{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,2,11]],"date-time":"2026-02-11T18:54:27Z","timestamp":1770836067647,"version":"3.50.1"},"reference-count":51,"publisher":"Springer Science and Business Media LLC","issue":"1","license":[{"start":{"date-parts":[[2025,2,7]],"date-time":"2025-02-07T00:00:00Z","timestamp":1738886400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0"},{"start":{"date-parts":[[2025,2,7]],"date-time":"2025-02-07T00:00:00Z","timestamp":1738886400000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0"}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["BMC Gastroenterol"],"DOI":"10.1186\/s12876-025-03644-1","type":"journal-article","created":{"date-parts":[[2025,2,7]],"date-time":"2025-02-07T16:38:07Z","timestamp":1738946287000},"update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":7,"title":["Efficacy analysis of folic acid in chronic atrophic gastritis with Helicobacter pylori infection: a systematic review and meta-analysis"],"prefix":"10.1186","volume":"25","author":[{"given":"Hui","family":"Li","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jincheng","family":"Li","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Mingyu","family":"Lai","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"297","published-online":{"date-parts":[[2025,2,7]]},"reference":[{"key":"3644_CR1","doi-asserted-by":"publisher","first-page":"420","DOI":"10.1001\/jamaoncol.2021.6987","volume":"8","author":"JM Kocarnik","year":"2022","unstructured":"Kocarnik JM, Compton K, Dean FE, Fu W, Gaw BL, Harvey JD, Henrikson HJ, Lu D, Pennini A, Xu R, et al. Cancer incidence, mortality, years of life lost, years lived with disability, and disability-adjusted life years for 29 cancer groups from 2010 to 2019: a systematic analysis for the global burden of disease study 2019. JAMA Oncol. 2022;8:420\u201344.","journal-title":"JAMA Oncol"},{"issue":"1","key":"3644_CR2","doi-asserted-by":"publisher","first-page":"429","DOI":"10.1186\/s12967-023-04736-w","volume":"22","author":"J Li","year":"2024","unstructured":"Li J, Pan J, Xiao D, et al. Chronic atrophic gastritis and risk of incident upper gastrointestinal cancers: a systematic review and meta-analysis. J Transl Med. 2024;22(1):429.","journal-title":"J Transl Med"},{"key":"3644_CR3","doi-asserted-by":"publisher","first-page":"116912","DOI":"10.1016\/j.biopha.2024.116912","volume":"176","author":"J Jia","year":"2024","unstructured":"Jia J, Zhao H, Li F, et al. Research on drug treatment and the novel signaling pathway of chronic atrophic gastritis. Biomed Pharmacother. 2024;176:116912.","journal-title":"Biomed Pharmacother"},{"issue":"02","key":"3644_CR4","first-page":"121","volume":"28","author":"X Cheng","year":"2022","unstructured":"Cheng X, Niu MQ, Wang N, et al. Comparative observation of rabeprazole quadruple therapy combined with vitamin B12 folic acid in the treatment of Helicobacter pylori-associated chronic atrophic gastritis. J Clin Psychosom Dis. 2022;28(02):121\u20133.","journal-title":"J Clin Psychosom Dis"},{"key":"3644_CR5","doi-asserted-by":"publisher","first-page":"2195","DOI":"10.1093\/carcin\/20.12.2195","volume":"20","author":"CT Stadtlander","year":"1999","unstructured":"Stadtlander CT, Waterbor JW. Molecular epidemiology, pathogenesis and prevention of gastric cancer. Carcinogenesis. 1999;20:2195\u2013208.","journal-title":"Carcinogenesis"},{"key":"3644_CR6","doi-asserted-by":"publisher","first-page":"S29","DOI":"10.1097\/00004836-200305001-00006","volume":"36","author":"CR Kapadia","year":"2003","unstructured":"Kapadia CR. Gastric atrophy, metaplasia, and dysplasia: a clinical perspective. J Clin Gastroenterol. 2003;36:S29\u201336.","journal-title":"J Clin Gastroenterol"},{"key":"3644_CR7","doi-asserted-by":"publisher","first-page":"31","DOI":"10.1111\/apm.1965.64.1.31","volume":"64","author":"P Laur\u00e8n","year":"1965","unstructured":"Laur\u00e8n P. The two histological main types of gastric carcinoma: are diffuse and so-called intestinal-type carcinoma. Acta Pathol MicrobiolScand. 1965;64:31\u201349.","journal-title":"Acta Pathol MicrobiolScand"},{"key":"3644_CR8","doi-asserted-by":"publisher","first-page":"1720","DOI":"10.1007\/BF00051709","volume":"4","author":"A Fukao","year":"1993","unstructured":"Fukao A, Hisamichi S, Ohsato N, et al. Correlation between the prevalence of gastritis and gastric cancer in Japan. Cancer Causes Control. 1993;4:1720.","journal-title":"Cancer Causes Control"},{"key":"3644_CR9","doi-asserted-by":"publisher","first-page":"17","DOI":"10.1111\/j.1365-2036.1998.00003.x","volume":"12","author":"RM Genta","year":"1998","unstructured":"Genta RM. Gastric atrophy and atrophic gastritis \u2013 nebulous concepts in search of a definition. Aliment Pharmacol Ther. 1998;12:17\u201323.","journal-title":"Aliment Pharmacol Ther"},{"issue":"19","key":"3644_CR10","doi-asserted-by":"publisher","first-page":"1777","DOI":"10.11569\/wcjd.v25.i19.1777","volume":"25","author":"YY Dai","year":"2017","unstructured":"Dai YY, Ye ZD, Huang HH. Effect of Helicobacter pylori eradication therapy combined with folic acid on chronic hepatitis B long-term effects in patients with atrophic gastritis. World Chin J Digestion. 2017;25(19):1777\u201382.","journal-title":"World Chin J Digestion"},{"issue":"1","key":"3644_CR11","doi-asserted-by":"publisher","first-page":"25","DOI":"10.1159\/000443995","volume":"3","author":"XJ Cheng","year":"2016","unstructured":"Cheng XJ, Lin JC, Tu SP. Etiology and Prevention of Gastric Cancer. Gastrointest Tumors. 2016;3(1):25\u201336.","journal-title":"Gastrointest Tumors"},{"key":"3644_CR12","doi-asserted-by":"publisher","first-page":"379","DOI":"10.1056\/NEJMc2306877","volume":"389","author":"Y Usui","year":"2023","unstructured":"Usui Y, Matsuo K, Momozawa Y. Helicobacter pylori, homologous-recombination genes, and gastric cancer. Reply N Engl J Med. 2023;389:379\u201381.","journal-title":"Reply N Engl J Med"},{"key":"3644_CR13","doi-asserted-by":"publisher","DOI":"10.1136\/gutjnl-2022-327745","author":"P Malfertheiner","year":"2022","unstructured":"Malfertheiner P, Megraud F, Rokkas T, et al. Management of Helicobacter pylori infection: the Maastricht VI\/Florence consensus report. Gut. 2022. https:\/\/doi.org\/10.1136\/gutjnl-2022-327745. Epub ahead of print.","journal-title":"Gut"},{"key":"3644_CR14","first-page":"2899","volume":"135","author":"L Zhou","year":"2022","unstructured":"Zhou L, Lu H, Song Z, et al. 2022 Chinese national clinical practice guideline on Helicobacter pylori eradication treatment. Chin Med J (Engl). 2022;135:2899\u2013910.","journal-title":"Chin Med J (Engl)"},{"issue":"4","key":"3644_CR15","doi-asserted-by":"crossref","first-page":"663","DOI":"10.1007\/s10238-021-00711-1","volume":"21","author":"JD Liu","year":"2021","unstructured":"Liu JD. Effect of Helicobacter pylori eradication on digestive tract symptoms in patients with chronic atrophic gastritis. Chin Med Clin. 2021;21(4):663\u20135.","journal-title":"Chin Med Clin"},{"key":"3644_CR16","first-page":"313","volume":"206","author":"I Eto","year":"1986","unstructured":"Eto I, Krumdieck CL. Role of vitamin B12 and folate deficiencies in carcinogenesis. Adv Exp Med Biol. 1986;206:313\u201330.","journal-title":"Adv Exp Med Biol"},{"key":"3644_CR17","doi-asserted-by":"publisher","first-page":"129","DOI":"10.1093\/jn\/130.2.129","volume":"130","author":"SW Choi","year":"2000","unstructured":"Choi SW, Mason JB. Folate and carcinogenesis: an integrated scheme. J Nutr. 2000;130:129\u201332.","journal-title":"J Nutr"},{"issue":"11","key":"3644_CR18","doi-asserted-by":"publisher","first-page":"1571","DOI":"10.3748\/wjg.v11.i11.1571","volume":"11","author":"DZ Cao","year":"2005","unstructured":"Cao DZ, Sun WH, Ou XL, et al. Effects of folic acid on epithelial apoptosis and expression of Bcl-2 and p53 in premalignant gastric lesions. World J Gastroenterol WJG. 2005;11(11):1571.","journal-title":"World J Gastroenterol WJG"},{"issue":"5","key":"3644_CR19","doi-asserted-by":"publisher","first-page":"656","DOI":"10.1007\/s005350050152","volume":"33","author":"JY Fang","year":"1998","unstructured":"Fang JY, Xiao SD. Effect of trans-retinoic acid and folic acid on apoptosis in human gastric cancer cell lines MKN-45 and MKN-28. J Gastroenterol. 1998;33(5):656\u201361.","journal-title":"J Gastroenterol"},{"key":"3644_CR20","doi-asserted-by":"publisher","first-page":"d5928","DOI":"10.1136\/bmj.d5928","volume":"343","author":"JP Higgins","year":"2011","unstructured":"Higgins JP, Altman DG, Gotzsche PC, et al. The Cochrane collaboration\u2019s tool for assessing the risk of bias in randomized trials. BMJ. 2011;343:d5928.","journal-title":"BMJ"},{"issue":"1","key":"3644_CR21","doi-asserted-by":"publisher","first-page":"370","DOI":"10.1186\/s12876-022-02390-y","volume":"22","author":"J Lei","year":"2022","unstructured":"Lei J, Ren F, Li W, et al. Use of folic acid supplementation to halt and even reverse the progression of gastric precancerous conditions: a meta-analysis. BMC Gastroenterol. 2022;22(1):370.","journal-title":"BMC Gastroenterol"},{"key":"3644_CR22","doi-asserted-by":"publisher","first-page":"n71","DOI":"10.1136\/bmj.n71","volume":"372","author":"MJ Page","year":"2021","unstructured":"Page MJ, McKenzie JE, Bossuyt PM, et al. The PRISMA 2020 statement: an updated guideline for reporting systematic reviews. BMJ. 2021;372:n71.","journal-title":"BMJ"},{"key":"3644_CR23","doi-asserted-by":"publisher","first-page":"5","DOI":"10.1186\/s40798-021-00374-y","volume":"8","author":"J Berezanskaya","year":"2022","unstructured":"Berezanskaya J, Cade W, Best TM, et al. ADHD prescription medications and their effect on athletic performance: a systematic review and meta-analysis. Sports Med Open. 2022;8:5. https:\/\/doi.org\/10.1186\/s40798-021-00374-y.","journal-title":"Sports Med Open"},{"key":"3644_CR24","unstructured":"Higgins J, Green S. In: Higgins JPT, Green S, editors. Cochrane Handbook for Systematic Reviews of interventions Version 5.1.0 [updated March 2011]. The Cochrane Collaboration; 2011."},{"key":"3644_CR25","doi-asserted-by":"publisher","first-page":"557","DOI":"10.1136\/bmj.327.7414.557","volume":"327","author":"JP Higgins","year":"2003","unstructured":"Higgins JP, Thompson SG, Deeks JJ, Altman DG. Measuring inconsistency in meta-analyses. BMJ. 2003;327:557\u201360.","journal-title":"BMJ"},{"issue":"2","key":"3644_CR26","doi-asserted-by":"publisher","first-page":"212","DOI":"10.1080\/01635581.2015.989375","volume":"67","author":"SC Chang","year":"2015","unstructured":"Chang SC, Goldstein BY, Mu L, et al. Plasma folate, vitamin B12, and homocysteine and cancers of the esophagus, stomach, and liver in a Chinese population. Nutr Cancer. 2015;67(2):212\u201323.","journal-title":"Nutr Cancer"},{"issue":"1","key":"3644_CR27","first-page":"93","volume":"15","author":"XX Huang","year":"2022","unstructured":"Huang XX. Clinical efficacy of rabeprazole combined with folic acid and teprenone in the treatment of elderly patients with Helicobacter pylori positive chronic atrophic gastritis. J Ration Use Drugs Clin Pract. 2022;15(1):93\u20135.","journal-title":"J Ration Use Drugs Clin Pract"},{"issue":"17","key":"3644_CR28","first-page":"56","volume":"22","author":"XX Liu","year":"2022","unstructured":"Liu XX. Effect of folic acid combined with VB12 and quadruple therapy in the treatment of elderly patients with hp positive chronic atrophic gastritis. Practical Integr Traditional Chin Western Med Clin Pract. 2022;22(17):56\u20138.","journal-title":"Practical Integr Traditional Chin Western Med Clin Pract"},{"issue":"3","key":"3644_CR29","first-page":"45","volume":"45","author":"JJ Zhang","year":"2022","unstructured":"Zhang JJ, Li HP, Wu XR. Effect of folic acid combined with VB12 in the treatment of patients with HP-associated chronic atrophic gastritis. Heilongjiang Med Sci. 2022;45(3):45\u20136.","journal-title":"Heilongjiang Med Sci"},{"issue":"3","key":"3644_CR30","first-page":"55","volume":"29","author":"SQ Wang","year":"2022","unstructured":"Wang SQ. Efficacy of vitamin B12 and folic acid combined with quadruple therapy in the treatment of HP-related CAG and its effect on E-Cad and MMP-9. J Practical Rural Doctors China. 2022;29(3):55\u20139.","journal-title":"J Practical Rural Doctors China"},{"issue":"10","key":"3644_CR31","first-page":"4","volume":"19","author":"JC Zhang","year":"2021","unstructured":"Zhang JC, Guo SJ, Long S. Application significance of folic acid combined with quadruple therapy in patients with hp positive chronic atrophic gastritis. Chin Foreign Med Res. 2021;19(10):4\u20136.","journal-title":"Chin Foreign Med Res"},{"issue":"13","key":"3644_CR32","first-page":"1794","volume":"36","author":"XJ Liu","year":"2020","unstructured":"Liu XJ, Gao WT. Clinical study of sequential therapy combined with folic acid and teprenone in the treatment of elderly patients with Helicobacter pylori positive chronic atrophic gastritis. Chin J Clin Pharmacol. 2020;36(13):1794\u20136.","journal-title":"Chin J Clin Pharmacol"},{"issue":"16","key":"3644_CR33","first-page":"150","volume":"17","author":"HL Sun","year":"2019","unstructured":"Sun HL. Effect of folic acid combined with Helicobacter pylori eradication in the treatment of patients with chronic atrophic gastritis. Chin Med Guidelines. 2019;17(16):150.","journal-title":"Chin Med Guidelines"},{"issue":"29","key":"3644_CR34","first-page":"105","volume":"19","author":"Y Meng","year":"2019","unstructured":"Meng Y. Efficacy of folic acid combined with Helicobacter pylori eradication in the treatment of patients with chronic atrophic gastritis. Abstract Latest Med Inform World. 2019;19(29):105\u20136.","journal-title":"Abstract Latest Med Inform World"},{"key":"3644_CR35","first-page":"0092","volume":"2","author":"X Hu","year":"2024","unstructured":"Hu X. Clinical value of folic acid combined with Helicobacter pylori eradication in the treatment of chronic atrophic gastritis. Chin Sci Technol J Database Med. 2024;2:0092\u20135.","journal-title":"Chin Sci Technol J Database Med"},{"issue":"A02","key":"3644_CR36","first-page":"1668","volume":"24","author":"CJ Yang","year":"2019","unstructured":"Yang CJ, Zhang H, Yao JF, et al. Clinical efficacy of folic acid and Helicobacter pylori in the treatment of chronic atrophic gastritis. Mod Dig Interventional Diagnosis Treat. 2019;24(A02):1668\u20139.","journal-title":"Mod Dig Interventional Diagnosis Treat"},{"key":"3644_CR37","unstructured":"Zhang XX. Clinical efficacy of folic acid combined with Helicobacter pylori eradication in the treatment of chronic atrophic gastritis. Kang Yi. 2023;(10):194\u20136."},{"issue":"35","key":"3644_CR38","first-page":"68","volume":"7","author":"Q An","year":"2020","unstructured":"An Q. Characteristics of Helicobacter pylori infection in patients with chronic atrophic gastritis and prognosis evaluation of eradication therapy. Electron J Gen Dentistry. 2020;7(35):68\u20137098.","journal-title":"Electron J Gen Dentistry"},{"issue":"8","key":"3644_CR39","first-page":"101","volume":"3","author":"YL Ja","year":"2022","unstructured":"Ja YL, Chen J, Feng HX. Clinical efficacy of folic acid combined with Helicobacter pylori eradication in the treatment of chronic atrophic gastritis. Reflexology Rehabilitation Med. 2022;3(8):101\u20133.","journal-title":"Reflexology Rehabilitation Med"},{"issue":"1","key":"3644_CR40","first-page":"111","volume":"42","author":"ZL Yang","year":"2020","unstructured":"Yang ZL. Clinical analysis of folic acid combined with rebamipide in the treatment of Hp-positive chronic atrophic gastritis. Fujian Med J. 2020;42(1):111\u20133.","journal-title":"Fujian Med J"},{"issue":"27","key":"3644_CR41","first-page":"66","volume":"12","author":"LL Wang","year":"2019","unstructured":"Wang LL. Clinical efficacy of folic acid combined with Helicobacter pylori eradication in the treatment of chronic atrophic gastritis. J Ration Use Drugs Clin Pract. 2019;12(27):66\u20137.","journal-title":"J Ration Use Drugs Clin Pract"},{"key":"3644_CR42","unstructured":"Qin Y. Effect of folic acid combined with Helicobacter pylori eradication on patients with chronic atrophic gastritis. Famous Doctors. 2018; (12):206\u20137."},{"key":"3644_CR43","doi-asserted-by":"publisher","unstructured":"Pimentel-Nunes P, Lib\u00e2nio D, Marcos-Pinto R, Areia M, Leja M, Esposito G, Garrido M, Kikuchi I, Megraud F, Matysiak-Budnik T, Annibale B, Dumonceau JM, Barros R, Fl\u00e9jou JF, Carneiro F, van Hooft JE, Kuipers EJ, Dinis-Ribeiro M. Management of epithelial precancerous conditions and lesions in the stomach (MAPS II): European Society of Gastrointestinal Endoscopy (ESGE), European Helicobacter and Microbiota Study Group (EHMSG), European Society of Pathology (ESP), and Sociedade Portuguesa De Endoscopia Digestiva (SPED) guideline update 2019. Endoscopy. 2019;51(4):365\u201388. https:\/\/doi.org\/10.1055\/a-0859-1883.","DOI":"10.1055\/a-0859-1883"},{"issue":"12","key":"3644_CR44","doi-asserted-by":"publisher","first-page":"1621","DOI":"10.1016\/j.dld.2019.09.016","volume":"51","author":"E Lahner","year":"2019","unstructured":"Lahner E, Zagari RM, Zullo A, Di Sabatino A, Meggio A, Cesaro P, Lenti MV, Annibale B, Corazza GR. Chronic atrophic gastritis: natural history, diagnosis, and therapeutic management. A position paper by the Italian Society of Hospital Gastroenterologists and Digestive endoscopists [AIGO], the Italian Society of Digestive Endoscopy [SIED], the Italian Society of Gastroenterology [SIGE], and the Italian Society of Internal Medicine [SIMI]. Dig Liver Dis. 2019;51(12):1621\u201332.","journal-title":"Dig Liver Dis"},{"key":"3644_CR45","doi-asserted-by":"publisher","first-page":"212","DOI":"10.1038\/ajg.2016.563","volume":"112","author":"WD Chey","year":"2017","unstructured":"Chey WD, Leontiadis GI, Howden CW, Moss SF. ACG clinical guideline: treatment of Helicobacter pylori infection. Am J Gastroenterol. 2017;112:212\u201339.","journal-title":"Am J Gastroenterol"},{"key":"3644_CR46","doi-asserted-by":"publisher","first-page":"51","DOI":"10.1053\/j.gastro.2016.04.006","volume":"151","author":"CA Fallone","year":"2016","unstructured":"Fallone CA, Chiba N, van Zanten SV, et al. The Toronto consensus for the treatment of Helicobacter pylori infection in adults. Gastroenterology. 2016;151:51\u201369. e14.","journal-title":"Gastroenterology"},{"key":"3644_CR47","first-page":"1158","volume":"117","author":"L Laine","year":"2022","unstructured":"Laine L, Sharma P, Mulford DJ, et al. Pharmacodynamics and pharmacokinetics of the potassium-competitive acid blocker vonoprazan and the proton pump inhibitor lansoprazole in US subjects.Am. J Gastroenterol. 2022;117:1158\u201361.","journal-title":"J Gastroenterol"},{"key":"3644_CR48","doi-asserted-by":"publisher","first-page":"794","DOI":"10.1111\/apt.16295","volume":"53","author":"Y Abdel-Aziz","year":"2021","unstructured":"Abdel-Aziz Y, Metz DC, Howden CW. Review article: potassium-competitive acid blockers for the treatment of acid-related disorders. Aliment Pharmacol Ther. 2021;53:794\u2013809.","journal-title":"Aliment Pharmacol Ther"},{"issue":"3","key":"3644_CR49","first-page":"234","volume":"21","author":"HT Li","year":"2024","unstructured":"Li HT, Zhang X, Ji YX. Clinical efficacy of vonoprazan fumarate in the treatment of chronic atrophic gastritis. Drug use Monit China. 2024;21(3):234\u20138.","journal-title":"Drug use Monit China"},{"issue":"30","key":"3644_CR50","first-page":"10","volume":"20","author":"YM Hu","year":"2023","unstructured":"Hu YM, Jiang YG, Zhang SJ, et al. Effect of vonoprazan combined with quadruple therapy in the treatment of Helicobacter pylori positive patients with chronic atrophic gastritis and its influence on gastrointestinal hormones. Med Innov China. 2023;20(30):10\u20135.","journal-title":"Med Innov China"},{"issue":"3","key":"3644_CR51","first-page":"458","volume":"21","author":"LH Sun","year":"2023","unstructured":"Sun LH, Kong FF, Zhao Q, et al. Efficacy of vonolaxan fumarate combined with targeted health education intervention in the treatment of Hp-positive chronic atrophic gastritis. Gen Pract China. 2023;21(3):458\u201362.","journal-title":"Gen Pract China"}],"container-title":["BMC Gastroenterology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1186\/s12876-025-03644-1.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/article\/10.1186\/s12876-025-03644-1\/fulltext.html","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1186\/s12876-025-03644-1.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,2,7]],"date-time":"2025-02-07T16:38:18Z","timestamp":1738946298000},"score":1,"resource":{"primary":{"URL":"https:\/\/bmcgastroenterol.biomedcentral.com\/articles\/10.1186\/s12876-025-03644-1"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2025,2,7]]},"references-count":51,"journal-issue":{"issue":"1","published-online":{"date-parts":[[2025,12]]}},"alternative-id":["3644"],"URL":"https:\/\/doi.org\/10.1186\/s12876-025-03644-1","relation":{},"ISSN":["1471-230X"],"issn-type":[{"value":"1471-230X","type":"electronic"}],"subject":[],"published":{"date-parts":[[2025,2,7]]},"assertion":[{"value":"14 October 2024","order":1,"name":"received","label":"Received","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"23 January 2025","order":2,"name":"accepted","label":"Accepted","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"7 February 2025","order":3,"name":"first_online","label":"First Online","group":{"name":"ArticleHistory","label":"Article History"}},{"order":1,"name":"Ethics","group":{"name":"EthicsHeading","label":"Declarations"}},{"value":"Not applicable.","order":2,"name":"Ethics","group":{"name":"EthicsHeading","label":"Ethics approval and consent to participate"}},{"value":"Not applicable.","order":3,"name":"Ethics","group":{"name":"EthicsHeading","label":"Consent for publication"}},{"value":"The authors declare no competing interests.","order":4,"name":"Ethics","group":{"name":"EthicsHeading","label":"Competing interests"}}],"article-number":"69"}}