{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,6]],"date-time":"2026-10-06T14:32:31Z","timestamp":1791297151482,"version":"4.1.0"},"reference-count":15,"publisher":"Springer Science and Business Media LLC","issue":"1","license":[{"start":{"date-parts":[[2022,7,26]],"date-time":"2022-07-26T00:00:00Z","timestamp":1658793600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0"},{"start":{"date-parts":[[2022,7,26]],"date-time":"2022-07-26T00:00:00Z","timestamp":1658793600000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0"}],"funder":[{"name":"National Key Research and Development Project","award":["2019YFC1316000"],"award-info":[{"award-number":["2019YFC1316000"]}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["81830089"],"award-info":[{"award-number":["81830089"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["81801640"],"award-info":[{"award-number":["81801640"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["81802359"],"award-info":[{"award-number":["81802359"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["81871545"],"award-info":[{"award-number":["81871545"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["81802334"],"award-info":[{"award-number":["81802334"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100004731","name":"Natural Science Foundation of Zhejiang Province","doi-asserted-by":"publisher","award":["LD19H150001"],"award-info":[{"award-number":["LD19H150001"]}],"id":[{"id":"10.13039\/501100004731","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["BMC Gastroenterol"],"published-print":{"date-parts":[[2022,12]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec>\n                <jats:title>Background<\/jats:title>\n                <jats:p>Situs inversus totalis (SIT) is a rare congenital anomaly characterized by a complete transposition of all the viscera. SIT cases were usually reported because of the presence of tumors, leading to false association between them. Therefore, any research that advances our understanding on SIT is highly required. This study firstly describes a very rare case of SIT with \u201cjumping\u201d metastasis to pancreas of gallbladder carcinoma.<\/jats:p>\n              <\/jats:sec><jats:sec>\n                <jats:title>Case presentation<\/jats:title>\n                <jats:p>A 69-year-old female patient presented at our hospital with complaints of one month of epigastric pain was studied. She had not sought for treatment prior the visit. Imaging examinations of this patient revealed SIT and a variation of the common hepatic artery with concomitant tumors of gallbladder and pancreas. However, there was no evidence of distant metastases beyond the abdominal cavity. She underwent a combination of radical cholecystectomy, total pancreatectomy, splenectomy and hepatic artery-splenic artery reconstruction. Histological analyses revealed metastasis of the gallbladder carcinoma in to the pancreas. Although the patient opted against chemotherapy, she survived without tumor for 16\u00a0months following the surgery. A review of the current literature on association with SIT and tumor occurrence was presented.<\/jats:p>\n              <\/jats:sec><jats:sec>\n                <jats:title>Conclusions<\/jats:title>\n                <jats:p>It is a great surgical challenge for the resection of multicenter hepatobiliary and pancreatic tumors in such rare SIT anatomical abnormalities with vascular variants. A reliable surgical plan based on detailed preoperative imaging and intraoperative anatomical exploration is crucial to achieving radical resection.<\/jats:p>\n              <\/jats:sec>","DOI":"10.1186\/s12876-022-02377-9","type":"journal-article","created":{"date-parts":[[2022,7,26]],"date-time":"2022-07-26T13:05:43Z","timestamp":1658840743000},"update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":12,"title":["Situs inversus totalis with local metastasis of gallbladder carcinoma and variation of the common hepatic artery"],"prefix":"10.1186","volume":"22","author":[{"given":"Cheng","family":"Zhang","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Bo","family":"Zhang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Haifeng","family":"Huang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Qida","family":"Hu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yibing","family":"Jin","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Qingsong","family":"Yu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Junsen","family":"Wang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xin","family":"Zhang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-0339-4223","authenticated-orcid":false,"given":"Yun","family":"Zhang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2022,7,26]]},"reference":[{"key":"2377_CR1","doi-asserted-by":"publisher","first-page":"312","DOI":"10.1186\/1477-7819-11-312","volume":"11","author":"D Kyuno","year":"2013","unstructured":"Kyuno D, Kimura Y, Imamura M, et al. Pancreaticoduodenectomy for biliary tract carcinoma with situs inversus totalis: difficulties and technical notes based on two cases. World J Surg Oncol. 2013;11:312. https:\/\/doi.org\/10.1186\/1477-7819-11-312.","journal-title":"World J Surg Oncol"},{"key":"2377_CR2","doi-asserted-by":"publisher","first-page":"506","DOI":"10.1111\/ans.13431","volume":"88","author":"C Chen","year":"2018","unstructured":"Chen C, Yi X, He Y, et al. Pancreatic head cancer involving variant common hepatic artery with situs inversus totalis. ANZ J Surg. 2018;88:506\u20138. https:\/\/doi.org\/10.1111\/ans.13431.","journal-title":"ANZ J Surg"},{"key":"2377_CR3","doi-asserted-by":"publisher","first-page":"398","DOI":"10.11604\/pamj.2021.38.398.29228","volume":"38","author":"DEY Gan","year":"2021","unstructured":"Gan DEY, Alagoo D, Chan KH, et al. Choledochal cyst and aberrant biliary configuration along with situs inversus totalis: a case report. Pan Afr Med J. 2021;38:398. https:\/\/doi.org\/10.11604\/pamj.2021.38.398.29228.","journal-title":"Pan Afr Med J"},{"key":"2377_CR4","doi-asserted-by":"publisher","DOI":"10.1016\/j.tcr.2022.100626","volume":"38","author":"MF Che Ani","year":"2022","unstructured":"Che Ani MF, Ismail MAT, Abdul Rashid NF, et al. Concurrent hollow and visceral organs traumatic injury secondary to metal shrapnel penetration in a male with situs inversus totalis: a case report. Trauma Case Rep. 2022;38: 100626. https:\/\/doi.org\/10.1016\/j.tcr.2022.100626.","journal-title":"Trauma Case Rep"},{"key":"2377_CR5","doi-asserted-by":"publisher","first-page":"127","DOI":"10.1053\/j.semdp.2012.08.010","volume":"29","author":"NV Adsay","year":"2012","unstructured":"Adsay NV, Bagci P, Tajiri T, et al. Pathologic staging of pancreatic, ampullary, biliary, and gallbladder cancers: pitfalls and practical limitations of the current AJCC\/UICC TNM staging system and opportunities for improvement. 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And written informed consent was obtained from the patient. Meanwhile, imaging screening for twenty-one relatives of the patient was ethically approved, and written informed consent was obtained from them.","order":2,"name":"Ethics","group":{"name":"EthicsHeading","label":"Ethics approval and consent to participate"}},{"value":"The patient gave written consent form for his personal and clinical details to be published in this study.","order":3,"name":"Ethics","group":{"name":"EthicsHeading","label":"Consent for publication"}},{"value":"The authors declare that they have no competing interests.","order":4,"name":"Ethics","group":{"name":"EthicsHeading","label":"Competing interests"}}],"article-number":"357"}}