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Logistic regression models were used for the prediction, and the area under the receiver operating characteristic (AUROC) was used to assess the diagnostic accuracy.<\/jats:p>\n              <\/jats:sec><jats:sec>\n                <jats:title>Results<\/jats:title>\n                <jats:p>A total of 631 (52.1%) and 275 (22.7%) patients had significant fibrosis (\u2265\u2009S2) and advanced fibrosis (\u2265\u2009S3), respectively. The GPR showed significantly higher diagnostic accuracy than that of APRI, FiB-4, and AST\/ALT to predict\u2009\u2265\u2009S2(significant fibrosis) and \u2265\u2009S3 fibrosis(advanced fibrosis), with an AUROC was 0.69 (95%CI: 0.66\u20130.71) and 0.72 (0.69\u20130.75), respectively. After stratified by the status of HBeAg ( positive or negative), GPR, APRI, and FiB-4 showed improved predicting performance for significant fibrosis and advanced fibrosis in HBeAg positive patients, with the most significant improvement was shown for GPR in predicting significant fibrosis (AUROC\u2009=\u20090.74, 95%CI: 0.70\u20130.78).<\/jats:p>\n              <\/jats:sec><jats:sec>\n                <jats:title>Conclusions<\/jats:title>\n                <jats:p>Among the four noninvasive models, GPR has the best performance in the diagnosis of hepatic fibrosis in CHB patients and is more valuable in HBeAg-positive patients.<\/jats:p>\n              <\/jats:sec>","DOI":"10.1186\/s12876-024-03270-3","type":"journal-article","created":{"date-parts":[[2024,5,24]],"date-time":"2024-05-24T03:43:18Z","timestamp":1716522198000},"update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":6,"title":["Noninvasive models for the prediction of liver fibrosis in patients with chronic hepatitis B"],"prefix":"10.1186","volume":"24","author":[{"given":"Juanxia","family":"Wang","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xince","family":"Sun","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shibo","family":"Wei","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xinyue","family":"Chen","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Haoyu","family":"Zhu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Youyou","family":"Liantang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ruikun","family":"Bao","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yufeng","family":"Du","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2024,5,24]]},"reference":[{"issue":"2","key":"3270_CR1","first-page":"e00046","volume":"33","author":"HN Mindie","year":"2020","unstructured":"Mindie HN, Grace W, Edward G, et al. 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Informed consent requirements were waived because the use of retrospective data and obtaining consent from every participant were not feasible.","order":2,"name":"Ethics","group":{"name":"EthicsHeading","label":"Ethics approval and consent to participate"}},{"value":"Not applicable.","order":3,"name":"Ethics","group":{"name":"EthicsHeading","label":"Consent for publication"}},{"value":"The authors declare no competing interests.","order":4,"name":"Ethics","group":{"name":"EthicsHeading","label":"Competing interests"}},{"value":"<sup>1<\/sup> Department of Infectious Diseases, Lanzhou University Second Hospital, Lanzhou 730030, China. <sup>2<\/sup> The Second Clinical Medical College of Lanzhou University, Lanzhou 730030, China. <sup>3<\/sup> Department of Epidemiology and Statistics, School of Public Health, Lanzhou University, Lanzhou 730000, China.","order":5,"name":"Ethics","group":{"name":"EthicsHeading","label":"Author details"}}],"article-number":"183"}}