{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,29]],"date-time":"2026-07-29T17:00:31Z","timestamp":1785344431900,"version":"3.55.0"},"reference-count":30,"publisher":"Springer Science and Business Media LLC","issue":"1","license":[{"start":{"date-parts":[[2024,4,12]],"date-time":"2024-04-12T00:00:00Z","timestamp":1712880000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0"},{"start":{"date-parts":[[2024,4,12]],"date-time":"2024-04-12T00:00:00Z","timestamp":1712880000000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0"}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["BMC Gastroenterol"],"abstract":"<jats:title>Abstract<\/jats:title><jats:sec>\n                <jats:title>Background<\/jats:title>\n                <jats:p>Different split regimens of polyethylene glycol are routinely used and no guidelines are available to select an optimal protocol of ingestion. This study aims to compare the efficacy and side effect profile of two different regimens of polyethylene glycol bowel preparation solution: PEG (3\u2009+\u20091) vs. PEG (2\u2009+\u20092).<\/jats:p>\n              <\/jats:sec><jats:sec>\n                <jats:title>Methods<\/jats:title>\n                <jats:p>240 patients above the age of 18 years were included in the study between June 1st and November 31<jats:sup>st,<\/jats:sup> 2023. Patients were randomly assigned either to Group A, consisting of 115 patients receiving a 3\u00a0L of PEG the night before the colonoscopy, and 1\u00a0L the same morning of the procedure. Or to group B, where 125 patients ingested 2\u00a0L the night before the procedure, and the remaining 2\u00a0L the same morning. The cleansing efficacy was evaluated by the attending endoscopist using the Boston Bowel Preparation Scale, through a score assigned for each segment of the colon (0\u20133). Side effects, tolerability, and willingness to retake the same preparation were listed by an independent investigator using a questionnaire administered before the procedure.<\/jats:p>\n              <\/jats:sec><jats:sec>\n                <jats:title>Results<\/jats:title>\n                <jats:p>A higher percentage of patients had gastric fullness with the 3\u2009+\u20091 vs. 2\u2009+\u20092 preparation (58.3% vs. 31.2%; <jats:italic>p<\/jats:italic>\u2009&lt;.001). A higher Boston bowel preparation score was seen in patients who took the 2\u2009+\u20092 vs. 3\u2009+\u20091 preparation (7.87 vs. 7.23). Using the 2\u2009+\u20092 preparation was significantly associated with higher Boston bowel preparation scores vs. the 3\u2009+\u20091 preparation (OR\u2009=\u20091.37, <jats:italic>p<\/jats:italic>\u2009=.001, 95% CI 1.14, 1.64). After adjustment over other variables (age, gender, comorbidities, previous abdominal surgeries, presence of adenoma, and time between last dose and colonoscopy), results remained the same (aOR\u2009=\u20091.34, <jats:italic>p<\/jats:italic>\u2009=.003, 95% CI 1.10, 1.62).<\/jats:p>\n              <\/jats:sec><jats:sec>\n                <jats:title>Conclusion<\/jats:title>\n                <jats:p>While both (2\u2009+\u20092) and (3\u2009+\u20091) regimens of polyethylene glycol are a good choice for a successful colonoscopy, we recommend the use of (2\u2009+\u20092) regimen for its superior efficacy in bowel cleansing.<\/jats:p>\n              <\/jats:sec>","DOI":"10.1186\/s12876-024-03212-z","type":"journal-article","created":{"date-parts":[[2024,4,12]],"date-time":"2024-04-12T09:02:14Z","timestamp":1712912534000},"update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":2,"title":["Prospective, randomized study comparing two different regimens of split-dose polyethylene glycol and their effect on endoscopic outcomes"],"prefix":"10.1186","volume":"24","author":[{"given":"Jawad","family":"Abou Zeid","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Souheil","family":"Hallit","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Bassem","family":"Akiki","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zeina","family":"Abou Zeid","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Charbel","family":"Yazbeck","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2024,4,12]]},"reference":[{"key":"3212_CR1","doi-asserted-by":"publisher","unstructured":"de Miranda Neto AA, de Moura DTH, Hathorn KE, Tustumi F, de Moura EGH, Ribeiro IB. 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Written informed consent was obtained from all subjects. All methods were performed in accordance with the relevant guidelines and regulations.","order":2,"name":"Ethics","group":{"name":"EthicsHeading","label":"Ethics approval and consent to participate"}},{"value":"Not applicable.","order":3,"name":"Ethics","group":{"name":"EthicsHeading","label":"Consent for publication"}},{"value":"The authors have nothing to disclose.","order":4,"name":"Ethics","group":{"name":"EthicsHeading","label":"Competing interests"}}],"article-number":"132"}}