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In half of the animals a conventional anastomosis was performed, and in the other half, the distal 25\u00a0cm of the remnant jejunum was reversed before the intestinal continuity was recreated. Weight was measured daily until day 28, where the animals were euthanized. Glucagon-Like Peptide-2 (GLP-2) and Glucose-dependent Insulinotropic Peptide (GIP) was measured pre- and postoperatively at day 28.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>The group with reversal of small intestine had a significant lower weight gain at 5.26\u2009\u00b1\u20093.39\u00a0kg (mean\u2009\u00b1\u2009SD) compared to the control group with 11.14\u2009\u00b1\u20093.83\u00a0kg (p\u2009&lt;\u20090.05). In the control group greater villus height and crypt depth was found distally, and greater muscular thickness was found proximally in the intervention group. GLP-2 and GIP levels increased significantly in the control group.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>Treatment of short bowel syndrome with a reversed jejunal segment of 25\u00a0cm had a detrimental effect on the weight gain.<\/jats:p><\/jats:sec>","DOI":"10.1186\/s12876-022-02418-3","type":"journal-article","created":{"date-parts":[[2022,7,20]],"date-time":"2022-07-20T05:02:58Z","timestamp":1658293378000},"update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":1,"title":["Segmental reversal of the distal small intestine in a short bowel syndrome model in piglets showed detrimental effect on weight gain"],"prefix":"10.1186","volume":"22","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-6720-5911","authenticated-orcid":false,"given":"Lasse Hartmann","family":"Schmidt","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-0230-1531","authenticated-orcid":false,"given":"Jesper Stensig","family":"Aa","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-8509-2036","authenticated-orcid":false,"given":"Bolette","family":"Hartmann","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Gunvor Iben","family":"Madsen","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-1113-195X","authenticated-orcid":false,"given":"Niels","family":"Qvist","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-6550-7505","authenticated-orcid":false,"given":"Mark Bremholm","family":"Elleb\u00e6k","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2022,7,20]]},"reference":[{"issue":"1","key":"2418_CR1","doi-asserted-by":"publisher","first-page":"6","DOI":"10.1016\/j.cgh.2005.10.002","volume":"4","author":"SJ O\u2019Keefe","year":"2006","unstructured":"O\u2019Keefe SJ, Buchman AL, Fishbein TM, Jeejeebhoy KN, Jeppesen PB, Shaffer J. 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All procedures performed involving animals were in accordance with the ethical standards of the institution or practice at which the study was conducted. Pre-study euthanization was planned if animals showed significant signs of distress or failure to thrive irrespective of treatment. The humane endpoint was 25% weight loss.\u00a0The study was approved by The Animal Experiments Inspectorate (2018-15-0201-01417).","order":2,"name":"Ethics","group":{"name":"EthicsHeading","label":"Ethics approval and consent to participate"}},{"value":"Not applicable.","order":3,"name":"Ethics","group":{"name":"EthicsHeading","label":"Consent for publication"}},{"value":"The authors declare that they have no competing interests.","order":4,"name":"Ethics","group":{"name":"EthicsHeading","label":"Competing interests"}}],"article-number":"349"}}