{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,2]],"date-time":"2026-07-02T15:32:53Z","timestamp":1783006373563,"version":"3.54.5"},"reference-count":31,"publisher":"Springer Science and Business Media LLC","issue":"1","license":[{"start":{"date-parts":[[2024,4,2]],"date-time":"2024-04-02T00:00:00Z","timestamp":1712016000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0"},{"start":{"date-parts":[[2024,4,2]],"date-time":"2024-04-02T00:00:00Z","timestamp":1712016000000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0"}],"funder":[{"name":"Shandong Provincial Medical Association Analgesia and Sedation-Anesthesia Optimization Special Project","award":["YXH2022ZX05280"],"award-info":[{"award-number":["YXH2022ZX05280"]}]}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["BMC Gastroenterol"],"abstract":"<jats:title>Abstract<\/jats:title><jats:sec>\n                <jats:title>Background<\/jats:title>\n                <jats:p>Proper sedation of patients, particularly elderly individuals, who are more susceptible to sedation-related complications, is of significant importance in endoscopic retrograde cholangiopancreatography (ERCP). This study aims to assess the safety and efficacy of a low-dose combination of midazolam, alfentanil, and propofol for deep sedation in elderly patients undergoing ERCP, compared to a group of middle-aged patients.<\/jats:p>\n              <\/jats:sec><jats:sec>\n                <jats:title>Methods<\/jats:title>\n                <jats:p>The medical records of 610 patients with common bile duct stones who underwent elective ERCP under deep sedation with a three-drug regimen, including midazolam, alfentanil, and propofol at Shandong Provincial Third Hospital from January 2023 to September 2023 were retrospectively reviewed in this study. Patients were categorized into three groups: middle-aged (50\u201364 years, <jats:italic>n<\/jats:italic>\u2009=\u2009202), elderly (65\u201379 years, <jats:italic>n<\/jats:italic>\u2009=\u2009216), and very elderly (\u2265\u200980 years, <jats:italic>n<\/jats:italic>\u2009=\u2009192). Intraoperative vital signs and complications were compared among these groups.<\/jats:p>\n              <\/jats:sec><jats:sec>\n                <jats:title>Results<\/jats:title>\n                <jats:p>The three groups showed no significant difference in terms of intraoperative variation of systolic blood pressure (<jats:italic>P<\/jats:italic>\u2009=\u20090.291), diastolic blood pressure (<jats:italic>P<\/jats:italic>\u2009=\u20090.737), heart rate (<jats:italic>P<\/jats:italic>\u2009=\u20090.107), peripheral oxygen saturation (<jats:italic>P<\/jats:italic>\u2009=\u20090.188), bispectral index (<jats:italic>P<\/jats:italic>\u2009=\u20090.158), and the occurrence of sedation-related adverse events including hypotension (<jats:italic>P<\/jats:italic>\u2009=\u20090.170) and hypoxemia (<jats:italic>P<\/jats:italic>\u2009=\u20090.423).<\/jats:p>\n              <\/jats:sec><jats:sec>\n                <jats:title>Conclusion<\/jats:title>\n                <jats:p>The results suggest that a low-dose three-drug regimen consisting of midazolam, alfentanil, and propofol seems safe and effective for deep sedation of elderly and very elderly patients undergoing ERCP procedures. However, further studies are required to verify these findings and clarify the benefits and risks of this method.<\/jats:p>\n              <\/jats:sec>","DOI":"10.1186\/s12876-024-03197-9","type":"journal-article","created":{"date-parts":[[2024,4,2]],"date-time":"2024-04-02T11:02:21Z","timestamp":1712055741000},"update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":7,"title":["Safety and efficacy of a low-dose combination of midazolam, alfentanil, and propofol for deep sedation of elderly patients undergoing ERCP"],"prefix":"10.1186","volume":"24","author":[{"given":"Yanping","family":"Zhang","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ning","family":"Zhang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jing","family":"Hu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Changlin","family":"Liu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Guanjun","family":"Li","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2024,4,2]]},"reference":[{"key":"3197_CR1","doi-asserted-by":"publisher","first-page":"3302","DOI":"10.1007\/s10620-016-4283-2","volume":"61","author":"M Ukkonen","year":"2016","unstructured":"Ukkonen M, Siiki A, Antila A, Tyrv\u00e4inen T, Sand J, Laukkarinen J. 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