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Our study aims to determine the role of elevated serum TG levels at admission in developing pancreatic necrosis.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>We analyzed the clinical data collected prospectively from patients with AP. According to TG levels measured in the first 24\u00a0h after admission, we stratified patients into four groups: Normal TG (&lt;\u2009150\u00a0mg\/dL), Borderline-high TG (150\u2013199\u00a0mg\/dL), High TG (200\u2013499\u00a0mg\/dL) and Very high TG (\u2265\u2009500\u00a0mg\/dL). We analyzed the association of TG levels and other risk factors with the development of pancreatic necrosis.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>\n                      A total of 211 patients were included. In the Normal TG group: 122, in Borderline-high TG group: 38, in High TG group: 44, and in Very high TG group: 7. Pancreatic necrosis developed in 29.5% of the patients in the Normal TG group, 26.3% in the Borderline-high TG group, 52.3% in the High TG group, and 85.7% in the Very high TG group. The trend analysis observed a significant association between higher TG levels and pancreatic necrosis (\n                      <jats:italic>p<\/jats:italic>\n                      \u2009=\u20090.001). A multivariable analysis using logistic regression showed that elevated TG levels\u2009\u2265\u2009200\u00a0mg\/dL (High TG and Very high TG groups) were independently associated with pancreatic necrosis (OR: 3.27, 95% CI\u2009\u2212\u20096.27,\n                      <jats:italic>p<\/jats:italic>\n                      \u2009&lt;\u20090.001).\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions<\/jats:title>\n                    <jats:p>An elevated TG level at admission\u2009\u2265\u2009200\u00a0mg\/dl is independently associated with the development of pancreatic necrosis. The incidence of pancreatic necrosis increases proportionally with the severity of HTG.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1186\/s12876-023-02684-9","type":"journal-article","created":{"date-parts":[[2023,2,24]],"date-time":"2023-02-24T12:02:57Z","timestamp":1677240177000},"update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":13,"title":["The role of high serum triglyceride levels on pancreatic necrosis development and related complications"],"prefix":"10.1186","volume":"23","author":[{"given":"Nils Jimmy","family":"Hidalgo","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-6898-5502","authenticated-orcid":false,"given":"Elizabeth","family":"Pando","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Piero","family":"Alberti","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Rodrigo","family":"Mata","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nair","family":"Fernandes","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Montse","family":"Adell","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sara","family":"Villasante","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Laia","family":"Blanco","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Joaquim","family":"Balsells","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ramon","family":"Charco","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2023,2,24]]},"reference":[{"key":"2684_CR1","doi-asserted-by":"publisher","first-page":"491","DOI":"10.1016\/j.annepidem.2007.02.002","volume":"17","author":"PJ Fagenholz","year":"2007","unstructured":"Fagenholz PJ, Castillo CF, Harris NS, Pelletier AJ, Camargo CA. 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