{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,8]],"date-time":"2026-07-08T15:21:15Z","timestamp":1783524075059,"version":"3.55.0"},"reference-count":43,"publisher":"Springer Science and Business Media LLC","issue":"1","license":[{"start":{"date-parts":[[2025,1,13]],"date-time":"2025-01-13T00:00:00Z","timestamp":1736726400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0"},{"start":{"date-parts":[[2025,1,13]],"date-time":"2025-01-13T00:00:00Z","timestamp":1736726400000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0"}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["BMC Gastroenterol"],"DOI":"10.1186\/s12876-025-03601-y","type":"journal-article","created":{"date-parts":[[2025,1,16]],"date-time":"2025-01-16T08:15:30Z","timestamp":1737015330000},"update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":13,"title":["Investigating neutropenic enterocolitis: a systematic review of case reports and clinical insights"],"prefix":"10.1186","volume":"25","author":[{"given":"Samane","family":"Nematolahi","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ali","family":"Amanati","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hossein Molavi","family":"Vardanjani","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mohammadreza","family":"Pourali","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mahnaz Hosseini","family":"Bensenjan","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Farnoosh","family":"Nozari","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mohebat","family":"Vali","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Seyed Reza","family":"Abdipour Mehrian","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Seyed Ali","family":"Nabavizadeh","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Farima","family":"Safari","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2025,1,13]]},"reference":[{"issue":"1","key":"3601_CR1","doi-asserted-by":"publisher","first-page":"42","DOI":"10.3748\/wjg.v23.i1.42","volume":"23","author":"FG Rodrigues","year":"2017","unstructured":"Rodrigues FG, Dasilva G, Wexner SD. Neutropenic enterocolitis. World J Gastroenterol. 2017;23(1):42\u20137.","journal-title":"World J Gastroenterol"},{"issue":"3","key":"3601_CR2","doi-asserted-by":"publisher","first-page":"36","DOI":"10.4291\/wjgp.v10.i3.36","volume":"10","author":"R Xia","year":"2019","unstructured":"Xia R, Zhang X. Neutropenic enterocolitis: a clinico-pathological review. World J Gastrointest Pathophysiol. 2019;10(3):36\u201341.","journal-title":"World J Gastrointest Pathophysiol"},{"issue":"3","key":"3601_CR3","doi-asserted-by":"publisher","first-page":"307","DOI":"10.1089\/sur.2008.061","volume":"10","author":"BW Ullery","year":"2009","unstructured":"Ullery BW, Pieracci FM, Rodney JR, Barie PS. Neutropenic enterocolitis. Surg Infect. 2009;10(3):307\u201314.","journal-title":"Surg Infect"},{"issue":"6","key":"3601_CR4","doi-asserted-by":"publisher","first-page":"638","DOI":"10.3390\/medicina57060638","volume":"57","author":"G Bertozzi","year":"2021","unstructured":"Bertozzi G, Maiese A, Passaro G, Tosoni A, Mirijello A, Simone SD, Baldari B, Cipolloni L, La Russa R. Neutropenic enterocolitis and sepsis: towards the definition of a pathologic profile. Medicina. 2021;57(6):638.","journal-title":"Medicina"},{"issue":"12","key":"3601_CR5","doi-asserted-by":"publisher","first-page":"1635","DOI":"10.1097\/PAS.0000000000000517","volume":"39","author":"T Sachak","year":"2015","unstructured":"Sachak T, Arnold MA, Naini BV, Graham RP, Shah SS, Cruise M, Park JY, Clark L, Lamps L, Frankel WL. Neutropenic enterocolitis: new insights into a deadly entity. Am J Surg Pathol. 2015;39(12):1635\u201342.","journal-title":"Am J Surg Pathol"},{"issue":"9","key":"3601_CR6","doi-asserted-by":"publisher","first-page":"1397","DOI":"10.3748\/wjg.v12.i9.1397","volume":"12","author":"CF Dietrich","year":"2006","unstructured":"Dietrich CF, Hermann S, Klein S, Braden B. Sonographic signs of neutropenic enterocolitis. World J Gastroenterol. 2006;12(9):1397\u2013402.","journal-title":"World J Gastroenterol"},{"issue":"9","key":"3601_CR7","doi-asserted-by":"publisher","first-page":"979","DOI":"10.1001\/archsurg.133.9.979","volume":"133","author":"HK Song","year":"1998","unstructured":"Song HK, Kreisel D, Canter R, Krupnick AS, Stadtmauer EA, Buzby G. Changing presentation and management of neutropenic enterocolitis. Arch Surg. 1998;133(9):979\u201382.","journal-title":"Arch Surg"},{"key":"3601_CR8","unstructured":"Inga EE, Badireddy M. Neutropenic enterocolitis. In Badireddy M, editor. StatPearls [Internet]. Treasure Island (FL): StatPearls Publishing. 2024. PMID: 32644483."},{"key":"3601_CR9","unstructured":"Neutropenic E. 2020."},{"issue":"18","key":"3601_CR10","doi-asserted-by":"publisher","first-page":"4277","DOI":"10.3390\/jcm10184277","volume":"10","author":"E Benedetti","year":"2021","unstructured":"Benedetti E, Bruno B, Martini F, Morganti R, Bramanti E, Caracciolo F, Galimberti S, Lippolis P, Neri E, Arena C, et al. Early diagnosis of neutropenic enterocolitis by bedside ultrasound in hematological malignancies: a prospective study. J Clin Med. 2021;10(18):4277.","journal-title":"J Clin Med"},{"issue":"5","key":"3601_CR11","doi-asserted-by":"publisher","first-page":"711","DOI":"10.1093\/cid\/cis998","volume":"56","author":"L Nesher","year":"2012","unstructured":"Nesher L, Rolston KVI. Neutropenic enterocolitis, a growing concern in the era of widespread use of aggressive chemotherapy. Clin Infect Dis. 2012;56(5):711\u20137.","journal-title":"Clin Infect Dis"},{"issue":"4","key":"3601_CR12","doi-asserted-by":"publisher","first-page":"264","DOI":"10.7326\/0003-4819-151-4-200908180-00135","volume":"151","author":"D Moher","year":"2009","unstructured":"Moher D, Liberati A, Tetzlaff J, Altman DG. PRISMA Group* t: preferred reporting items for systematic reviews and meta-analyses: the PRISMA statement. Ann Intern Med. 2009;151(4):264\u20139.","journal-title":"Ann Intern Med"},{"issue":"1","key":"3601_CR13","doi-asserted-by":"publisher","first-page":"226","DOI":"10.1186\/s13643-023-02322-1","volume":"12","author":"M Afifi","year":"2023","unstructured":"Afifi M, Stryhn H, Sanchez J. Data extraction and comparison for complex systematic reviews: a step-by-step guideline and an implementation example using open-source software. Syst Reviews. 2023;12(1):226.","journal-title":"Syst Reviews"},{"key":"3601_CR14","doi-asserted-by":"crossref","unstructured":"Godolphin P, Ndounga Diakou LA. Outcome adjudication in randomised trials in leading medical journals: Protocol for a methodological review. 2023.","DOI":"10.31219\/osf.io\/rb7u4"},{"key":"3601_CR15","doi-asserted-by":"publisher","first-page":"870","DOI":"10.1590\/S0102-86502013001200010","volume":"28","author":"R El Dib","year":"2013","unstructured":"El Dib R, Nascimento Junior P, Kapoor A. An alternative approach to deal with the absence of clinical trials: a proportional meta-analysis of case series studies. Acta Cirurgica Brasileira. 2013;28:870\u20136.","journal-title":"Acta Cirurgica Brasileira"},{"issue":"4","key":"3601_CR16","doi-asserted-by":"publisher","first-page":"1041","DOI":"10.1002\/1097-0142(19900215)65:4<1041::AID-CNCR2820650433>3.0.CO;2-A","volume":"65","author":"JA Katz","year":"1990","unstructured":"Katz JA, Wagner ML, Gresik MV, Mahoney DH Jr., Fernbach DJ. Typhlitis. An 18-year experience and postmortem review. Cancer. 1990;65(4):1041\u20137.","journal-title":"Cancer"},{"issue":"3","key":"3601_CR17","doi-asserted-by":"publisher","first-page":"603","DOI":"10.1002\/1097-0142(19860201)57:3<603::AID-CNCR2820570335>3.0.CO;2-K","volume":"57","author":"RC Shamberger","year":"1986","unstructured":"Shamberger RC, Weinstein HJ, Delorey MJ, Levey RH. The medical and surgical management of typhlitis in children with acute nonlymphocytic (myelogenous) leukemia. Cancer. 1986;57(3):603\u20139.","journal-title":"Cancer"},{"issue":"3","key":"3601_CR18","doi-asserted-by":"publisher","first-page":"e98","DOI":"10.1097\/MPH.0b013e3181eda606","volume":"33","author":"W El-Matary","year":"2011","unstructured":"El-Matary W, Soleimani M, Spady D, Belletrutti M. Typhlitis in children with malignancy: a single center experience. J Pediatr Hematol Oncol. 2011;33(3):e98\u2013100.","journal-title":"J Pediatr Hematol Oncol"},{"key":"3601_CR19","doi-asserted-by":"publisher","first-page":"48","DOI":"10.1016\/j.leukres.2018.03.004","volume":"68","author":"AN Seddon","year":"2018","unstructured":"Seddon AN, Chaim J, Akin O, Drill E, Michael AG, Adel N, Tallman MS. Similar incidence of typhlitis in patients receiving various doses of daunorubicin or idarubicin as induction for acute myeloid leukemia. Leuk Res. 2018;68:48\u201350.","journal-title":"Leuk Res"},{"key":"3601_CR20","doi-asserted-by":"publisher","first-page":"100944","DOI":"10.1016\/j.blre.2022.100944","volume":"54","author":"N Kapandji","year":"2022","unstructured":"Kapandji N, Azoulay E, Zafrani L. Recent advances in neutropenic enterocolitis: insights into the role of gut microbiota. Blood Rev. 2022;54:100944.","journal-title":"Blood Rev"},{"issue":"21","key":"3601_CR21","doi-asserted-by":"publisher","first-page":"5984","DOI":"10.1182\/blood.V124.21.5984.5984","volume":"124","author":"D Lebon","year":"2014","unstructured":"Lebon D, Canet E, Biard L, Schnell D, Roussel C, Buyse S, Schlemmer B, Azoulay E. Neutropenic enterocolitis: clinical features and outcomes. Blood. 2014;124(21):5984.","journal-title":"Blood"},{"issue":"21","key":"3601_CR22","doi-asserted-by":"publisher","first-page":"4324","DOI":"10.1182\/blood.V120.21.4324.4324","volume":"120","author":"RK Vora","year":"2012","unstructured":"Vora RK, Braunstein M, Cho J, Lesser ML, Ben-Levi E, Bradley TP, Allen SL, Kolitz JE. Neutropenic enterocolitis in adult patients with acute leukemia: a single center experience. Blood. 2012;120(21):4324\u20134324.","journal-title":"Blood"},{"issue":"2","key":"3601_CR23","doi-asserted-by":"publisher","first-page":"59","DOI":"10.14740\/jh1105","volume":"12","author":"R Babakhanlou","year":"2023","unstructured":"Babakhanlou R, Ravandi-Kashani F, Kontoyiannis DP. Neutropenic enterocolitis: an uncommon, but fearsome complication of leukemia. J Hematol. 2023;12(2):59\u201365.","journal-title":"J Hematol"},{"key":"3601_CR24","unstructured":"Qasim A, Nahas J. Neutropenic enterocolitis (Typhlitis). In StatPearls. Edn. Treasure Island (FL): StatPearls Publishing Copyright \u00a9 2024. StatPearls Publishing LLC. 2024."},{"issue":"1","key":"3601_CR25","doi-asserted-by":"publisher","first-page":"109","DOI":"10.1016\/j.clp.2012.12.008","volume":"40","author":"IG De Plaen","year":"2013","unstructured":"De Plaen IG. Inflammatory signaling in necrotizing enterocolitis. Clin Perinatol. 2013;40(1):109\u201324.","journal-title":"Clin Perinatol"},{"issue":"1","key":"3601_CR26","doi-asserted-by":"publisher","first-page":"32","DOI":"10.5005\/jp-journals-11002-0003","volume":"1","author":"E Managlia","year":"2022","unstructured":"Managlia E, Yan X, De Plaen IG. Intestinal epithelial barrier function and necrotizing enterocolitis. Newborn (Clarksville Md). 2022;1(1):32.","journal-title":"Newborn (Clarksville Md)"},{"issue":"5","key":"3601_CR27","doi-asserted-by":"publisher","first-page":"1105","DOI":"10.2214\/ajr.176.5.1761105","volume":"176","author":"M Macari","year":"2001","unstructured":"Macari M, Balthazar EJ. CT of bowel wall thickening: significance and pitfalls of interpretation. Am J Roentgenol. 2001;176(5):1105\u201316.","journal-title":"Am J Roentgenol"},{"key":"3601_CR28","doi-asserted-by":"crossref","unstructured":"Amanati A, Van Manen R, Sajedianfard S, Shojaadini H, Boroughani M, Molavi Vardanjani H. Antineoplastic agents associated with neutropenic enterocolitis in patients with malignancy: a quantitative safety signal analysis. J Oncol Pharm Pract. 2024:10781552241238195.","DOI":"10.1177\/10781552241238195"},{"issue":"7","key":"3601_CR29","doi-asserted-by":"publisher","first-page":"21865","DOI":"10.4088\/JCP.15f10150","volume":"76","author":"C Andrade","year":"2015","unstructured":"Andrade C. Understanding relative risk, odds ratio, and related terms: as simple as it can get. J Clin Psychiatry. 2015;76(7):21865.","journal-title":"J Clin Psychiatry"},{"issue":"5","key":"3601_CR30","doi-asserted-by":"publisher","first-page":"993","DOI":"10.1016\/S0039-6109(16)46137-2","volume":"73","author":"SE Ettinghausen","year":"1993","unstructured":"Ettinghausen SE. Collagenous colitis, eosinophilic colitis, and neutropenic colitis. Surg Clin North Am. 1993;73(5):993\u20131016.","journal-title":"Surg Clin North Am"},{"issue":"7","key":"3601_CR31","first-page":"293","volume":"2","author":"NO Machado","year":"2010","unstructured":"Machado NO. Neutropenic enterocolitis: a continuing medical and surgical challenge. North Am J Med Sci. 2010;2(7):293.","journal-title":"North Am J Med Sci"},{"key":"3601_CR32","doi-asserted-by":"publisher","first-page":"1","DOI":"10.1186\/1471-2334-6-35","volume":"6","author":"M Gorschl\u00fcter","year":"2006","unstructured":"Gorschl\u00fcter M, Mey U, Strehl J, Schmitz V, Rabe C, Pauls K, Ziske C, Schmidt-Wolf IG, Glasmacher A. Invasive fungal infections in neutropenic enterocolitis: a systematic analysis of pathogens, incidence, treatment and mortality in adult patients. BMC Infect Dis. 2006;6:1\u201311.","journal-title":"BMC Infect Dis"},{"key":"3601_CR33","doi-asserted-by":"publisher","first-page":"1","DOI":"10.1186\/s12879-021-06957-0","volume":"21","author":"A Amanati","year":"2021","unstructured":"Amanati A, Zekavat OR, Foroutan H, Azh O, Tadayon A, Monabati A, Anbardar MH, Bozorgi H. Case reports of invasive mucormycosis associated neutropenic enterocolitis in leukemic children: diagnostic and treatment challenges and review of literature. BMC Infect Dis. 2021;21:1\u20139.","journal-title":"BMC Infect Dis"},{"issue":"1","key":"3601_CR34","doi-asserted-by":"publisher","first-page":"33","DOI":"10.1080\/08977190500055836","volume":"23","author":"AW Roberts","year":"2005","unstructured":"Roberts AW. G-CSF: a key regulator of neutrophil production, but that\u2019s not all! Growth Factors. 2005;23(1):33\u201341.","journal-title":"Growth Factors"},{"key":"3601_CR35","doi-asserted-by":"publisher","first-page":"207","DOI":"10.1007\/s00277-003-0628-y","volume":"82","author":"K H\u00fcbel","year":"2003","unstructured":"H\u00fcbel K, Engert A. Clinical applications of granulocyte colony-stimulating factor: an update and summary. Ann Hematol. 2003;82:207\u201313.","journal-title":"Ann Hematol"},{"issue":"1","key":"3601_CR36","doi-asserted-by":"publisher","first-page":"42","DOI":"10.3748\/wjg.v23.i1.42","volume":"23","author":"FG Rodrigues","year":"2017","unstructured":"Rodrigues FG, Dasilva G, Wexner SD. Neutropenic enterocolitis. World J Gastroenterol. 2017;23(1):42.","journal-title":"World J Gastroenterol"},{"key":"3601_CR37","doi-asserted-by":"publisher","first-page":"ii116","DOI":"10.1093\/annonc\/mdn107","volume":"19","author":"R Greil","year":"2008","unstructured":"Greil R, Psenak O, Roila F, Group EGW. Hematopoietic growth factors: ESMO recommendations for the applications. Ann Oncol. 2008;19:ii116\u20138.","journal-title":"Ann Oncol"},{"issue":"1","key":"3601_CR38","doi-asserted-by":"publisher","first-page":"1","DOI":"10.1111\/j.1600-0609.2005.00442.x","volume":"75","author":"M Gorschl\u00fcter","year":"2005","unstructured":"Gorschl\u00fcter M, Mey U, Strehl J, Ziske C, Schepke M, Schmidt-Wolf IG, Sauerbruch T, Glasmacher A. Neutropenic enterocolitis in adults: systematic analysis of evidence quality. Eur J Haematol. 2005;75(1):1\u201313.","journal-title":"Eur J Haematol"},{"issue":"30","key":"3601_CR39","doi-asserted-by":"publisher","first-page":"3043","DOI":"10.1200\/JCO.18.00374","volume":"36","author":"RA Taplitz","year":"2018","unstructured":"Taplitz RA, Kennedy EB, Bow EJ, Crews J, Gleason C, Hawley DK, Langston AA, Nastoupil LJ, Rajotte M, Rolston KV. Antimicrobial prophylaxis for adult patients with cancer-related immunosuppression: ASCO and IDSA clinical practice guideline update. J Clin Oncol. 2018;36(30):3043\u201354.","journal-title":"J Clin Oncol"},{"issue":"12Part1","key":"3601_CR40","doi-asserted-by":"publisher","first-page":"979","DOI":"10.7326\/0003-4819-142-12_Part_1-200506210-00008","volume":"142","author":"A Gafter-Gvili","year":"2005","unstructured":"Gafter-Gvili A, Fraser A, Paul M, Leibovici L. Meta-analysis: antibiotic prophylaxis reduces mortality in neutropenic patients. Ann Intern Med. 2005;142(12Part1):979\u201395.","journal-title":"Ann Intern Med"},{"issue":"2","key":"3601_CR41","doi-asserted-by":"publisher","first-page":"79","DOI":"10.5327\/Z201600020010RBM","volume":"26","author":"WMN Eul\u00e1lio Filho","year":"2016","unstructured":"Eul\u00e1lio Filho WMN, Neto TG, Vieira SC. Typhlitis in breast cancer patient using Docetaxel\u2013based chemotherapy: case report. Revista Brasileira De Mastologia. 2016;26(2):79\u201382.","journal-title":"Revista Brasileira De Mastologia"},{"issue":"34","key":"3601_CR42","doi-asserted-by":"publisher","first-page":"e30104","DOI":"10.1097\/MD.0000000000030104","volume":"101","author":"B Deveci","year":"2022","unstructured":"Deveci B, Kublashvili G, Yilmaz S, \u00d6zcan B, Korkmaz HF, G\u00fcrsoy O, Topta\u015f T, D\u00f6\u015femeci L, Saba R. Investigation of typhlitis in bone marrow transplant patients in a stem cell transplant unit. Medicine. 2022;101(34):e30104.","journal-title":"Medicine"},{"key":"3601_CR43","unstructured":"Systematic review of the Neutropenic Enterocolitis. in cancer patients [https:\/\/ethics.research.ac.ir\/ProposalCertificateEn.php?id=263447&Print=true&NoPrintHeader=true&NoPrintFooter=true&NoPrintPageBorder=true&LetterPrint=true]."}],"container-title":["BMC Gastroenterology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1186\/s12876-025-03601-y.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/article\/10.1186\/s12876-025-03601-y\/fulltext.html","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1186\/s12876-025-03601-y.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,1,16]],"date-time":"2025-01-16T08:15:34Z","timestamp":1737015334000},"score":1,"resource":{"primary":{"URL":"https:\/\/bmcgastroenterol.biomedcentral.com\/articles\/10.1186\/s12876-025-03601-y"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2025,1,13]]},"references-count":43,"journal-issue":{"issue":"1","published-online":{"date-parts":[[2025,12]]}},"alternative-id":["3601"],"URL":"https:\/\/doi.org\/10.1186\/s12876-025-03601-y","relation":{},"ISSN":["1471-230X"],"issn-type":[{"value":"1471-230X","type":"electronic"}],"subject":[],"published":{"date-parts":[[2025,1,13]]},"assertion":[{"value":"27 September 2024","order":1,"name":"received","label":"Received","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"9 January 2025","order":2,"name":"accepted","label":"Accepted","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"13 January 2025","order":3,"name":"first_online","label":"First Online","group":{"name":"ArticleHistory","label":"Article History"}},{"order":1,"name":"Ethics","group":{"name":"EthicsHeading","label":"Declarations"}},{"value":"The study was designed to comply with national norms and regulations for conducting medical research in Iran as well as ethical principles. The study was approved by \u201cIran National Committee for Ethics in Biomedical Research\u201d with approval ID: IR.MUBAM.REC.1401.044 [].In accordance with the ethical standards for conducting systematic reviews, we confirm that all necessary consent for participation has been obtained from the original studies included in this review.","order":2,"name":"Ethics","group":{"name":"EthicsHeading","label":"Ethics approval and consent to participate"}},{"value":"Not applicable.","order":3,"name":"Ethics","group":{"name":"EthicsHeading","label":"Consent for publication"}},{"value":"The authors declare no competing interests.","order":4,"name":"Ethics","group":{"name":"EthicsHeading","label":"Competing interests"}},{"value":"Not applicable.","order":5,"name":"Ethics","group":{"name":"EthicsHeading","label":"Clinical trial number"}}],"article-number":"17"}}