{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,10]],"date-time":"2026-06-10T15:09:34Z","timestamp":1781104174429,"version":"3.54.1"},"reference-count":44,"publisher":"Springer Science and Business Media LLC","issue":"1","license":[{"start":{"date-parts":[[2023,6,12]],"date-time":"2023-06-12T00:00:00Z","timestamp":1686528000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0"},{"start":{"date-parts":[[2023,6,12]],"date-time":"2023-06-12T00:00:00Z","timestamp":1686528000000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0"}],"funder":[{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["82170651"],"award-info":[{"award-number":["82170651"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["81870442"],"award-info":[{"award-number":["81870442"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["BMC Gastroenterol"],"abstract":"<jats:title>Abstract<\/jats:title><jats:sec>\n                <jats:title>Background<\/jats:title>\n                <jats:p>Pancreatic endocrine insufficiency is more likely to occur after acute pancreatitis (AP), but the risk factors affecting pancreatic endocrine function remain controversial. Therefore, exploring the incidence and risk factors of fasting hyperglycaemia following first-attack AP is important.<\/jats:p>\n              <\/jats:sec><jats:sec>\n                <jats:title>Methods<\/jats:title>\n                <jats:p>Data were collected from 311 individuals with first-attack AP without previous diabetes mellitus (DM) or impaired fasting glucose (IFG) history treated in the Renmin Hospital of Wuhan University. Relevant statistical tests were performed. A two-sided p-value\u2009&lt;\u20090.05 was considered statistically significant.<\/jats:p>\n              <\/jats:sec><jats:sec>\n                <jats:title>Results<\/jats:title>\n                <jats:p>The incidence of fasting hyperglycaemia in individuals with first-attack AP was 45.3%. Univariate analysis showed that age (\u03c7<jats:sup>2<\/jats:sup>\u2009=\u20096.27, <jats:italic>P<\/jats:italic>\u2009=\u20090.012), aetiology (\u03c7<jats:sup>2<\/jats:sup>\u2009=\u200911.184, <jats:italic>P<\/jats:italic>\u2009=\u20090.004), serum total cholesterol (TC) (\u03c7<jats:sup>2<\/jats:sup>\u2009=\u200914.622, <jats:italic>P<\/jats:italic>\u2009&lt;\u20090.001), and serum triglyceride (TG) (\u03c7<jats:sup>2<\/jats:sup>\u2009=\u200915.006, <jats:italic>P<\/jats:italic>\u2009&lt;\u20090.001) were significantly different between the hyperglycaemia and non-hyperglycaemia groups (<jats:italic>P<\/jats:italic>\u2009&lt;\u20090.05). The serum calcium concentration (Z=-2.480, <jats:italic>P<\/jats:italic>\u2009=\u20090.013) was significantly different between the two groups (<jats:italic>P<\/jats:italic>\u2009&lt;\u20090.05). Multiple logistic regression analysis showed that age- \u226560 years (<jats:italic>P<\/jats:italic>\u2009&lt;\u20090.001, OR\u2009=\u20092.631, 95%Cl\u2009=\u20091.529\u20134.527) and TG\u2009\u2265\u20095.65 mmol\/L (<jats:italic>P<\/jats:italic>\u2009&lt;\u20090.001, OR\u2009=\u20093.964, 95%Cl\u2009=\u20091.990\u20137.895) were independent risk factors for fasting hyperglycaemia in individuals with first-attack AP (<jats:italic>P<\/jats:italic>\u2009&lt;\u20090.05).<\/jats:p>\n              <\/jats:sec><jats:sec>\n                <jats:title>Conclusions<\/jats:title>\n                <jats:p>Old age, serum triglycerides, serum total cholesterol, hypocalcaemia, and aetiology are associated with fasting hyperglycaemia following first-attack AP. Age\u2009\u2265\u200960 years and TG\u2009\u2265\u20095.65 mmol\/L are independent risk factors for fasting hyperglycaemia following first-attack AP.<\/jats:p>\n              <\/jats:sec>","DOI":"10.1186\/s12876-023-02775-7","type":"journal-article","created":{"date-parts":[[2023,6,12]],"date-time":"2023-06-12T10:02:09Z","timestamp":1686564129000},"update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":5,"title":["Incidence and risk factors of fasting hyperglycaemia following first-attack acute pancreatitis before discharge: a retrospective study"],"prefix":"10.1186","volume":"23","author":[{"given":"Chengsi","family":"Liu","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Qiao","family":"Shi","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xiaoyi","family":"Zhang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Enfu","family":"Xue","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hanjun","family":"Li","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Weixing","family":"Wang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2023,6,12]]},"reference":[{"key":"2775_CR1","doi-asserted-by":"publisher","DOI":"10.1053\/j.gastro","author":"SD Crockett","year":"2018","unstructured":"Crockett SD, Wani S, Gardner TB, Falck-Ytter Y, Barkun AN, American Gastroenterological Association Institute Clinical Guidelines Committee. Gastroenterology. 2018;154(4):1096\u2013101. https:\/\/doi.org\/10.1053\/j.gastro. American Gastroenterological Association Institute Guideline on Initial Management of Acute Pancreatitis[J]."},{"issue":"9988","key":"2775_CR2","doi-asserted-by":"publisher","first-page":"85","DOI":"10.1016\/S0140-6736(14)60649-8","volume":"386","author":"PG Lankisch","year":"2015","unstructured":"Lankisch PG, Apte M, Banks PA. Acute pancreatitis[J]. Lancet. 2015;386(9988):85\u201396. https:\/\/doi.org\/10.1016\/S0140-6736(14)60649-8.","journal-title":"Lancet"},{"issue":"3","key":"2775_CR3","doi-asserted-by":"publisher","first-page":"245","DOI":"10.1159\/000212089","volume":"9","author":"H Pelli","year":"2009","unstructured":"Pelli H, Lappalainen-Lehto R, Piironen A, J\u00e4rvinen S, Sand J, Nordback I. Pancreatic damage after the First Episode of Acute Alcoholic Pancreatitis and its Association with the later recurrence Rate[J]. Pancreatology. 2009;9(3):245\u201351. https:\/\/doi.org\/10.1159\/000212089.","journal-title":"Pancreatology"},{"issue":"1","key":"2775_CR4","doi-asserted-by":"publisher","first-page":"117","DOI":"10.1016\/j.hfc.2015.08.010","volume":"12","author":"D Aronson","year":"2016","unstructured":"Aronson D, Edelman ER. Coronary artery disease and diabetes mellitus[J]. Heart Fail Clin. 2016;12(1):117\u201333. https:\/\/doi.org\/10.1016\/j.hfc.2015.08.010.","journal-title":"Heart Fail Clin"},{"issue":"3","key":"2775_CR5","doi-asserted-by":"publisher","first-page":"213","DOI":"10.2337\/diacare.17.3.213","volume":"17","author":"DS Bell","year":"1994","unstructured":"Bell DS. Stroke in the diabetic patient[J]. Diabetes Care. 1994;17(3):213\u20139. https:\/\/doi.org\/10.2337\/diacare.17.3.213.","journal-title":"Diabetes Care"},{"issue":"1","key":"2775_CR6","doi-asserted-by":"publisher","first-page":"164","DOI":"10.2337\/diacare.28.1.164","volume":"28","author":"JL Gross","year":"2005","unstructured":"Gross JL, de Azevedo MJ, Silveiro SP, Canani LH, Caramori ML, Zelmanovitz T. Diabetic nephropathy: diagnosis, prevention, and treatment[J]. Diabetes Care. 2005;28(1):164\u201376. https:\/\/doi.org\/10.2337\/diacare.28.1.164.","journal-title":"Diabetes Care"},{"issue":"9735","key":"2775_CR7","doi-asserted-by":"publisher","first-page":"124","DOI":"10.1016\/S0140-6736(09)62124-3","volume":"376","author":"N Cheung","year":"2010","unstructured":"Cheung N, Mitchell P, Wong TY. Diabetic retinopathy[J]. Lancet. 2010;376(9735):124\u201336. https:\/\/doi.org\/10.1016\/S0140-6736(09)62124-3.","journal-title":"Lancet"},{"issue":"8","key":"2775_CR8","doi-asserted-by":"publisher","first-page":"668","DOI":"10.1016\/S2468-1253(21)00019-4","volume":"6","author":"PA Hart","year":"2021","unstructured":"Hart PA, Bradley D, Conwell DL, et al. Diabetes following acute pancreatitis[J]. Lancet Gastroenterol Hepatol. 2021;6(8):668\u201375. https:\/\/doi.org\/10.1016\/S2468-1253(21)00019-4.","journal-title":"Lancet Gastroenterol Hepatol"},{"issue":"1","key":"2775_CR9","doi-asserted-by":"publisher","first-page":"4","DOI":"10.1016\/j.diabres.2009.10.007","volume":"87","author":"JE Shaw","year":"2010","unstructured":"Shaw JE, Sicree RA, Zimmet PZ. Global estimates of the prevalence of diabetes for 2010 and 2030[J]. Diabetes Res Clin Pract. 2010;87(1):4\u201314. https:\/\/doi.org\/10.1016\/j.diabres.2009.10.007.","journal-title":"Diabetes Res Clin Pract"},{"issue":"2","key":"2775_CR10","doi-asserted-by":"publisher","first-page":"e2448","DOI":"10.1097\/MD.0000000000002448","volume":"95","author":"YK Lee","year":"2016","unstructured":"Lee YK, Huang MY, Hsu CY, Su YC. Bidirectional relationship between diabetes and Acute Pancreatitis: a Population-Based Cohort Study in Taiwan[J]. Medicine(Baltimore). 2016;95(2):e2448. https:\/\/doi.org\/10.1097\/MD.0000000000002448.","journal-title":"Medicine(Baltimore)"},{"key":"2775_CR11","doi-asserted-by":"publisher","unstructured":"Jivanji CJ, Asrani VM, Windsor JA, Petrov MS. New-Onset Diabetes After Acute and Critical Illness: A Systematic Review[J]. Mayo Clin Proc. 2017;92(5):762\u2013773. doi: https:\/\/doi.org\/10.1016\/j.mayocp.2016.12.020.","DOI":"10.1016\/j.mayocp.2016.12.020"},{"key":"2775_CR12","doi-asserted-by":"publisher","first-page":"637","DOI":"10.3389\/fphys.2019.00637","volume":"10","author":"M Zhi","year":"2019","unstructured":"Zhi M, Zhu X, Lugea A, et al. Incidence of New Onset Diabetes Mellitus secondary to Acute Pancreatitis: a systematic review and Meta-Analysis[J]. Front Physiol. 2019;10:637. https:\/\/doi.org\/10.3389\/fphys.2019.00637.","journal-title":"Front Physiol"},{"key":"2775_CR13","doi-asserted-by":"publisher","first-page":"998499","DOI":"10.3389\/fendo.2022.998499","volume":"13","author":"X Yang","year":"2022","unstructured":"Yang X, Shi N, Yao L, et al. Impact of admission and early persistent stress hyperglycaemia on clinical outcomes in acute pancreatitis[J]. Front Endocrinol (Lausanne). 2022;13:998499. https:\/\/doi.org\/10.3389\/fendo.2022.998499.","journal-title":"Front Endocrinol (Lausanne)"},{"issue":"5","key":"2775_CR14","doi-asserted-by":"publisher","first-page":"1879","DOI":"10.1007\/s10620-021-06982-8","volume":"67","author":"X Yang","year":"2022","unstructured":"Yang X, Zhang R, Jin T, et al. Stress hyperglycaemia is independently Associated with Persistent Organ failure in Acute Pancreatitis[J]. Dig Dis Sci. 2022;67(5):1879\u201389. https:\/\/doi.org\/10.1007\/s10620-021-06982-8.","journal-title":"Dig Dis Sci"},{"issue":"8","key":"2775_CR15","doi-asserted-by":"publisher","first-page":"1108","DOI":"10.2337\/diacare.23.8.1108","volume":"23","author":"MM Gabir","year":"2000","unstructured":"Gabir MM, Hanson RL, Dabelea D, Imperatore G, Roumain J, Bennett PH, Knowler WC. The 1997 american Diabetes Association and 1999 World Health Organization criteria for hyperglycaemia in the diagnosis and prediction of diabetes[J]. Diabetes Care. 2000;23(8):1108\u201312. https:\/\/doi.org\/10.2337\/diacare.23.8.1108.","journal-title":"Diabetes Care"},{"issue":"1","key":"2775_CR16","doi-asserted-by":"publisher","first-page":"102","DOI":"10.1136\/gutjnl-2012-302779","volume":"62","author":"PA Banks","year":"2013","unstructured":"Banks PA, Bollen TL, Dervenis C, et al. Classification of acute pancreatitis\u20132012: revision of the Atlanta classification and definitions by international consensus[J]. Gut. 2013;62(1):102\u201311. https:\/\/doi.org\/10.1136\/gutjnl-2012-302779.","journal-title":"Gut"},{"issue":"5","key":"2775_CR17","first-page":"390","volume":"35","author":"Joint Committee for Developing Chinese guidelines on Prevention and Treatment of Dyslipidemia in Adults","year":"2007","unstructured":"Joint Committee for Developing Chinese guidelines on Prevention and Treatment of Dyslipidemia in Adults. [Chinese guidelines on prevention and treatment of dyslipidemia in adults]. Zhonghua xin xue guan bing za zhi. 2007;35(5):390\u2013419. Chinese. PMID: 17711682.","journal-title":"Zhonghua xin xue guan bing za zhi"},{"issue":"9","key":"2775_CR18","doi-asserted-by":"publisher","first-page":"621","DOI":"10.1136\/emermed-2017-207038.1","volume":"34","author":"J Wilson","year":"2017","unstructured":"Wilson J, Zarabi S. BET 1: SIRS criteria as a way of predicting mortality in acute pancreatitis[J]. Emerg Med J. 2017;34(9):621\u20132. https:\/\/doi.org\/10.1136\/emermed-2017-207038.1.","journal-title":"Emerg Med J"},{"issue":"4","key":"2775_CR19","doi-asserted-by":"publisher","first-page":"382","DOI":"10.1001\/jama.2020.20317","volume":"325","author":"MA Mederos","year":"2021","unstructured":"Mederos MA, Reber HA, Girgis MD. Acute Pancreatitis: a review [J]. JAMA. 2021;325(4):382\u201390. https:\/\/doi.org\/10.1001\/jama.2020.20317.","journal-title":"JAMA"},{"issue":"7","key":"2775_CR20","doi-asserted-by":"publisher","first-page":"455","DOI":"10.1042\/CS20211031","volume":"136","author":"N Hu","year":"2022","unstructured":"Hu N, Zhang X, Zhang X, et al. Inhibition of notch activity suppresses hyperglycaemia-augmented polarization of macrophages to the M1 phenotype and alleviates acute pancreatitis[J]. Clin Sci (Lond). 2022;136(7):455\u201371. https:\/\/doi.org\/10.1042\/CS20211031.","journal-title":"Clin Sci (Lond)"},{"key":"2775_CR21","doi-asserted-by":"publisher","unstructured":"Dungan KM, Braithwaite SS, Preiser JC. Stress hyperglycaemia[J]. Lancet. 2009;373(9677): 1798 \u2013 807. doi: https:\/\/doi.org\/10.1016\/S0140-6736(09)60553-5.","DOI":"10.1016\/S0140-6736(09)60553-5"},{"issue":"4","key":"2775_CR22","doi-asserted-by":"publisher","first-page":"523","DOI":"10.1016\/j.pan.2017.06.007","volume":"17","author":"MS Petrov","year":"2017","unstructured":"Petrov MS. Diabetes of the exocrine pancreas: american Diabetes Association-compliant lexicon[J]. Pancreatology. 2017;17(4):523\u20136. https:\/\/doi.org\/10.1016\/j.pan.2017.06.007.","journal-title":"Pancreatology"},{"issue":"1","key":"2775_CR23","doi-asserted-by":"publisher","first-page":"114","DOI":"10.1186\/s12876-017-0663-0","volume":"17","author":"JF Tu","year":"2017","unstructured":"Tu JF, Zhang JZ, Ke L, et al. Endocrine and exocrine pancreatic insufficiency after acute pancreatitis: long-term follow-up study[J]. BMC Gastroenterol. 2017;17(1):114. https:\/\/doi.org\/10.1186\/s12876-017-0663-0.","journal-title":"BMC Gastroenterol"},{"issue":"1","key":"2775_CR24","doi-asserted-by":"publisher","first-page":"G50","DOI":"10.1152\/ajpgi.00074.2016","volume":"311","author":"SA Pendharkar","year":"2016","unstructured":"Pendharkar SA, Asrani VM, Xiao AY, et al. Relationship between pancreatic hormones and glucose metabolism: a cross-sectional study in patients after acute pancreatitis[J]. Am J Physiol Gastrointest Liver Physiol. 2016;311(1):G50\u20138. https:\/\/doi.org\/10.1152\/ajpgi.00074.2016.","journal-title":"Am J Physiol Gastrointest Liver Physiol"},{"issue":"12","key":"2775_CR25","doi-asserted-by":"publisher","first-page":"1698","DOI":"10.1038\/ajg.2015.356","volume":"110","author":"HN Shen","year":"2015","unstructured":"Shen HN, Yang CC, Chang YH, Lu CL, Li CY. Risk of diabetes Mellitus after First-Attack Acute Pancreatitis: A National Population-Based Study[J]. Am J Gastroenterol. 2015;110(12):1698\u2013706. https:\/\/doi.org\/10.1038\/ajg.2015.356.","journal-title":"Am J Gastroenterol"},{"issue":"10","key":"2775_CR26","doi-asserted-by":"publisher","first-page":"2904","DOI":"10.1016\/j.celrep.2018.11.031","volume":"25","author":"M Wortham","year":"2018","unstructured":"Wortham M, Benthuysen JR, Wallace M, et al. Integrated in vivo quantitative proteomics and nutrient tracing reveals age-related metabolic rewiring of pancreatic \u03b2 cell Function[J]. Cell Rep. 2018;25(10):2904\u201318. https:\/\/doi.org\/10.1016\/j.celrep.2018.11.031. e8.","journal-title":"Cell Rep"},{"issue":"10027","key":"2775_CR27","doi-asserted-by":"publisher","first-page":"1513","DOI":"10.1016\/S0140-6736(16)00618-8","volume":"387","author":"NCD Risk Factor Collaboration (NCD-RisC)","year":"2016","unstructured":"NCD Risk Factor Collaboration (NCD-RisC). Worldwide trends in diabetes since 1980: a pooled analysis of 751 population-based studies with 4.4 million participants[J]. Lancet. 2016;387(10027):1513\u201330. https:\/\/doi.org\/10.1016\/S0140-6736(16)00618-8.","journal-title":"Lancet"},{"key":"2775_CR28","doi-asserted-by":"publisher","first-page":"1223","DOI":"10.1186\/1471-2458-13-1223","volume":"13","author":"SM Shamshirgaran","year":"2013","unstructured":"Shamshirgaran SM, Jorm L, Bambrick H, Hennessy A. Independent roles of country of birth and socioeconomic status in the occurrence of type 2 diabetes[J]. BMC Public Health. 2013;13:1223. https:\/\/doi.org\/10.1186\/1471-2458-13-1223.","journal-title":"BMC Public Health"},{"key":"2775_CR29","doi-asserted-by":"publisher","unstructured":"Egede LE, Dagogo-Jack S. Epidemiology of type 2 diabetes: focus on ethnic minorities. [J].Med Clin North Am. 2005;89(5):949 \u2013 75, viii. doi: https:\/\/doi.org\/10.1016\/j.mcna.2005.03.004.","DOI":"10.1016\/j.mcna.2005.03.004"},{"issue":"5","key":"2775_CR30","doi-asserted-by":"publisher","first-page":"818","DOI":"10.1136\/gutjnl-2013-305062","volume":"63","author":"SL Das","year":"2014","unstructured":"Das SL, Singh PP, Phillips AR, Murphy R, Windsor JA, Petrov MS. Newly diagnosed diabetes mellitus after acute pancreatitis: a systematic review and meta-analysis[J]. Gut. 2014;63(5):818\u201331. https:\/\/doi.org\/10.1136\/gutjnl-2013-305062.","journal-title":"Gut"},{"issue":"2","key":"2775_CR31","doi-asserted-by":"publisher","first-page":"209","DOI":"10.1097\/MPA.0000000000000738","volume":"46","author":"L Yuan","year":"2017","unstructured":"Yuan L, Tang M, Huang L, Gao Y, Li X. Risk factors of hyperglycaemia in patients after a first episode of Acute Pancreatitis: a retrospective Cohort[J]. Pancreas. 2017;46(2):209\u201318. https:\/\/doi.org\/10.1097\/MPA.0000000000000738.","journal-title":"Pancreas"},{"key":"2775_CR32","doi-asserted-by":"publisher","first-page":"2620750","DOI":"10.1155\/2019\/2620750","volume":"2019","author":"Q Li","year":"2019","unstructured":"Li Q, Hou C, Peng Y, et al. Diabetes and younger age are vital and independent risk factors for Acute Pancreatitis in patients with severe Hypertriglyceridemia[J]. Biomed Res Int. 2019;2019:2620750. https:\/\/doi.org\/10.1155\/2019\/2620750.","journal-title":"Biomed Res Int"},{"key":"2775_CR33","doi-asserted-by":"publisher","unstructured":"Mandalia A, Wamsteker EJ, DiMagno MJ. Recent advances in understanding and managing acute pancreatitis[J]. F1000Res. 2018;7:F1000 Faculty Rev-959. doi: https:\/\/doi.org\/10.12688\/f1000research.","DOI":"10.12688\/f1000research"},{"issue":"2","key":"2775_CR34","doi-asserted-by":"publisher","first-page":"262","DOI":"10.1136\/gutjnl-2011-300566","volume":"61","author":"O Sadr-Azodi","year":"2012","unstructured":"Sadr-Azodi O, Andr\u00e9n-Sandberg \u00c3, Orsini N, Wolk A. Cigarette smoking, smoking cessation and acute pancreatitis: a prospective population-based study[J]. Gut. 2012;61(2):262\u20137. https:\/\/doi.org\/10.1136\/gutjnl-2011-300566.","journal-title":"Gut"},{"issue":"12","key":"2775_CR35","doi-asserted-by":"publisher","first-page":"e53224","DOI":"10.1371\/journal.pone.0053224","volume":"7","author":"H Urushihara","year":"2012","unstructured":"Urushihara H, Taketsuna M, Liu Y, et al. Increased risk of acute pancreatitis in patients with type 2 diabetes: an observational study using a japanese hospital database[J]. PLoS ONE. 2012;7(12):e53224. https:\/\/doi.org\/10.1371\/journal.pone.0053224.","journal-title":"PLoS ONE"},{"issue":"9","key":"2775_CR36","doi-asserted-by":"publisher","first-page":"766","DOI":"10.1111\/j.1463-1326.2010.01231.x","volume":"12","author":"CJ Girman","year":"2010","unstructured":"Girman CJ, Kou TD, Cai B, et al. Patients with type 2 diabetes mellitus have higher risk for acute pancreatitis compared with those without diabetes[J]. Diabetes Obes Metab. 2010;12(9):766\u201371. https:\/\/doi.org\/10.1111\/j.1463-1326.2010.01231.x.","journal-title":"Diabetes Obes Metab"},{"issue":"7","key":"2775_CR37","doi-asserted-by":"publisher","first-page":"2008","DOI":"10.1053\/j.gastro.2018.12.041","volume":"156","author":"PK Garg","year":"2019","unstructured":"Garg PK, Singh VP. Organ failure due to systemic Injury in Acute Pancreatitis[J]. Gastroenterology. 2019;156(7):2008\u201323. https:\/\/doi.org\/10.1053\/j.gastro.2018.12.041.","journal-title":"Gastroenterology"},{"issue":"2","key":"2775_CR38","doi-asserted-by":"publisher","first-page":"348","DOI":"10.1097\/SLA.0000000000002766","volume":"270","author":"H Sternby","year":"2019","unstructured":"Sternby H, Bolado F, Canaval-Zuleta HJ, et al. Determinants of severity in Acute Pancreatitis: a Nation-wide Multicenter prospective cohort Study[J]. Ann Surg. 2019;270(2):348\u201355. https:\/\/doi.org\/10.1097\/SLA.0000000000002766.","journal-title":"Ann Surg"},{"issue":"6","key":"2775_CR39","doi-asserted-by":"publisher","first-page":"1044","DOI":"10.1136\/gutjnl-2017-314657","volume":"68","author":"NJ Schepers","year":"2019","unstructured":"Schepers NJ, Bakker OJ, Besselink MG, et al. Impact of characteristics of organ failure and infected necrosis on mortality in necrotising pancreatitis[J]. Gut. 2019;68(6):1044\u201351. https:\/\/doi.org\/10.1136\/gutjnl-2017-314657.","journal-title":"Gut"},{"issue":"10","key":"2775_CR40","doi-asserted-by":"publisher","first-page":"867","DOI":"10.1038\/s41419-021-04160-2","volume":"12","author":"X Zhang","year":"2021","unstructured":"Zhang X, Tao J, Yu J, et al. Inhibition of notch activity promotes pancreatic cytokeratin 5-positive cell differentiation to beta cells and improves glucose homeostasis following acute pancreatitis[J]. Cell Death Dis. 2021;12(10):867. https:\/\/doi.org\/10.1038\/s41419-021-04160-2.","journal-title":"Cell Death Dis"},{"issue":"3","key":"2775_CR41","doi-asserted-by":"publisher","first-page":"781","DOI":"10.1053\/j.gastro.2005.12.031","volume":"130","author":"DN Criddle","year":"2006","unstructured":"Criddle DN, Murphy J, Fistetto G, et al. Fatty acid ethyl esters cause pancreatic calcium toxicity via inositol trisphosphate receptors and loss of ATP synthesis[J]. Gastroenterology. 2006;130(3):781\u201393. https:\/\/doi.org\/10.1053\/j.gastro.2005.12.031.","journal-title":"Gastroenterology"},{"issue":"8","key":"2775_CR42","doi-asserted-by":"publisher","first-page":"479","DOI":"10.1038\/s41575-019-0158-2","volume":"16","author":"PJ Lee","year":"2019","unstructured":"Lee PJ, Papachristou GI. New insights into acute pancreatitis[J]. Nat Rev Gastroenterol Hepatol. 2019;16(8):479\u201396. https:\/\/doi.org\/10.1038\/s41575-019-0158-2.","journal-title":"Nat Rev Gastroenterol Hepatol"},{"key":"2775_CR43","doi-asserted-by":"publisher","unstructured":"Pokharel A, Sigdel PR, Phuyal S, Kansakar PBS, Vaidya P. Prediction of Severity of Acute Pancreatitis Using Total Serum Calcium and Albumin-Corrected Calcium: A Prospective Study in Tertiary Center Hospital in Nepal[J]. Surg Res Pract. 2017;2017:1869091. oi: https:\/\/doi.org\/10.1155\/2017\/1869091.","DOI":"10.1155\/2017\/1869091"},{"issue":"7","key":"2775_CR44","doi-asserted-by":"publisher","first-page":"1106","DOI":"10.2215\/CJN.13191118","volume":"14","author":"TI Nassar","year":"2019","unstructured":"Nassar TI, Qunibi WY. AKI Associated with Acute Pancreatitis[J]. Clin J Am Soc Nephrol. 2019;14(7):1106\u201315. https:\/\/doi.org\/10.2215\/CJN.13191118.","journal-title":"Clin J Am Soc Nephrol"}],"container-title":["BMC Gastroenterology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1186\/s12876-023-02775-7.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/article\/10.1186\/s12876-023-02775-7\/fulltext.html","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1186\/s12876-023-02775-7.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,6,12]],"date-time":"2023-06-12T10:03:48Z","timestamp":1686564228000},"score":1,"resource":{"primary":{"URL":"https:\/\/bmcgastroenterol.biomedcentral.com\/articles\/10.1186\/s12876-023-02775-7"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2023,6,12]]},"references-count":44,"journal-issue":{"issue":"1","published-online":{"date-parts":[[2023,12]]}},"alternative-id":["2775"],"URL":"https:\/\/doi.org\/10.1186\/s12876-023-02775-7","relation":{"references":[{"id-type":"uri","id":"","asserted-by":"subject"}]},"ISSN":["1471-230X"],"issn-type":[{"value":"1471-230X","type":"electronic"}],"subject":[],"published":{"date-parts":[[2023,6,12]]},"assertion":[{"value":"16 August 2022","order":1,"name":"received","label":"Received","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"20 April 2023","order":2,"name":"accepted","label":"Accepted","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"12 June 2023","order":3,"name":"first_online","label":"First Online","group":{"name":"ArticleHistory","label":"Article History"}},{"order":1,"name":"Ethics","group":{"name":"EthicsHeading","label":"Declarations"}},{"value":"All procedures followed were in accordance with the ethical standards of the responsible committee on human experimentation (institutional and national) and with the Helsinki Declaration of 1964 and later versions. The research group was approved by the Ethics Committee of The Renmin Hospital of Wuhan University (Registration Number: WDRY 2020-K177). The need for patient consent to data extraction was waived by the Ethics Committee of The Renmin Hospital of Wuhan University because of the retrospective design of this study.","order":2,"name":"Ethics","group":{"name":"EthicsHeading","label":"Ethics approval and consent to participate"}},{"value":"Not applicable.","order":3,"name":"Ethics","group":{"name":"EthicsHeading","label":"Consent for publication"}},{"value":"The authors declare that they have no competing interests.","order":4,"name":"Ethics","group":{"name":"EthicsHeading","label":"Competing interests"}}],"article-number":"203"}}