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This study attempted to evaluate the differences and relationships between the clinical and histological features of aberrant cytokeratin 7 (CK7) expression by hepatocytes in PBC patients.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>The clinicopathological data of patients diagnosed with PBC at the Second Hospital of Nanjing between January 2016 and September 2018 were analysed with SPSS 20.0.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Eighty-nine PBC patients who underwent liver biopsy were enrolled in this study, and 15, 29 and 45 patients had aberrant CK7 expression by hepatocytes (CK7<jats:sup>+<\/jats:sup>Hs (2\u2009+), CK7<jats:sup>+<\/jats:sup>Hs (1\u2009+), and CK7<jats:sup>\u2212<\/jats:sup>Hs, respectively). There were significant differences in TB, DB, ALP, TA, IgM, interface activity, and ductopenia grade between patients with CK7<jats:sup>\u2212<\/jats:sup>Hs and CK7<jats:sup>+<\/jats:sup>Hs (2\u2009+) (<jats:italic>P<\/jats:italic>\u2009&lt;\u20090.05). The ductopenia grade was also significantly different between patients with CK7<jats:sup>+<\/jats:sup>Hs (2\u2009+) and CK7<jats:sup>+<\/jats:sup>Hs (1\u2009+) according to sex (<jats:italic>P<\/jats:italic>\u2009&lt;\u20090.05). Upon merging the data of CK7<jats:sup>+<\/jats:sup>Hs (2\u2009+) and CK7<jats:sup>+<\/jats:sup>Hs (1\u2009+) into CK7<jats:sup>+<\/jats:sup>Hs, we found significant differences in AMA, AMA-M2, anti-gp210, TB, DB, ALP, TA, IgM, fibrosis, and ductopenia grade between CK7<jats:sup>+<\/jats:sup>Hs and CK7<jats:sup>\u2212<\/jats:sup>Hs (<jats:italic>P<\/jats:italic>\u2009&lt;\u20090.05). The odds ratios (ORs) (and 95% confidence intervals (CIs)) of CK7<jats:sup>+<\/jats:sup>Hs according to anti-gp210, ductopenia grade, and interface activity were 6.413 (95% CI 1.363\u201330.162), 4.145 (95% CI 1.898\u20139.052) and 3.247 (95% CI 1.556\u20136.775), respectively (<jats:italic>P<\/jats:italic>\u2009&lt;\u20090.05). Spearman's rank correlation according to interface activity and ductopenia grade in patients with CK7<jats:sup>+<\/jats:sup>Hs (2\u2009+\u2009, 1\u2009+\u2009, 0) was<jats:italic>r<\/jats:italic>\u2009=\u20090.359 (<jats:italic>P<\/jats:italic>\u2009=\u20090.001) and<jats:italic>r<\/jats:italic>\u2009=\u20090.396 (<jats:italic>P<\/jats:italic>\u2009&lt;\u20090.001), respectively.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>CK7<jats:sup>+<\/jats:sup>Hs serves as a cholestasis index of PBC and are associated with the ductopenia grade and interface activity. Aberrant cytokeratin 7 expression by hepatocytes can predict the ductopenia grade in primary biliary cholangitis.<\/jats:p><\/jats:sec>","DOI":"10.1186\/s12876-022-02538-w","type":"journal-article","created":{"date-parts":[[2022,11,2]],"date-time":"2022-11-02T12:05:10Z","timestamp":1667390710000},"update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":11,"title":["Aberrant cytokeratin 7 expression by hepatocytes can predict the ductopenia grade in primary biliary cholangitis"],"prefix":"10.1186","volume":"22","author":[{"given":"Hong-Li","family":"Liu","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"An-Yin","family":"Yang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Qing-Fang","family":"Xiong","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yan-Dan","family":"Zhong","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Du-Xian","family":"Liu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ping","family":"Huang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xiao-Ning","family":"Feng","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yu","family":"Zhang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yong-Feng","family":"Yang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2022,11,2]]},"reference":[{"issue":"1","key":"2538_CR1","doi-asserted-by":"publisher","first-page":"47","DOI":"10.1016\/j.ceb.2012.10.018","volume":"25","author":"X Pan","year":"2013","unstructured":"Pan X, Hobbs RP, Coulombe PA. 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This study was approved by the examination of the Second Hospital of Nanjing (No. 2019-ly-kt073). The study protocol conformed to the ethical guidelines of the Declaration of Helsinki.","order":2,"name":"Ethics","group":{"name":"EthicsHeading","label":"Ethics approval and consent to participate"}},{"value":"Not applicable.","order":3,"name":"Ethics","group":{"name":"EthicsHeading","label":"Consent of publication"}},{"value":"The authors declare that they have no competing interests.","order":4,"name":"Ethics","group":{"name":"EthicsHeading","label":"Competing interests"}}],"article-number":"443"}}