{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,3,17]],"date-time":"2026-03-17T22:35:42Z","timestamp":1773786942345,"version":"3.50.1"},"reference-count":34,"publisher":"Springer Science and Business Media LLC","issue":"1","license":[{"start":{"date-parts":[[2025,5,12]],"date-time":"2025-05-12T00:00:00Z","timestamp":1747008000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0"},{"start":{"date-parts":[[2025,5,12]],"date-time":"2025-05-12T00:00:00Z","timestamp":1747008000000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0"}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["BMC Gastroenterol"],"DOI":"10.1186\/s12876-025-03769-3","type":"journal-article","created":{"date-parts":[[2025,5,12]],"date-time":"2025-05-12T09:18:26Z","timestamp":1747041506000},"update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":1,"title":["Eradication of Helicobacter pylori that contributes to hepatogenic ulcer is beneficial to the healing of hepatogenic ulcer"],"prefix":"10.1186","volume":"25","author":[{"given":"Guanen","family":"Qiao","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Le","family":"Feng","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Meng","family":"Wang","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Chaoyang","family":"Wang","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Changjuan","family":"Li","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Shuxiang","family":"Han","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yanmei","family":"Wang","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Shubo","family":"Li","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Shuanli","family":"Xin","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"297","published-online":{"date-parts":[[2025,5,12]]},"reference":[{"issue":"9","key":"3769_CR1","doi-asserted-by":"publisher","first-page":"1419","DOI":"10.14309\/ajg.0000000000001843","volume":"117","author":"H Azhari","year":"2022","unstructured":"Azhari H, King JA, Coward S, Windsor JW, Ma C, Shah SC, Ng SC, Mak JWY, Kotze PG, Ben-Horin S, et al. The global incidence of peptic ulcer disease is decreasing since the turn of the 21st century: A study of the organisation for economic Co-Operation and development (OECD). Am J Gastroenterol. 2022;117(9):1419\u201327.","journal-title":"Am J Gastroenterol"},{"key":"3769_CR2","unstructured":"Khmelnitski\u012d SI, Kriuchina EA. Hepatogenic gastroduodenal ulcer. Klin Khir 1998(4):42\u20135."},{"key":"3769_CR3","doi-asserted-by":"crossref","unstructured":"Jeng KS, Chang CF, Sheen IS, Jeng CJ, Wang CH. Upper Gastrointestinal cancer and liver cirrhosis. Cancers 2022;14(9).","DOI":"10.3390\/cancers14092269"},{"issue":"6","key":"3769_CR4","doi-asserted-by":"publisher","first-page":"617","DOI":"10.1080\/17474124.2018.1456918","volume":"12","author":"J Zhu","year":"2018","unstructured":"Zhu J, Qi X, Yu H, Su C, Guo X. Acid suppression in patients treated with endoscopic therapy for the management of gastroesophageal varices: a systematic review and meta-analysis. Expert Rev Gastroenterol Hepatol. 2018;12(6):617\u201324.","journal-title":"Expert Rev Gastroenterol Hepatol"},{"issue":"1","key":"3769_CR5","doi-asserted-by":"publisher","first-page":"1610","DOI":"10.1080\/14756366.2022.2081846","volume":"37","author":"RH Elkousy","year":"2022","unstructured":"Elkousy RH, Mostafa NM, Abd-Alkhalek AM, El Hassab MA, Al-Rashood ST, Eldehna WM, Eldahshan OA. GC\/MS analysis and potential synergistic effect of Mandarin and marjoram oils on Helicobacter pylori. J Enzyme Inhib Med Chem. 2022;37(1):1610\u20139.","journal-title":"J Enzyme Inhib Med Chem"},{"key":"3769_CR6","doi-asserted-by":"crossref","unstructured":"Hu Y, Xu X, Ouyang YB, He C, Li NS, Xie C, Peng C, Zhu ZH, Xie Y, Shu X et al. Analysis of oral microbiota alterations induced by Helicobacter pylori infection and vonoprazan-amoxicillin dual therapy for Helicobacter pylori eradication. Helicobacter 2022:e12923.","DOI":"10.3389\/fcimb.2022.881968"},{"issue":"10094","key":"3769_CR7","doi-asserted-by":"publisher","first-page":"613","DOI":"10.1016\/S0140-6736(16)32404-7","volume":"390","author":"A Lanas","year":"2017","unstructured":"Lanas A, Chan FKL. Peptic ulcer disease. Lancet (London England). 2017;390(10094):613\u201324.","journal-title":"Lancet (London England)"},{"issue":"10","key":"3769_CR8","doi-asserted-by":"publisher","first-page":"1815","DOI":"10.1136\/gutjnl-2021-324032","volume":"70","author":"F Megraud","year":"2021","unstructured":"Megraud F, Bruyndonckx R, Coenen S, Wittkop L, Huang TD, Hoebeke M, B\u00e9n\u00e9jat L, Lehours P, Goossens H, Glupczynski Y. Helicobacter pylori resistance to antibiotics in Europe in 2018 and its relationship to antibiotic consumption in the community. Gut. 2021;70(10):1815\u201322.","journal-title":"Gut"},{"key":"3769_CR9","doi-asserted-by":"crossref","unstructured":"Nyssen OP, Vaira D, Saracino IM, Fiorini G, Caldas M, Bujanda L, Pellicano R, Keco-Huerga A, Pab\u00f3n-Carrasco M, Oblitas Susanibar E et al. Experience with Rifabutin-Containing therapy in 500 patients from the European registry on Helicobacter pylori management (Hp-EuReg). J Clin Med 2022, 11(6).","DOI":"10.3390\/jcm11061658"},{"issue":"5","key":"3769_CR10","first-page":"451","volume":"32","author":"T Voulgaris","year":"2019","unstructured":"Voulgaris T, Karagiannakis D, Siakavellas S, Kalogera D, Angelopoulos T, Chloupi E, Karamanolis G, Papatheodoridis G, Vlachogiannakos J. High prevalence of asymptomatic peptic ulcers diagnosed during screening endoscopy in patients with cirrhosis. Annals Gastroenterol. 2019;32(5):451\u20136.","journal-title":"Annals Gastroenterol"},{"issue":"7","key":"3769_CR11","doi-asserted-by":"publisher","first-page":"717","DOI":"10.1097\/00042737-200207000-00002","volume":"14","author":"M Vergara","year":"2002","unstructured":"Vergara M, Calvet X, Roqu\u00e9 M. Helicobacter pylori is a risk factor for peptic ulcer disease in cirrhotic patients. A meta-analysis. Eur J Gastroenterol Hepatol. 2002;14(7):717\u201322.","journal-title":"Eur J Gastroenterol Hepatol"},{"issue":"1","key":"3769_CR12","doi-asserted-by":"publisher","first-page":"24","DOI":"10.1186\/s13099-022-00502-3","volume":"14","author":"ET Azab","year":"2022","unstructured":"Azab ET, Thabit AK, McKee S, Al-Qiraiqiri A. Levofloxacin versus clarithromycin for Helicobacter pylori eradication: are 14\u00a0day regimens better than 10\u00a0day regimens? Gut Pathogens. 2022;14(1):24.","journal-title":"Gut Pathogens"},{"issue":"1","key":"3769_CR13","first-page":"62","volume":"29","author":"S Siringo","year":"1997","unstructured":"Siringo S, Bolondi L, Piscaglia F, Gaetani M, Misitano B, Carbone C, Corinaldesi R, Burroughs AK. Peptic ulcer in patients with liver cirrhosis: a retrospective endoscopic and clinical study. Italian J Gastroenterol Hepatol. 1997;29(1):62\u20138.","journal-title":"Italian J Gastroenterol Hepatol"},{"issue":"1","key":"3769_CR14","first-page":"26","volume":"4","author":"GI Kirchner","year":"2011","unstructured":"Kirchner GI, Beil W, Bleck JS, Manns MP, Wagner S. Prevalence of Helicobacter pylori and occurrence of gastroduodenal lesions in patients with liver cirrhosis. Int J Clin Exp Med. 2011;4(1):26\u201331.","journal-title":"Int J Clin Exp Med"},{"issue":"6","key":"3769_CR15","first-page":"32","volume":"67","author":"SS Kataev","year":"1989","unstructured":"Kataev SS, Shifrin OS, Golovanova O, Tsvetkova LI, Lebedev SP. [Hepatogenic ulcer (various aspects of its pathogenesis)]. Klinicheskaia Meditsina. 1989;67(6):32\u20136.","journal-title":"Klinicheskaia Meditsina"},{"issue":"35","key":"3769_CR16","doi-asserted-by":"publisher","first-page":"5890","DOI":"10.3748\/wjg.v27.i35.5890","volume":"27","author":"RE Rossi","year":"2021","unstructured":"Rossi RE, Elvevi A, Citterio D, Coppa J, Invernizzi P, Mazzaferro V, Massironi S. Gastrinoma and Zollinger Ellison syndrome: A roadmap for the management between new and old therapies. World J Gastroenterol. 2021;27(35):5890\u2013907.","journal-title":"World J Gastroenterol"},{"key":"3769_CR17","volume-title":"LiverTox: clinical and research information on Drug-Induced liver injury","author":"Histamine Type-2","year":"2012","unstructured":"Histamine Type-2. Receptor antagonists (H2 Blockers). LiverTox: clinical and research information on Drug-Induced liver injury. edn. Bethesda (MD): National Institute of Diabetes and Digestive and Kidney Diseases; 2012."},{"issue":"4","key":"3769_CR18","doi-asserted-by":"publisher","first-page":"605","DOI":"10.1016\/j.gie.2013.08.026","volume":"79","author":"PG Venkatesh","year":"2014","unstructured":"Venkatesh PG, Parasa S, Njei B, Sanaka MR, Navaneethan U. Increased mortality with peptic ulcer bleeding in patients with both compensated and decompensated cirrhosis. Gastrointest Endosc. 2014;79(4):605\u2013e614603.","journal-title":"Gastrointest Endosc"},{"issue":"5","key":"3769_CR19","doi-asserted-by":"publisher","first-page":"1829","DOI":"10.1002\/hep.23917","volume":"52","author":"JP Nolan","year":"2010","unstructured":"Nolan JP. The role of intestinal endotoxin in liver injury: a long and evolving history. Hepatology (Baltimore MD). 2010;52(5):1829\u201335.","journal-title":"Hepatology (Baltimore MD)"},{"issue":"Suppl 3","key":"3769_CR20","first-page":"47","volume":"25","author":"WE Fleig","year":"1987","unstructured":"Fleig WE, Stange EF, Winkler K. [Is there a hepatogenic ulcer? Prospective study of the incidence of peptic ulcer in portal hypertension]. Z Gastroenterol. 1987;25(Suppl 3):47\u201351.","journal-title":"Z Gastroenterol"},{"key":"3769_CR21","doi-asserted-by":"publisher","first-page":"2241","DOI":"10.1055\/s-0028-1113267","volume":"89","author":"G Strobach","year":"1964","unstructured":"Strobach G, Wildhirt E. [IS THERE A HEPATOGENIC ULCER?]. Dtsch Med Wochenschr. 1964;89:2241\u20134.","journal-title":"Dtsch Med Wochenschr"},{"issue":"2","key":"3769_CR22","first-page":"73","volume":"16","author":"H Thiel","year":"1978","unstructured":"Thiel H. [Hepatogenic ulcer: theories and facts (author\u2019s transl)]. Z Gastroenterol. 1978;16(2):73\u201384.","journal-title":"Z Gastroenterol"},{"issue":"9","key":"3769_CR23","doi-asserted-by":"publisher","first-page":"843","DOI":"10.1111\/j.1469-0691.2009.02719.x","volume":"15","author":"Y Huang","year":"2009","unstructured":"Huang Y, Tian XF, Fan XG, Fu CY, Zhu C. The pathological effect of Helicobacter pylori infection on liver tissues in mice. Clin Microbiol Infect. 2009;15(9):843\u20139.","journal-title":"Clin Microbiol Infect"},{"issue":"3","key":"3769_CR24","doi-asserted-by":"publisher","first-page":"357","DOI":"10.1016\/j.gie.2005.06.003","volume":"62","author":"RJ Saad","year":"2005","unstructured":"Saad RJ, Chey WD. Peptic ulcer disease in patients with chronic liver disease: looking beyond Bugs and drugs. Gastrointest Endosc. 2005;62(3):357\u20139.","journal-title":"Gastrointest Endosc"},{"key":"3769_CR25","doi-asserted-by":"publisher","first-page":"902255","DOI":"10.3389\/fmed.2022.902255","volume":"9","author":"SJ Alarfaj","year":"2022","unstructured":"Alarfaj SJ, Abdallah Mostafa S, Abdelsalam RA, Negm WA, El-Masry TA, Hussein IA, El Nakib AM. Helicobacter pylori infection in cirrhotic patients with portal hypertensive gastropathy: A new enigma?? Front Med (Lausanne). 2022;9:902255.","journal-title":"Front Med (Lausanne)"},{"issue":"9","key":"3769_CR26","doi-asserted-by":"publisher","first-page":"1444","DOI":"10.1111\/jgh.12221","volume":"28","author":"Y Sakamoto","year":"2013","unstructured":"Sakamoto Y, Oho K, Toyonaga A, Kumamoto M, Haruta T, Inoue H, Emori K, Tsuruta O, Sata M. Effect of Helicobacter pylori infection on esophagogastric variceal bleeding in patients with liver cirrhosis and portal hypertension. J Gastroenterol Hepatol. 2013;28(9):1444\u20139.","journal-title":"J Gastroenterol Hepatol"},{"issue":"4","key":"3769_CR27","first-page":"166","volume":"27","author":"R Villalan","year":"2006","unstructured":"Villalan R, Maroju NK, Kate V, Ananthakrishnan N. Is Helicobacter pylori eradication indicated in cirrhotic patients with peptic ulcer disease? Trop Gastroenterology: Official J Dig Dis Foundation. 2006;27(4):166\u20138.","journal-title":"Trop Gastroenterology: Official J Dig Dis Foundation"},{"issue":"6","key":"3769_CR28","doi-asserted-by":"publisher","first-page":"744","DOI":"10.1097\/MCG.0b013e3180381571","volume":"42","author":"C Tzathas","year":"2008","unstructured":"Tzathas C, Triantafyllou K, Mallas E, Triantafyllou G, Ladas SD. Effect of Helicobacter pylori eradication and antisecretory maintenance therapy on peptic ulcer recurrence in cirrhotic patients: a prospective, cohort 2-year follow-up study. J Clin Gastroenterol. 2008;42(6):744\u20139.","journal-title":"J Clin Gastroenterol"},{"issue":"8","key":"3769_CR29","doi-asserted-by":"publisher","first-page":"451","DOI":"10.1111\/1751-2980.12159","volume":"15","author":"SS Chang","year":"2014","unstructured":"Chang SS, Hu HY. H. pylori eradication lower ulcers in cirrhosis. [Corrected] J Dig Dis. 2014;15(8):451\u20138.","journal-title":"[Corrected] J Dig Dis"},{"issue":"6","key":"3769_CR30","doi-asserted-by":"publisher","first-page":"408","DOI":"10.1080\/08923973.2016.1247855","volume":"38","author":"R Licinio","year":"2016","unstructured":"Licinio R, Losurdo G, Carparelli S, Iannone A, Giorgio F, Barone M, Principi M, Ierardi E, Di Leo A. Helicobacter pylori, liver cirrhosis, and portal hypertension: an updated appraisal. Immunopharmacol Immunotoxicol. 2016;38(6):408\u201313.","journal-title":"Immunopharmacol Immunotoxicol"},{"issue":"5","key":"3769_CR31","doi-asserted-by":"publisher","first-page":"337","DOI":"10.1080\/17425255.2022.2098107","volume":"18","author":"I Ben Ghezala","year":"2022","unstructured":"Ben Ghezala I, Luu M, Bardou M. An update on drug-drug interactions associated with proton pump inhibitors. Expert Opin Drug Metab Toxicol. 2022;18(5):337\u201346.","journal-title":"Expert Opin Drug Metab Toxicol"},{"issue":"Suppl 3","key":"3769_CR32","doi-asserted-by":"publisher","first-page":"11","DOI":"10.1046\/j.1365-2036.1999.00020.x","volume":"13","author":"SK Swan","year":"1999","unstructured":"Swan SK, Hoyumpa AM, Merritt GJ. Review Article: the pharmacokinetics of Rabeprazole in health and disease. Aliment Pharmacol Ther. 1999;13(Suppl 3):11\u20137.","journal-title":"Aliment Pharmacol Ther"},{"issue":"02","key":"3769_CR33","first-page":"22","volume":"17","author":"L Na","year":"2020","unstructured":"Na L, Jie C, Kun C, Jianling Z. To observe the efficacy of Rabeprazole, Levofloxacin combined with amoxicillin in the treatment of gastric ulcer Helicobacter pylori infection. Pharm North China. 2020;17(02):22\u20133.","journal-title":"Pharm North China"},{"issue":"11","key":"3769_CR34","first-page":"1370","volume":"48","author":"L Jinhong","year":"2020","unstructured":"Jinhong L. Transport and distribution characteristics of amoxicillin and Levofloxacin in the stomach of patients with Helicobacter pylori infection treated with triple therapy. J Clin Military Med. 2020;48(11):1370\u20131.","journal-title":"J Clin Military Med"}],"container-title":["BMC Gastroenterology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1186\/s12876-025-03769-3.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/article\/10.1186\/s12876-025-03769-3\/fulltext.html","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1186\/s12876-025-03769-3.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,5,12]],"date-time":"2025-05-12T09:18:29Z","timestamp":1747041509000},"score":1,"resource":{"primary":{"URL":"https:\/\/bmcgastroenterol.biomedcentral.com\/articles\/10.1186\/s12876-025-03769-3"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2025,5,12]]},"references-count":34,"journal-issue":{"issue":"1","published-online":{"date-parts":[[2025,12]]}},"alternative-id":["3769"],"URL":"https:\/\/doi.org\/10.1186\/s12876-025-03769-3","relation":{},"ISSN":["1471-230X"],"issn-type":[{"value":"1471-230X","type":"electronic"}],"subject":[],"published":{"date-parts":[[2025,5,12]]},"assertion":[{"value":"8 October 2023","order":1,"name":"received","label":"Received","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"7 March 2025","order":2,"name":"accepted","label":"Accepted","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"12 May 2025","order":3,"name":"first_online","label":"First Online","group":{"name":"ArticleHistory","label":"Article History"}},{"order":1,"name":"Ethics","group":{"name":"EthicsHeading","label":"Declarations"}},{"value":"All participants were collected from the Handan First Hospital. This study was approved by the Ethics Committee of Handan First Hospital (2022-017) and was performed in accordance with the Declaration of Helsinki.","order":2,"name":"Ethics","group":{"name":"EthicsHeading","label":"Ethical approval"}},{"value":"This study was registered at Chinese Clinical Trial Registry (Chictr.org.cn, ChiCTR2200061355, 2022\/06\/21), which waived the need for consent forms because this was a retrospective study and has been approved by the Ethics Committee of Handan First Hospital.","order":3,"name":"Ethics","group":{"name":"EthicsHeading","label":"Patient anonymity and informed consent"}},{"value":"The authors declare no competing interests.","order":4,"name":"Ethics","group":{"name":"EthicsHeading","label":"Competing interests"}}],"article-number":"359"}}