{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,15]],"date-time":"2026-10-15T04:25:10Z","timestamp":1792038310321,"version":"4.4.0"},"reference-count":25,"publisher":"Springer Science and Business Media LLC","issue":"1","license":[{"start":{"date-parts":[[2022,12,8]],"date-time":"2022-12-08T00:00:00Z","timestamp":1670457600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0"},{"start":{"date-parts":[[2022,12,8]],"date-time":"2022-12-08T00:00:00Z","timestamp":1670457600000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0"}],"funder":[{"name":"the municipal health commission of Pudong new area","award":["PW2021B-11"],"award-info":[{"award-number":["PW2021B-11"]}]},{"name":"the Shanghai Committee of Science and Technology","award":["21JC1405200"],"award-info":[{"award-number":["21JC1405200"]}]},{"name":"Medical Discipline Construction Project of Pudong Health Committee of Shanghai","award":["PWYgf2021-2"],"award-info":[{"award-number":["PWYgf2021-2"]}]}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["BMC Gastroenterol"],"abstract":"<jats:title>Abstract<\/jats:title><jats:sec>\n                <jats:title>Background<\/jats:title>\n                <jats:p>There\u00a0has always been\u00a0a debate\u00a0on\u00a0the\u00a0optimal timing\u00a0of\u00a0endoscopy in patients with acute variceal bleeding\u00a0(AVB).\n<\/jats:p>\n              <\/jats:sec><jats:sec>\n                <jats:title>Objective<\/jats:title>\n                <jats:p>This study aimed to examine the relation between the timing of endoscopy and the short-term outcomes of patients with AVB.<\/jats:p>\n              <\/jats:sec><jats:sec>\n                <jats:title>Methods<\/jats:title>\n                <jats:p>Patients with AVB who underwent endoscopy within 24\u00a0h after admission at our tertiary care center from 2014 to 2022 were evaluated retrospectively. The primary outcomes were the 6-week mortality and re-bleeding. The secondary outcomes included the total number of blood units transfused, the length of hospital stay, and the need for salvage therapy. We\u00a0used\u00a0Cox proportional hazards model to analyze the predictors of 6-week mortality in all patients\u00a0as\u00a0well\u00a0as\u00a0in those who were at high risk of further bleeding or death.<\/jats:p>\n              <\/jats:sec><jats:sec>\n                <jats:title>Results<\/jats:title>\n                <jats:p>A total of 312 patients were enrolled. Among them, 170 patients (54.49%) underwent urgent endoscopy (&lt;\u20096\u00a0h), and 142 patients (45.51%) underwent early endoscopy (6\u201324\u00a0h). There were no significant differences between the urgent-endoscopy group and the early-endoscopy group, regarding the 6-week mortality (16.47% vs. 10.56%; <jats:italic>P<\/jats:italic> value\u2009=\u20090.132) and 6-week re-bleeding rate (11.2% vs. 16.2%; <jats:italic>P<\/jats:italic> value\u2009=\u20090.196). In multivariate analysis, time to endoscopy was independent of 6-week mortality (<jats:italic>P<\/jats:italic> value\u2009=\u20090.170), but the time between the beginning of bleeding and endoscopy (within 12\u00a0h) was significantly associated with low 6-week mortality (OR: 0.16; 95% CI: 0.06\u20130.46; <jats:italic>P<\/jats:italic> value\u2009=\u20090.001). Time to endoscopy was still not associated with 6-week mortality in patients at high risk for further bleeding or death (Glasgow-Blatchford score\u2009\u2265\u200912, <jats:italic>n<\/jats:italic>\u2009=\u2009138, <jats:italic>P<\/jats:italic> value\u2009=\u20090.902).<\/jats:p>\n              <\/jats:sec><jats:sec>\n                <jats:title>Conclusions<\/jats:title>\n                <jats:p>Endoscopy performed within 6\u00a0h of admission, rather than within 6 to 24\u00a0h, did not improve six-week clinical outcomes in patients in stable condition with AVB and even those who were at high risk of further bleeding and death.<\/jats:p>\n              <\/jats:sec>","DOI":"10.1186\/s12876-022-02595-1","type":"journal-article","created":{"date-parts":[[2022,12,8]],"date-time":"2022-12-08T14:24:01Z","timestamp":1670509441000},"update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":13,"title":["The influences of timing of urgent endoscopy in patients with acute variceal bleeding: a cohort study"],"prefix":"10.1186","volume":"22","author":[{"given":"Xiaohan","family":"Yan","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zhuyun","family":"Leng","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Qinwei","family":"Xu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zehua","family":"Zhang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Meidong","family":"Xu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jingze","family":"Li","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2022,12,8]]},"reference":[{"issue":"5","key":"2595_CR1","doi-asserted-by":"publisher","first-page":"682","DOI":"10.1136\/gut.49.5.682","volume":"49","author":"PA McCormick","year":"2001","unstructured":"McCormick PA, O\u2019Keefe C. 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All methods were performed in accordance with the relevant guidelines and regulations. We obtained written informed consent from all patients.","order":2,"name":"Ethics","group":{"name":"EthicsHeading","label":"Ethics approval and consent to participate"}},{"value":"Not Applicable.","order":3,"name":"Ethics","group":{"name":"EthicsHeading","label":"Consent for publication"}},{"value":"The authors who have taken part in this study declared that they do not have anything to disclose regarding funding or conflicts of interest with respect to this manuscript.","order":4,"name":"Ethics","group":{"name":"EthicsHeading","label":"Competing interests"}}],"article-number":"506"}}