{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,4,29]],"date-time":"2026-04-29T08:37:49Z","timestamp":1777451869389,"version":"3.51.4"},"reference-count":33,"publisher":"Springer Science and Business Media LLC","issue":"1","license":[{"start":{"date-parts":[[2024,8,7]],"date-time":"2024-08-07T00:00:00Z","timestamp":1722988800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0"},{"start":{"date-parts":[[2024,8,7]],"date-time":"2024-08-07T00:00:00Z","timestamp":1722988800000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0"}],"funder":[{"DOI":"10.13039\/501100004160","name":"Mazandaran University of Medical Sciences","doi-asserted-by":"publisher","award":["3251"],"award-info":[{"award-number":["3251"]}],"id":[{"id":"10.13039\/501100004160","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["BMC Gastroenterol"],"DOI":"10.1186\/s12876-024-03347-z","type":"journal-article","created":{"date-parts":[[2024,8,7]],"date-time":"2024-08-07T12:05:54Z","timestamp":1723032354000},"update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":1,"title":["Evaluation of the Rock1 and microRNA-148a expression in biopsies collected from patients with Helicobacter pylori induced gastritis"],"prefix":"10.1186","volume":"24","author":[{"given":"Ebrahim","family":"Gholamhosseinzadeh","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Hossein","family":"Ghalehnoei","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Arash","family":"Kazemi Veisari","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Narjes","family":"Jafari","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Hamid Reza","family":"Goli","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"297","published-online":{"date-parts":[[2024,8,7]]},"reference":[{"issue":"4","key":"3347_CR1","doi-asserted-by":"publisher","first-page":"597","DOI":"10.1128\/CMR.00006-06","volume":"19","author":"HMS Algood","year":"2006","unstructured":"Algood HMS, Cover TL. Helicobacter pylori persistence: an overview of interactions between H. Pylori and host immune defenses. Clin Microbiol Rev. 2006;19(4):597\u2013613.","journal-title":"Clin Microbiol Rev"},{"issue":"3","key":"3347_CR2","doi-asserted-by":"publisher","first-page":"449","DOI":"10.1128\/CMR.00054-05","volume":"19","author":"JG Kusters","year":"2006","unstructured":"Kusters JG, Van Vliet AH, Kuipers EJ. Pathogenesis of Helicobacter pylori infection. Clin Microbiol Rev. 2006;19(3):449\u201390.","journal-title":"Clin Microbiol Rev"},{"issue":"5","key":"3347_CR3","first-page":"455","volume":"79","author":"J Duynhoven YTv","year":"2001","unstructured":"Duynhoven YTv J. Transmission of Helicobacter pylori: a role for food? Bull World Health Organ. 2001;79(5):455\u201360.","journal-title":"Bull World Health Organ"},{"key":"3347_CR4","doi-asserted-by":"publisher","first-page":"325","DOI":"10.1590\/S0021-75572006000600004","volume":"82","author":"PF Bittencourt","year":"2006","unstructured":"Bittencourt PF, Rocha GA, Penna FJ, Queiroz DM. Gastroduodenal peptic ulcer and Helicobacter pylori infection in children and adolescents. Jornal De Pediatria. 2006;82:325\u201334.","journal-title":"Jornal De Pediatria"},{"issue":"11","key":"3347_CR5","doi-asserted-by":"publisher","first-page":"780","DOI":"10.1007\/s12094-006-0132-7","volume":"8","author":"M Dolores Delgado","year":"2006","unstructured":"Dolores Delgado M, Le\u00f3n J. Gene expression regulation and cancer. Clin Transl Oncol. 2006;8(11):780\u20137.","journal-title":"Clin Transl Oncol"},{"issue":"7","key":"3347_CR6","doi-asserted-by":"publisher","first-page":"1243","DOI":"10.1101\/gr.132514.111","volume":"22","author":"J Lu","year":"2012","unstructured":"Lu J, Clark AG. Impact of microRNA regulation on variation in human gene expression. Genome Res. 2012;22(7):1243\u201354.","journal-title":"Genome Res"},{"issue":"5","key":"3347_CR7","doi-asserted-by":"publisher","first-page":"437","DOI":"10.1136\/hrt.71.5.437","volume":"71","author":"MA Mendall","year":"1994","unstructured":"Mendall MA, Goggin PM, Molineaux N, Levy J, Toosy T, Strachan D, Camm AJ, Northfield TC. Relation of Helicobacter pylori infection and coronary heart disease. Heart. 1994;71(5):437\u20139.","journal-title":"Heart"},{"issue":"10","key":"3347_CR8","doi-asserted-by":"publisher","first-page":"1233","DOI":"10.7150\/jca.14616","volume":"7","author":"Y Li","year":"2016","unstructured":"Li Y, Deng X, Zeng X, Peng X. The role of Mir-148a in cancer. J Cancer. 2016;7(10):1233.","journal-title":"J Cancer"},{"issue":"24","key":"3347_CR9","doi-asserted-by":"publisher","first-page":"7574","DOI":"10.1158\/1078-0432.CCR-11-1714","volume":"17","author":"B Zheng","year":"2011","unstructured":"Zheng B, Liang L, Wang C, Huang S, Cao X, Zha R, Liu L, Jia D, Tian Q, Wu J. MicroRNA-148a suppresses Tumor Cell Invasion and Metastasis by Downregulating ROCK1 in gastric CancerMiR-148a inhibits Invasion and Metastasis in Gastric Cancer. Clin Cancer Res. 2011;17(24):7574\u201383.","journal-title":"Clin Cancer Res"},{"issue":"11","key":"3347_CR10","doi-asserted-by":"publisher","first-page":"1702","DOI":"10.1038\/cdd.2011.28","volume":"18","author":"H Zhang","year":"2011","unstructured":"Zhang H, Li Y, Huang Q, Ren X, Hu H, Sheng H, Lai M. MiR-148a promotes apoptosis by targeting Bcl-2 in colorectal cancer. Cell Death Differ. 2011;18(11):1702\u201310.","journal-title":"Cell Death Differ"},{"key":"3347_CR11","doi-asserted-by":"crossref","unstructured":"Guo M-m, Zhang K, Zhang J-h. Human Breast Milk\u2013Derived Exosomal miR-148a-3p Protects Against Necrotizing Enterocolitis by Regulating p53 and Sirtuin 1. Inflammation 2022, 45(3):1254\u20131268.","DOI":"10.1007\/s10753-021-01618-5"},{"issue":"3","key":"3347_CR12","doi-asserted-by":"publisher","first-page":"1","DOI":"10.3892\/etm.2021.9674","volume":"21","author":"AI Gaia\u2013Oltean","year":"2021","unstructured":"Gaia\u2013Oltean AI, Braicu C, Gulei D, Ciortea R, Mihu D, Roman H, Irimie A, Berindan\u2013Neagoe I. Ovarian endometriosis, a precursor of ovarian cancer: histological aspects, gene expression and microRNA alterations. Experimental Therapeutic Med. 2021;21(3):1\u20131.","journal-title":"Experimental Therapeutic Med"},{"issue":"12","key":"3347_CR13","doi-asserted-by":"publisher","first-page":"2199","DOI":"10.1038\/cdd.2017.151","volume":"24","author":"Y Zhu","year":"2017","unstructured":"Zhu Y, Gu L, Li Y, Lin X, Shen H, Cui K, Chen L, Zhou F, Zhao Q, Zhang J. miR-148a inhibits colitis and colitis-associated tumorigenesis in mice. Cell Death Differ. 2017;24(12):2199\u2013209.","journal-title":"Cell Death Differ"},{"issue":"38","key":"3347_CR14","doi-asserted-by":"publisher","first-page":"13756","DOI":"10.3748\/wjg.v20.i38.13756","volume":"20","author":"T Matsuoka","year":"2014","unstructured":"Matsuoka T, Yashiro M. Rho\/ROCK signaling in motility and metastasis of gastric cancer. World J Gastroenterology: WJG. 2014;20(38):13756.","journal-title":"World J Gastroenterology: WJG"},{"key":"3347_CR15","doi-asserted-by":"crossref","unstructured":"Gilkes DM, Xiang L, Lee SJ, Chaturvedi P, Hubbi ME, Wirtz D, Semenza GL. Hypoxia-inducible factors mediate coordinated RhoA-ROCK1 expression and signaling in breast cancer cells. Proceedings of the National Academy of Sciences 2014, 111(3):E384-E393.","DOI":"10.1073\/pnas.1321510111"},{"issue":"20","key":"3347_CR16","doi-asserted-by":"publisher","first-page":"e179","DOI":"10.1093\/nar\/gni178","volume":"33","author":"C Chen","year":"2005","unstructured":"Chen C, Ridzon DA, Broomer AJ, Zhou Z, Lee DH, Nguyen JT, Barbisin M, Xu NL, Mahuvakar VR, Andersen MR. Real-time quantification of microRNAs by stem\u2013loop RT\u2013PCR. Nucleic Acids Res. 2005;33(20):e179\u2013179.","journal-title":"Nucleic Acids Res"},{"issue":"2","key":"3347_CR17","doi-asserted-by":"publisher","first-page":"1070","DOI":"10.1128\/JVI.01740-14","volume":"89","author":"Y-R Fu","year":"2015","unstructured":"Fu Y-R, Liu X-J, Li X-J, Shen Z-z, Yang B, Wu C-C, Li J-F, Miao L-F, Ye H-Q, Qiao G-H. MicroRNA miR-21 attenuates human cytomegalovirus replication in neural cells by targeting Cdc25a. J Virol. 2015;89(2):1070\u201382.","journal-title":"J Virol"},{"key":"3347_CR18","doi-asserted-by":"crossref","unstructured":"Watson CN, Belli A, Di Pietro V. Small non-coding RNAs: new class of biomarkers and potential therapeutic targets in neurodegenerative disease. Front Genet 2019:364.","DOI":"10.3389\/fgene.2019.00364"},{"issue":"4","key":"3347_CR19","doi-asserted-by":"publisher","first-page":"402","DOI":"10.1006\/meth.2001.1262","volume":"25","author":"Livak","year":"2001","unstructured":"Livak KJ. TD Schmittgen 2001 Analysis of relative gene expression data using real-time quantitative PCR and the 2\u2009\u2013\u2009\u2206\u2206CT method. Methods 25 4 402\u20138.","journal-title":"Methods"},{"issue":"4","key":"3347_CR20","doi-asserted-by":"publisher","first-page":"1715","DOI":"10.3892\/or.2014.3052","volume":"31","author":"J Xie","year":"2014","unstructured":"Xie J, Chen M, Zhou J, Mo M-S, Zhu L-H, Liu Y-P, Gui Q-J, Zhang L, Li G-Q. miR-7 inhibits the invasion and metastasis of gastric cancer cells by suppressing epidermal growth factor receptor expression. Oncol Rep. 2014;31(4):1715\u201322.","journal-title":"Oncol Rep"},{"issue":"9","key":"3347_CR21","doi-asserted-by":"publisher","first-page":"806","DOI":"10.1111\/j.1469-0691.2009.02960.x","volume":"15","author":"C Belair","year":"2009","unstructured":"Belair C, Darfeuille F, Staedel C. Helicobacter pylori and gastric cancer: possible role of microRNAs in this intimate relationship. Clin Microbiol Infect. 2009;15(9):806\u201312.","journal-title":"Clin Microbiol Infect"},{"issue":"11","key":"3347_CR22","doi-asserted-by":"publisher","first-page":"1985","DOI":"10.1002\/cncr.28002","volume":"119","author":"Z Chen","year":"2013","unstructured":"Chen Z, Saad R, Jia P, Peng D, Zhu S, Washington MK, Zhao Z, Xu Z, El-Rifai W. Gastric adenocarcinoma has a unique microRNA signature not present in esophageal adenocarcinoma. Cancer. 2013;119(11):1985\u201393.","journal-title":"Cancer"},{"issue":"3","key":"3347_CR23","doi-asserted-by":"publisher","first-page":"679","DOI":"10.3892\/ol.2014.1797","volume":"7","author":"G Zheng","year":"2014","unstructured":"Zheng G, Xiong Y, Xu W, Wang Y, Chen F, Wang Z, Yan Z. A two\u2013microRNA signature as a potential biomarker for early gastric cancer. Oncol Lett. 2014;7(3):679\u201384.","journal-title":"Oncol Lett"},{"issue":"7","key":"3347_CR24","doi-asserted-by":"publisher","first-page":"1170","DOI":"10.1007\/s11605-010-1202-2","volume":"14","author":"Y Chen","year":"2010","unstructured":"Chen Y, Song Y, Wang Z, Yue Z, Xu H, Xing C, Liu Z. Altered expression of MiR-148a and MiR-152 in gastrointestinal cancers and its clinical significance. J Gastrointest Surg. 2010;14(7):1170\u20139.","journal-title":"J Gastrointest Surg"},{"key":"3347_CR25","first-page":"853","volume":"7","author":"J Sun","year":"2014","unstructured":"Sun J, Song Y, Wang Z, Wang G, Gao P, Chen X, Gao Z, Xu H. Clinical significance of promoter region hypermethylation of microRNA-148a in gastrointestinal cancers. OncoTargets Therapy. 2014;7:853.","journal-title":"OncoTargets Therapy"},{"issue":"1","key":"3347_CR26","doi-asserted-by":"publisher","first-page":"1","DOI":"10.1038\/srep07080","volume":"4","author":"P Song","year":"2014","unstructured":"Song P, Zhu H, Zhang D, Chu H, Wu D, Kang M, Wang M, Gong W, Zhou J, Zhang Z. A genetic variant of miR-148a binding site in the SCRN1 3\u2032-UTR is associated with susceptibility and prognosis of gastric cancer. Sci Rep. 2014;4(1):1\u20137.","journal-title":"Sci Rep"},{"issue":"2","key":"3347_CR27","doi-asserted-by":"publisher","first-page":"196","DOI":"10.1016\/j.canlet.2011.10.034","volume":"316","author":"H Liu","year":"2012","unstructured":"Liu H, Zhu L, Liu B, Yang L, Meng X, Zhang W, Ma Y, Xiao H. Genome-wide microRNA profiles identify miR-378 as a serum biomarker for early detection of gastric cancer. Cancer Lett. 2012;316(2):196\u2013203.","journal-title":"Cancer Lett"},{"issue":"11","key":"3347_CR28","doi-asserted-by":"publisher","first-page":"1546","DOI":"10.1136\/gut.2009.179531","volume":"58","author":"T Paranjape","year":"2009","unstructured":"Paranjape T, Slack F, Weidhaas J. MicroRNAs: tools for cancer diagnostics. Gut. 2009;58(11):1546\u201354.","journal-title":"Gut"},{"issue":"2","key":"3347_CR29","first-page":"559","volume":"27","author":"B Xiao","year":"2012","unstructured":"Xiao B, Zhu E-D, Li N, Lu D-S, Li W, Li B-S, Zhao Y-L, Mao X-H, Guo G, Yu P-W. Increased miR-146a in gastric cancer directly targets SMAD4 and is involved in modulating cell proliferation and apoptosis. Oncol Rep. 2012;27(2):559\u201366.","journal-title":"Oncol Rep"},{"issue":"1","key":"3347_CR30","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1186\/s12885-018-5219-3","volume":"19","author":"H Liu","year":"2019","unstructured":"Liu H, Li P-w, Yang W-q, Mi H, Pan J-l, Huang Y-c. Hou Z-k, Hou Q-k, Luo Q, Liu F-b: identification of non-invasive biomarkers for chronic atrophic gastritis from serum exosomal microRNAs. BMC Cancer. 2019;19(1):1\u201310.","journal-title":"BMC Cancer"},{"issue":"3","key":"3347_CR31","doi-asserted-by":"publisher","first-page":"1883","DOI":"10.3390\/ijms23031883","volume":"23","author":"O Sokolova","year":"2022","unstructured":"Sokolova O, Naumann M. Matrix metalloproteinases in Helicobacter pylori\u2013Associated gastritis and gastric Cancer. Int J Mol Sci. 2022;23(3):1883.","journal-title":"Int J Mol Sci"},{"issue":"4","key":"3347_CR32","first-page":"4944","volume":"15","author":"H Shi","year":"2018","unstructured":"Shi H, Chen X, Jiang H, Wang X, Yu H, Sun P, Sui X. miR-148a suppresses cell invasion and migration in gastric cancer by targeting DNA methyltransferase 1. Oncol Lett. 2018;15(4):4944\u201350.","journal-title":"Oncol Lett"},{"issue":"1","key":"3347_CR33","doi-asserted-by":"publisher","first-page":"61","DOI":"10.1016\/j.jcmgh.2019.08.008","volume":"9","author":"T Shimizu","year":"2020","unstructured":"Shimizu T, Sohn Y, Choi E, Petersen CP, Prasad N, Goldenring JR. Decrease in MiR-148a expression during initiation of chief cell transdifferentiation. Cell Mol Gastroenterol Hepatol. 2020;9(1):61\u201378.","journal-title":"Cell Mol Gastroenterol Hepatol"}],"container-title":["BMC Gastroenterology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1186\/s12876-024-03347-z.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/article\/10.1186\/s12876-024-03347-z\/fulltext.html","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1186\/s12876-024-03347-z.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2024,8,7]],"date-time":"2024-08-07T12:06:41Z","timestamp":1723032401000},"score":1,"resource":{"primary":{"URL":"https:\/\/bmcgastroenterol.biomedcentral.com\/articles\/10.1186\/s12876-024-03347-z"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2024,8,7]]},"references-count":33,"journal-issue":{"issue":"1","published-online":{"date-parts":[[2024,12]]}},"alternative-id":["3347"],"URL":"https:\/\/doi.org\/10.1186\/s12876-024-03347-z","relation":{},"ISSN":["1471-230X"],"issn-type":[{"value":"1471-230X","type":"electronic"}],"subject":[],"published":{"date-parts":[[2024,8,7]]},"assertion":[{"value":"7 June 2023","order":1,"name":"received","label":"Received","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"1 August 2024","order":2,"name":"accepted","label":"Accepted","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"7 August 2024","order":3,"name":"first_online","label":"First Online","group":{"name":"ArticleHistory","label":"Article History"}},{"order":1,"name":"Ethics","group":{"name":"EthicsHeading","label":"Declarations"}},{"value":"First, a printed informed consent form was provided by the patients with gastric inflammation. The clinical samples of patients were taken by a qualified gastroenterologist in an endoscopy center affiliated with the Mazandaran University of Medical Sciences. This study was done according to the Declaration of Helsinki, and the categorizing data of patients was kept secret. Moreover, this research was approved by the Iran National Committee for Ethics in Biomedical Research with the national ethical code IR.MAZUMS.REC.1397.382.","order":2,"name":"Ethics","group":{"name":"EthicsHeading","label":"Ethical approval statement and consent of participants"}},{"value":"Not applicable.","order":3,"name":"Ethics","group":{"name":"EthicsHeading","label":"Consent for publication"}},{"value":"The authors declare no competing interests.","order":4,"name":"Ethics","group":{"name":"EthicsHeading","label":"Competing interests"}}],"article-number":"251"}}