{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,22]],"date-time":"2026-09-22T21:44:26Z","timestamp":1790113466059,"version":"4.0.1"},"reference-count":21,"publisher":"Springer Science and Business Media LLC","issue":"1","license":[{"start":{"date-parts":[[2024,7,24]],"date-time":"2024-07-24T00:00:00Z","timestamp":1721779200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0"},{"start":{"date-parts":[[2024,7,24]],"date-time":"2024-07-24T00:00:00Z","timestamp":1721779200000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0"}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["BMC Gastroenterol"],"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:p>\n                    This study aimed to assess the significance of serum albumin levels within 24\u00a0h of patient admission in correlation with the incidence of outcomes and mortality in patients diagnosed with acute pancreatitis. A retrospective study was conducted over a 5-year period, from January 2018 to December 2023, at the Mohammed VI University Hospital in Oujda, Morocco. The study included 371 patients diagnosed with acute pancreatitis. Hypoalbuminemia (\u2264\u200930\u00a0g\/L) was observed in 124 patients (33.4% of cases), and these patients had a higher mean age compared to those with normal albumin levels (\n                    <jats:italic>P<\/jats:italic>\n                    \u2009=\u20090.003). Hypoalbuminemia was significantly associated with persistent Systemic Inflammatory Response Syndrome (SIRS) (70.8% vs. 29.2%,\n                    <jats:italic>P<\/jats:italic>\n                    \u2009=\u20090.000), a higher BISAP score (66.7% vs. 33.3%,\n                    <jats:italic>P<\/jats:italic>\n                    \u2009=\u20090.000), and a higher CTSI score (51.7% vs. 48.3%,\n                    <jats:italic>P<\/jats:italic>\n                    \u2009=\u20090.000). Hypoalbuminemia was also associated with the presence of pleural effusion (\n                    <jats:italic>P<\/jats:italic>\n                    \u2009=\u20090.000). The mortality in the sample was 4.6%, and it was significantly associated with hypoalbuminemia (76.5%,\n                    <jats:italic>P<\/jats:italic>\n                    \u2009=\u20090.000). In conclusion, serum albumin levels within 24\u00a0h of patient admission appear to be a significant prognostic biomarker in acute pancreatitis, particularly in anticipating persistent organ failure and mortality.\n                  <\/jats:p>","DOI":"10.1186\/s12876-024-03314-8","type":"journal-article","created":{"date-parts":[[2024,7,24]],"date-time":"2024-07-24T07:02:19Z","timestamp":1721804539000},"update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":26,"title":["Is serum albumin a pivotal biomarker in anticipating acute pancreatitis outcomes?"],"prefix":"10.1186","volume":"24","author":[{"given":"Fakhrddine","family":"Amri","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Maissae","family":"Rahaoui","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hanane","family":"Aissaoui","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ouiam","family":"Elmqaddem","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hajar","family":"Koulali","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Abdelkrim","family":"Zazour","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Naima","family":"Abda","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zahi","family":"Ismaili","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ghizlane","family":"Kharrasse","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2024,7,24]]},"reference":[{"key":"3314_CR1","doi-asserted-by":"publisher","first-page":"1251","DOI":"10.1007\/s40265-022-01766-4","volume":"82","author":"P Szatmary","year":"2022","unstructured":"Szatmary P, Grammatikopoulos T, Cai W, et al. Sutton, Acute Pancreatitis: diagnosis and treatment. Drugs. 2022;82:1251\u201376. https:\/\/doi.org\/10.1007\/s40265-022-01766-4.","journal-title":"Drugs"},{"key":"3314_CR2","doi-asserted-by":"publisher","first-page":"59","DOI":"10.1186\/s12876-017-0615-8","volume":"17","author":"S Li","year":"2017","unstructured":"Li S, Zhang Y, Li M, et al. Serum albumin, a good indicator of persistent organ failure in acute pancreatitis. BMC Gastroenterol. 2017;17:59. https:\/\/doi.org\/10.1186\/s12876-017-0615-8.","journal-title":"BMC Gastroenterol"},{"key":"3314_CR3","doi-asserted-by":"publisher","first-page":"1","DOI":"10.1155\/2017\/1219464","volume":"2017","author":"DB Kim","year":"2017","unstructured":"Kim DB, Chung WC, Lee JM, Jeon, et al. Analysis of Factors Associated with the severity of Acute Pancreatitis according to etiology. Gastroenterol Res Pract. 2017;2017:1\u20135. https:\/\/doi.org\/10.1155\/2017\/1219464.","journal-title":"Gastroenterol Res Pract"},{"key":"3314_CR4","doi-asserted-by":"publisher","first-page":"580","DOI":"10.1038\/sj.bjp.0707251","volume":"151","author":"K Oettl","year":"2007","unstructured":"Oettl K, Stauber RE. Physiological and pathological changes in the redox state of human serum albumin critically influence its binding properties. Br J Pharmacol. 2007;151:580\u201390. https:\/\/doi.org\/10.1038\/sj.bjp.0707251.","journal-title":"Br J Pharmacol"},{"key":"3314_CR5","doi-asserted-by":"publisher","first-page":"195","DOI":"10.1186\/s12876-023-02801-8","volume":"23","author":"H Xu","year":"2023","unstructured":"Xu H, Wan J, He W, et al. Albumin infusion may decrease the mortality of hypoalbuminemia patients with severe acute pancreatitis: a retrospective cohort study. 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The Digestive Diseases Research Laboratory at Mohammed VI University Hospital in Oujda has an established ethics committee\/Institutional Review Board (IRB) that reviewed and approved this study.The need for written informed consent to participate was waived by the Ethics Committee of the Digestive Diseases Research Laboratory due to the retrospective nature of the study, in accordance with national regulations. Data anonymity was ensured following national and international guidelines. All methods were carried out in accordance with relevant guidelines and regulations of the Declaration of Helsinki.","order":4,"name":"Ethics","group":{"name":"EthicsHeading","label":"Ethical approval and consent to participate"}}],"article-number":"234"}}