{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,25]],"date-time":"2026-07-25T22:28:47Z","timestamp":1785018527607,"version":"3.55.0"},"reference-count":31,"publisher":"Springer Science and Business Media LLC","issue":"1","license":[{"start":{"date-parts":[[2025,3,6]],"date-time":"2025-03-06T00:00:00Z","timestamp":1741219200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0"},{"start":{"date-parts":[[2025,3,6]],"date-time":"2025-03-06T00:00:00Z","timestamp":1741219200000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0"}],"funder":[{"name":"Liver and gastrointestinal diseases research center, Tabriz University of medical sciences, Tabriz, Iran, Iran, Islamic Republic Of"}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["BMC Gastroenterol"],"DOI":"10.1186\/s12876-025-03733-1","type":"journal-article","created":{"date-parts":[[2025,3,6]],"date-time":"2025-03-06T09:07:56Z","timestamp":1741252076000},"update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":1,"title":["Effect of montelukast on remission maintenance in patients with ulcerative colitis: a Randomized, double-blind controlled clinical trial"],"prefix":"10.1186","volume":"25","author":[{"given":"Kourosh","family":"Masnadi Shirazi","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mehran","family":"Nezam Diba","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Arman","family":"Masnadi Shirazinezhad","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zeinab","family":"Nikniaz","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2025,3,6]]},"reference":[{"issue":"10080","key":"3733_CR1","doi-asserted-by":"publisher","first-page":"1756","DOI":"10.1016\/S0140-6736(16)32126-2","volume":"389","author":"R Ungaro","year":"2017","unstructured":"Ungaro R, Mehandru S, Allen PB, Peyrin-Biroulet L, Colombel J-F. Ulcerative colitis. Lancet. 2017;389(10080):1756\u201370.","journal-title":"Lancet"},{"issue":"4947","key":"3733_CR2","doi-asserted-by":"publisher","first-page":"1041","DOI":"10.1136\/bmj.2.4947.1041","volume":"2","author":"SC Truelove","year":"1955","unstructured":"Truelove SC, Witts L. Cortisone in ulcerative colitis. BMJ. 1955;2(4947):1041.","journal-title":"BMJ"},{"issue":"1","key":"3733_CR3","doi-asserted-by":"publisher","first-page":"1565889","DOI":"10.1080\/20016689.2019.1565889","volume":"7","author":"M Okayasu","year":"2019","unstructured":"Okayasu M, Ogata H, Yoshiyama Y. Use of corticosteroids for remission induction therapy in patients with new-onset ulcerative colitis in real-world settings. J Market Access Health Policy. 2019;7(1):1565889.","journal-title":"J Market Access Health Policy"},{"key":"3733_CR4","doi-asserted-by":"publisher","first-page":"215","DOI":"10.1016\/j.ctim.2018.09.026","volume":"41","author":"KM Shirazi","year":"2018","unstructured":"Shirazi KM, Nikniaz Z, Shirazi AM, Rohani M. Vitamin A supplementation decreases disease activity index in patients with ulcerative colitis: A randomized controlled clinical trial. Complement Ther Med. 2018;41:215\u20139.","journal-title":"Complement Ther Med"},{"issue":"3","key":"3733_CR5","doi-asserted-by":"publisher","first-page":"233","DOI":"10.1258\/acb.2010.010093","volume":"48","author":"Z Faghfoori","year":"2011","unstructured":"Faghfoori Z, Navai L, Shakerhosseini R, Somi MH, Nikniaz Z, Norouzi MF. Effects of an oral supplementation of germinated barley foodstuff on serum tumour necrosis factor-\u03b1, interleukin-6 and-8 in patients with ulcerative colitis. Ann Clin Biochem. 2011;48(3):233\u20137.","journal-title":"Ann Clin Biochem"},{"issue":"11","key":"3733_CR6","doi-asserted-by":"publisher","first-page":"1617","DOI":"10.1136\/gut.2003.037747","volume":"53","author":"W Kruis","year":"2004","unstructured":"Kruis W, Fric P, Pokrotnieks J, Luk\u00e1s M, Fixa B, Kasc\u00e1k M, Kamm MA, Weismueller J, Beglinger C, Stolte M, et al. Maintaining remission of ulcerative colitis with the probiotic Escherichia coli Nissle 1917 is as effective as with standard mesalazine. Gut. 2004;53(11):1617\u201323.","journal-title":"Gut"},{"issue":"1","key":"3733_CR7","doi-asserted-by":"publisher","first-page":"336","DOI":"10.1002\/ibd.21374","volume":"17","author":"D Turner","year":"2011","unstructured":"Turner D, Shah PS, Steinhart AH, Zlotkin S, Griffiths AM. Maintenance of remission in inflammatory bowel disease using omega-3 fatty acids (fish oil): a systematic review and meta-analyses. Inflamm Bowel Dis. 2011;17(1):336\u201345.","journal-title":"Inflamm Bowel Dis"},{"issue":"4","key":"3733_CR8","doi-asserted-by":"publisher","first-page":"101532","DOI":"10.1016\/j.clinre.2020.08.010","volume":"45","author":"KM Shirazi","year":"2021","unstructured":"Shirazi KM, Sotoudeh S, Shirazi AM, Moaddab S-Y, Nourpanah Z, Nikniaz Z. Effect of N-acetylcysteine on remission maintenance in patients with ulcerative colitis: A randomized, double-blind controlled clinical trial. Clin Res Hepatol Gastroenterol. 2021;45(4):101532.","journal-title":"Clin Res Hepatol Gastroenterol"},{"issue":"2","key":"3733_CR9","doi-asserted-by":"publisher","first-page":"251","DOI":"10.2165\/00003495-199856020-00010","volume":"56","author":"A Markham","year":"1998","unstructured":"Markham A, Faulds D. Montelukast. Drugs. 1998;56(2):251\u20136. discussion 257.","journal-title":"Drugs"},{"issue":"1","key":"3733_CR10","doi-asserted-by":"publisher","first-page":"57","DOI":"10.1016\/0163-7258(90)90035-Z","volume":"46","author":"SD Brain","year":"1990","unstructured":"Brain SD, Williams TJ. Leukotrienes and inflammation. Pharmacol Ther. 1990;46(1):57\u201366.","journal-title":"Pharmacol Ther"},{"issue":"9","key":"3733_CR11","doi-asserted-by":"publisher","first-page":"922","DOI":"10.3109\/02770903.2013.823447","volume":"50","author":"RK Singh","year":"2013","unstructured":"Singh RK, Tandon R, Dastidar SG, Ray A. A review on leukotrienes and their receptors with reference to asthma. J Asthma. 2013;50(9):922\u201331.","journal-title":"J Asthma"},{"issue":"2","key":"3733_CR12","doi-asserted-by":"publisher","first-page":"225","DOI":"10.3109\/14397595.2013.854056","volume":"24","author":"B Yousefi","year":"2014","unstructured":"Yousefi B, Jadidi-Niaragh F, Azizi G, Hajighasemi F, Mirshafiey A. The role of leukotrienes in Immunopathogenesis of rheumatoid arthritis. Mod Rheumatol. 2014;24(2):225\u201335.","journal-title":"Mod Rheumatol"},{"issue":"5","key":"3733_CR13","doi-asserted-by":"publisher","first-page":"537","DOI":"10.1002\/ibd.20094","volume":"13","author":"J Jupp","year":"2007","unstructured":"Jupp J, Hillier K, Elliott DH, Fine DR, Bateman AC, Johnson PA, Cazaly AM, Penrose JF, Sampson AP. Colonic expression of leukotriene-pathway enzymes in inflammatory bowel diseases. Inflamm Bowel Dis. 2007;13(5):537\u201346.","journal-title":"Inflamm Bowel Dis"},{"issue":"4","key":"3733_CR14","doi-asserted-by":"publisher","first-page":"372","DOI":"10.1016\/S1081-1206(10)61156-8","volume":"95","author":"I Stelmach","year":"2005","unstructured":"Stelmach I, Korzeniewska A, Stelmach W, Majak P, Grzelewski T, Jerzynska J. Effects of Montelukast treatment on clinical and inflammatory variables in patients with cystic fibrosis. Ann Allergy Asthma Immunol. 2005;95(4):372\u201380.","journal-title":"Ann Allergy Asthma Immunol"},{"issue":"8","key":"3733_CR15","doi-asserted-by":"publisher","first-page":"1321","DOI":"10.1093\/ecco-jcc\/jjac024","volume":"16","author":"A Mookhoek","year":"2022","unstructured":"Mookhoek A, Haasnoot ML, Bredenoord AJ, Ma C, Jairath V, Pai RK. The clinical significance of eosinophils in ulcerative colitis: A systematic review. J Crohn\u2019s Colitis. 2022;16(8):1321\u201334.","journal-title":"J Crohn\u2019s Colitis"},{"issue":"6","key":"3733_CR16","doi-asserted-by":"publisher","first-page":"819","DOI":"10.25122\/jml-2021-0269","volume":"15","author":"ZA Alnfakh","year":"2022","unstructured":"Alnfakh ZA, Al-Mudhafar DH, Al-Nafakh RT, Jasim AE, Hadi NR. The anti-inflammatory and antioxidant effects of Montelukast on lung sepsis in adult mice. J Med Life. 2022;15(6):819\u201327.","journal-title":"J Med Life"},{"issue":"4","key":"3733_CR17","doi-asserted-by":"publisher","first-page":"331","DOI":"10.1016\/0165-2427(95)05477-4","volume":"49","author":"HM Alzuherri","year":"1996","unstructured":"Alzuherri HM, Woodall CJ, Clarke CJ. Increased intestinal TNF-alpha, IL-1 beta and IL-6 expression in ovine paratuberculosis. Vet Immunol Immunopathol. 1996;49(4):331\u201345.","journal-title":"Vet Immunol Immunopathol"},{"key":"3733_CR18","doi-asserted-by":"publisher","first-page":"1011141","DOI":"10.3389\/fphar.2022.1011141","volume":"13","author":"B Ghorbanzadeh","year":"2022","unstructured":"Ghorbanzadeh B, Behmanesh MA, Mahmoudinejad R, Zamaniyan M, Ekhtiar S, Paridar Y. The effect of Montelukast, a leukotriene receptor antagonist, on the acetic acid-induced model of colitis in rats: involvement of NO-cGMP-K(ATP) channels pathway. Front Pharmacol. 2022;13:1011141.","journal-title":"Front Pharmacol"},{"issue":"3","key":"3733_CR19","first-page":"455","volume":"58","author":"R Holma","year":"2007","unstructured":"Holma R, Salmenper\u00e4 P, Virtanen I, Vapaatalo H, Korpela R. Prophylactic potential of Montelukast against mild colitis induced by dextran sulphate sodium in rats. J Physiol Pharmacol. 2007;58(3):455\u201367.","journal-title":"J Physiol Pharmacol"},{"issue":"4","key":"3733_CR20","doi-asserted-by":"publisher","first-page":"968","DOI":"10.3748\/wjg.v20.i4.968","volume":"20","author":"S Savari","year":"2014","unstructured":"Savari S, Vinnakota K, Zhang Y, Sj\u00f6lander A. Cysteinyl leukotrienes and their receptors: bridging inflammation and colorectal cancer. World J Gastroenterol. 2014;20(4):968\u201377.","journal-title":"World J Gastroenterol"},{"issue":"8","key":"3733_CR21","doi-asserted-by":"publisher","first-page":"1787","DOI":"10.1023\/A:1010682310928","volume":"46","author":"DA Schwartz","year":"2001","unstructured":"Schwartz DA, Pardi DS, Murray JA. Use of Montelukast as steroid-sparing agent for recurrent eosinophilic gastroenteritis. Dig Dis Sci. 2001;46(8):1787\u201390.","journal-title":"Dig Dis Sci"},{"issue":"4947","key":"3733_CR22","doi-asserted-by":"publisher","first-page":"1041","DOI":"10.1136\/bmj.2.4947.1041","volume":"2","author":"SC Truelove","year":"1955","unstructured":"Truelove SC, Witts LJ. Cortisone in ulcerative colitis; final report on a therapeutic trial. Br Med J. 1955;2(4947):1041\u20138.","journal-title":"Br Med J"},{"key":"3733_CR23","doi-asserted-by":"publisher","first-page":"556","DOI":"10.1016\/j.cca.2020.08.025","volume":"510","author":"F Khaki-Khatibi","year":"2020","unstructured":"Khaki-Khatibi F, Qujeq D, Kashifard M, Moein S, Maniati M, Vaghari-Tabari M. Calprotectin in inflammatory bowel disease. Clin Chim Acta. 2020;510:556\u201365.","journal-title":"Clin Chim Acta"},{"issue":"3","key":"3733_CR24","first-page":"455","volume":"58","author":"R Holma","year":"2007","unstructured":"Holma R, Salmenper\u00e4 P, Virtanen I, Vapaatalo H, Korpela R. Prophylactic potential of Montelukast against mild. J Physiol Pharmacol. 2007;58(3):455\u201367.","journal-title":"J Physiol Pharmacol"},{"issue":"1","key":"3733_CR25","doi-asserted-by":"publisher","first-page":"55","DOI":"10.1006\/phrs.1998.0409","volume":"39","author":"R Gonz\u00e1lez","year":"1999","unstructured":"Gonz\u00e1lez R, Rodr\u00edguez S, Romay C, Ancheta O, Gonz\u00e1lez A, Armesto J, Remirez D, Merino N. Anti-inflammatory activity of phycocyanin extract in acetic acid-induced colitis in rats. Pharmacol Res. 1999;39(1):55\u20139.","journal-title":"Pharmacol Res"},{"key":"3733_CR26","doi-asserted-by":"publisher","first-page":"2098293","DOI":"10.1155\/2017\/2098293","volume":"2017","author":"V Kristensen","year":"2017","unstructured":"Kristensen V, R\u00f8seth A, Ahmad T, Skar V, Moum B. Fecal calprotectin: A reliable predictor of mucosal healing after treatment for active ulcerative colitis. Gastroenterol Res Pract. 2017;2017:2098293.","journal-title":"Gastroenterol Res Pract"},{"issue":"1\u20133","key":"3733_CR27","doi-asserted-by":"publisher","first-page":"309","DOI":"10.1016\/S0014-2999(01)01330-9","volume":"429","author":"R Holma","year":"2001","unstructured":"Holma R, Salmenper\u00e4 P, Riutta A, Virtanen I, Korpela R, Vapaatalo H. Acute effects of the cys-leukotriene-1 receptor antagonist, Montelukast, on experimental colitis in rats. Eur J Pharmacol. 2001;429(1\u20133):309\u201318.","journal-title":"Eur J Pharmacol"},{"issue":"5b","key":"3733_CR28","doi-asserted-by":"publisher","first-page":"s37","DOI":"10.1016\/S0002-9343(99)00115-1","volume":"106","author":"LS Simon","year":"1999","unstructured":"Simon LS. Role and regulation of cyclooxygenase-2 during inflammation. Am J Med. 1999;106(5b):s37\u201342.","journal-title":"Am J Med"},{"issue":"4","key":"3733_CR29","doi-asserted-by":"publisher","first-page":"238","DOI":"10.4103\/sjg.SJG_599_16","volume":"23","author":"EA Hassan","year":"2017","unstructured":"Hassan EA, Ramadan HK, Ismael AA, Mohamed KF, El-Attar MM, Alhelali I. Noninvasive biomarkers as surrogate predictors of clinical and endoscopic remission after Infliximab induction in patients with refractory ulcerative colitis. Saudi J Gastroenterol. 2017;23(4):238\u201345.","journal-title":"Saudi J Gastroenterol"},{"issue":"11","key":"3733_CR30","doi-asserted-by":"publisher","first-page":"1359","DOI":"10.3109\/00365521.2013.832371","volume":"48","author":"A Tursi","year":"2013","unstructured":"Tursi A, Elisei W, Giorgetti G, Picchio M, Brandimarte G. Rapid fecal calprotectin correlates with clinical and endoscopic severity of inflammatory bowel diseases. Scand J Gastroenterol. 2013;48(11):1359\u201360.","journal-title":"Scand J Gastroenterol"},{"issue":"7321","key":"3733_CR31","doi-asserted-by":"publisher","first-page":"1123","DOI":"10.1136\/bmj.323.7321.1123","volume":"323","author":"AJ Vickers","year":"2001","unstructured":"Vickers AJ, Altman DG. Statistics notes: analysing controlled trials with baseline and follow up measurements. BMJ. 2001;323(7321):1123\u20134.","journal-title":"BMJ"}],"container-title":["BMC Gastroenterology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1186\/s12876-025-03733-1.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/article\/10.1186\/s12876-025-03733-1\/fulltext.html","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1186\/s12876-025-03733-1.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,3,6]],"date-time":"2025-03-06T09:08:01Z","timestamp":1741252081000},"score":1,"resource":{"primary":{"URL":"https:\/\/bmcgastroenterol.biomedcentral.com\/articles\/10.1186\/s12876-025-03733-1"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2025,3,6]]},"references-count":31,"journal-issue":{"issue":"1","published-online":{"date-parts":[[2025,12]]}},"alternative-id":["3733"],"URL":"https:\/\/doi.org\/10.1186\/s12876-025-03733-1","relation":{},"ISSN":["1471-230X"],"issn-type":[{"value":"1471-230X","type":"electronic"}],"subject":[],"published":{"date-parts":[[2025,3,6]]},"assertion":[{"value":"19 November 2024","order":1,"name":"received","label":"Received","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"25 February 2025","order":2,"name":"accepted","label":"Accepted","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"6 March 2025","order":3,"name":"first_online","label":"First Online","group":{"name":"ArticleHistory","label":"Article History"}},{"order":1,"name":"Ethics","group":{"name":"EthicsHeading","label":"Declarations"}},{"value":"All participants provided informed written consent. The ethics committee of Tabriz University of medical sciences approved the study protocol (Ethics code: IR.TBZMED.REC.1401.496). The study was carried out in accordance with the ethical guidelines of Tabriz University of medical sciences and adhered to the declaration of Helsinki.","order":2,"name":"Ethics","group":{"name":"EthicsHeading","label":"Ethics approval and consent to participate"}},{"value":"Not applicable.","order":3,"name":"Ethics","group":{"name":"EthicsHeading","label":"Consent for publication"}},{"value":"The authors declare no competing interests.","order":4,"name":"Ethics","group":{"name":"EthicsHeading","label":"Competing interests"}}],"article-number":"145"}}