{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,28]],"date-time":"2026-10-28T11:41:04Z","timestamp":1793187664389,"version":"4.5.0"},"reference-count":35,"publisher":"Springer Science and Business Media LLC","issue":"1","license":[{"start":{"date-parts":[[2025,5,10]],"date-time":"2025-05-10T00:00:00Z","timestamp":1746835200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0"},{"start":{"date-parts":[[2025,5,10]],"date-time":"2025-05-10T00:00:00Z","timestamp":1746835200000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0"}],"funder":[{"DOI":"10.13039\/501100001809","name":"Natural Science Foundation of China","doi-asserted-by":"crossref","award":["82072094"],"award-info":[{"award-number":["82072094"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"crossref"}]}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["BMC Gastroenterol"],"DOI":"10.1186\/s12876-025-03964-2","type":"journal-article","created":{"date-parts":[[2025,5,10]],"date-time":"2025-05-10T01:13:20Z","timestamp":1746839600000},"update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":10,"title":["Dual energy CT-derived quantitative parameters and hematological characteristics predict pathological complete response in neoadjuvant chemoradiotherapy esophageal squamous cell carcinoma patients"],"prefix":"10.1186","volume":"25","author":[{"given":"Miaomiao","family":"Li","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yongbin","family":"Cui","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yuanyuan","family":"Yan","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Junfeng","family":"Zhao","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xinjun","family":"Lin","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Qianyu","family":"Liu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shushan","family":"Dong","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mingming","family":"Nie","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yong","family":"Huang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Baosheng","family":"Li","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yong","family":"Yin","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2025,5,10]]},"reference":[{"issue":"3","key":"3964_CR1","doi-asserted-by":"publisher","first-page":"229","DOI":"10.3322\/caac.21834","volume":"74","author":"F Bray","year":"2024","unstructured":"Bray F, Laversanne M. Global cancer statistics 2022: GLOBOCAN estimates of incidence and mortality worldwide for 36 cancers in 185 countries [J]. CA Cancer J Clin. 2024;74(3):229\u201363.","journal-title":"CA Cancer J Clin"},{"key":"3964_CR2","doi-asserted-by":"crossref","unstructured":"Shapiro J, Van Lanschot J J B, Hulshof M, et al. Neoadjuvant chemoradiotherapy plus surgery versus surgery alone for oesophageal or junctional cancer (CROSS): long-term results of a randomised controlled trial [J]. Lancet Oncol. 2015;16(9):1090\u20138.","DOI":"10.1016\/S1470-2045(15)00040-6"},{"key":"3964_CR3","doi-asserted-by":"crossref","unstructured":"Eyck B M, Van Lanschot J J B, Hulshof M, et al. Ten-Year outcome of neoadjuvant chemoradiotherapy plus surgery for esophageal cancer: the randomized controlled CROSS trial [J]. J Clin Oncol. 2021;39(18):1995\u20132004.","DOI":"10.1200\/JCO.20.03614"},{"key":"3964_CR4","doi-asserted-by":"crossref","unstructured":"Berger A C, Farma J, Scott W J, et al. Complete response to neoadjuvant chemoradiotherapy in esophageal carcinoma is associated with significantly improved survival [J]. J Clin Oncol. 2005;23(19):4330\u20137.","DOI":"10.1200\/JCO.2005.05.017"},{"key":"3964_CR5","doi-asserted-by":"crossref","unstructured":"Shen J, Kong M, Yang H, et al. Pathological complete response after neoadjuvant treatment determines survival in esophageal squamous cell carcinoma patients (NEOCRTEC5010) [J]. Ann Transl Med. 2021;9(20):1516.","DOI":"10.21037\/atm-21-3331"},{"key":"3964_CR6","doi-asserted-by":"crossref","unstructured":"Tang H, Wang H, Fang Y, et al. Neoadjuvant chemoradiotherapy versus neoadjuvant chemotherapy followed by minimally invasive esophagectomy for locally advanced esophageal squamous cell carcinoma: a prospective multicenter randomized clinical trial [J]. Ann Oncol. 2023;34(2):163\u201372.","DOI":"10.1016\/j.annonc.2022.10.508"},{"key":"3964_CR7","doi-asserted-by":"crossref","unstructured":"Noordman B J, Wijnhoven B P L, Lagarde SM, et al. Neoadjuvant chemoradiotherapy plus surgery versus active surveillance for oesophageal cancer: a stepped-wedge cluster randomised trial [J]. BMC Cancer. 2018;18(1):142.","DOI":"10.1186\/s12885-018-4034-1"},{"key":"3964_CR8","doi-asserted-by":"crossref","unstructured":"Luo Y, Liu L, Liu D, et al. Extracellular volume fraction determined by equilibrium contrast-enhanced CT for the prediction of the pathological complete response to neoadjuvant chemoradiotherapy for locally advanced rectal cancer [J]. Eur Radiol. 2023;33(6):4042\u201351.","DOI":"10.1007\/s00330-022-09307-z"},{"key":"3964_CR9","doi-asserted-by":"crossref","unstructured":"Wongwaiyut K, Ruangsin S, Laohawiriyakamol S, et al. Pretreatment esophageal wall thickness associated with response to chemoradiotherapy in locally advanced esophageal Cancer [J]. J Gastrointest Cancer. 2020;51(3):947\u201351.","DOI":"10.1007\/s12029-019-00337-3"},{"key":"3964_CR10","doi-asserted-by":"crossref","unstructured":"Wang X, Yang W, Zhou Q, et al. The role of (18)F-FDG PET\/CT in predicting the pathological response to neoadjuvant PD-1 Blockade in combination with chemotherapy for resectable esophageal squamous cell carcinoma [J]. Eur J Nucl Med Mol Imaging. 2022;49(12):4241\u201351.","DOI":"10.1007\/s00259-022-05872-z"},{"key":"3964_CR11","doi-asserted-by":"crossref","unstructured":"Maffazzioli L, Zilio M B, Klamt A L, et al. ADC as a predictor of pathologic response to neoadjuvant therapy in esophageal cancer: a systematic review and meta-analysis [J]. Eur Radiol. 2020;30(7):3934\u201342.","DOI":"10.1007\/s00330-020-06723-x"},{"key":"3964_CR12","doi-asserted-by":"crossref","unstructured":"Liu P, Lin L, Xu C, et al. Quantitative analysis of late iodine enhancement using dual-layer spectral detector computed tomography: comparison with magnetic resonance imaging [J]. Quant Imaging Med Surg. 2022;12(1):310\u201320.","DOI":"10.21037\/qims-21-344"},{"key":"3964_CR13","doi-asserted-by":"crossref","unstructured":"Yeo B, Shin K M, Park B, et al. Clinical feasibility of Dual-Layer CT with virtual monochromatic image for preoperative staging in patients with breast cancer: A comparison with breast MRI [J]. Korean J Radiol, 2024, 25(9).","DOI":"10.3348\/kjr.2023.1312"},{"key":"3964_CR14","doi-asserted-by":"crossref","unstructured":"Wang Y, Tian W. Spectral CT - a new supplementary method for preoperative assessment of pathological grades of esophageal squamous cell carcinoma [J]. BMC Med Imaging. 2023;23(1):110.","DOI":"10.1186\/s12880-023-01068-5"},{"issue":"6","key":"3964_CR15","doi-asserted-by":"publisher","first-page":"2622","DOI":"10.21037\/qims-20-1045","volume":"11","author":"L Gao","year":"2021","unstructured":"Gao L, Lu X, Wen Q, et al. Added value of spectral parameters for the assessment of lymph node metastasis of lung cancer with dual-layer spectral detector computed tomography [J]. Quant Imaging Med Surg. 2021;11(6):2622\u201333.","journal-title":"Quant Imaging Med Surg"},{"key":"3964_CR16","doi-asserted-by":"crossref","unstructured":"Liu Y, Cheng F, Wang L et al. Quantitative parameters derived from dual-energy computed tomography for the preoperative prediction of early recurrence in patients with esophageal squamous cell carcinoma [J]. Eur Radiol, 2023.","DOI":"10.1007\/s00330-023-09818-3"},{"key":"3964_CR17","doi-asserted-by":"crossref","unstructured":"Gaber C E, Sarker J, Abdelaziz A I, et al. Pathologic complete response in patients with esophageal cancer receiving neoadjuvant chemotherapy or chemoradiation: A systematic review and meta-analysis [J]. Cancer Med. 2024;13(4):e7076.","DOI":"10.1002\/cam4.7076"},{"key":"3964_CR18","doi-asserted-by":"crossref","unstructured":"Goto W, Kashiwagi S, Asano Y, et al. Predictive value of lymphocyte-to-monocyte ratio in the preoperative setting for progression of patients with breast cancer [J]. BMC Cancer. 2018;18(1):1137.","DOI":"10.1186\/s12885-018-5051-9"},{"key":"3964_CR19","doi-asserted-by":"crossref","unstructured":"Hu X, Tian T, Sun Q, et al. Prognostic value of the neutrophil-to-lymphocyte ratio and platelet-to-lymphocyte ratio in laryngeal cancer: what should we expect from a meta-analysis? [J]. Front Oncol. 2022;12:945820.","DOI":"10.3389\/fonc.2022.945820"},{"key":"3964_CR20","doi-asserted-by":"crossref","unstructured":"Rice T W, Ishwaran H, Ferguson M K, et al. Cancer of the esophagus and esophagogastric junction: an eighth edition staging primer [J]. J Thorac Oncol. 2017;12(1):36\u201342.","DOI":"10.1016\/j.jtho.2016.10.016"},{"key":"3964_CR21","doi-asserted-by":"crossref","unstructured":"Mandard AM, Dalibard F, Mandard JC, et al. Pathologic assessment of tumor regression after preoperative chemoradiotherapy of esophageal carcinoma. Clinicopathol Correlat Cancer. 1994;73(11):2680\u20136.","DOI":"10.1002\/1097-0142(19940601)73:11<2680::AID-CNCR2820731105>3.0.CO;2-C"},{"key":"3964_CR22","doi-asserted-by":"crossref","unstructured":"Mahnken A H, Klotz E, Schreiber S, et al. Volumetric arterial enhancement fraction predicts tumor recurrence after hepatic radiofrequency ablation of liver metastases: initial results [J]. Am J Roentgenol. 2011;196(5):W573\u20139.","DOI":"10.2214\/AJR.10.4410"},{"key":"3964_CR23","doi-asserted-by":"crossref","unstructured":"Mao X, Guo Y, Wen F, et al. Applying arterial enhancement fraction (AEF) texture features to predict the tumor response in hepatocellular carcinoma (HCC) treated with transarterial chemoembolization (TACE) [J]. Cancer Imaging. 2021;21(1):49.","DOI":"10.1186\/s40644-021-00418-2"},{"key":"3964_CR24","doi-asserted-by":"crossref","unstructured":"Chai B, Xiang D, Wang W, et al. Arterial enhancement fraction in evaluating the therapeutic effect and survival for hepatocellular carcinoma patients treated with DEB-TACE [J]. Cancer Imaging, 2022, 22(1).","DOI":"10.1186\/s40644-022-00477-z"},{"key":"3964_CR25","doi-asserted-by":"crossref","unstructured":"Zhou Y, Xu Y K Gengd, et al. Added value of arterial enhancement fraction derived from dual-energy computed tomography for preoperative diagnosis of cervical lymph node metastasis in papillary thyroid cancer: initial results [J]. Eur Radiol. 2024;34(2):1292\u2013301.","DOI":"10.1007\/s00330-023-10109-0"},{"key":"3964_CR26","doi-asserted-by":"crossref","unstructured":"Roeder F, Meldolesi E. Gerum S, Recent advances in (chemo-)radiation therapy for rectal cancer: a comprehensive review [J]. Radiat Oncol, 2020, 15(1).","DOI":"10.1186\/s13014-020-01695-0"},{"key":"3964_CR27","doi-asserted-by":"crossref","unstructured":"Sahai E, Astsaturov I. A framework for advancing our Understanding of cancer-associated fibroblasts [J]. Nat Rev Cancer. 2020;20(3):174\u201386.","DOI":"10.1038\/s41568-019-0238-1"},{"key":"3964_CR28","doi-asserted-by":"crossref","unstructured":"Fukukura Y, Kumagae Y, Higashi R, et al. Extracellular volume fraction determined by equilibrium contrast-enhanced multidetector computed tomography as a prognostic factor in unresectable pancreatic adenocarcinoma treated with chemotherapy [J]. Eur Radiol. 2018;29(1):353\u201361.","DOI":"10.1007\/s00330-018-5570-4"},{"key":"3964_CR29","doi-asserted-by":"crossref","unstructured":"Fukukura Y, Kumagae Y, Higashi R, et al. Extracellular volume fraction determined by equilibrium contrast-enhanced dual-energy CT as a prognostic factor in patients with stage IV pancreatic ductal adenocarcinoma [J]. Eur Radiol. 2020;30(3):1679\u201389.","DOI":"10.1007\/s00330-019-06517-w"},{"key":"3964_CR30","doi-asserted-by":"crossref","unstructured":"Zhao F, Pang G, Li X et al. Value of perfusion parameters histogram analysis of triphasic CT in differentiating intrahepatic mass forming cholangiocarcinoma from hepatocellular carcinoma [J]. Sci Rep, 2021, 11(1).","DOI":"10.1038\/s41598-021-02667-4"},{"key":"3964_CR31","doi-asserted-by":"crossref","unstructured":"Cai W, Zhu Y, Teng Z, et al. Extracellular volume-based scoring system for tracking tumor progression in pancreatic cancer patients receiving intraoperative radiotherapy [J]. Insights Imaging. 2024;15(1):116.","DOI":"10.1186\/s13244-024-01689-6"},{"key":"3964_CR32","doi-asserted-by":"crossref","unstructured":"Dicato M, Plawny L. Anemia in cancer [J]. Ann Oncol. 2010;21(Suppl 7):vii167\u201372.","DOI":"10.1093\/annonc\/mdq284"},{"key":"3964_CR33","doi-asserted-by":"crossref","unstructured":"Ge X, Yu J, Wang Z, et al. Comparative study of dual energy CT iodine imaging and standardized concentrations before and after chemoradiotherapy for esophageal cancer [J]. BMC Cancer. 2018;18(1):1120.","DOI":"10.1186\/s12885-018-5058-2"},{"key":"3964_CR34","doi-asserted-by":"crossref","unstructured":"Moore Jl, Subesinghe M, Santaolalla A, et al. Metabolic tumour and nodal response to neoadjuvant chemotherapy on FDG PET-CT as a predictor of pathological response and survival in patients with oesophageal adenocarcinoma [J]. Eur Radiol. 2023;33(5):3647\u201359.","DOI":"10.1007\/s00330-023-09482-7"},{"key":"3964_CR35","doi-asserted-by":"crossref","unstructured":"Xu X, Sun Z-Y, Wu H-W, et al. Diffusion-weighted MRI and 18F-FDG PET\/CT in assessing the response to neoadjuvant chemoradiotherapy in locally advanced esophageal squamous cell carcinoma [J]. Radiat Oncol, 2021, 16(1).","DOI":"10.1186\/s13014-021-01852-z"}],"container-title":["BMC Gastroenterology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1186\/s12876-025-03964-2.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/article\/10.1186\/s12876-025-03964-2\/fulltext.html","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1186\/s12876-025-03964-2.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,5,10]],"date-time":"2025-05-10T01:13:36Z","timestamp":1746839616000},"score":1,"resource":{"primary":{"URL":"https:\/\/bmcgastroenterol.biomedcentral.com\/articles\/10.1186\/s12876-025-03964-2"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2025,5,10]]},"references-count":35,"journal-issue":{"issue":"1","published-online":{"date-parts":[[2025,12]]}},"alternative-id":["3964"],"URL":"https:\/\/doi.org\/10.1186\/s12876-025-03964-2","relation":{"has-preprint":[{"id-type":"doi","id":"10.21203\/rs.3.rs-5366173\/v1","asserted-by":"object"}]},"ISSN":["1471-230X"],"issn-type":[{"value":"1471-230X","type":"electronic"}],"subject":[],"published":{"date-parts":[[2025,5,10]]},"assertion":[{"value":"31 October 2024","order":1,"name":"received","label":"Received","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"30 April 2025","order":2,"name":"accepted","label":"Accepted","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"10 May 2025","order":3,"name":"first_online","label":"First Online","group":{"name":"ArticleHistory","label":"Article History"}},{"order":1,"name":"Ethics","group":{"name":"EthicsHeading","label":"Declarations"}},{"value":"This study was approved by the Ethics Committee of Cancer Hospital Affiliated to Shandong First Medical University, which waived the need for informed consent because of the retrospective nature of the study.","order":2,"name":"Ethics","group":{"name":"EthicsHeading","label":"Ethics approval and consent to participate"}},{"value":"Not applicable.","order":3,"name":"Ethics","group":{"name":"EthicsHeading","label":"Consent for publication"}},{"value":"The authors declare no competing interests.","order":4,"name":"Ethics","group":{"name":"EthicsHeading","label":"Competing interests"}}],"article-number":"357"}}