{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,27]],"date-time":"2026-07-27T19:12:13Z","timestamp":1785179533812,"version":"3.55.0"},"reference-count":20,"publisher":"Springer Science and Business Media LLC","issue":"1","license":[{"start":{"date-parts":[[2024,11,12]],"date-time":"2024-11-12T00:00:00Z","timestamp":1731369600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0"},{"start":{"date-parts":[[2024,11,12]],"date-time":"2024-11-12T00:00:00Z","timestamp":1731369600000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0"}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["BMC Gastroenterol"],"DOI":"10.1186\/s12876-024-03499-y","type":"journal-article","created":{"date-parts":[[2024,11,12]],"date-time":"2024-11-12T07:28:40Z","timestamp":1731396520000},"update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":6,"title":["7-hydroxycoumarin ameliorates ulcerative colitis in mice by inhibiting the MAPK pathway and alleviating gut microbiota dysbiosis"],"prefix":"10.1186","volume":"24","author":[{"given":"Mengqi","family":"Liu","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Huayi","family":"Sun","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hao","family":"Fu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lingping","family":"Fu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xiao","family":"Zheng","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yu","family":"Chen","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2024,11,12]]},"reference":[{"key":"3499_CR1","doi-asserted-by":"publisher","unstructured":"Eisenstein M. Ulcerative colitis: towards remission. Nature. 2018;563(S33). https:\/\/doi.org\/10.1038\/d41586-018-07276-2.","DOI":"10.1038\/d41586-018-07276-2"},{"key":"3499_CR2","doi-asserted-by":"publisher","first-page":"1606","DOI":"10.1016\/s0140-6736(23)00966-2","volume":"380","author":"I Ord\u00e1s","year":"2012","unstructured":"Ord\u00e1s I, Eckmann L, Talamini M, et al. Ulcerative colitis. Lancet. 2012;380:1606\u201319. https:\/\/doi.org\/10.1016\/s0140-6736(23)00966-2.","journal-title":"Lancet"},{"key":"3499_CR3","doi-asserted-by":"publisher","first-page":"662","DOI":"10.16333\/j.1001-6880.2023.4.014","volume":"35","author":"Y Huang","year":"2023","unstructured":"Huang Y, Li S, Wu QH, et al. Study on the mechanism of action of seven compounds in the treatment of ulcerative colitis based on network pharmacology. Nat Prod Res Dev. 2023;35:662\u201376. https:\/\/doi.org\/10.16333\/j.1001-6880.2023.4.014.","journal-title":"Nat Prod Res Dev"},{"key":"3499_CR4","doi-asserted-by":"publisher","unstructured":"Jesus RLC, Silva ILP, Ara\u00fajo FA, et al. 7-Hydroxycoumarin induces vasorelaxation in animals with essential hypertension: focus on Potassium channels and intracellular ca(2+). Mobilization Molecules. 2022;27. https:\/\/doi.org\/10.3390\/molecules27217324.","DOI":"10.3390\/molecules27217324"},{"key":"3499_CR5","doi-asserted-by":"publisher","first-page":"13doi","DOI":"10.1186\/1758-2946-6-13","volume":"6","author":"J Ru","year":"2014","unstructured":"Ru J, Li P, Wang J, et al. TCMSP: a database of systems pharmacology for drug discovery from herbal medicines. J Cheminf. 2014;6:13. https:\/\/doi.org\/10.1186\/1758-2946-6-13.","journal-title":"J Cheminf"},{"key":"3499_CR6","doi-asserted-by":"publisher","first-page":"126","DOI":"10.1016\/j.ejphar.2009.03.027","volume":"609","author":"JF Vasconcelos","year":"2009","unstructured":"Vasconcelos JF, Teixeira MM, Barbosa-Filho JM, et al. Effects of umbelliferone in a murine model of allergic airway inflammation. Eur J Pharmacol. 2009;609:126\u201331. https:\/\/doi.org\/10.1016\/j.ejphar.2009.03.027.","journal-title":"Eur J Pharmacol"},{"key":"3499_CR7","doi-asserted-by":"publisher","first-page":"153202","DOI":"10.1016\/j.phymed.2020.153202","volume":"69","author":"WF Wu","year":"2020","unstructured":"Wu WF, Wang JN, Li Z, et al. 7-Hydroxycoumarin protects against cisplatin-induced acute kidney injury by inhibiting necroptosis and promoting Sox9-mediated tubular epithelial cell proliferation. Phytomedicine. 2020;69:153202. https:\/\/doi.org\/10.1016\/j.phymed.2020.153202.","journal-title":"Phytomedicine"},{"key":"3499_CR8","doi-asserted-by":"publisher","first-page":"121104","DOI":"10.1016\/j.lfs.2022.121104","volume":"310","author":"DH Sami","year":"2022","unstructured":"Sami DH, Soliman AS, Khowailed AA, et al. 7-hydroxycoumarin modulates Nrf2\/HO-1 and microRNA-34a\/SIRT1 signaling and prevents cisplatin-induced oxidative stress, inflammation, and kidney injury in rats. Life Sci. 2022;310:121104. https:\/\/doi.org\/10.1016\/j.lfs.2022.121104.","journal-title":"Life Sci"},{"key":"3499_CR9","doi-asserted-by":"publisher","first-page":"63","DOI":"10.1016\/j.cbi.2013.08.010","volume":"206","author":"LM Kabeya","year":"2013","unstructured":"Kabeya LM, Fuzissaki CN, Taleb SH, et al. 7-Hydroxycoumarin modulates the oxidative metabolism, degranulation and microbial killing of human neutrophils. Chem Biol Interact. 2013;206:63\u201375. https:\/\/doi.org\/10.1016\/j.cbi.2013.08.010.","journal-title":"Chem Biol Interact"},{"key":"3499_CR10","doi-asserted-by":"publisher","first-page":"110432doi","DOI":"10.1016\/j.biopha.2020.110432","volume":"129","author":"LF Cruz","year":"2020","unstructured":"Cruz LF, Figueiredo GF, Pedro LP, et al. Umbelliferone (7-hydroxycoumarin): a non-toxic antidiarrheal and antiulcerogenic coumarin. Biomed Pharmacother. 2020;129:110432doi. https:\/\/doi.org\/10.1016\/j.biopha.2020.110432.","journal-title":"Biomed Pharmacother"},{"key":"3499_CR11","doi-asserted-by":"publisher","first-page":"1812","DOI":"10.16438\/j.0513-4870.2019-0936","volume":"55","author":"Y Huang","year":"2019","unstructured":"Huang Y, Yang SS, Lin X, et al. Study on the mechanism of action of Fuzi Lizhong pills in treating ulcerative colitis based on network pharmacological-molecular docking. Chin J Pharm Sci. 2019;55:1812\u201322. https:\/\/doi.org\/10.16438\/j.0513-4870.2019-0936.","journal-title":"Chin J Pharm Sci"},{"key":"3499_CR12","doi-asserted-by":"publisher","first-page":"1146doi","DOI":"10.3389\/fphar.2020.01146","volume":"11","author":"J Wang","year":"2020","unstructured":"Wang J, Ishfaq M, Fan Q, et al. 7-Hydroxycoumarin attenuates Colistin-Induced kidney injury in mice through the decreased level of histone deacetylase 1 and the activation of Nrf2 signaling pathway. Front Pharmacol. 2020;11:1146doi. https:\/\/doi.org\/10.3389\/fphar.2020.01146.","journal-title":"Front Pharmacol"},{"key":"3499_CR13","doi-asserted-by":"publisher","first-page":"116847","DOI":"10.1016\/j.jep.2023.116847","volume":"317","author":"L Wang","year":"2023","unstructured":"Wang L, Liu Y, Shen G, et al. Mechanisms of Si-Wu Decoction in the treatment of ulcerative colitis revealed by network pharmacology and experimental verification. J Ethnopharmacol. 2023;317:116847. https:\/\/doi.org\/10.1016\/j.jep.2023.116847.","journal-title":"J Ethnopharmacol"},{"key":"3499_CR14","first-page":"1642","volume":"34","author":"M Tang","year":"2018","unstructured":"Tang M, Liu Q, Liu H, et al. Research progress of ulcerative colitis related signaling pathways. Chin Pharm Bull. 2018;34:1642\u20137.","journal-title":"Chin Pharm Bull"},{"key":"3499_CR15","first-page":"1883","volume":"37","author":"ZH Li","year":"2015","unstructured":"Li ZH, Wang J, Cai RL. Effects of Shenling Baizhu powder on the expressions of AQP3 and AQP4 in UC rats via ERK\/p38 MAPK signal pathway. Chin Tradit Pat Med. 2015;37:1883\u20138.","journal-title":"Chin Tradit Pat Med"},{"key":"3499_CR16","first-page":"2826","volume":"28","author":"S Chen","year":"2017","unstructured":"Chen S, He Y, Wu Q. The research on observing the effect of Baishaoqiwu granules acting mechanism in treating Ulcerative colitis from NOXs-ROS-P38MAPK related signal pathway. Lishizhen Med Mater Med Res. 2017;28:2826\u20138.","journal-title":"Lishizhen Med Mater Med Res"},{"key":"3499_CR17","doi-asserted-by":"publisher","first-page":"5768","DOI":"10.1039\/c9fo00664h","volume":"10","author":"L Lian","year":"2019","unstructured":"Lian L, Zhang S, Yu Z, et al. The dietary freeze-dried fruit powder of Actinidia arguta ameliorates dextran sulphate sodium-induced ulcerative colitis in mice by inhibiting the activation of MAPKs. Food Funct. 2019;10:5768\u201378. https:\/\/doi.org\/10.1039\/c9fo00664h.","journal-title":"Food Funct"},{"key":"3499_CR18","doi-asserted-by":"publisher","first-page":"833","DOI":"10.1038\/s41419-020-03038-z","volume":"11","author":"J Yang","year":"2020","unstructured":"Yang J, Cheng M, Gu B, et al. CircRNA_09505 aggravates inflammation and joint damage in collagen-induced arthritis mice via miR-6089\/AKT1\/NF-\u03baB axis. Cell Death Dis. 2020;11:833. https:\/\/doi.org\/10.1038\/s41419-020-03038-z.","journal-title":"Cell Death Dis"},{"key":"3499_CR19","doi-asserted-by":"publisher","first-page":"683","DOI":"10.1016\/j.jcmgh.2020.10.007","volume":"11","author":"C Zhang","year":"2021","unstructured":"Zhang C, Chen H, He Q, et al. Fibrinogen\/AKT\/Microfilament Axis promotes colitis by enhancing vascular permeability. Cell Mol Gastroenterol Hepatol. 2021;11:683\u201396. https:\/\/doi.org\/10.1016\/j.jcmgh.2020.10.007.","journal-title":"Cell Mol Gastroenterol Hepatol"},{"key":"3499_CR20","doi-asserted-by":"publisher","first-page":"591","DOI":"10.1016\/j.gastro.2005.06.004","volume":"129","author":"DF McCole","year":"2005","unstructured":"McCole DF, Rogler G, Varki N, et al. Epidermal growth factor partially restores colonic ion transport responses in mouse models of chronic colitis. Gastroenterology. 2005;129:591\u2013608. https:\/\/doi.org\/10.1016\/j.gastro.2005.06.004.","journal-title":"Gastroenterology"}],"container-title":["BMC Gastroenterology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1186\/s12876-024-03499-y.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/article\/10.1186\/s12876-024-03499-y\/fulltext.html","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1186\/s12876-024-03499-y.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2024,11,12]],"date-time":"2024-11-12T08:04:06Z","timestamp":1731398646000},"score":1,"resource":{"primary":{"URL":"https:\/\/bmcgastroenterol.biomedcentral.com\/articles\/10.1186\/s12876-024-03499-y"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2024,11,12]]},"references-count":20,"journal-issue":{"issue":"1","published-online":{"date-parts":[[2024,12]]}},"alternative-id":["3499"],"URL":"https:\/\/doi.org\/10.1186\/s12876-024-03499-y","relation":{},"ISSN":["1471-230X"],"issn-type":[{"value":"1471-230X","type":"electronic"}],"subject":[],"published":{"date-parts":[[2024,11,12]]},"assertion":[{"value":"6 July 2024","order":1,"name":"received","label":"Received","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"7 November 2024","order":2,"name":"accepted","label":"Accepted","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"12 November 2024","order":3,"name":"first_online","label":"First Online","group":{"name":"ArticleHistory","label":"Article History"}},{"order":1,"name":"Ethics","group":{"name":"EthicsHeading","label":"Declarations"}},{"value":"The Medical and Experimental Animal Ethics Committee of the Chengdu University of Traditional Chinese Medicine granted ethical approval for these experiments under Ethics Approval No. SYXK2020-124, ensuring compliance with established ethical standards.","order":2,"name":"Ethics","group":{"name":"EthicsHeading","label":"Ethics approval and consent to participate"}},{"value":"Not applicable.","order":3,"name":"Ethics","group":{"name":"EthicsHeading","label":"Consent for publication"}},{"value":"The authors declare no competing interests.","order":4,"name":"Ethics","group":{"name":"EthicsHeading","label":"Competing interests"}},{"value":"No conflicts of interest are associated with this publication.","order":5,"name":"Ethics","group":{"name":"EthicsHeading","label":"Conflict of interest"}}],"article-number":"405"}}