{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,7]],"date-time":"2026-10-07T18:47:44Z","timestamp":1791398864870,"version":"4.3.3"},"reference-count":33,"publisher":"Springer Science and Business Media LLC","issue":"1","license":[{"start":{"date-parts":[[2025,9,2]],"date-time":"2025-09-02T00:00:00Z","timestamp":1756771200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0"},{"start":{"date-parts":[[2025,9,2]],"date-time":"2025-09-02T00:00:00Z","timestamp":1756771200000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0"}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["BMC Gastroenterol"],"DOI":"10.1186\/s12876-025-04255-6","type":"journal-article","created":{"date-parts":[[2025,9,2]],"date-time":"2025-09-02T09:15:04Z","timestamp":1756804504000},"update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":6,"title":["Histopathologic discrepancies between endoscopic forceps biopsy and resection specimens in duodenal papillary lesions: a retrospective study"],"prefix":"10.1186","volume":"25","author":[{"given":"Zhuoqun","family":"Zheng","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jin","family":"Ding","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yanping","family":"Chen","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hongjun","family":"Hua","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2025,9,2]]},"reference":[{"issue":"19","key":"4255_CR1","doi-asserted-by":"publisher","first-page":"3138","DOI":"10.3390\/diagnostics13193138","volume":"13","author":"R Maselli","year":"2023","unstructured":"Maselli R, De Sire R, Fugazza A, et al. Updates on the management of ampullary neoplastic lesions. Diagnostics (Basel). 2023;13(19):3138. https:\/\/doi.org\/10.3390\/diagnostics13193138.","journal-title":"Diagnostics (Basel)"},{"issue":"17","key":"4255_CR2","doi-asserted-by":"publisher","first-page":"1855","DOI":"10.3390\/diagnostics14171855","volume":"14","author":"C Stornello","year":"2024","unstructured":"Stornello C, Cristofori C, Checchin D, et al. The role of endoscopic ultrasound in ampullary lesion management. Diagnostics (Basel). 2024;14(17):1855. https:\/\/doi.org\/10.3390\/diagnostics14171855.","journal-title":"Diagnostics (Basel)"},{"issue":"10","key":"4255_CR3","doi-asserted-by":"publisher","first-page":"1466","DOI":"10.4251\/wjgo.v13.i10.1466","volume":"13","author":"SL Li","year":"2021","unstructured":"Li SL, Li W, Yin J, et al. Endoscopic papillectomy for ampullary adenomatous lesions: A literature review. World J Gastrointest Oncol. 2021;13(10):1466\u201374. https:\/\/doi.org\/10.4251\/wjgo.v13.i10.1466.","journal-title":"World J Gastrointest Oncol"},{"issue":"4","key":"4255_CR4","doi-asserted-by":"publisher","first-page":"747","DOI":"10.5009\/gnl230451","volume":"18","author":"J Lee","year":"2024","unstructured":"Lee J, Oh D, Seo DW, et al. Long-term outcomes of ampullary adenoma according to resected margin status after endoscopic papillectomy. Gut Liver. 2024;18(4):747\u201355. https:\/\/doi.org\/10.5009\/gnl230451.","journal-title":"Gut Liver"},{"issue":"4","key":"4255_CR5","doi-asserted-by":"publisher","first-page":"429","DOI":"10.1055\/a-1397-3198","volume":"53","author":"G Vanbiervliet","year":"2021","unstructured":"Vanbiervliet G, Strijker M, Arvanitakis M, et al. Endoscopic management of ampullary tumors: European society of Gastrointestinal endoscopy (ESGE) guideline. Endoscopy. 2021;53(4):429\u201348. https:\/\/doi.org\/10.1055\/a-1397-3198.","journal-title":"Endoscopy"},{"issue":"3","key":"4255_CR6","doi-asserted-by":"publisher","first-page":"394","DOI":"10.1111\/den.14233","volume":"34","author":"T Itoi","year":"2022","unstructured":"Itoi T, Ryozawa S, Katanuma A, et al. Clinical practice guidelines for endoscopic papillectomy. Dig Endosc. 2022;34(3):394\u2013411. https:\/\/doi.org\/10.1111\/den.14233.","journal-title":"Dig Endosc"},{"issue":"5","key":"4255_CR7","doi-asserted-by":"publisher","first-page":"301","DOI":"10.1007\/s00534-004-0898-3","volume":"11","author":"HP Fischer","year":"2004","unstructured":"Fischer HP, Zhou H. Pathogenesis of carcinoma of the papilla of vater. J Hepatobiliary Pancreat Surg. 2004;11(5):301\u20139. https:\/\/doi.org\/10.1007\/s00534-004-0898-3.","journal-title":"J Hepatobiliary Pancreat Surg"},{"issue":"6","key":"4255_CR8","doi-asserted-by":"publisher","first-page":"588","DOI":"10.1016\/s0016-5107(90)71170-4","volume":"36","author":"K Yamaguchi","year":"1990","unstructured":"Yamaguchi K, Enjoji M, Kitamura K. Endoscopic biopsy has limited accuracy in diagnosis of ampullary tumors. Gastrointest Endosc. 1990;36(6):588\u201392. https:\/\/doi.org\/10.1016\/s0016-5107(90)71170-4.","journal-title":"Gastrointest Endosc"},{"issue":"10","key":"4255_CR9","doi-asserted-by":"publisher","first-page":"e30403","DOI":"10.7759\/cureus.30403","volume":"14","author":"PP Dawande","year":"2022","unstructured":"Dawande PP, Akhtar F, Wankhade RS, et al. Signet ring cell carcinoma at the ampulla of vater: A very rare diagnosis. Cureus. 2022;14(10):e30403. https:\/\/doi.org\/10.7759\/cureus.30403.","journal-title":"Cureus"},{"key":"4255_CR10","doi-asserted-by":"publisher","first-page":"263177451989978","DOI":"10.1177\/2631774519899786","volume":"13","author":"JW Poley","year":"2020","unstructured":"Poley JW, Campos S. Methods and outcome of the endoscopic treatment of ampullary tumors. Ther Adv Gastrointest Endosc. 2020;13:2631774519899786. https:\/\/doi.org\/10.1177\/2631774519899786.","journal-title":"Ther Adv Gastrointest Endosc"},{"issue":"8","key":"4255_CR11","doi-asserted-by":"publisher","first-page":"330","DOI":"10.1016\/j.vgie.2023.05.006","volume":"8","author":"GE Kim","year":"2023","unstructured":"Kim GE, Siddiqui UD. Endoscopic resection techniques for duodenal and ampullary adenomas. VideoGIE. 2023;8(8):330\u20135. https:\/\/doi.org\/10.1016\/j.vgie.2023.05.006.","journal-title":"VideoGIE"},{"issue":"10","key":"4255_CR12","doi-asserted-by":"publisher","first-page":"3532","DOI":"10.3390\/jcm14103532","volume":"14","author":"MTT Nguyen","year":"2025","unstructured":"Nguyen MTT, Paladiya R, Dahiya DS, et al. Endoscopic management of ampullary adenomas: A comprehensive review. J Clin Med. 2025;14(10):3532. https:\/\/doi.org\/10.3390\/jcm14103532.","journal-title":"J Clin Med"},{"issue":"5","key":"4255_CR13","doi-asserted-by":"publisher","first-page":"773","DOI":"10.1016\/j.gie.2015.06.027","volume":"82","author":"KV Chathadi","year":"2015","unstructured":"Chathadi KV, Khashab MA, Acosta RD, et al. The role of endoscopy in ampullary and duodenal adenomas. Gastrointest Endosc. 2015;82(5):773\u201381. https:\/\/doi.org\/10.1016\/j.gie.2015.06.027.","journal-title":"Gastrointest Endosc"},{"issue":"1","key":"4255_CR14","doi-asserted-by":"publisher","first-page":"114","DOI":"10.1186\/s12876-021-01694-9","volume":"21","author":"L Yang","year":"2021","unstructured":"Yang L, Jin H, Xie XL, et al. Endoscopic resections for superficial esophageal squamous cell epithelial neoplasia: focus on histological discrepancies between biopsy and resected specimens. BMC Gastroenterol. 2021;21(1):114. https:\/\/doi.org\/10.1186\/s12876-021-01694-9.","journal-title":"BMC Gastroenterol"},{"issue":"10","key":"4255_CR15","doi-asserted-by":"publisher","first-page":"596","DOI":"10.1111\/1751-2980.12669","volume":"19","author":"L Yang","year":"2018","unstructured":"Yang L, Jin P, Wang X, et al. Risk factors associated with histological upgrade of gastric low-grade dysplasia on pretreatment biopsy. J Dig Dis. 2018;19(10):596\u2013604. https:\/\/doi.org\/10.1111\/1751-2980.12669.","journal-title":"J Dig Dis"},{"issue":"1","key":"4255_CR16","doi-asserted-by":"publisher","first-page":"e70038","DOI":"10.1002\/deo2.70038","volume":"5","author":"T Uozumi","year":"2025","unstructured":"Uozumi T, Nonaka S, Mizuguchi Y, et al. Endoscopic features of the duodenal pyloric gland adenoma: A case series of 14 patients. DEN Open. 2025;5(1):e70038. https:\/\/doi.org\/10.1002\/deo2.70038.","journal-title":"DEN Open"},{"issue":"8","key":"4255_CR17","doi-asserted-by":"publisher","first-page":"1398","DOI":"10.1038\/bjc.2015.104","volume":"112","author":"A Matsubara","year":"2015","unstructured":"Matsubara A, Ogawa R, Suzuki H, et al. Activating GNAS and KRAS mutations in gastric foveolar metaplasia, gastric heterotopia, and adenocarcinoma of the duodenum. Br J Cancer. 2015;112(8):1398\u2013404. https:\/\/doi.org\/10.1038\/bjc.2015.104.","journal-title":"Br J Cancer"},{"key":"4255_CR18","doi-asserted-by":"publisher","first-page":"e2021011","DOI":"10.4178\/epih.e2021011","volume":"43","author":"D Huang","year":"2021","unstructured":"Huang D, Joo H, Song N, et al. Association between gallstones and the risk of biliary tract cancer: a systematic review and meta-analysis. Epidemiol Health. 2021;43:e2021011. https:\/\/doi.org\/10.4178\/epih.e2021011.","journal-title":"Epidemiol Health"},{"issue":"3","key":"4255_CR19","doi-asserted-by":"publisher","first-page":"542","DOI":"10.1053\/gast.2001.27083","volume":"121","author":"J Lagergren","year":"2001","unstructured":"Lagergren J, Ye W, Ekbom A. Intestinal cancer after cholecystectomy: is bile involved in carcinogenesis? Gastroenterology. 2001;121(3):542\u20137. https:\/\/doi.org\/10.1053\/gast.2001.27083.","journal-title":"Gastroenterology"},{"issue":"1","key":"4255_CR20","doi-asserted-by":"publisher","first-page":"79","DOI":"10.3390\/jcm8010079","volume":"8","author":"WJ Yoon","year":"2019","unstructured":"Yoon WJ, Kim HN, Park E, et al. The impact of cholecystectomy on the gut microbiota: A Case-Control study. J Clin Med. 2019;8(1):79. https:\/\/doi.org\/10.3390\/jcm8010079.","journal-title":"J Clin Med"},{"issue":"7","key":"4255_CR21","doi-asserted-by":"publisher","first-page":"730","DOI":"10.1002\/ueg2.12281","volume":"10","author":"P Zaccari","year":"2022","unstructured":"Zaccari P, Archibugi L, Belfiori G, et al. Risk factors for the occurrence of ampullary tumors: A case-control study. United Eur Gastroenterol J. 2022;10(7):730\u20135. https:\/\/doi.org\/10.1002\/ueg2.12281.","journal-title":"United Eur Gastroenterol J"},{"issue":"11","key":"4255_CR22","doi-asserted-by":"publisher","first-page":"913","DOI":"10.1055\/s-2002-35414","volume":"40","author":"A Kaiser","year":"2002","unstructured":"Kaiser A, Jurowich C, Sch\u00f6nek\u00e4s H, et al. The adenoma-carcinoma sequence applies to epithelial tumours of the papilla of vater. Z Gastroenterol. 2002;40(11):913\u201320. https:\/\/doi.org\/10.1055\/s-2002-35414.","journal-title":"Z Gastroenterol"},{"issue":"8","key":"4255_CR23","doi-asserted-by":"publisher","first-page":"1395","DOI":"10.21037\/gs-22-412","volume":"11","author":"Y Zhang","year":"2022","unstructured":"Zhang Y, Duan Z, Yu X, et al. Defects of endoscopic biopsy in the diagnosis of periampullary carcinoma and recommendations for diagnosis and treatment: a retrospective study before and after surgery. Gland Surg. 2022;11(8):1395\u2013403. https:\/\/doi.org\/10.21037\/gs-22-412.","journal-title":"Gland Surg"},{"issue":"1","key":"4255_CR24","doi-asserted-by":"publisher","first-page":"44","DOI":"10.1177\/2050640619868367","volume":"8","author":"M Spadaccini","year":"2020","unstructured":"Spadaccini M, Fugazza A, Frazzoni L, et al. Endoscopic papillectomy for neoplastic ampullary lesions: A systematic review with pooled analysis. United Eur Gastroenterol J. 2020;8(1):44\u201351. https:\/\/doi.org\/10.1177\/2050640619868367.","journal-title":"United Eur Gastroenterol J"},{"issue":"2","key":"4255_CR25","doi-asserted-by":"publisher","first-page":"379","DOI":"10.1007\/s11605-009-1080-7","volume":"14","author":"JM Winter","year":"2010","unstructured":"Winter JM, Cameron JL, Olino K, et al. Clinicopathologic analysis of ampullary neoplasms in 450 patients: implications for surgical strategy and long-term prognosis. J Gastrointest Surg. 2010;14(2):379\u201387. https:\/\/doi.org\/10.1007\/s11605-009-1080-7.","journal-title":"J Gastrointest Surg"},{"issue":"4","key":"4255_CR26","doi-asserted-by":"publisher","first-page":"346","DOI":"10.1097\/MCG.0b013e318272f2ef","volume":"47","author":"HN Kim","year":"2013","unstructured":"Kim HN, Kim KM, Shin JU, et al. Prediction of carcinoma after resection in subjects with ampullary adenomas on endoscopic biopsy. J Clin Gastroenterol. 2013;47(4):346\u201351. https:\/\/doi.org\/10.1097\/MCG.0b013e318272f2ef.","journal-title":"J Clin Gastroenterol"},{"issue":"1","key":"4255_CR27","doi-asserted-by":"publisher","first-page":"204","DOI":"10.19723\/j.issn.1671-167X.2021.01.031","volume":"53","author":"YC Wang","year":"2020","unstructured":"Wang YC, Huang YH, Chang H, et al. Characteristics of benign and malignant lesions of ampullary polyps and the accuracy of forceps biopsy. Beijing Da Xue Xue Bao Yi Xue Ban. 2020;53(1):204\u20139. https:\/\/doi.org\/10.19723\/j.issn.1671-167X.2021.01.031.","journal-title":"Beijing Da Xue Xue Bao Yi Xue Ban"},{"issue":"5","key":"4255_CR28","doi-asserted-by":"publisher","first-page":"483","DOI":"10.1007\/s00535-006-1800-7","volume":"41","author":"Y Uchiyama","year":"2006","unstructured":"Uchiyama Y, Imazu H, Kakutani H, et al. New approach to diagnosing ampullary tumors by magnifying endoscopy combined with a narrow-band imaging system. J J Gastroenterol. 2006;41(5):483\u201390. https:\/\/doi.org\/10.1007\/s00535-006-1800-7.","journal-title":"J J Gastroenterol"},{"issue":"99\u2013100","key":"4255_CR29","first-page":"462","volume":"57","author":"N Yoshimura","year":"2010","unstructured":"Yoshimura N, Goda K, Tajiri H, et al. Endoscopic features of nonampullary duodenal tumors with narrow-band imaging. Hepatogastroenterology. 2010;57(99\u2013100):462\u20137.","journal-title":"Hepatogastroenterology"},{"issue":"10","key":"4255_CR30","doi-asserted-by":"publisher","first-page":"2544","DOI":"10.1007\/s10620-014-3204-5","volume":"59","author":"T Hisabe","year":"2014","unstructured":"Hisabe T, Yao K, Imamura K, et al. White opaque substance visualized using magnifying endoscopy with narrow-band imaging in colorectal epithelial neoplasms. Dig Dis Sci. 2014;59(10):2544\u20139. https:\/\/doi.org\/10.1007\/s10620-014-3204-5.","journal-title":"Dig Dis Sci"},{"issue":"6","key":"4255_CR31","doi-asserted-by":"publisher","first-page":"419","DOI":"10.1111\/j.1443-1661.2012.01314.x","volume":"24","author":"K Yao","year":"2012","unstructured":"Yao K, Iwashita A, Nambu M, et al. Nature of white opaque substance in gastric epithelial neoplasia as visualized by magnifying endoscopy with narrow-band imaging. Dig Endosc. 2012;24(6):419\u201325. https:\/\/doi.org\/10.1111\/j.1443-1661.2012.01314.x.","journal-title":"Dig Endosc"},{"issue":"11","key":"4255_CR32","doi-asserted-by":"publisher","first-page":"E1151","DOI":"10.1055\/s-0042-116487","volume":"4","author":"K Imamura","year":"2016","unstructured":"Imamura K, Yao K, Hisabe T, et al. The nature of the white opaque substance within colorectal neoplastic epithelium as visualized by magnifying endoscopy with narrow-band imaging. Endosc Int Open. 2016;4(11):E1151\u20137. https:\/\/doi.org\/10.1055\/s-0042-116487.","journal-title":"Endosc Int Open"},{"issue":"47","key":"4255_CR33","doi-asserted-by":"publisher","first-page":"8367","DOI":"10.3748\/wjg.v23.i47.8367","volume":"23","author":"K Kawasaki","year":"2017","unstructured":"Kawasaki K, Eizuka M, Nakamura S, et al. Association between white opaque substance under magnifying colonoscopy and lipid droplets in colorectal epithelial neoplasms. World J Gastroenterol. 2017;23(47):8367\u201375. https:\/\/doi.org\/10.3748\/wjg.v23.i47.8367.","journal-title":"World J Gastroenterol"}],"container-title":["BMC Gastroenterology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1186\/s12876-025-04255-6.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/article\/10.1186\/s12876-025-04255-6\/fulltext.html","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1186\/s12876-025-04255-6.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,9,3]],"date-time":"2025-09-03T11:35:35Z","timestamp":1756899335000},"score":1,"resource":{"primary":{"URL":"https:\/\/bmcgastroenterol.biomedcentral.com\/articles\/10.1186\/s12876-025-04255-6"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2025,9,2]]},"references-count":33,"journal-issue":{"issue":"1","published-online":{"date-parts":[[2025,12]]}},"alternative-id":["4255"],"URL":"https:\/\/doi.org\/10.1186\/s12876-025-04255-6","relation":{},"ISSN":["1471-230X"],"issn-type":[{"value":"1471-230X","type":"electronic"}],"subject":[],"published":{"date-parts":[[2025,9,2]]},"assertion":[{"value":"9 June 2025","order":1,"name":"received","label":"Received","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"19 August 2025","order":2,"name":"accepted","label":"Accepted","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"2 September 2025","order":3,"name":"first_online","label":"First Online","group":{"name":"ArticleHistory","label":"Article History"}},{"order":1,"name":"Ethics","group":{"name":"EthicsHeading","label":"Declarations"}},{"value":"This study was approved by the Ethics Committee of the Jinhua Hospital (approval number: 61, date: March 03, 2025). Written informed parental consent was waived due to the retrospective nature of the study. All methods were carried out in accordance with Declaration of Helsinki.","order":2,"name":"Ethics","group":{"name":"EthicsHeading","label":"Ethics approval and consent to participate"}},{"value":"Not applicable.","order":3,"name":"Ethics","group":{"name":"EthicsHeading","label":"Consent for publication"}},{"value":"The authors declare no competing interests.","order":4,"name":"Ethics","group":{"name":"EthicsHeading","label":"Competing interests"}}],"article-number":"632"}}