{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,4,19]],"date-time":"2026-04-19T08:16:09Z","timestamp":1776586569990,"version":"3.51.2"},"reference-count":57,"publisher":"Springer Science and Business Media LLC","issue":"1","license":[{"start":{"date-parts":[[2022,11,19]],"date-time":"2022-11-19T00:00:00Z","timestamp":1668816000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0"},{"start":{"date-parts":[[2022,11,19]],"date-time":"2022-11-19T00:00:00Z","timestamp":1668816000000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0"}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["BMC Gastroenterol"],"abstract":"<jats:title>Abstract<\/jats:title><jats:sec>\n                <jats:title>Purpose<\/jats:title>\n                <jats:p>The aim of this study was to investigate the efficacy and safety of the combination of low-molecular-weight heparin\u2009+\u2009dexamethasone after partial splenic embolization in cirrhotic patients with massive splenomegaly.<\/jats:p>\n              <\/jats:sec><jats:sec>\n                <jats:title>Methods<\/jats:title>\n                <jats:p>This study included 116 patients with liver cirrhosis complicated with massive splenomegaly who underwent PSE in Union Hospital from January 2016 to December 2019, and they met the criteria. They were divided into two groups: PSE\u2009+\u2009Hep\u2009+\u2009Dex group (N\u2009=\u200954) and PSE group (N\u2009=\u200962). We conducted a retrospective study to analyze the efficacy and safety of the two groups of patients.<\/jats:p>\n              <\/jats:sec><jats:sec>\n                <jats:title>Results<\/jats:title>\n                <jats:p>The volume of splenic embolization was 622.34\u2009\u00b1\u2009157.06\u00a0cm<jats:sup>3<\/jats:sup> in the PSE\u2009+\u2009Hep\u2009+\u2009DEX group and 587.62\u2009\u00b1\u2009175.33\u00a0cm<jats:sup>3<\/jats:sup> in the PSE group (<jats:italic>P<\/jats:italic>\u2009=\u20090.306). There was no statistically difference in the embolization rate of the spleen between the two groups (<jats:italic>P<\/jats:italic>\u2009=\u20090.573). WBC peaked 1\u00a0week after PSE and PLT peaked 1\u00a0month after PSE in both groups; it gradually decreased later, but was significantly higher than the preoperative level during the 12-month follow-up period. The incidences of abdominal pain (46.3% vs 66.1%, <jats:italic>P<\/jats:italic>\u2009=\u20090.039), fever (38.9% vs 75.8%, <jats:italic>P<\/jats:italic>\u2009&lt;\u20090.001), PVT (1.9% vs 12.9%, <jats:italic>P<\/jats:italic>\u2009=\u20090.026), refractory ascites (5.6% vs 19.4%, <jats:italic>P<\/jats:italic>\u2009=\u20090.027) were lower in the PSE\u2009+\u2009Hep\u2009+\u2009DEX group than in the PSE group. The VAS score of abdominal pain in PSE group was higher than that in PSE\u2009+\u2009Hep\u2009+\u2009DEX group on postoperative days 2\u20138 (<jats:italic>P<\/jats:italic>\u2009&lt;\u20090.05). Splenic abscess occurred in 1(1.6%) patient in the PSE group and none (0.0%) in the PSE\u2009+\u2009Hep\u2009+\u2009DEX group (<jats:italic>P<\/jats:italic>\u2009=\u20090.349).<\/jats:p>\n              <\/jats:sec><jats:sec>\n                <jats:title>Conclusions<\/jats:title>\n                <jats:p>The combined use of dexamethasone and low-molecular-weight heparin after PSE is a safe and effective treatment strategy that can significantly reduce the incidence of complications after PSE (such as post-embolization syndrome, PVT, refractory ascites).<\/jats:p>\n              <\/jats:sec>","DOI":"10.1186\/s12876-022-02580-8","type":"journal-article","created":{"date-parts":[[2022,11,19]],"date-time":"2022-11-19T07:03:09Z","timestamp":1668841389000},"update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":9,"title":["Efficacy and safety of heparin plus dexamethasone after partial splenic embolization for liver cirrhosis with massive splenomegaly"],"prefix":"10.1186","volume":"22","author":[{"given":"Haohao","family":"Lu","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Chuansheng","family":"Zheng","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Bin","family":"Xiong","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Xiangwen","family":"Xia","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"297","published-online":{"date-parts":[[2022,11,19]]},"reference":[{"issue":"23","key":"2580_CR1","doi-asserted-by":"publisher","first-page":"7312","DOI":"10.3748\/wjg.v20.i23.7312","volume":"20","author":"WC Zhou","year":"2014","unstructured":"Zhou WC, Zhang QB, Qiao L. 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Although the ethics committee gave up the written consent, for the safety and rationality of the research, we still signed the informed consent for all the participants. During follow-up, we informed patients about the study and they agreed to use their data. We confirm that all methods were performed in accordance with the relevant guidelines and Declaration of Helsinki.","order":2,"name":"Ethics","group":{"name":"EthicsHeading","label":"Ethics approval and consent to participate"}},{"value":"All participants' information, images and inspection results are agreed to be published and have obtained informed consent. The details, images will be freely available on the internet and may be seen by the general public. The consent form is available if requested. These patients have not been reported in any other submission by anyone.","order":3,"name":"Ethics","group":{"name":"EthicsHeading","label":"Consent for publication"}},{"value":"We declare that we have no financial and personal relationships with other people or organizations that can inappropriately influence our work, there is no professional or other personal interest of any nature or kind in any product, service and company that could be construed as influencing the position presented in this manuscript.","order":4,"name":"Ethics","group":{"name":"EthicsHeading","label":"Competing interests"}}],"article-number":"470"}}