{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,2,27]],"date-time":"2026-02-27T04:13:42Z","timestamp":1772165622389,"version":"3.50.1"},"reference-count":19,"publisher":"Springer Science and Business Media LLC","issue":"1","license":[{"start":{"date-parts":[[2023,12,16]],"date-time":"2023-12-16T00:00:00Z","timestamp":1702684800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0"},{"start":{"date-parts":[[2023,12,16]],"date-time":"2023-12-16T00:00:00Z","timestamp":1702684800000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0"}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["BMC Gastroenterol"],"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Background<\/jats:title>\n                    <jats:p>Acute appendicitis (AA) is among the most common nontraumatic indications for emergent abdominal surgical procedures. However, accurately diagnosing all cases can be challenging, physical examination, biochemical markers, and imaging techniques can sometimes be insufficient. This study aimed to (a) compare the mean platelet volume (MPV) and total white blood cell count (TWBCs) in patients with or without histological evidence of an inflamed appendix and (b) determine the positive predictive value, negative predictive value, sensitivity, and specificity of both MPV and TWBCs as diagnostic biomarkers in the diagnosis of AA. We conducted this research at Omdurman Military Hospital, focusing on patients who presented with symptoms suggestive of AA.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Materials and methods<\/jats:title>\n                    <jats:p>An analytical cross-sectional study conducted at Omdurman Military Hospital from December 2020 - December 2021. The study population was patients who presented to our emergency department with symptoms and signs suggestive of AA. Participants were patients operated on as cases of AA. Data variables included sociodemographic characteristics, clinical presentations, intraoperative appendix macroscopic findings, preoperative MPV and total white blood cell count (TWBCs), and postoperative histopathological findings.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>A total of 106 patients were included in this study, with 75 (68.2%) males; half were 10\u201319 years old. Sixty-three patients (57.3%) had low (&lt;\u20097.5 fL) MPV, whereas 47 (42.7%) had normal values. Comparing MPV to total white blood cells (TWBCs) revealed that MPV was more sensitive (84.6%) and specific (90%) than TWBCs during the first 24\u00a0h of inflammation. However, the TWBCs were more sensitive (97.2%) but less specific (94.7% vs. 100%) after 24\u00a0h of onset.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion<\/jats:title>\n                    <jats:p>In this study, MPV was lower in patients with AA, while there was an increase in TWBCs. The high sensitivity and specificity of TWBCs and MPV indicated that they form a promising diagnostic marker for AA.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1186\/s12876-023-03091-w","type":"journal-article","created":{"date-parts":[[2023,12,16]],"date-time":"2023-12-16T12:01:38Z","timestamp":1702728098000},"update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":2,"title":["Mean platelet volume and total white blood cells as diagnostic biomarkers for acute appendicitis at Omdurman military hospital: a cross-sectional study \u2212\u20092021"],"prefix":"10.1186","volume":"23","author":[{"given":"Mohamed Osman Suliman","family":"Basher","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ahmed Abdelfattah","family":"Ahmed","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Aamir Abdullahi","family":"Hamza","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"297","published-online":{"date-parts":[[2023,12,16]]},"reference":[{"issue":"10","key":"3091_CR1","doi-asserted-by":"publisher","first-page":"693","DOI":"10.4240\/wjgs.v8","volume":"8","author":"M Ceresoli","year":"2016","unstructured":"Ceresoli M, et al. Acute Appendicitis: Epidemiology, treatment and outcomes- analysis of 16544 consecutive cases. World J Gastrointest Surg. 2016;8(10):693. https:\/\/doi.org\/10.4240\/wjgs.v8.","journal-title":"World J Gastrointest Surg"},{"key":"3091_CR2","doi-asserted-by":"publisher","DOI":"10.1007\/s00268-021-06077-5","author":"DP Wickramasinghe","year":"2021","unstructured":"Wickramasinghe DP, Xavier C, &Samarasekera DN. World J Surg. 2021;45:1999\u20132008. https:\/\/doi.org\/10.1007\/s00268-021-06077-5. The Worldwide Epidemiology of AA: An Analysis of the Global Health Data Exchange Dataset."},{"key":"3091_CR3","unstructured":"Di Saverio S, Podda M, De Simone B, Ceresoli M, Augustin G, Gori A et al. Diagnosis and treatment of acute Appendicitis: 2020 update of the WSES Jerusalem guidelines. 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