{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,23]],"date-time":"2026-10-23T11:49:00Z","timestamp":1792756140267,"version":"4.5.0"},"reference-count":66,"publisher":"Springer Science and Business Media LLC","issue":"1","license":[{"start":{"date-parts":[[2025,1,22]],"date-time":"2025-01-22T00:00:00Z","timestamp":1737504000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0"},{"start":{"date-parts":[[2025,1,22]],"date-time":"2025-01-22T00:00:00Z","timestamp":1737504000000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0"}],"funder":[{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["82374456"],"award-info":[{"award-number":["82374456"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["82374456"],"award-info":[{"award-number":["82374456"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["BMC Gastroenterol"],"DOI":"10.1186\/s12876-024-03575-3","type":"journal-article","created":{"date-parts":[[2025,1,22]],"date-time":"2025-01-22T14:55:54Z","timestamp":1737557754000},"update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":6,"title":["Association of anxiety status and anxiety duration with constipation in adult Americans: a cross-sectional study using data from the NHANES 2007\u20132010"],"prefix":"10.1186","volume":"25","author":[{"given":"Xinran","family":"Li","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Conghui","family":"Bian","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hui","family":"Dai","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xingrui","family":"Chen","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Haihua","family":"Qian","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Dan","family":"Zhang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2025,1,22]]},"reference":[{"issue":"8","key":"3575_CR1","doi-asserted-by":"publisher","first-page":"1986","DOI":"10.1111\/j.1572-0241.2002.05843.x","volume":"97","author":"EJ Irvine","year":"2002","unstructured":"Irvine EJ, Ferrazzi S, Pare P, Thompson WG, Rance L. Health-related quality of life in functional GI disorders: focus on constipation and resource utilization. Am J Gastroenterol. 2002;97(8):1986\u201393.","journal-title":"Am J Gastroenterol"},{"issue":"5","key":"3575_CR2","doi-asserted-by":"publisher","first-page":"1232","DOI":"10.1053\/j.gastro.2019.12.034","volume":"158","author":"AE Bharucha","year":"2020","unstructured":"Bharucha AE, Lacy BE. Mechanisms, evaluation, and management of chronic constipation. Gastroenterology. 2020;158(5):1232\u2013e12491233.","journal-title":"Gastroenterology"},{"issue":"9","key":"3575_CR3","doi-asserted-by":"publisher","first-page":"1582","DOI":"10.1038\/ajg.2011.164","volume":"106","author":"NC Suares","year":"2011","unstructured":"Suares NC, Ford AC. Prevalence of, and risk factors for, chronic idiopathic constipation in the community: systematic review and meta-analysis. Am J Gastroenterol. 2011;106(9):1582\u201391. quiz 1581, 1592.","journal-title":"Am J Gastroenterol"},{"issue":"12","key":"3575_CR4","first-page":"43","volume":"19","author":"BC Martin","year":"2006","unstructured":"Martin BC, Barghout V, Cerulli A. Direct medical costs of constipation in the United States. Manag Care Interface. 2006;19(12):43\u20139.","journal-title":"Manag Care Interface"},{"issue":"1","key":"3575_CR5","doi-asserted-by":"publisher","first-page":"39","DOI":"10.1080\/17474124.2020.1708718","volume":"14","author":"I Aziz","year":"2020","unstructured":"Aziz I, Whitehead WE, Palsson OS, T\u00f6rnblom H, Simr\u00e9n M. An approach to the diagnosis and management of Rome IV functional disorders of chronic constipation. Expert Rev Gastroenterol Hepatol. 2020;14(1):39\u201346.","journal-title":"Expert Rev Gastroenterol Hepatol"},{"key":"3575_CR6","doi-asserted-by":"publisher","first-page":"1483515","DOI":"10.3389\/fnut.2024.1483515","volume":"11","author":"X Liu","year":"2024","unstructured":"Liu X, Liu Y, Shu Y, Tao H, Sheng Z, Peng Y, Cai M, Zhang X, Lan W. Association between dietary vitamin B6 intake and constipation: a population-based study. Front Nutr. 2024;11:1483515.","journal-title":"Front Nutr"},{"issue":"5","key":"3575_CR7","doi-asserted-by":"publisher","first-page":"599","DOI":"10.1111\/j.1365-2036.2006.03238.x","volume":"25","author":"JF Johanson","year":"2007","unstructured":"Johanson JF, Kralstein J. Chronic constipation: a survey of the patient perspective. Aliment Pharmacol Ther. 2007;25(5):599\u2013608.","journal-title":"Aliment Pharmacol Ther"},{"issue":"1","key":"3575_CR8","doi-asserted-by":"publisher","first-page":"27","DOI":"10.1007\/s00535-019-01611-8","volume":"55","author":"Y Kawamura","year":"2020","unstructured":"Kawamura Y, Yamamoto S, Funaki Y, Ohashi W, Yamamoto K, Ozeki T, Yamaguchi Y, Tamura Y, Izawa S, Hijikata Y, et al. Internet survey on the actual situation of constipation in the Japanese population under 70 years old: focus on functional constipation and constipation-predominant irritable bowel syndrome. J Gastroenterol. 2020;55(1):27\u201338.","journal-title":"J Gastroenterol"},{"issue":"5","key":"3575_CR9","doi-asserted-by":"publisher","first-page":"592","DOI":"10.1080\/10253890.2019.1617267","volume":"22","author":"N Li","year":"2019","unstructured":"Li N, Wang Q, Wang Y, Sun A, Lin Y, Jin Y, Li X. Fecal microbiota transplantation from chronic unpredictable mild stress mice donors affects anxiety-like and depression-like behavior in recipient mice via the gut microbiota-inflammation-brain axis. Stress. 2019;22(5):592\u2013602.","journal-title":"Stress"},{"issue":"5","key":"3575_CR10","doi-asserted-by":"publisher","first-page":"465","DOI":"10.1001\/jamapsychiatry.2017.0056","volume":"74","author":"AM Ruscio","year":"2017","unstructured":"Ruscio AM, Hallion LS, Lim CCW, Aguilar-Gaxiola S, Al-Hamzawi A, Alonso J, Andrade LH, Borges G, Bromet EJ, Bunting B, et al. Cross-sectional comparison of the epidemiology of DSM-5 Generalized Anxiety Disorder across the Globe. JAMA Psychiatry. 2017;74(5):465\u201375.","journal-title":"JAMA Psychiatry"},{"key":"3575_CR11","doi-asserted-by":"publisher","first-page":"187","DOI":"10.1007\/978-981-32-9705-0_12","volume":"1191","author":"SC Park","year":"2020","unstructured":"Park SC, Kim YK. Anxiety disorders in the DSM-5: changes, controversies, and future directions. Adv Exp Med Biol. 2020;1191:187\u201396.","journal-title":"Adv Exp Med Biol"},{"key":"3575_CR12","doi-asserted-by":"crossref","unstructured":"First MB. Diagnostic and statistical manual of mental disorders, 5th edition, and clinical utility. J Nerv Ment Dis 2013, 201(9):727\u2013729.","DOI":"10.1097\/NMD.0b013e3182a2168a"},{"key":"3575_CR13","doi-asserted-by":"publisher","first-page":"1249672","DOI":"10.3389\/fmed.2023.1249672","volume":"10","author":"G Li","year":"2023","unstructured":"Li G, Lv T, Jin B, Fan Z. The role of repetitive transcranial magnetic stimulation therapy in functional bowel disease. Front Med (Lausanne). 2023;10:1249672.","journal-title":"Front Med (Lausanne)"},{"issue":"3","key":"3575_CR14","doi-asserted-by":"publisher","first-page":"443","DOI":"10.1111\/nmo.12508","volume":"27","author":"F De Vadder","year":"2015","unstructured":"De Vadder F, Plessier F, Gautier-Stein A, Mithieux G. Vasoactive intestinal peptide is a local mediator in a gut-brain neural axis activating intestinal gluconeogenesis. Neurogastroenterol Motil. 2015;27(3):443\u20138.","journal-title":"Neurogastroenterol Motil"},{"issue":"9","key":"3575_CR15","doi-asserted-by":"publisher","first-page":"1284","DOI":"10.1136\/gutjnl-2011-300474","volume":"61","author":"NA Koloski","year":"2012","unstructured":"Koloski NA, Jones M, Kalantar J, Weltman M, Zaguirre J, Talley NJ. The brain\u2013gut pathway in functional gastrointestinal disorders is bidirectional: a 12-year prospective population-based study. Gut. 2012;61(9):1284\u201390.","journal-title":"Gut"},{"key":"3575_CR16","doi-asserted-by":"publisher","first-page":"219","DOI":"10.1146\/annurev.physiol.010908.163221","volume":"71","author":"A Stengel","year":"2009","unstructured":"Stengel A, Tach\u00e9 Y. Neuroendocrine control of the gut during stress: corticotropin-releasing factor signaling pathways in the spotlight. Annu Rev Physiol. 2009;71:219\u201339.","journal-title":"Annu Rev Physiol"},{"issue":"6","key":"3575_CR17","doi-asserted-by":"publisher","first-page":"574","DOI":"10.1038\/mp.2009.141","volume":"15","author":"EB Binder","year":"2010","unstructured":"Binder EB, Nemeroff CB. The CRF system, stress, depression and anxiety-insights from human genetic studies. Mol Psychiatry. 2010;15(6):574\u201388.","journal-title":"Mol Psychiatry"},{"issue":"2","key":"3575_CR18","first-page":"203","volume":"28","author":"M Carabotti","year":"2015","unstructured":"Carabotti M, Scirocco A, Maselli MA, Severi C. The gut-brain axis: interactions between enteric microbiota, central and enteric nervous systems. Ann Gastroenterol. 2015;28(2):203\u20139.","journal-title":"Ann Gastroenterol"},{"key":"3575_CR19","doi-asserted-by":"publisher","first-page":"1415567","DOI":"10.3389\/fnmol.2024.1415567","volume":"17","author":"J Morys","year":"2024","unstructured":"Morys J, Ma\u0142ecki A, Nowacka-Chmielewska M. Stress and the gut-brain axis: an inflammatory perspective. Front Mol Neurosci. 2024;17:1415567.","journal-title":"Front Mol Neurosci"},{"key":"3575_CR20","doi-asserted-by":"publisher","first-page":"1296163","DOI":"10.3389\/fmicb.2023.1296163","volume":"14","author":"H Li","year":"2023","unstructured":"Li H, Lv N, Li D, Qian Y, Si X, Hua Y, Wang Y, Han X, Xu T. Tongbian decoction restores intestinal microbiota and activates 5-hydroxytryptamine signaling: implication in slow transit constipation. Front Microbiol. 2023;14:1296163.","journal-title":"Front Microbiol"},{"issue":"1","key":"3575_CR21","doi-asserted-by":"publisher","first-page":"21","DOI":"10.1186\/s12876-018-0749-3","volume":"18","author":"M Avramidou","year":"2018","unstructured":"Avramidou M, Angst F, Angst J, Aeschlimann A, R\u00f6ssler W, Schnyder U. Epidemiology of gastrointestinal symptoms in young and middle-aged Swiss adults: prevalences and comorbidities in a longitudinal population cohort over 28 years. BMC Gastroenterol. 2018;18(1):21.","journal-title":"BMC Gastroenterol"},{"key":"3575_CR22","doi-asserted-by":"publisher","first-page":"856138","DOI":"10.3389\/fnut.2022.856138","volume":"9","author":"S Yang","year":"2022","unstructured":"Yang S, Wu XL, Wang SQ, Guo XL, Guo FZ, Sun XF. Association of Dietary Energy Intake with Constipation among men and women: results from the National Health and Nutrition Examination Survey. Front Nutr. 2022;9:856138.","journal-title":"Front Nutr"},{"key":"3575_CR23","doi-asserted-by":"publisher","first-page":"1393596","DOI":"10.3389\/fnut.2024.1393596","volume":"11","author":"Y Hong","year":"2024","unstructured":"Hong Y, Shen H, Chen X, Li G. Gender differences in the association between dietary protein intake and constipation: findings from NHANES. Front Nutr. 2024;11:1393596.","journal-title":"Front Nutr"},{"issue":"10","key":"3575_CR24","doi-asserted-by":"publisher","first-page":"1389","DOI":"10.1111\/nmo.12630","volume":"27","author":"S Taba Taba Vakili","year":"2015","unstructured":"Taba Taba Vakili S, Nezami BG, Shetty A, Chetty VK, Srinivasan S. Association of high dietary saturated fat intake and uncontrolled diabetes with constipation: evidence from the National Health and Nutrition Examination Survey. Neurogastroenterol Motil. 2015;27(10):1389\u201397.","journal-title":"Neurogastroenterol Motil"},{"issue":"1","key":"3575_CR25","doi-asserted-by":"publisher","first-page":"97","DOI":"10.5056\/jnm20051","volume":"27","author":"Y Li","year":"2021","unstructured":"Li Y, Tong WD, Qian Y. Effect of physical activity on the Association between Dietary Fiber and Constipation: evidence from the National Health and Nutrition Examination Survey 2005\u20132010. J Neurogastroenterol Motil. 2021;27(1):97\u2013107.","journal-title":"J Neurogastroenterol Motil"},{"issue":"4","key":"3575_CR26","doi-asserted-by":"publisher","first-page":"H956","DOI":"10.1152\/ajpheart.00519.2024","volume":"327","author":"T Zheng","year":"2024","unstructured":"Zheng T, Camargo Tavares L, D\u2019Amato M, Marques FZ. Constipation is associated with an increased risk of major adverse cardiac events in a UK population. Am J Physiol Heart Circ Physiol. 2024;327(4):H956\u201364.","journal-title":"Am J Physiol Heart Circ Physiol"},{"key":"3575_CR27","doi-asserted-by":"crossref","unstructured":"Ito H, Shibuya M, Iwami R, Ina H, Okawa M, Miura IC, Matsumoto S, Inoue S, Antoku H. S : Deterioration of the defecation status after hospitalization in patients with type 2 diabetes is Associated with Albuminuria Rather than Diabetic Neuropathy. Intern Med 2024.","DOI":"10.2169\/internalmedicine.4546-24"},{"issue":"3","key":"3575_CR28","doi-asserted-by":"publisher","first-page":"421","DOI":"10.1111\/jch.13489","volume":"21","author":"Y Ishiyama","year":"2019","unstructured":"Ishiyama Y, Hoshide S, Mizuno H, Kario K. Constipation-induced pressor effects as triggers for cardiovascular events. J Clin Hypertens (Greenwich). 2019;21(3):421\u20135.","journal-title":"J Clin Hypertens (Greenwich)"},{"issue":"40","key":"3575_CR29","doi-asserted-by":"publisher","first-page":"e39943","DOI":"10.1097\/MD.0000000000039943","volume":"103","author":"KY Huang","year":"2024","unstructured":"Huang KY, Yu ZZ, Tu JJ, Tang XY, Huang JM, Lu TM, Lu YQ, Huang MC, Zhou J, Maier AB, et al. Positive association between constipation and mild cognitive impairment in elders: a cross-sectional study. Med (Baltim). 2024;103(40):e39943.","journal-title":"Med (Baltim)"},{"issue":"3","key":"3575_CR30","doi-asserted-by":"publisher","first-page":"262","DOI":"10.1097\/CM9.0000000000000552","volume":"133","author":"Y Yuan","year":"2020","unstructured":"Yuan Y, Qiu L, Li ZY, Zhang L, Xu T, Lang JH, Li ZA, Gong J, Liu Q, Liu XC, et al. An epidemiology study of fecal incontinence in adult Chinese women living in urban areas. Chin Med J (Engl). 2020;133(3):262\u20138.","journal-title":"Chin Med J (Engl)"},{"key":"3575_CR31","doi-asserted-by":"publisher","first-page":"1428003","DOI":"10.3389\/fonc.2024.1428003","volume":"14","author":"Y Dang","year":"2024","unstructured":"Dang Y, He X, Liu X, Wang Y, Geng S, Cheng Y, Ma H, Zhao X. Causal associations between constipation and pan-cancer: a bidirectional mendelian randomization study. Front Oncol. 2024;14:1428003.","journal-title":"Front Oncol"},{"issue":"1","key":"3575_CR32","doi-asserted-by":"publisher","first-page":"3","DOI":"10.1186\/s12889-023-17502-w","volume":"24","author":"Y Kang","year":"2024","unstructured":"Kang Y, Yan J. Exploring the connection between caffeine intake and constipation: a cross-sectional study using national health and nutrition examination survey data. BMC Public Health. 2024;24(1):3.","journal-title":"BMC Public Health"},{"issue":"2","key":"3575_CR33","doi-asserted-by":"publisher","first-page":"526","DOI":"10.1016\/j.tjnut.2023.11.032","volume":"154","author":"C Yang","year":"2024","unstructured":"Yang C, Hong Q, Wu T, Fan Y, Shen X, Dong X. Association between Dietary Intake of live microbes and chronic constipation in adults. J Nutr. 2024;154(2):526\u201334.","journal-title":"J Nutr"},{"issue":"54","key":"3575_CR34","doi-asserted-by":"publisher","first-page":"115776","DOI":"10.1007\/s11356-023-30542-4","volume":"30","author":"R Duan","year":"2023","unstructured":"Duan R, Zheng Y, Kong W, Wang Y, Zhou Y. Association of environmental tobacco smoke exposure with chronic constipation: a nationwide survey (NHANES 2005\u20132010). Environ Sci Pollut Res Int. 2023;30(54):115776\u201387.","journal-title":"Environ Sci Pollut Res Int"},{"issue":"1","key":"3575_CR35","doi-asserted-by":"publisher","first-page":"231","DOI":"10.1007\/s00384-023-04520-8","volume":"38","author":"Y Wang","year":"2023","unstructured":"Wang Y, Shen X, Wang P. Constipation is associated with depression of any severity, but not with suicidal ideation: insights from a large cross-sectional study. Int J Colorectal Dis. 2023;38(1):231.","journal-title":"Int J Colorectal Dis"},{"issue":"5","key":"3575_CR36","doi-asserted-by":"publisher","first-page":"339","DOI":"10.1136\/jech.57.5.339","volume":"57","author":"EM Andresen","year":"2003","unstructured":"Andresen EM, Catlin TK, Wyrwich KW, Jackson-Thompson J. Retest reliability of surveillance questions on health related quality of life. J Epidemiol Community Health. 2003;57(5):339\u201343.","journal-title":"J Epidemiol Community Health"},{"issue":"5","key":"3575_CR37","doi-asserted-by":"publisher","first-page":"1743","DOI":"10.1016\/j.jaip.2019.12.028","volume":"8","author":"JA Dantzer","year":"2020","unstructured":"Dantzer JA, Keet CA. Anxiety associated with food allergy in adults and adolescents: an analysis of data from the National Health and Nutrition Examination Survey (NHANES) 2007\u20132010. J Allergy Clin Immunol Pract. 2020;8(5):1743\u2013e17461745.","journal-title":"J Allergy Clin Immunol Pract"},{"key":"3575_CR38","doi-asserted-by":"publisher","first-page":"1402715","DOI":"10.3389\/fpubh.2024.1402715","volume":"12","author":"L Bai","year":"2024","unstructured":"Bai L, Wen Z, Zhu Y, Jama HA, Sawmadal JD, Chen J. Association of blood cadmium, lead, and mercury with anxiety: a cross-sectional study from NHANES 2007\u20132012. Front Public Health. 2024;12:1402715.","journal-title":"Front Public Health"},{"key":"3575_CR39","doi-asserted-by":"publisher","first-page":"188","DOI":"10.1016\/j.jad.2022.03.005","volume":"305","author":"Y Zhang","year":"2022","unstructured":"Zhang Y, Li X, Chan VKY, Luo H, Chan SSM, Wong GHY, Wong ICK, Lum TYS. Depression duration and risk of incident cardiovascular disease: a population-based six-year cohort study. J Affect Disord. 2022;305:188\u201395.","journal-title":"J Affect Disord"},{"issue":"13","key":"3575_CR40","doi-asserted-by":"publisher","first-page":"2696","DOI":"10.1016\/j.cgh.2019.03.046","volume":"17","author":"S Ballou","year":"2019","unstructured":"Ballou S, Katon J, Singh P, Rangan V, Lee HN, McMahon C, Iturrino J, Lembo A, Nee J. Chronic diarrhea and constipation are more common in depressed individuals. Clin Gastroenterol Hepatol. 2019;17(13):2696\u2013703.","journal-title":"Clin Gastroenterol Hepatol"},{"key":"3575_CR41","doi-asserted-by":"crossref","unstructured":"Wang J, Zhang C, Zhang A. The Association between blood lead levels and urgency urinary incontinence among adult females: a retrospective study based on NHANES 2005\u20132020. Biol Trace Elem Res 2024.","DOI":"10.1007\/s12011-024-04445-5"},{"issue":"9","key":"3575_CR42","doi-asserted-by":"publisher","first-page":"3205","DOI":"10.1007\/s12011-020-02451-x","volume":"199","author":"C Wang","year":"2021","unstructured":"Wang C, Zhang L, Li L. Association between Selenium Intake with chronic constipation and chronic diarrhea in adults: findings from the National Health and Nutrition Examination Survey. Biol Trace Elem Res. 2021;199(9):3205\u201312.","journal-title":"Biol Trace Elem Res"},{"issue":"2","key":"3575_CR43","doi-asserted-by":"publisher","first-page":"169","DOI":"10.1159\/000536318","volume":"17","author":"Y Hong","year":"2024","unstructured":"Hong Y, Chen X, Liu J. Analysis of Factors Associated with Constipation in the Population with obesity: evidence from the National Health and Nutrition Examination Survey. Obes Facts. 2024;17(2):169\u201382.","journal-title":"Obes Facts"},{"issue":"32","key":"3575_CR44","doi-asserted-by":"publisher","first-page":"45462","DOI":"10.1007\/s11356-024-33940-4","volume":"31","author":"BJ Tan","year":"2024","unstructured":"Tan BJ, Zhou ZD, Chan LL, Tan EK. Comments on Association of environmental tobacco smoke exposure with chronic constipation: a nationwide survey (NHANES 2005\u20132010) Duan R, et. al., doi (10.1007\/s11356-023-30542-4). Environ Sci Pollut Res Int. 2024;31(32):45462\u20133.","journal-title":"Environ Sci Pollut Res Int"},{"issue":"9","key":"3575_CR45","doi-asserted-by":"publisher","first-page":"e0311168","DOI":"10.1371\/journal.pone.0311168","volume":"19","author":"S Wei","year":"2024","unstructured":"Wei S, Yu S, Lan Y, Jia Y. Association between the composite dietary antioxidant index and constipation: evidence from NHANES 2005\u20132010. PLoS ONE. 2024;19(9):e0311168.","journal-title":"PLoS ONE"},{"issue":"7","key":"3575_CR46","doi-asserted-by":"publisher","first-page":"1272","DOI":"10.14309\/ajg.0000000000002800","volume":"119","author":"I Hanna-Jairala","year":"2024","unstructured":"Hanna-Jairala I, Drossman DA. Central neuromodulators in irritable bowel syndrome: why, how, and when. Am J Gastroenterol. 2024;119(7):1272\u201384.","journal-title":"Am J Gastroenterol"},{"issue":"2","key":"3575_CR47","doi-asserted-by":"publisher","first-page":"G173","DOI":"10.1152\/ajpgi.2001.280.2.G173","volume":"280","author":"Y Tach\u00e9","year":"2001","unstructured":"Tach\u00e9 Y, Martinez V, Million M, Wang L. Stress and the gastrointestinal tract III. Stress-related alterations of gut motor function: role of brain corticotropin-releasing factor receptors. Am J Physiol Gastrointest Liver Physiol. 2001;280(2):G173\u2013177.","journal-title":"Am J Physiol Gastrointest Liver Physiol"},{"issue":"1","key":"3575_CR48","doi-asserted-by":"publisher","first-page":"15","DOI":"10.1016\/S0167-0115(97)01005-7","volume":"71","author":"SC Heinrichs","year":"1997","unstructured":"Heinrichs SC, Lapsansky J, Lovenberg TW, De Souza EB, Chalmers DT. Corticotropin-releasing factor CRF1, but not CRF2, receptors mediate anxiogenic-like behavior. Regul Pept. 1997;71(1):15\u201321.","journal-title":"Regul Pept"},{"key":"3575_CR49","doi-asserted-by":"publisher","first-page":"1337739","DOI":"10.3389\/fnins.2024.1337739","volume":"18","author":"XY Zhang","year":"2024","unstructured":"Zhang XY, Ye F, Yin ZH, Li YQ, Bao QN, Xia MZ, Chen ZH, Zhong WQ, Wu KX, Yao J, et al. Research status and trends of physical activity on depression or anxiety: a bibliometric analysis. Front Neurosci. 2024;18:1337739.","journal-title":"Front Neurosci"},{"issue":"1","key":"3575_CR50","doi-asserted-by":"publisher","first-page":"307","DOI":"10.1186\/s12916-023-03019-x","volume":"21","author":"H Chen","year":"2023","unstructured":"Chen H, Cao Z, Hou Y, Yang H, Wang X, Xu C. The associations of dietary patterns with depressive and anxiety symptoms: a prospective study. BMC Med. 2023;21(1):307.","journal-title":"BMC Med"},{"issue":"4","key":"3575_CR51","doi-asserted-by":"publisher","first-page":"737","DOI":"10.1016\/j.jpainsymman.2008.04.016","volume":"37","author":"GL McCrea","year":"2009","unstructured":"McCrea GL, Miaskowski C, Stotts NA, Macera L, Varma MG. A review of the literature on gender and age differences in the prevalence and characteristics of constipation in North America. J Pain Symptom Manage. 2009;37(4):737\u201345.","journal-title":"J Pain Symptom Manage"},{"issue":"19","key":"3575_CR52","doi-asserted-by":"publisher","first-page":"e37883","DOI":"10.1016\/j.heliyon.2024.e37883","volume":"10","author":"JK Abankwah","year":"2024","unstructured":"Abankwah JK, Wang Y, Wang J, Ogbe SE, Pozzo LD, Chu X, Bian Y. Gut aging: a wane from the normal to repercussion and gerotherapeutic strategies. Heliyon. 2024;10(19):e37883.","journal-title":"Heliyon"},{"key":"3575_CR53","doi-asserted-by":"publisher","first-page":"4921","DOI":"10.2147\/PRBM.S429132","volume":"16","author":"Z Wang","year":"2023","unstructured":"Wang Z, Lu Y, Li L, Wu X, Liu J, Tang J, Wang W, Lu L. Relationship between severity of gastrointestinal symptoms and anxiety symptoms in patients with chronic gastrointestinal disease: the mediating role of illness perception. Psychol Res Behav Manag. 2023;16:4921\u201333.","journal-title":"Psychol Res Behav Manag"},{"key":"3575_CR54","doi-asserted-by":"publisher","first-page":"1013","DOI":"10.1016\/j.jad.2024.10.077","volume":"369","author":"E Bergmann","year":"2025","unstructured":"Bergmann E, Harlev D, Wolpe N. Depressive symptoms are linked to age-specific neuroanatomical and cognitive variations. J Affect Disord. 2025;369:1013\u201320.","journal-title":"J Affect Disord"},{"issue":"10","key":"3575_CR55","doi-asserted-by":"publisher","first-page":"1353","DOI":"10.1038\/nn.4086","volume":"18","author":"BS McEwen","year":"2015","unstructured":"McEwen BS, Bowles NP, Gray JD, Hill MN, Hunter RG, Karatsoreos IN, Nasca C. Mechanisms of stress in the brain. Nat Neurosci. 2015;18(10):1353\u201363.","journal-title":"Nat Neurosci"},{"key":"3575_CR56","doi-asserted-by":"publisher","first-page":"583","DOI":"10.1016\/j.bbi.2019.05.004","volume":"80","author":"A Gururajan","year":"2019","unstructured":"Gururajan A, van de Wouw M, Boehme M, Becker T, O\u2019Connor R, Bastiaanssen TFS, Moloney GM, Lyte JM, Ventura Silva AP, Merckx B, et al. Resilience to chronic stress is associated with specific neurobiological, neuroendocrine and immune responses. Brain Behav Immun. 2019;80:583\u201394.","journal-title":"Brain Behav Immun"},{"issue":"3","key":"3575_CR57","doi-asserted-by":"publisher","first-page":"1205","DOI":"10.1152\/physrev.00042.2023","volume":"104","author":"R Kalisch","year":"2024","unstructured":"Kalisch R, Russo SJ, M\u00fcller MB. Neurobiology and systems biology of stress resilience. Physiol Rev. 2024;104(3):1205\u201363.","journal-title":"Physiol Rev"},{"issue":"7","key":"3575_CR58","doi-asserted-by":"publisher","first-page":"488","DOI":"10.1093\/abm\/kaae026","volume":"58","author":"CE Rosas","year":"2024","unstructured":"Rosas CE, Pirzada A, Durazo-Arvizu R, Gallo LC, Talavera GA, Elfassy T, Cai J, Llabre MM, Perreira KM, Wassertheil-Smoller S, et al. Associations of anxiety symptoms with 6-Year blood pressure changes and Incident Hypertension: results from the Hispanic Community Health Study\/Study of latinos. Ann Behav Med. 2024;58(7):488\u201397.","journal-title":"Ann Behav Med"},{"key":"3575_CR59","doi-asserted-by":"crossref","unstructured":"Qiu T, Jiang Z, Chen X, Dai Y, Zhao H. Comorbidity of Anxiety and Hypertension: Common Risk Factors and Potential Mechanisms. Int J Hypertens 2023, 2023:9619388.","DOI":"10.1155\/2023\/9619388"},{"issue":"11","key":"3575_CR60","doi-asserted-by":"publisher","first-page":"1804","DOI":"10.1161\/CIRCRESAHA.114.302524","volume":"114","author":"G Mancia","year":"2014","unstructured":"Mancia G, Grassi G. The autonomic nervous system and hypertension. Circ Res. 2014;114(11):1804\u201314.","journal-title":"Circ Res"},{"issue":"1","key":"3575_CR61","doi-asserted-by":"publisher","first-page":"10943","DOI":"10.1038\/s41598-023-38068-y","volume":"13","author":"CP Judkins","year":"2023","unstructured":"Judkins CP, Wang Y, Jelinic M, Bobik A, Vinh A, Sobey CG, Drummond GR. Association of constipation with increased risk of hypertension and cardiovascular events in elderly Australian patients. Sci Rep. 2023;13(1):10943.","journal-title":"Sci Rep"},{"issue":"3","key":"3575_CR62","doi-asserted-by":"publisher","first-page":"319","DOI":"10.1046\/j.1365-2036.2003.01663.x","volume":"18","author":"C Cheng","year":"2003","unstructured":"Cheng C, Chan AO, Hui WM, Lam SK. Coping strategies, illness perception, anxiety and depression of patients with idiopathic constipation: a population-based study. Aliment Pharmacol Ther. 2003;18(3):319\u201326.","journal-title":"Aliment Pharmacol Ther"},{"issue":"1","key":"3575_CR63","doi-asserted-by":"publisher","first-page":"434","DOI":"10.1186\/s12876-024-03526-y","volume":"24","author":"Z Deng","year":"2024","unstructured":"Deng Z, Zeng X, Wang H, Bi W, Huang Y, Fu H. Causal relationship between major depressive disorder, anxiety disorder and constipation: a two-sample mendelian randomization study. BMC Gastroenterol. 2024;24(1):434.","journal-title":"BMC Gastroenterol"},{"issue":"9","key":"3575_CR64","doi-asserted-by":"publisher","first-page":"1428","DOI":"10.1007\/BF01538081","volume":"34","author":"G Devroede","year":"1989","unstructured":"Devroede G, Girard G, Bouchoucha M, Roy T, Black R, Camerlain M, Pinard G, Schang JC, Arhan P. Idiopathic constipation by colonic dysfunction. Relationship with personality and anxiety. Dig Dis Sci. 1989;34(9):1428\u201333.","journal-title":"Dig Dis Sci"},{"issue":"11","key":"3575_CR65","doi-asserted-by":"publisher","first-page":"e083668","DOI":"10.1136\/bmjopen-2023-083668","volume":"14","author":"Y Karasawa","year":"2024","unstructured":"Karasawa Y, Nozawa K, Nomoto K, Fukudo S. Constipation among workers with depression\/anxiety: a retrospective study using a claims database and survey data in Japan. BMJ Open. 2024;14(11):e083668.","journal-title":"BMJ Open"},{"key":"3575_CR66","doi-asserted-by":"crossref","unstructured":"Liang J, Zhao Y, Xi Y, Xiang C, Yong C, Huo J, Zou H, Hou Y, Pan Y, Wu M et al. Association between Depression, Anxiety Symptoms and Gut Microbiota in Chinese Elderly with Functional Constipation. Nutrients 2022, 14(23).","DOI":"10.3390\/nu14235013"}],"container-title":["BMC Gastroenterology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1186\/s12876-024-03575-3.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/article\/10.1186\/s12876-024-03575-3\/fulltext.html","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1186\/s12876-024-03575-3.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,1,22]],"date-time":"2025-01-22T14:56:03Z","timestamp":1737557763000},"score":1,"resource":{"primary":{"URL":"https:\/\/bmcgastroenterol.biomedcentral.com\/articles\/10.1186\/s12876-024-03575-3"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2025,1,22]]},"references-count":66,"journal-issue":{"issue":"1","published-online":{"date-parts":[[2025,12]]}},"alternative-id":["3575"],"URL":"https:\/\/doi.org\/10.1186\/s12876-024-03575-3","relation":{},"ISSN":["1471-230X"],"issn-type":[{"value":"1471-230X","type":"electronic"}],"subject":[],"published":{"date-parts":[[2025,1,22]]},"assertion":[{"value":"12 October 2024","order":1,"name":"received","label":"Received","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"20 December 2024","order":2,"name":"accepted","label":"Accepted","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"22 January 2025","order":3,"name":"first_online","label":"First Online","group":{"name":"ArticleHistory","label":"Article History"}},{"order":1,"name":"Ethics","group":{"name":"EthicsHeading","label":"Declarations"}},{"value":"This study was conducted according to the guidelines laid down in the Declaration of Helsinki and all procedures involving research study participants were approved by the NCHS Institutional Review Board. Written informed consent was obtained from all subjects\/patients.","order":2,"name":"Ethics","group":{"name":"EthicsHeading","label":"Ethics approval and consent to participate"}},{"value":"Not applicable.","order":3,"name":"Ethics","group":{"name":"EthicsHeading","label":"Consent for publication"}},{"value":"The authors declare no competing interests.","order":4,"name":"Ethics","group":{"name":"EthicsHeading","label":"Competing interests"}},{"value":"The authors declare that the research was conducted in the absence of any commercial or financial relationships that could be construed as a potential conflict of interest.","order":5,"name":"Ethics","group":{"name":"EthicsHeading","label":"Conflict of interest"}}],"article-number":"31"}}