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Genetic insights into the interaction between age-related alterations in the gut microbiota and immune function remain largely unexplored.<\/jats:p>\n              <\/jats:sec><jats:sec>\n                <jats:title>Methods<\/jats:title>\n                <jats:p>We investigated\u00a0publicly available transcriptomic gut profiles of young germ-free mouse hosts transplanted with old donor gut microbiota to identify immune-associated differentially expressed genes (DEGs). Literature screening of the Gene Expression Omnibus and PubMed identified one murine (<jats:italic>Mus musculus<\/jats:italic>) gene expression dataset (GSE130026) that included small intestine tissues from young (5\u20136\u00a0weeks old) germ-free mice hosts that were compared following 8\u00a0weeks after transplantation with either old (~\u200924-month old; <jats:italic>n<\/jats:italic>\u2009=\u20095) or young (5\u20136\u00a0weeks old; <jats:italic>n<\/jats:italic>\u2009=\u20094) mouse donor gut microbiota.<\/jats:p>\n              <\/jats:sec><jats:sec>\n                <jats:title>Results<\/jats:title>\n                <jats:p>A total of 112 differentially expressed genes (DEGs) were identified and used to construct a gut network of encoded proteins, in which DEGs were functionally annotated as being involved in an immune process based on gene ontology. The association between the expression of immune-process DEGs and abundance of immune infiltrates from gene signatures in normal colorectal tissues was estimated from The Cancer Genome Atlas (TCGA) and Genotype-Tissue Expression (GTEx) project. The analysis revealed a 25-gene signature of immune-associated DEGs and their expression profile was positively correlated with na\u00efve T-cell, effector memory T-cell, central memory T-cell, resident memory T-cell, exhausted T-cell, resting Treg T-cell, effector Treg T-cell and Th1-like colorectal gene signatures.<\/jats:p>\n                <jats:p><jats:bold>Conclusions<\/jats:bold><\/jats:p>\n                <jats:p>These genes may have a potential role as candidate markers of immune dysregulation during gut microbiota ageing. Moreover, these DEGs may\u00a0provide insights into the altered immune response to microbiota in the ageing gut, including reduced antigen presentation and alterations in cytokine and chemokine production.<\/jats:p>\n              <\/jats:sec>","DOI":"10.1186\/s12876-022-02613-2","type":"journal-article","created":{"date-parts":[[2022,12,21]],"date-time":"2022-12-21T17:05:03Z","timestamp":1671642303000},"update-policy":"http:\/\/dx.doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":6,"title":["Markers of immune dysregulation in response to the ageing gut: insights from aged murine gut microbiota transplants"],"prefix":"10.1186","volume":"22","author":[{"given":"Panagiotis","family":"Giannos","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Konstantinos","family":"Prokopidis","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Masoud","family":"Isanejad","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Helen L.","family":"Wright","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"297","published-online":{"date-parts":[[2022,12,21]]},"reference":[{"key":"2613_CR1","doi-asserted-by":"publisher","first-page":"21","DOI":"10.1016\/j.jim.2018.08.005","volume":"463","author":"AAS Akha","year":"2018","unstructured":"Akha AAS. 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