{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,4,24]],"date-time":"2026-04-24T14:09:31Z","timestamp":1777039771112,"version":"3.51.4"},"reference-count":55,"publisher":"Springer Science and Business Media LLC","issue":"1","license":[{"start":{"date-parts":[[2025,9,26]],"date-time":"2025-09-26T00:00:00Z","timestamp":1758844800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0"},{"start":{"date-parts":[[2025,9,26]],"date-time":"2025-09-26T00:00:00Z","timestamp":1758844800000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0"}],"funder":[{"DOI":"10.13039\/501100001809","name":"the National Natural Science Foundation of China","doi-asserted-by":"crossref","award":["82303436"],"award-info":[{"award-number":["82303436"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"crossref"}]},{"DOI":"10.13039\/501100001809","name":"the National Natural Science Foundation of China","doi-asserted-by":"crossref","award":["82174137"],"award-info":[{"award-number":["82174137"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"crossref"}]},{"DOI":"10.13039\/501100021171","name":"Guangdong Basic and Applied Basic Research Foundation","doi-asserted-by":"crossref","award":["2021A1515110526"],"award-info":[{"award-number":["2021A1515110526"]}],"id":[{"id":"10.13039\/501100021171","id-type":"DOI","asserted-by":"crossref"}]},{"DOI":"10.13039\/501100021171","name":"Guangdong Basic and Applied Basic Research Foundation","doi-asserted-by":"crossref","award":["2023A1515011950"],"award-info":[{"award-number":["2023A1515011950"]}],"id":[{"id":"10.13039\/501100021171","id-type":"DOI","asserted-by":"crossref"}]},{"name":"The Science and Technology Planning Project of Shenzhen City","award":["JCYJ20220531103010022"],"award-info":[{"award-number":["JCYJ20220531103010022"]}]},{"name":"Shenzhen Science and Technology Program","award":["JCYJ20220531094215034"],"award-info":[{"award-number":["JCYJ20220531094215034"]}]},{"name":"Talent Development Foundation of The First Dongguan Affiliated Hospital of Guangdong Medical University","award":["GCC2023019"],"award-info":[{"award-number":["GCC2023019"]}]}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["BMC Gastroenterol"],"DOI":"10.1186\/s12876-025-04241-y","type":"journal-article","created":{"date-parts":[[2025,9,26]],"date-time":"2025-09-26T09:27:11Z","timestamp":1758878831000},"update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":1,"title":["Identification of a dihydroartemisinin-related prognostic signature and its contribution to cancer associated fibroblast of the tumor microenvironment of pancreatic cancer"],"prefix":"10.1186","volume":"25","author":[{"given":"Jinglin","family":"Lai","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Tongning","family":"Zhong","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Citing","family":"Zhang","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Chongzhou","family":"Fang","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Defeng","family":"Lei","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yong","family":"Xie","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Xu","family":"Liu","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Zhengquan","family":"Lai","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Zilong","family":"Yan","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Weipeng","family":"Ai","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jianhua","family":"Qu","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Biao","family":"Zheng","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"297","published-online":{"date-parts":[[2025,9,26]]},"reference":[{"key":"4241_CR1","doi-asserted-by":"publisher","first-page":"1146280","DOI":"10.3389\/fphar.2023.1146280","volume":"14","author":"L Yu","year":"2023","unstructured":"Yu L, He R, Cui Y. Characterization of tumor microenvironment and programmed death-related genes to identify molecular subtypes and drug resistance in pancreatic cancer. Front Pharmacol. 2023;14:1146280.","journal-title":"Front Pharmacol"},{"issue":"1","key":"4241_CR2","doi-asserted-by":"publisher","first-page":"16425","DOI":"10.1038\/s41598-020-73525-y","volume":"10","author":"A Bengtsson","year":"2020","unstructured":"Bengtsson A, Andersson R, Ansari D. The actual 5-year survivors of pancreatic ductal adenocarcinoma based on real-world data. Sci Rep. 2020;10(1):16425.","journal-title":"Sci Rep"},{"key":"4241_CR3","doi-asserted-by":"crossref","unstructured":"Siegel RL, Giaquinto AN, Jemal A. Cancer statistics. Cancer J Clin. 2024;74(1).","DOI":"10.3322\/caac.21820"},{"issue":"10039","key":"4241_CR4","doi-asserted-by":"publisher","first-page":"73","DOI":"10.1016\/S0140-6736(16)00141-0","volume":"388","author":"T Kamisawa","year":"2016","unstructured":"Kamisawa T, Wood LD, Itoi T, Takaori K. Pancreatic cancer. Lancet. 2016;388(10039):73\u201385.","journal-title":"Lancet"},{"issue":"1","key":"4241_CR5","first-page":"7","volume":"70","author":"RL Siegel","year":"2020","unstructured":"Siegel RL, Miller KD, Jemal A. Cancer statistics, 2020. CA Cancer J Clin. 2020;70(1):7\u201330.","journal-title":"CA Cancer J Clin"},{"issue":"21","key":"4241_CR6","doi-asserted-by":"publisher","first-page":"3436","DOI":"10.3390\/cells11213436","volume":"11","author":"H Chi","year":"2022","unstructured":"Chi H, Peng G, Wang R, Yang F, Xie X, Zhang J, Xu K, Gu T, Yang X, Tian G. Cuprotosis programmed-cell-death-related LncRNA signature predicts prognosis and immune landscape in PAAD patients. Cells. 2022;11(21):3436.","journal-title":"Cells"},{"issue":"16","key":"4241_CR7","doi-asserted-by":"publisher","first-page":"1929","DOI":"10.2217\/fon-2016-0010","volume":"12","author":"D Ansari","year":"2016","unstructured":"Ansari D, Tingstedt B, Andersson B, Holmquist F, Sturesson C, Williamsson C, Sasor A, Borg D, Bauden M, Andersson R. Pancreatic cancer: yesterday, today and tomorrow. Future Oncol. 2016;12(16):1929\u201346.","journal-title":"Future Oncol"},{"issue":"1","key":"4241_CR8","doi-asserted-by":"publisher","first-page":"208","DOI":"10.1186\/s12951-022-01382-0","volume":"20","author":"Y Li","year":"2022","unstructured":"Li Y, Zhao W, Wang Y, Wang H, Liu S. Extracellular vesicle-mediated crosstalk between pancreatic cancer and stromal cells in the tumor microenvironment. J Nanobiotechnol. 2022;20(1):208.","journal-title":"J Nanobiotechnol"},{"key":"4241_CR9","doi-asserted-by":"publisher","first-page":"120546","DOI":"10.1016\/j.biomaterials.2020.120546","volume":"268","author":"W Zhou","year":"2021","unstructured":"Zhou W, Zhou Y, Chen X, Ning T, Chen H, Guo Q, Zhang Y, Liu P, Zhang Y, Li C. Pancreatic cancer-targeting exosomes for enhancing immunotherapy and reprogramming tumor microenvironment. Biomaterials. 2021;268:120546.","journal-title":"Biomaterials"},{"issue":"7","key":"4241_CR10","doi-asserted-by":"publisher","first-page":"1461","DOI":"10.1158\/0008-5472.CAN-19-2578","volume":"80","author":"C Tian","year":"2020","unstructured":"Tian C, \u00d6hlund D, Rickelt S, Lidstr\u00f6m T, Huang Y, Hao L, Zhao RT, Franklin O, Bhatia SN, Tuveson DA. Cancer cell\u2013derived matrisome proteins promote metastasis in pancreatic ductal adenocarcinoma. Cancer Res. 2020;80(7):1461\u201374.","journal-title":"Cancer Res"},{"issue":"4","key":"4241_CR11","doi-asserted-by":"publisher","first-page":"820","DOI":"10.1053\/j.gastro.2017.11.280","volume":"154","author":"C Vennin","year":"2018","unstructured":"Vennin C, Murphy KJ, Morton JP, Cox TR, Pajic M, Timpson P. Reshaping the tumor stroma for treatment of pancreatic cancer. Gastroenterology. 2018;154(4):820\u201338.","journal-title":"Gastroenterology"},{"issue":"16","key":"4241_CR12","doi-asserted-by":"publisher","first-page":"4266","DOI":"10.1158\/1078-0432.CCR-11-3114","volume":"18","author":"C Feig","year":"2012","unstructured":"Feig C, Gopinathan A, Neesse A, Chan DS, Cook N, Tuveson DA. The pancreas cancer microenvironment. Clin Cancer Res. 2012;18(16):4266\u201376.","journal-title":"Clin Cancer Res"},{"issue":"6","key":"4241_CR13","doi-asserted-by":"publisher","first-page":"439","DOI":"10.1016\/j.molmed.2023.03.002","volume":"29","author":"R Rebelo","year":"2023","unstructured":"Rebelo R, Xavier CP, Giovannetti E, Vasconcelos MH. Fibroblasts in pancreatic cancer: molecular and clinical perspectives. Trends Mol Med. 2023;29(6):439\u201353.","journal-title":"Trends Mol Med"},{"key":"4241_CR14","doi-asserted-by":"publisher","DOI":"10.1016\/j.pharmthera.2020.107753","volume":"221","author":"Y Xiao","year":"2021","unstructured":"Xiao Y, Yu D. Tumor microenvironment as a therapeutic target in cancer. Pharmacol Ther. 2021;221: 107753.","journal-title":"Pharmacol Ther"},{"issue":"18","key":"4241_CR15","doi-asserted-by":"publisher","first-page":"4557","DOI":"10.1158\/0008-5472.CAN-18-3962","volume":"79","author":"DC Hinshaw","year":"2019","unstructured":"Hinshaw DC, Shevde LA. The tumor microenvironment innately modulates cancer progression. Cancer Res. 2019;79(18):4557\u201366.","journal-title":"Cancer Res"},{"issue":"2","key":"4241_CR16","doi-asserted-by":"publisher","first-page":"603","DOI":"10.7150\/ijbs.50364","volume":"17","author":"X Dai","year":"2021","unstructured":"Dai X, Zhang X, Chen W, Chen Y, Zhang Q, Mo S, Lu J. Dihydroartemisinin: a potential natural anticancer drug. Int J Biol Sci. 2021;17(2):603.","journal-title":"Int J Biol Sci"},{"issue":"8","key":"4241_CR17","doi-asserted-by":"publisher","first-page":"1243","DOI":"10.1016\/j.intimp.2006.03.004","volume":"6","author":"W-d Li","year":"2006","unstructured":"Li W-d, Dong Y-j, Tu Y-y, Lin Z-b. Dihydroarteannuin ameliorates lupus symptom of BXSB mice by inhibiting production of TNF-alpha and blocking the signaling pathway NF-kappa B translocation. Int Immunopharmacol. 2006;6(8):1243\u201350.","journal-title":"Int Immunopharmacol"},{"key":"4241_CR18","doi-asserted-by":"publisher","first-page":"114730","DOI":"10.1016\/j.bcp.2021.114730","volume":"192","author":"S Xia","year":"2021","unstructured":"Xia S, Wang Z, Chen L, Zhou Y, Li Y, Wang S, Chen A, Xu X, Shao J, Zhang Z. Dihydroartemisinin regulates lipid droplet metabolism in hepatic stellate cells by inhibiting lncRNA-H19-induced AMPK signal. Biochem Pharmacol. 2021;192:114730.","journal-title":"Biochem Pharmacol"},{"issue":"5","key":"4241_CR19","doi-asserted-by":"publisher","first-page":"801","DOI":"10.1002\/biof.1764","volume":"47","author":"Z Zhang","year":"2021","unstructured":"Zhang Z, Wang X, Wang Z, Zhang Z, Cao Y, Wei Z, Shao J, Chen A, Zhang F, Zheng S. Dihydroartemisinin alleviates hepatic fibrosis through inducing ferroptosis in hepatic stellate cells. Biofactors. 2021;47(5):801\u201318.","journal-title":"Biofactors"},{"issue":"4","key":"4241_CR20","first-page":"475","volume":"17","author":"KH Wong","year":"2022","unstructured":"Wong KH, Yang D, Chen S, He C, Chen M. Development of nanoscale drug delivery systems of Dihydroartemisinin for cancer therapy: a review. Asian J Pharm Sci. 2022;17(4):475\u201390.","journal-title":"Asian J Pharm Sci"},{"issue":"7","key":"4241_CR21","doi-asserted-by":"publisher","first-page":"705","DOI":"10.1038\/s41419-021-03996-y","volume":"12","author":"J Du","year":"2021","unstructured":"Du J, Wang X, Li Y, Ren X, Zhou Y, Hu W, Zhou C, Jing Q, Yang C, Wang L, et al. DHA exhibits synergistic therapeutic efficacy with cisplatin to induce ferroptosis in pancreatic ductal adenocarcinoma via modulation of iron metabolism. Cell Death Dis. 2021;12(7):705.","journal-title":"Cell Death Dis"},{"issue":"5","key":"4241_CR22","doi-asserted-by":"publisher","DOI":"10.1002\/smtd.202200888","volume":"7","author":"Y Wang","year":"2023","unstructured":"Wang Y, Chen F, Zhou H, Huang L, Ye J, Liu X, Sheng W, Gao W, Yu H, Wang F. Redox dyshomeostasis with dual stimuli-activatable dihydroartemisinin nanoparticles to potentiate ferroptotic therapy of pancreatic cancer. Small Methods. 2023;7(5): e2200888.","journal-title":"Small Methods"},{"issue":"11","key":"4241_CR23","doi-asserted-by":"publisher","first-page":"5704","DOI":"10.1002\/cam4.1827","volume":"7","author":"Y Liu","year":"2018","unstructured":"Liu Y, Gao S, Zhu J, Zheng Y, Zhang H, Sun H. Dihydroartemisinin induces apoptosis and inhibits proliferation, migration, and invasion in epithelial ovarian cancer via inhibition of the Hedgehog signaling pathway. Cancer Med. 2018;7(11):5704\u201315.","journal-title":"Cancer Med"},{"key":"4241_CR24","doi-asserted-by":"publisher","first-page":"14","DOI":"10.1016\/j.mvr.2013.02.006","volume":"87","author":"J-L Zhang","year":"2013","unstructured":"Zhang J-L, Wang Z, Hu W, Chen S-S, Lou X-E, Zhou H-J. DHA regulates angiogenesis and improves the efficiency of CDDP for the treatment of lung carcinoma. Microvasc Res. 2013;87:14\u201324.","journal-title":"Microvasc Res"},{"key":"4241_CR25","doi-asserted-by":"publisher","first-page":"232","DOI":"10.1016\/j.ejphar.2019.04.018","volume":"854","author":"S Li","year":"2019","unstructured":"Li S, Huang P, Gan J, Ling X, Du X, Liao Y, Li L, Meng Y, Li Y, Bai Y. Dihydroartemisinin represses esophageal cancer glycolysis by down-regulating pyruvate kinase M2. Eur J Pharmacol. 2019;854:232\u20139.","journal-title":"Eur J Pharmacol"},{"issue":"12","key":"4241_CR26","doi-asserted-by":"publisher","first-page":"2789","DOI":"10.1002\/ijc.28608","volume":"134","author":"T Triulzi","year":"2014","unstructured":"Triulzi T, Ratti M, Tortoreto M, Ghirelli C, Aiello P, Regondi V, Di Modica M, Cominetti D, Carcangiu ML, Moliterni A. Maspin influences response to doxorubicin by changing the tumor microenvironment organization. Int J Cancer. 2014;134(12):2789\u201397.","journal-title":"Int J Cancer"},{"issue":"5146","key":"4241_CR27","doi-asserted-by":"publisher","first-page":"526","DOI":"10.1126\/science.8290962","volume":"263","author":"Z Zou","year":"1994","unstructured":"Zou Z, Anisowicz A, Hendrix MJ, Thor A, Neveu M, Sheng S, Rafidi K, Seftor E, Sager R. Maspin, a serpin with tumor-suppressing activity in human mammary epithelial cells. Science. 1994;263(5146):526\u20139.","journal-title":"Science"},{"issue":"4","key":"4241_CR28","doi-asserted-by":"publisher","first-page":"452","DOI":"10.1002\/ijc.10500","volume":"100","author":"Y Umekita","year":"2002","unstructured":"Umekita Y, Ohi Y, Sagara Y, Yoshida H. Expression of Maspin predicts poor prognosis in breast-cancer patients. Int J Cancer. 2002;100(4):452\u20135.","journal-title":"Int J Cancer"},{"issue":"5","key":"4241_CR29","doi-asserted-by":"publisher","first-page":"570","DOI":"10.1038\/modpathol.3800772","volume":"20","author":"D Cao","year":"2007","unstructured":"Cao D, Zhang Q, Wu LS-F, Salaria SN, Winter JW, Hruban RH, Goggins MS, Abbruzzese JL, Maitra A, Ho L. Prognostic significance of Maspin in pancreatic ductal adenocarcinoma: tissue microarray analysis of 223 surgically resected cases. Mod Pathol. 2007;20(5):570\u20138.","journal-title":"Mod Pathol"},{"issue":"1","key":"4241_CR30","doi-asserted-by":"publisher","first-page":"114","DOI":"10.1111\/his.12921","volume":"69","author":"Y Matsuoka","year":"2016","unstructured":"Matsuoka Y, Takagi Y, Nosaka K, Sakabe T, Haruki T, Araki K, Taniguchi Y, Shiomi T, Nakamura H, Umekita Y. Cytoplasmic expression of Maspin predicts unfavourable prognosis in patients with squamous cell carcinoma of the lung. Histopathology. 2016;69(1):114\u201320.","journal-title":"Histopathology"},{"issue":"4","key":"4241_CR31","doi-asserted-by":"publisher","first-page":"886","DOI":"10.1158\/0008-5472.CAN-16-2219","volume":"77","author":"SH Dzinic","year":"2017","unstructured":"Dzinic SH, Bernardo MM, Li X, Fernandez-Valdivia R, Ho Y-S, Mi Q-S, Bandyopadhyay S, Lonardo F, Vranic S, Oliveira DS. An essential role of Maspin in embryogenesis and tumor suppression. Cancer Res. 2017;77(4):886\u201396.","journal-title":"Cancer Res"},{"issue":"20","key":"4241_CR32","doi-asserted-by":"publisher","DOI":"10.3390\/jcm11206097","volume":"11","author":"K Fukushi","year":"2022","unstructured":"Fukushi K, Yamamiya A, Tominaga K, Abe Y, Hoshi K, Nagashima K, Kashima K, Kunogi Y, Sakuma F, Yamagishi H. Usefulness of adding maspin staining to p53 staining for EUS-FNA specimens of pancreatic ductal adenocarcinoma. J Clin Med. 2022;11(20): 6097.","journal-title":"J Clin Med"},{"issue":"22","key":"4241_CR33","doi-asserted-by":"publisher","first-page":"10274","DOI":"10.7150\/thno.47001","volume":"10","author":"B Zheng","year":"2020","unstructured":"Zheng B, Qu J, Ohuchida K, Feng H, Chong SJF, Yan Z, Piao Y, Liu P, Sheng N, Eguchi D. LAMA4 upregulation is associated with high liver metastasis potential and poor survival outcome of pancreatic cancer. Theranostics. 2020;10(22):10274.","journal-title":"Theranostics"},{"issue":"W1","key":"4241_CR34","doi-asserted-by":"publisher","first-page":"W242","DOI":"10.1093\/nar\/gkab418","volume":"49","author":"C Li","year":"2021","unstructured":"Li C, Tang Z, Zhang W, Ye Z, Liu F. GEPIA2021: integrating multiple deconvolution-based analysis into GEPIA. Nucleic Acids Res. 2021;49(W1):W242-6.","journal-title":"Nucleic Acids Res"},{"issue":"1","key":"4241_CR35","doi-asserted-by":"publisher","first-page":"1523","DOI":"10.1038\/s41467-019-09234-6","volume":"10","author":"Y Zhou","year":"2019","unstructured":"Zhou Y, Zhou B, Pache L, Chang M, Khodabakhshi AH, Tanaseichuk O, Benner C, Chanda SK. Metascape provides a biologist-oriented resource for the analysis of systems-level datasets. Nat Commun. 2019;10(1):1523.","journal-title":"Nat Commun"},{"issue":"2","key":"4241_CR36","doi-asserted-by":"publisher","first-page":"193","DOI":"10.1016\/S0304-3835(03)00390-2","volume":"199","author":"N Ohike","year":"2003","unstructured":"Ohike N, Maass N, Mundhenke C, Biallek M, Zhang M, Jonat W, L\u00fcttges J, Morohoshi T, Kl\u00f6ppel G, Nagasaki K. Clinicopathological significance and molecular regulation of Maspin expression in ductal adenocarcinoma of the pancreas. Cancer Lett. 2003;199(2):193\u2013200.","journal-title":"Cancer Lett"},{"key":"4241_CR37","doi-asserted-by":"publisher","first-page":"12","DOI":"10.18632\/genesandcancer.210","volume":"12","author":"MK Sakharkar","year":"2021","unstructured":"Sakharkar MK, Dhillon SK, Mazumder M, Yang J. Key drug-targeting genes in pancreatic ductal adenocarcinoma. Genes Cancer. 2021;12:12\u201324.","journal-title":"Genes Cancer"},{"issue":"6220","key":"4241_CR38","doi-asserted-by":"publisher","first-page":"1260419","DOI":"10.1126\/science.1260419","volume":"347","author":"M Uhl\u00e9n","year":"2015","unstructured":"Uhl\u00e9n M, Fagerberg L, Hallstr\u00f6m BM, Lindskog C, Oksvold P, Mardinoglu A, Sivertsson \u00c5, Kampf C, Sj\u00f6stedt E, Asplund A. Tissue-based map of the human proteome. Science. 2015;347(6220):1260419.","journal-title":"Science"},{"key":"4241_CR39","first-page":"8","volume":"8","author":"GM Morris","year":"2008","unstructured":"Morris GM, Huey R, Olson AJ. Using autodock for ligand-receptor docking. Curr Protoc Bioinf. 2008;8:8\u201314.","journal-title":"Curr Protoc Bioinf"},{"issue":"1","key":"4241_CR40","doi-asserted-by":"publisher","first-page":"37","DOI":"10.1093\/protein\/9.1.37","volume":"9","author":"IA Vakser","year":"1996","unstructured":"Vakser IA. Long-distance potentials: an approach to the multiple-minima problem in ligand-receptor interaction. Protein Eng. 1996;9(1):37\u201341.","journal-title":"Protein Eng"},{"issue":"2","key":"4241_CR41","doi-asserted-by":"publisher","DOI":"10.1083\/jcb.202009045","volume":"220","author":"MC Bridges","year":"2021","unstructured":"Bridges MC, Daulagala AC, Kourtidis A. LNCcation: LncRNA localization and function. J Cell Biol. 2021;220(2): e202009045.","journal-title":"J Cell Biol"},{"key":"4241_CR42","doi-asserted-by":"crossref","unstructured":"Sharma GG, Okada Y, Von Hoff D, Goel A. Non-coding RNA biomarkers in pancreatic ductal adenocarcinoma. Semin Cancer Biol. 2021;75:153\u201368.","DOI":"10.1016\/j.semcancer.2020.10.001"},{"issue":"2","key":"4241_CR43","volume":"1874","author":"X Han","year":"2020","unstructured":"Han X, Zhang W-H, Wang W-Q, Yu X-J, Liu L. Cancer-associated fibroblasts in therapeutic resistance of pancreatic cancer: present situation, predicaments, and perspectives. Biochimica et Biophysica Acta (BBA). 2020;1874(2): 188444.","journal-title":"Biochimica et Biophysica Acta (BBA)"},{"issue":"1","key":"4241_CR44","doi-asserted-by":"publisher","first-page":"252","DOI":"10.1016\/j.canlet.2015.12.027","volume":"381","author":"M Topalovski","year":"2016","unstructured":"Topalovski M, Brekken RA. Matrix control of pancreatic cancer: new insights into fibronectin signaling. Cancer Lett. 2016;381(1):252\u20138.","journal-title":"Cancer Lett"},{"issue":"8","key":"4241_CR45","doi-asserted-by":"publisher","first-page":"1326","DOI":"10.3390\/cells11081326","volume":"11","author":"AW Khan","year":"2022","unstructured":"Khan AW, Farooq M, Haseeb M, Choi S. Role of plant-derived active constituents in cancer treatment and their mechanisms of action. Cells. 2022;11(8):1326.","journal-title":"Cells"},{"issue":"1","key":"4241_CR46","doi-asserted-by":"publisher","first-page":"99","DOI":"10.1016\/j.canlet.2010.01.001","volume":"293","author":"SJ Wang","year":"2010","unstructured":"Wang SJ, Gao Y, Chen H, Kong R, Jiang HC, Pan SH, Xue DB, Bai XW, Sun B. Dihydroartemisinin inactivates NF-kappaB and potentiates the anti-tumor effect of gemcitabine on pancreatic cancer both in vitro and in vivo. Cancer Lett. 2010;293(1):99\u2013108.","journal-title":"Cancer Lett"},{"issue":"1","key":"4241_CR47","doi-asserted-by":"publisher","first-page":"242","DOI":"10.1038\/s41418-019-0352-3","volume":"27","author":"G-Q Chen","year":"2020","unstructured":"Chen G-Q, Benthani FA, Wu J, Liang D, Bian Z-X, Jiang X. Artemisinin compounds sensitize cancer cells to ferroptosis by regulating iron homeostasis. Cell Death Differ. 2020;27(1):242\u201354.","journal-title":"Cell Death Differ"},{"issue":"1","key":"4241_CR48","first-page":"101","volume":"27","author":"B Wu","year":"2012","unstructured":"Wu B, Hu K, Li S, Zhu J, Gu L, Shen H, Hambly BD, Bao S, Di W. Dihydroartiminisin inhibits the growth and metastasis of epithelial ovarian cancer. Oncol Rep. 2012;27(1):101\u20138.","journal-title":"Oncol Rep"},{"key":"4241_CR49","doi-asserted-by":"publisher","DOI":"10.1016\/j.ejphar.2022.175028","volume":"926","author":"H Zhang","year":"2022","unstructured":"Zhang H, Zhuo Y, Li D, Zhang L, Gao Q, Yang L, Yuan X. Dihydroartemisinin inhibits the growth of pancreatic cells by inducing ferroptosis and activating antitumor immunity. Eur J Pharmacol. 2022;926: 175028.","journal-title":"Eur J Pharmacol"},{"issue":"7","key":"4241_CR50","doi-asserted-by":"publisher","first-page":"129","DOI":"10.1007\/s11095-020-02819-7","volume":"37","author":"CD Phung","year":"2020","unstructured":"Phung CD, Le TG, Nguyen VH, Vu TT, Nguyen HQ, Kim JO, Yong CS, Nguyen CN. PEGylated-paclitaxel and dihydroartemisinin nanoparticles for simultaneously delivering paclitaxel and dihydroartemisinin to colorectal cancer. Pharm Res. 2020;37(7):129.","journal-title":"Pharm Res"},{"issue":"1","key":"4241_CR51","doi-asserted-by":"publisher","first-page":"876","DOI":"10.1080\/10717544.2020.1775725","volume":"27","author":"Y Lu","year":"2020","unstructured":"Lu Y, Wen Q, Luo J, Xiong K, Wu Z, Wang B, Chen Y, Yang B, Fu S. Self-assembled dihydroartemisinin nanoparticles as a platform for cervical cancer chemotherapy. Drug Deliv. 2020;27(1):876\u201387.","journal-title":"Drug Deliv"},{"key":"4241_CR52","doi-asserted-by":"publisher","first-page":"121315","DOI":"10.1016\/j.biomaterials.2021.121315","volume":"280","author":"W Han","year":"2022","unstructured":"Han W, Duan X, Ni K, Li Y, Chan C, Lin W. Co-delivery of dihydroartemisinin and pyropheophorbide-iron elicits ferroptosis to potentiate cancer immunotherapy. Biomaterials. 2022;280:121315.","journal-title":"Biomaterials"},{"issue":"22","key":"4241_CR53","doi-asserted-by":"publisher","first-page":"651","DOI":"10.21037\/atm.2019.10.80","volume":"7","author":"I Chaib","year":"2019","unstructured":"Chaib I, Cai X, Llige D, Santarpia M, Jantus-Lewintre E, Filipska M, Pedraz C, Cui J, Yang J, Miao J, et al. Osimertinib and dihydroartemisinin: a novel drug combination targeting head and neck squamous cell carcinoma. Ann Transl Med. 2019;7(22):651.","journal-title":"Ann Transl Med"},{"issue":"4","key":"4241_CR54","doi-asserted-by":"publisher","first-page":"556","DOI":"10.5858\/2007-131-556-DISWPI","volume":"131","author":"A Bhardwaj","year":"2007","unstructured":"Bhardwaj A, Marsh J, William L, Nash JW, Barbacioru CC, Jones S, Frankel WL. Double immunohistochemical staining with MUC4\/p53 is useful in the distinction of pancreatic adenocarcinoma from chronic pancreatitis: a tissue microarray-based study. Arch Pathol Lab Med. 2007;131(4):556\u201362.","journal-title":"Arch Pathol Lab Med"},{"issue":"2","key":"4241_CR55","doi-asserted-by":"publisher","first-page":"131","DOI":"10.1097\/CAD.0b013e3283212ade","volume":"20","author":"H Chen","year":"2009","unstructured":"Chen H, Sun B, Pan S, Jiang H, Sun X. Dihydroartemisinin inhibits growth of pancreatic cancer cells in vitro and in vivo. Anticancer Drugs. 2009;20(2):131\u201340.","journal-title":"Anticancer Drugs"}],"container-title":["BMC Gastroenterology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1186\/s12876-025-04241-y.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/article\/10.1186\/s12876-025-04241-y\/fulltext.html","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1186\/s12876-025-04241-y.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,9,26]],"date-time":"2025-09-26T10:05:37Z","timestamp":1758881137000},"score":1,"resource":{"primary":{"URL":"https:\/\/bmcgastroenterol.biomedcentral.com\/articles\/10.1186\/s12876-025-04241-y"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2025,9,26]]},"references-count":55,"journal-issue":{"issue":"1","published-online":{"date-parts":[[2025,12]]}},"alternative-id":["4241"],"URL":"https:\/\/doi.org\/10.1186\/s12876-025-04241-y","relation":{},"ISSN":["1471-230X"],"issn-type":[{"value":"1471-230X","type":"electronic"}],"subject":[],"published":{"date-parts":[[2025,9,26]]},"assertion":[{"value":"9 December 2024","order":1,"name":"received","label":"Received","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"11 August 2025","order":2,"name":"accepted","label":"Accepted","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"26 September 2025","order":3,"name":"first_online","label":"First Online","group":{"name":"ArticleHistory","label":"Article History"}},{"order":1,"name":"Ethics","group":{"name":"EthicsHeading","label":"Declarations"}},{"value":"The study was conducted in accordance with the guidelines of the Declaration of Helsinki and approved by the Ethics Committee of Peking University Shenzhen Hospital and the Ethics Committee of Shanghai Outdo Biotech Company (YBM-05-02, January 2019). Written informed consent was obtained from individual or guardian participants.","order":2,"name":"Ethics","group":{"name":"EthicsHeading","label":"Ethics approval and consent to participate"}},{"value":"Not applicable.","order":3,"name":"Ethics","group":{"name":"EthicsHeading","label":"Consent for publication"}},{"value":"The authors declare no competing interests.","order":4,"name":"Ethics","group":{"name":"EthicsHeading","label":"Competing interests"}}],"article-number":"656"}}