{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,30]],"date-time":"2026-09-30T10:06:00Z","timestamp":1790762760275,"version":"4.1.0"},"reference-count":17,"publisher":"Springer Science and Business Media LLC","issue":"1","license":[{"start":{"date-parts":[[2022,6,23]],"date-time":"2022-06-23T00:00:00Z","timestamp":1655942400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0"},{"start":{"date-parts":[[2022,6,23]],"date-time":"2022-06-23T00:00:00Z","timestamp":1655942400000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0"}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["BMC Gastroenterol"],"published-print":{"date-parts":[[2022,12]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec>\n                <jats:title>Background<\/jats:title>\n                <jats:p>Hypercontractile esophagus is a rare hypercontractile esophageal motility disorder. The etiology of hypercontractile esophagus is unknown but an association between acid reflux and hypercontractile esophagus has been suggested. We present the first report on the use of potassium-competitive acid blockers in the treatment of hypercontractile esophagus.<\/jats:p>\n              <\/jats:sec><jats:sec>\n                <jats:title>Case presentation<\/jats:title>\n                <jats:p>A 43-year-old man presented with dysphagia, chest pain and regurgitation for a period of 1\u00a0year. Initial workup showed a twisted lumen with abnormal contractions in the distal esophagus during upper gastrointestinal endoscopy and abnormal acid exposure under 24-h esophageal pH monitoring. The use of standard-dose proton pump inhibitors didn\u2019t relieve his symptoms. Subsequent high-resolution esophageal manometry made a diagnosis of hypercontractile esophagus. Treatment with vonoprazan resulted in symptomatic resolution and abnormal contractions were no longer detected on follow-up high-resolution manometry.<\/jats:p>\n              <\/jats:sec><jats:sec>\n                <jats:title>Conclusions<\/jats:title>\n                <jats:p>Potassium-competitive acid blockers like vonoprazan offer an alternative therapeutic method for patients with hypercontractile esophagus who are refractory to proton pump inhibitor therapy. The use of potassium-competitive acid blockers in hypercontractile esophagus warrants further research and may provide evidence for an acid-related etiology of hypercontractile esophagus.<\/jats:p>\n              <\/jats:sec>","DOI":"10.1186\/s12876-022-02375-x","type":"journal-article","created":{"date-parts":[[2022,6,23]],"date-time":"2022-06-23T12:15:04Z","timestamp":1655986504000},"update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":2,"title":["Hypercontractile esophagus responsive to potassium-competitive acid blockers: a case report"],"prefix":"10.1186","volume":"22","author":[{"given":"Yuyang","family":"Shao","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Chen","family":"Xie","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Huang","family":"Feng","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Donglin","family":"Yan","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Weichang","family":"Chen","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2022,6,23]]},"reference":[{"key":"2375_CR1","doi-asserted-by":"publisher","unstructured":"Yadlapati R, Kahrilas PJ, Fox MR, et al. Esophageal motility disorders on high-resolution manometry: Chicago classification version 4.0\u00a9. Neurogastroenterol Motil. 2021;33(1):e14058. doi:https:\/\/doi.org\/10.1111\/nmo.14058","DOI":"10.1111\/nmo.14058"},{"issue":"10","key":"2375_CR2","doi-asserted-by":"publisher","first-page":"1136","DOI":"10.1016\/j.dld.2016.06.030","volume":"48","author":"AL Mallet","year":"2016","unstructured":"Mallet AL, Ropert A, Bouguen G, et al. Prevalence and characteristics of acid gastro-oesophageal reflux disease in Jackhammer oesophagus. Dig Liver Dis. 2016;48(10):1136\u201341. https:\/\/doi.org\/10.1016\/j.dld.2016.06.030.","journal-title":"Dig Liver Dis"},{"issue":"1","key":"2375_CR3","doi-asserted-by":"publisher","first-page":"9949","DOI":"10.1038\/s41598-018-27756-9","volume":"8","author":"I Kristo","year":"2018","unstructured":"Kristo I, Schwameis K, Maschke S, et al. Phenotypes of Jackhammer esophagus in patients with typical symptoms of gastroesophageal reflux disease responsive to proton pump inhibitors. Sci Rep. 2018;8(1):9949. https:\/\/doi.org\/10.1038\/s41598-018-27756-9.","journal-title":"Sci Rep"},{"issue":"11\u201312","key":"2375_CR4","doi-asserted-by":"publisher","first-page":"1129","DOI":"10.1046\/j.1365-2306.2003.01788.x","volume":"18","author":"M Borjesson","year":"2003","unstructured":"Borjesson M, Rolny P, Mannheimer C, Pilhall M. Nutcracker oesophagus: a double-blind, placebo-controlled, cross-over study of the effects of lansoprazole: acid suppression for nutcracker oesophagus. Aliment Pharmacol Ther. 2003;18(11\u201312):1129\u201335. https:\/\/doi.org\/10.1046\/j.1365-2306.2003.01788.x.","journal-title":"Aliment Pharmacol Ther"},{"issue":"5","key":"2375_CR5","doi-asserted-by":"publisher","first-page":"377","DOI":"10.1007\/s12328-018-0868-y","volume":"11","author":"S Tanaka","year":"2018","unstructured":"Tanaka S, Toyonaga T, Kawara F, et al. A case of Jackhammer esophagus caused by eosinophilic esophagitis in which per-oral endoscopic myotomy resulted in symptom improvement. Clin J Gastroenterol. 2018;11(5):377\u201381. https:\/\/doi.org\/10.1007\/s12328-018-0868-y.","journal-title":"Clin J Gastroenterol"},{"key":"2375_CR6","doi-asserted-by":"publisher","first-page":"5036160","DOI":"10.1155\/2019\/5036160","volume":"2019","author":"M Cl\u00e9ment","year":"2019","unstructured":"Cl\u00e9ment M, Zhu WJ, Neshkova E, Bouin M. Jackhammer esophagus: from manometric diagnosis to clinical presentation. Can J Gastroenterol Hepatol. 2019;2019:5036160. https:\/\/doi.org\/10.1155\/2019\/5036160.","journal-title":"Can J Gastroenterol Hepatol"},{"key":"2375_CR7","doi-asserted-by":"publisher","unstructured":"Milito P, Siboni S, Bonavina L. High-Pressure Tactics: Jackhammer Esophagus\u2014Diagnosing Is Easier than Treating. Dig Dis Sci. Published online October 21, 2021. doi:https:\/\/doi.org\/10.1007\/s10620-021-07279-6","DOI":"10.1007\/s10620-021-07279-6"},{"key":"2375_CR8","unstructured":"Crozier RE, Veerman JM. Acid-provoked esophageal spasm as a cause of noncardiac chest pain. 1991;86(11):6."},{"issue":"6","key":"2375_CR9","doi-asserted-by":"publisher","first-page":"1073","DOI":"10.1016\/j.cgh.2018.06.018","volume":"17","author":"J Abdallah","year":"2019","unstructured":"Abdallah J, George N, Yamasaki T, Ganocy S, Fass R. Most patients with gastroesophageal reflux disease who failed proton pump inhibitor therapy also have functional esophageal disorders. Clin Gastroenterol Hepatol. 2019;17(6):1073-1080.e1. https:\/\/doi.org\/10.1016\/j.cgh.2018.06.018.","journal-title":"Clin Gastroenterol Hepatol"},{"issue":"10","key":"2375_CR10","doi-asserted-by":"publisher","first-page":"1647","DOI":"10.1016\/j.cgh.2013.10.026","volume":"12","author":"WO Rohof","year":"2014","unstructured":"Rohof WO, Bennink RJ, de Jonge H, Boeckxstaens GE. Increased proximal reflux in a hypersensitive esophagus might explain symptoms resistant to proton pump inhibitors in patients with gastroesophageal reflux disease. Clin Gastroenterol Hepatol. 2014;12(10):1647\u201355. https:\/\/doi.org\/10.1016\/j.cgh.2013.10.026.","journal-title":"Clin Gastroenterol Hepatol"},{"issue":"4","key":"2375_CR11","doi-asserted-by":"publisher","first-page":"495","DOI":"10.5056\/jnm17097","volume":"23","author":"T Yamasaki","year":"2017","unstructured":"Yamasaki T, Fass R. Reflux hypersensitivity: a new functional esophageal disorder. J Neurogastroenterol Motil. 2017;23(4):495\u2013503. https:\/\/doi.org\/10.5056\/jnm17097.","journal-title":"J Neurogastroenterol Motil"},{"issue":"S2","key":"2375_CR12","doi-asserted-by":"publisher","first-page":"S33","DOI":"10.1038\/ajg.2009.50","volume":"104","author":"R Fass","year":"2009","unstructured":"Fass R. Proton pump inhibitor failure\u2014what are the therapeutic options? Am J Gastroenterol. 2009;104(S2):S33\u20138. https:\/\/doi.org\/10.1038\/ajg.2009.50.","journal-title":"Am J Gastroenterol"},{"key":"2375_CR13","doi-asserted-by":"publisher","unstructured":"Sugano K. Vonoprazan fumarate, a novel potassium-competitive acid blocker, in the management of gastroesophageal reflux disease: safety and clinical evidence to date. Therap Adv Gastroenterol. 2018;11:1756283X17745776. doi:https:\/\/doi.org\/10.1177\/1756283X17745776","DOI":"10.1177\/1756283X17745776"},{"issue":"1","key":"2375_CR14","doi-asserted-by":"publisher","first-page":"222","DOI":"10.1186\/s12876-021-01808-3","volume":"21","author":"A Sirinawasatien","year":"2021","unstructured":"Sirinawasatien A, Sakulthongthawin P. Manometrically jackhammer esophagus with fluoroscopically\/endoscopically distal esophageal spasm: a case report. BMC Gastroenterol. 2021;21(1):222. https:\/\/doi.org\/10.1186\/s12876-021-01808-3.","journal-title":"BMC Gastroenterol"},{"key":"2375_CR15","doi-asserted-by":"publisher","first-page":"590","DOI":"10.4253\/wjge.v9.i12.590","volume":"9","author":"JY Li","year":"2017","unstructured":"Li JY, Zhang WH, Huang CL, Huang D, Zuo GW, Liang LX. Deanxit relieves symptoms in a patient with jackhammer esophagus: a case report. World J Gastrointest Endosc. 2017;9:590\u20133.","journal-title":"World J Gastrointest Endosc"},{"issue":"8","key":"2375_CR16","doi-asserted-by":"publisher","first-page":"735","DOI":"10.1111\/dote.12282","volume":"28","author":"S Marjoux","year":"2015","unstructured":"Marjoux S, Brochard C, Roman S, et al. Botulinum toxin injection for hypercontractile or spastic esophageal motility disorders: may high-resolution manometry help to select cases?: HRM and esophageal botulinum toxin. Dis Esophagus. 2015;28(8):735\u201341. https:\/\/doi.org\/10.1111\/dote.12282.","journal-title":"Dis Esophagus"},{"issue":"2","key":"2375_CR17","doi-asserted-by":"publisher","first-page":"256","DOI":"10.1016\/j.jamcollsurg.2015.03.057","volume":"221","author":"H Inoue","year":"2015","unstructured":"Inoue H, Sato H, Ikeda H, et al. Per-oral endoscopic myotomy: a series of 500 patients. J Am Coll Surg. 2015;221(2):256\u201364. https:\/\/doi.org\/10.1016\/j.jamcollsurg.2015.03.057.","journal-title":"J Am Coll Surg"}],"container-title":["BMC Gastroenterology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1186\/s12876-022-02375-x.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/article\/10.1186\/s12876-022-02375-x\/fulltext.html","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1186\/s12876-022-02375-x.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2022,6,23]],"date-time":"2022-06-23T12:15:22Z","timestamp":1655986522000},"score":1,"resource":{"primary":{"URL":"https:\/\/bmcgastroenterol.biomedcentral.com\/articles\/10.1186\/s12876-022-02375-x"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2022,6,23]]},"references-count":17,"journal-issue":{"issue":"1","published-print":{"date-parts":[[2022,12]]}},"alternative-id":["2375"],"URL":"https:\/\/doi.org\/10.1186\/s12876-022-02375-x","relation":{},"ISSN":["1471-230X"],"issn-type":[{"value":"1471-230X","type":"electronic"}],"subject":[],"published":{"date-parts":[[2022,6,23]]},"assertion":[{"value":"21 December 2021","order":1,"name":"received","label":"Received","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"11 June 2022","order":2,"name":"accepted","label":"Accepted","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"23 June 2022","order":3,"name":"first_online","label":"First Online","group":{"name":"ArticleHistory","label":"Article History"}},{"order":1,"name":"Ethics","group":{"name":"EthicsHeading","label":"Declarations"}},{"value":"Ethical approval was obtained from the ethics committee of the First affiliated hospital of Soochow University.","order":2,"name":"Ethics","group":{"name":"EthicsHeading","label":"Ethics approval and consent to participate"}},{"value":"Written informed consent for publication of the clinical details and clinical images was obtained from the patient. A copy of the consent form is available for review by the Editor of this journal.","order":3,"name":"Ethics","group":{"name":"EthicsHeading","label":"Consent for publication"}},{"value":"The authors have no conflicts of interest to disclose.","order":4,"name":"Ethics","group":{"name":"EthicsHeading","label":"Competing interests"}}],"article-number":"307"}}