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The characteristics of lesions on conventional Ultrasonography (US) and CEUS were recorded.<\/jats:p>\n              <\/jats:sec><jats:sec>\n                <jats:title>Results<\/jats:title>\n                <jats:p>Significant differences were observed in enhancement patterns between benign and malignant PLGs during both arterial (P\u2009&lt;\u20090.001) and venous phases (P\u2009&lt;\u20090.001). The malignant lesions typically yielded a \u201cfast-in and fast-out\u201d enhancement pattern. There was no significant difference in Arrival time (AT) between malignant and benign PLGs. If we consider wash-out time\u2009\u2264\u200940\u00a0s as a diagnostic standard for malignant lesions, the sensitivity, specificity, and accuracy were 88.24%, 85.62%, and 86.11%, respectively. Destruction of the Gallbladder (GB) wall was a particularly important indication of malignant PLGs, and the sensitivity, specificity, and accuracy were 93.33%, 92.12%, and 92.22%, respectively. The accuracy of CEUS in the diagnosis of PLGs, as well as malignant and benign lesions, was 92.22%, 92.47%, and 91.17%, respectively.<\/jats:p>\n              <\/jats:sec><jats:sec>\n                <jats:title>Conclusions<\/jats:title>\n                <jats:p>The \u201cfast-in and fast-out\u201d enhancement pattern, hyper-enhancement in comparison to the GB wall in the arterial phase, wash-out time\u2009\u2264\u200940\u00a0s, GB wall destruction, and hepatic parenchymal infiltration are the characteristic findings of malignant PLGs. Besides, CEUS provides a valuable reference to classify some of the benign lesions.<\/jats:p>\n              <\/jats:sec>","DOI":"10.1186\/s12876-022-02373-z","type":"journal-article","created":{"date-parts":[[2022,7,25]],"date-time":"2022-07-25T16:03:48Z","timestamp":1658765028000},"update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":6,"title":["Value of contrast-enhanced ultrasound in diagnosis and differential diagnosis of polypoid lesions of gallbladder\u2009\u2265\u20091\u00a0cm"],"prefix":"10.1186","volume":"22","author":[{"given":"Xiaoyue","family":"Zhang","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Shaoshan","family":"Tang","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Liping","family":"Huang","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Hong","family":"Jin","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yijiao","family":"Wang","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yao","family":"Wang","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Zhan","family":"Liu","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Chunyu","family":"Lu","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"297","published-online":{"date-parts":[[2022,7,25]]},"reference":[{"issue":"5","key":"2373_CR1","first-page":"278","volume":"14","author":"NR Bhatt","year":"2016","unstructured":"Bhatt NR, Gillis A, Smoothey CO, Awan FN, Ridgway PF. 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All experimental protocols were approved by the ethics committee of Shengjing Hospital of China Medical University. Informed consent was obtained from all subjects and\/or their legal guardian(s).","order":2,"name":"Ethics","group":{"name":"EthicsHeading","label":"Ethics approval and consent to participate"}},{"value":"Not applicable.","order":3,"name":"Ethics","group":{"name":"EthicsHeading","label":"Consent for publication"}},{"value":"The authors declare that they have no competing interests.","order":4,"name":"Ethics","group":{"name":"EthicsHeading","label":"Competing interests"}}],"article-number":"354"}}