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The aim of this study was to develop a quantitative CTE scoring system for ileocolonic Crohn's disease activity.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>Forty-nine CD patients with ileocolonic involvement were retrospectively included between March 2015 and May 2018. All patients underwent CTE and ileocolonoscopy. Mural hyperenhancement and mural thickening at CTE were scored quantitatively, while mural stratification, submucosal fat deposition, comb sign, perienteric fat hypertrophy and mesenteric fibrofatty proliferation were qualitative variables. A Tobit regression model was applied for assessing the association between Crohn's disease endoscopic index of severity (CDEIS) and CTE variables.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>A total of 280 intestinal segments were evaluated. Independent predictors for CDEIS were mural thickness (p\u2009&lt;\u20090.001), mural stratification (p\u2009&lt;\u20090.001) and comb sign (p\u2009=\u20090.002). In order to quantify disease activity based on CTE findings in each segment, a simplified CT enterography index of activity (CTEIA) was derived from logistic regression analysis.\u00a0The\u00a0formula\u00a0was as\u00a0follows: CTEIA (segment)\u2009=\u20092.1 mural thickness(mm)\u2009+\u20099.7 mural stratification\u2009+\u20095.2 comb sign. There was a high and significant correlation coefficient between CDEIS and CTEIA (r\u2009=\u20090.779, p\u2009&lt;\u20090.001) for per-segment analysis. The model for the detection of ulcerative lesions in the colon and terminal ileum achieved an area under the receiver-operating curve of 0.901 using a cut-off point of 6.25.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions<\/jats:title>\n                    <jats:p>CTEIA is a new qualitative tool for evaluation of ileocolonic Crohn\u2019s disease, which need to be validated in further studies.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1186\/s12876-022-02389-5","type":"journal-article","created":{"date-parts":[[2022,6,30]],"date-time":"2022-06-30T13:07:49Z","timestamp":1656594469000},"update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":21,"title":["CT enterography for evaluation of disease activity in patients with ileocolonic Crohn's disease"],"prefix":"10.1186","volume":"22","author":[{"given":"Jinlu","family":"Tong","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Qi","family":"Feng","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Chenpeng","family":"Zhang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xitao","family":"Xu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zhihua","family":"Ran","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2022,6,30]]},"reference":[{"issue":"6","key":"2389_CR1","doi-asserted-by":"publisher","first-page":"1042e1042","DOI":"10.1016\/j.cgh.2013.09.006","volume":"13","author":"G Bouguen","year":"2015","unstructured":"Bouguen G, Levesque BG, Feagan BG, Kavanaugh A, Peyrin-Biroulet L, Colombel JF, Hanauer SB, Sandborn WJ. 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This was a retrospective cohort study and patient consent was not required for data collection or analysis, as approved by the aforementioned institutional review board. All methods were performed in accordance with the relevant guidelines and regulations.","order":2,"name":"Ethics","group":{"name":"EthicsHeading","label":"Ethics approval and consent to participate"}},{"value":"Not applicable.","order":3,"name":"Ethics","group":{"name":"EthicsHeading","label":"Consent for publication"}},{"value":"The authors of this manuscript declare no relationships with any companies, whose products or services may be related to the subject matter of the article.","order":4,"name":"Ethics","group":{"name":"EthicsHeading","label":"Competing interests"}}],"article-number":"324"}}