-12-01T00:00:00Z","timestamp":1638316800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0"},{"start":{"date-parts":[[2021,12,7]],"date-time":"2021-12-07T00:00:00Z","timestamp":1638835200000},"content-version":"vor","delay-in-days":6,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0"}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["BMC Gastroenterol"],"published-print":{"date-parts":[[2021,12]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec>\n                <jats:title>Background<\/jats:title>\n                <jats:p><jats:italic>Helicobacter pylori<\/jats:italic> (<jats:italic>Hp<\/jats:italic>) is a class I carcinogen in gastric carcinogenesis, but its role in Barrett\u2019s esophagus (BE) is unknown. Therefore, we aimed to explore the possible relationship.<\/jats:p>\n              <\/jats:sec><jats:sec>\n                <jats:title>Methods<\/jats:title>\n                <jats:p>We reviewed observational studies published in English until October 2019. Summary odds ratios (ORs) and 95% confidence intervals (CIs) were calculated for included studies.<\/jats:p>\n              <\/jats:sec><jats:sec>\n                <jats:title>Results<\/jats:title>\n                <jats:p>46 studies from 1505 potential citations were eligible for inclusion. A significant inverse relationship with considerable heterogeneity was found between <jats:italic>Hp<\/jats:italic> (OR\u2009=\u20090.70; 95%\u00a0CI, 0.51\u20130.96; <jats:italic>P<\/jats:italic>\u2009=\u20090.03) and BE, especially the CagA-positive <jats:italic>Hp<\/jats:italic> strain (OR\u2009=\u20090.28; 95%\u00a0CI, 0.15\u20130.54; <jats:italic>P<\/jats:italic>\u2009=\u20090.0002). However, <jats:italic>Hp<\/jats:italic> infection prevalence was not significantly different between patients with BE and the gastroesophageal reflux disease (GERD) control (OR\u2009=\u20090.99; 95%\u00a0CI, 0.82\u20131.19; <jats:italic>P<\/jats:italic>\u2009=\u20090.92). <jats:italic>Hp<\/jats:italic> was negatively correlated with long-segment BE (OR\u2009=\u20090.47; 95%\u00a0CI, 0.25\u20130.90; <jats:italic>P<\/jats:italic>\u2009=\u20090.02) and associated with a reduced risk of dysplasia. However, <jats:italic>Hp<\/jats:italic> had no correlated with short-segment BE (OR\u2009=\u20091.11; 95%\u00a0CI, 0.78\u20131.56; <jats:italic>P<\/jats:italic>\u2009=\u20090.57). In the present infected subgroup, <jats:italic>Hp<\/jats:italic> infection prevalence in BE was significantly lower than that in controls (OR\u2009=\u20090.69; 95%\u00a0CI, 0.54\u20130.89; <jats:italic>P<\/jats:italic>\u2009=\u20090.005); however, this disappeared in the infection history subgroup (OR\u2009=\u20090.88; 95%\u00a0CI, 0.43\u20131.78; <jats:italic>P<\/jats:italic>\u2009=\u20090.73).<\/jats:p>\n              <\/jats:sec><jats:sec>\n                <jats:title>Conclusions<\/jats:title>\n                <jats:p><jats:italic>Hp<\/jats:italic>, especially the CagA-positive <jats:italic>Hp<\/jats:italic> strain, and BE are inversely related with considerable heterogeneity, which is likely mediated by a decrease in GERD prevalence, although this is not observed in the absence of current <jats:italic>Hp<\/jats:italic> infection.<\/jats:p>\n              <\/jats:sec>","DOI":"10.1186\/s12876-021-02036-5","type":"journal-article","created":{"date-parts":[[2021,12,7]],"date-time":"2021-12-07T12:03:26Z","timestamp":1638878606000},"update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":25,"title":["Helicobacter pylori infection is associated with reduced risk of Barrett\u2019s esophagus: a meta-analysis and systematic review"],"prefix":"10.1186","volume":"21","author":[{"given":"Yan-Lin","family":"Du","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ru-Qiao","family":"Duan","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Li-Ping","family":"Duan","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"297","published-online":{"date-parts":[[2021,12,7]]},"reference":[{"issue":"2","key":"2036_CR1","doi-asserted-by":"crossref","first-page":"420","DOI":"10.1053\/j.gastro.2017.04.022","volume":"153","author":"JKY Hooi","year":"2017","unstructured":"Hooi JKY, Lai WY, Ng WK, Suen MMY, Underwood FE, Tanyingoh D, Malfertheiner P, Graham DY, Wong VWS, Wu JCY, et al. 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