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We report a case of diaphragmatic perforation after repeated TACE sessions conducted via the right inferior phrenic artery.<\/jats:p>\n              <\/jats:sec><jats:sec>\n                <jats:title>Case presentation<\/jats:title>\n                <jats:p>A 43-year-old man diagnosed with hepatocellular carcinoma was admitted to the hospital with a chief complaint of cough. The patient underwent TACE via the right inferior phrenic artery 3\u00a0months prior and was discharged without specific complications. Physical examination revealed decreased breathing sounds in the right lower lung zone. Chest radiograph demonstrated a small right pleural effusion. Chest CT scan revealed a small diaphragmatic perforation. The patient was unable to undergo surgical exploration, and a follow-up CT scan after 2\u00a0months revealed progression of the right diaphragmatic perforation with massive herniation of omental fat into the thoracic cavity.<\/jats:p>\n              <\/jats:sec><jats:sec>\n                <jats:title>Conclusions<\/jats:title>\n                <jats:p>Although TACE via the inferior phrenic artery is a relatively safe procedure, it can be associated with rare but serious complications after repeated procedures. This is a rare case report of diaphragmatic perforation after TACE via the right inferior phrenic artery. Early recognition and prompt surgical management are essential to prevent catastrophic outcomes.<\/jats:p>\n              <\/jats:sec>","DOI":"10.1186\/s12876-022-02110-6","type":"journal-article","created":{"date-parts":[[2022,2,5]],"date-time":"2022-02-05T12:02:29Z","timestamp":1644062549000},"update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":6,"title":["Diaphragmatic perforation after transcatheter arterial chemoembolization of hepatocellular carcinoma via inferior phrenic artery: a case report"],"prefix":"10.1186","volume":"22","author":[{"given":"Ji Soo","family":"Kim","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-2135-9384","authenticated-orcid":false,"given":"Hyoung Nam","family":"Lee","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Woong Hee","family":"Lee","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Suk Hyun","family":"Bae","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"297","published-online":{"date-parts":[[2022,2,5]]},"reference":[{"issue":"3","key":"2110_CR1","doi-asserted-by":"publisher","first-page":"165","DOI":"10.1159\/000367739","volume":"4","author":"M Tsurusaki","year":"2015","unstructured":"Tsurusaki M, Murakami T. 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