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Subjects were classified into two groups according to whether they had ICP: 688 cases of ICP were assigned to an exposure group while 38,556 cases of non-ICP were assigned to a non-exposed group. Univariate analysis was performed on qualitative or quantitative data using the Chi-Squared test or Mann\u2013Whitney<jats:italic>U<\/jats:italic>test, and the adjusted odds ratio (aOR) and 95% confidence interval (CI) of the two groups of related variables were calculated by multivariate binary logistic regression analysis.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>The incidence rate of ICP was 1.75%. Pregnant women with hepatitis B virus were correlated with ICP. Hepatitis B carriers (aOR\u2009=\u20093.873), preeclampsia (PE, aOR\u2009=\u20093.712), thrombocytopenia (aOR\u2009=\u20091.992), gestational hypertension (GH, aOR\u2009=\u20091.627), hyperlipidemia (aOR\u2009=\u20091.602) and gestational diabetes mellitus (GDM, aOR\u2009=\u20091.265) were all risk factors for ICP. In contrast, Body Mass Index (BMI) \u2265 30\u00a0kg\/m<jats:sup>2<\/jats:sup>(aOR\u2009=\u20090.446), 25\u2009m<jats:sup>2<\/jats:sup>&lt;\u2009maternal BMI\u2009&lt;\u200929.9\u00a0kg\/m<jats:sup>2<\/jats:sup>(aOR\u2009=\u20090.699) and parity\u2009\u2265\u20091 (aOR\u2009=\u20090.722) were protective factors for ICP. Pregnant women in the ICP group had an increased risk of gestation days\u2009&lt;\u2009259 days\u00a0(aOR\u2009=\u20094.574) and cesarean delivery (aOR\u2009=\u20091.930) after ICP, and a decreased risk of longer gestational days (aOR\u2009=\u20090.105), premature rupture of membranes (aOR\u2009=\u20090.384) and fetal macrosomia (aOR\u2009=\u20090.551).<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>By analyzing a Chinese population with ICP, we identified that pregnant women who are hepatitis B carriers or with PE, thrombocytopenia, GH, hyperlipidemia, and GDM are at higher risk of ICP. Moreover, ICP is associated with adverse pregnancy outcomes; in particular, ICP may increase the incidence of shorter gestational days and non-vaginal delivery methods such as cesarean section but reduce the incidence of premature rupture of membranes and fetal macrosomia.<\/jats:p><\/jats:sec>","DOI":"10.1186\/s12876-023-02652-3","type":"journal-article","created":{"date-parts":[[2023,1,18]],"date-time":"2023-01-18T05:02:39Z","timestamp":1674018159000},"update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":34,"title":["The impact of intrahepatic cholestasis on pregnancy outcomes: a retrospective cohort study"],"prefix":"10.1186","volume":"23","author":[{"given":"Yiming","family":"Chen","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Huimin","family":"Zhang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Wenwen","family":"Ning","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yijie","family":"Chen","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Caihe","family":"Wen","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2023,1,18]]},"reference":[{"issue":"1","key":"2652_CR1","doi-asserted-by":"publisher","first-page":"120","DOI":"10.1097\/AOG.0000000000000346","volume":"124","author":"C Williamson","year":"2014","unstructured":"Williamson C, Geenes V. 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