{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,10]],"date-time":"2026-10-10T13:23:28Z","timestamp":1791638608324,"version":"4.3.4"},"reference-count":31,"publisher":"Springer Science and Business Media LLC","issue":"1","license":[{"start":{"date-parts":[[2025,9,29]],"date-time":"2025-09-29T00:00:00Z","timestamp":1759104000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0"},{"start":{"date-parts":[[2025,9,29]],"date-time":"2025-09-29T00:00:00Z","timestamp":1759104000000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0"}],"funder":[{"name":"Administration of Traditional Chinese Medicine of Jiangsu Province","award":["QN202217"],"award-info":[{"award-number":["QN202217"]}]}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["BMC Gastroenterol"],"DOI":"10.1186\/s12876-025-04273-4","type":"journal-article","created":{"date-parts":[[2025,9,29]],"date-time":"2025-09-29T13:14:55Z","timestamp":1759151695000},"update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":7,"title":["Serum biomarkers of intestinal barrier dysfunction predict postoperative endoscopic recurrence in Crohn\u2019s disease patients"],"prefix":"10.1186","volume":"25","author":[{"given":"Luxuan","family":"Tan","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yi","family":"Li","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Chengliang","family":"Ding","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jingjing","family":"Qian","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xiufang","family":"Cui","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2025,9,29]]},"reference":[{"issue":"1","key":"4273_CR1","first-page":"1","volume":"12","author":"WA Bemelman","year":"2018","unstructured":"Bemelman WA, Warusavitarne J, Sampietro GM, Serclova Z, Zmora O, Luglio G, et al. ECCO-ESCP consensus on surgery for crohn\u2019s disease. J Crohns Colitis. 2018;12(1):1\u201316.","journal-title":"J Crohns Colitis"},{"issue":"1","key":"4273_CR2","doi-asserted-by":"publisher","first-page":"1","DOI":"10.1093\/ibd\/izab044","volume":"28","author":"V Joustra","year":"2022","unstructured":"Joustra V, Duijvestein M, Mookhoek A, Bemelman W, Buskens C, Ko\u017eelj M, et al. Natural history and risk stratification of recurrent crohn\u2019s disease after ileocolonic resection: a multicenter retrospective cohort study. Inflamm Bowel Dis. 2022;28(1):1\u20138.","journal-title":"Inflamm Bowel Dis"},{"issue":"1","key":"4273_CR3","first-page":"40","volume":"59","author":"Y Li","year":"2021","unstructured":"Li Y, Cao L, Guo Z, Gu LL, Duan M, Wu EH, et al. Characteristics and predictors of postoperative outcome of Crohn disease patients requiring abdominal surgery: a series of 1 048 cases from a single inflammatory bowel disease centre. Zhonghua Wai Ke Za Zhi. 2021;59(1):40\u20135.","journal-title":"Zhonghua Wai Ke Za Zhi"},{"issue":"9976","key":"4273_CR4","doi-asserted-by":"publisher","first-page":"1406","DOI":"10.1016\/S0140-6736(14)61908-5","volume":"385","author":"P De Cruz","year":"2015","unstructured":"De Cruz P, Kamm MA, Hamilton AL, Ritchie KJ, Krejany EO, Gorelik A, et al. Crohn\u2019s disease management after intestinal resection: a randomised trial. Lancet. 2015;385(9976):1406\u201317.","journal-title":"Lancet"},{"issue":"9","key":"4273_CR5","doi-asserted-by":"publisher","first-page":"829","DOI":"10.1080\/17474124.2020.1807325","volume":"14","author":"E Vespa","year":"2020","unstructured":"Vespa E, Furfaro F, Allocca M, Fiorino G, Correale C, Gilardi D, et al. Endoscopy after surgery in inflammatory bowel disease: Crohn\u2019s disease recurrence and pouch surveillance. Expert Rev Gastroenterol Hepatol. 2020;14(9):829\u201341.","journal-title":"Expert Rev Gastroenterol Hepatol"},{"issue":"2","key":"4273_CR6","doi-asserted-by":"publisher","DOI":"10.3390\/jcm11020353","volume":"11","author":"L Alfarone","year":"2022","unstructured":"Alfarone L, Buono AD, Craviotto V, Zilli A, Fiorino G, Furfaro F, et al. Cross-sectional imaging instead of colonoscopy in inflammatory bowel diseases: lights and shadows. J Clin Med. 2022;11(2):353.","journal-title":"J Clin Med"},{"issue":"2","key":"4273_CR7","doi-asserted-by":"publisher","first-page":"362","DOI":"10.1053\/j.gastro.2016.10.005","volume":"152","author":"J Panes","year":"2017","unstructured":"Panes J, Jairath V, Levesque BG. Advances in use of endoscopy, radiology, and biomarkers to monitor inflammatory bowel diseases. Gastroenterology. 2017;152(2):362\u201373.","journal-title":"Gastroenterology"},{"issue":"5","key":"4273_CR8","doi-asserted-by":"publisher","first-page":"1570","DOI":"10.1053\/j.gastro.2020.12.031","volume":"160","author":"D Turner","year":"2021","unstructured":"Turner D, Ricciuto A, Lewis A, D\u2019Amico F, Dhaliwal J, Griffiths AM, et al. STRIDE-II: an update on the selecting therapeutic targets in inflammatory bowel disease (STRIDE) initiative of the international organization for the study of IBD (IOIBD): determining therapeutic goals for treat-to-target strategies in IBD. Gastroenterology. 2021;160(5):1570\u201383.","journal-title":"Gastroenterology"},{"issue":"1","key":"4273_CR9","doi-asserted-by":"publisher","first-page":"152","DOI":"10.1093\/ecco-jcc\/jjaa093","volume":"15","author":"F D\u2019Amico","year":"2021","unstructured":"D\u2019Amico F, Nancey S, Danese S, Peyrin-Biroulet L. A practical guide for faecal calprotectin measurement: myths and realities. J Crohns Colitis. 2021;15(1):152\u201361.","journal-title":"J Crohns Colitis"},{"key":"4273_CR10","doi-asserted-by":"publisher","first-page":"1825","DOI":"10.2147\/PPA.S172143","volume":"12","author":"JM Osborne","year":"2018","unstructured":"Osborne JM, Flight I, Wilson CJ, Chen G, Ratcliffe J, Young GP. The impact of sample type and procedural attributes on relative acceptability of different colorectal cancer screening regimens. Patient Prefer Adherence. 2018;12:1825\u201336.","journal-title":"Patient Prefer Adherence"},{"issue":"10","key":"4273_CR11","doi-asserted-by":"publisher","first-page":"899","DOI":"10.1080\/17474124.2017.1356226","volume":"11","author":"T Yamamoto","year":"2017","unstructured":"Yamamoto T, Shimoyama T. Monitoring and detection of disease recurrence after resection for Crohn\u2019s disease: the role of non-invasive fecal biomarkers. Expert Rev Gastroenterol Hepatol. 2017;11(10):899\u2013909.","journal-title":"Expert Rev Gastroenterol Hepatol"},{"issue":"7\u20138","key":"4273_CR12","first-page":"598","volume":"130","author":"D Cibor","year":"2020","unstructured":"Cibor D, Szczeklik K, Kozio\u0142 K, Pocztar H, Mach T, Owczarek D. Serum concentration of selected biochemical markers of endothelial dysfunction and inflammation in patients with the varying activity of inflammatory bowel disease. Pol Arch Intern Med. 2020;130(7\u20138):598\u2013606.","journal-title":"Pol Arch Intern Med"},{"issue":"1","key":"4273_CR13","doi-asserted-by":"publisher","first-page":"118","DOI":"10.1002\/ibd.21355","volume":"17","author":"M Regueiro","year":"2011","unstructured":"Regueiro M, Kip KE, Schraut W, Baidoo L, Sepulveda AR, Pesci M, et al. Crohn\u2019s disease activity index does not correlate with endoscopic recurrence one year after Ileocolonic resection. Inflamm Bowel Dis. 2011;17(1):118\u201326.","journal-title":"Inflamm Bowel Dis"},{"issue":"5","key":"4273_CR14","doi-asserted-by":"publisher","first-page":"1165","DOI":"10.3748\/wjg.v20.i5.1165","volume":"20","author":"L Antoni","year":"2014","unstructured":"Antoni L, Nuding S, Wehkamp J, Stange EF. Intestinal barrier in inflammatory bowel disease. World J Gastroenterol. 2014;20(5):1165\u201379.","journal-title":"World J Gastroenterol"},{"issue":"8858","key":"4273_CR15","doi-asserted-by":"publisher","first-page":"1437","DOI":"10.1016\/0140-6736(93)90882-H","volume":"341","author":"J Wyatt","year":"1993","unstructured":"Wyatt J, Vogelsang H, H\u00fcbl W, Waldh\u00f6er T, Lochs H. Intestinal permeability and the prediction of relapse in Crohn\u2019s disease. Lancet. 1993;341(8858):1437\u20139.","journal-title":"Lancet"},{"issue":"1","key":"4273_CR16","first-page":"8536952","volume":"2019","author":"J Cai","year":"2019","unstructured":"Cai J, Chen H, Weng M, Jiang S, Gao J. Diagnostic and clinical significance of serum levels of D-lactate and Diamine oxidase in patients with crohn\u2019s disease. Gastroenterol Res Pract. 2019;2019(1):8536952.","journal-title":"Gastroenterol Res Pract"},{"issue":"1","key":"4273_CR17","doi-asserted-by":"publisher","first-page":"167","DOI":"10.1186\/s12876-018-0888-6","volume":"18","author":"M Linsalata","year":"2018","unstructured":"Linsalata M, Riezzo G, D\u2019Attoma B, Clemente C, Orlando A, Russo F. Noninvasive biomarkers of gut barrier function identify two subtypes of patients suffering from diarrhoea predominant-IBS: a case-control study. BMC Gastroenterol. 2018;18(1):167.","journal-title":"BMC Gastroenterol"},{"key":"4273_CR18","doi-asserted-by":"publisher","first-page":"127","DOI":"10.1016\/j.rvsc.2019.08.027","volume":"126","author":"T Fukuda","year":"2019","unstructured":"Fukuda T, Tsukano K, Nakatsuji H, Suzuki K. Plasma Diamine oxidase activity decline with diarrhea severity in calves indicating systemic dysfunction related to intestinal mucosal damage. Res Vet Sci. 2019;126:127\u201330.","journal-title":"Res Vet Sci"},{"issue":"4","key":"4273_CR19","doi-asserted-by":"publisher","first-page":"e1373208","DOI":"10.1080\/21688370.2017.1373208","volume":"5","author":"T Takiishi","year":"2017","unstructured":"Takiishi T, Fenero CIM, C\u00e2mara NOS. Intestinal barrier and gut microbiota: shaping our immune responses throughout life. Tissue Barriers. 2017;5(4):e1373208.","journal-title":"Tissue Barriers"},{"issue":"7","key":"4273_CR20","doi-asserted-by":"publisher","first-page":"1830","DOI":"10.1007\/s10620-018-5428-2","volume":"64","author":"Y Qing","year":"2019","unstructured":"Qing Y, Xie H, Su C, Wang Y, Yu Q, Pang Q, et al. Gut microbiome, short-chain fatty acids, and mucosa injury in young adults with human immunodeficiency virus infection. Dig Dis Sci. 2019;64(7):1830\u201343.","journal-title":"Dig Dis Sci"},{"issue":"4","key":"4273_CR21","doi-asserted-by":"publisher","first-page":"886","DOI":"10.1016\/j.jhep.2018.05.021","volume":"69","author":"T Shao","year":"2018","unstructured":"Shao T, Zhao C, Li F, Gu Z, Liu L, Zhang L, et al. Intestinal HIF-1\u03b1 deletion exacerbates alcoholic liver disease by inducing intestinal dysbiosis and barrier dysfunction. J Hepatol. 2018;69(4):886\u201395.","journal-title":"J Hepatol"},{"issue":"4","key":"4273_CR22","doi-asserted-by":"publisher","first-page":"956","DOI":"10.1016\/0016-5085(90)90613-6","volume":"99","author":"P Rutgeerts","year":"1990","unstructured":"Rutgeerts P, Geboes K, Vantrappen G, Beyls J, Kerremans R, Hiele M. Predictability of the postoperative course of Crohn\u2019s disease. Gastroenterology. 1990;99(4):956\u201363.","journal-title":"Gastroenterology"},{"key":"4273_CR23","doi-asserted-by":"publisher","DOI":"10.1093\/gastro\/goac070","volume":"10","author":"KE Lee","year":"2022","unstructured":"Lee KE, Cantrell S, Shen B, Faye AS. Post-operative prevention and monitoring of Crohn\u2019s disease recurrence. Gastroenterol Rep. 2022;10:goac070.","journal-title":"Gastroenterol Rep"},{"issue":"1","key":"4273_CR24","first-page":"9171436","volume":"2022","author":"Q Zhang","year":"2022","unstructured":"Zhang Q, Gao X, Wu J, Chen M. The correlation between endotoxin, D-lactate, and Diamine oxidase with endoscopic activity in inflammatory bowel disease. Dis Markers. 2022;2022(1):9171436.","journal-title":"Dis Markers"},{"issue":"3","key":"4273_CR25","doi-asserted-by":"publisher","first-page":"269","DOI":"10.1002\/ibd.20019","volume":"13","author":"OP Rojo","year":"2007","unstructured":"Rojo OP, Rom\u00e1n ALS, Arbizu EA, Mart\u00ednez ADLH, Sevillano ER, Mart\u00ednez AA. Serum lipopolysaccharide-binding protein in endotoxemic patients with inflammatory bowel disease. Inflamm Bowel Dis. 2007;13(3):269\u201377.","journal-title":"Inflamm Bowel Dis"},{"issue":"31","key":"4273_CR26","doi-asserted-by":"publisher","first-page":"3916","DOI":"10.3748\/wjg.15.3916","volume":"15","author":"WB Song","year":"2009","unstructured":"Song WB, Lv YH, Zhang ZS, Li YN, Xiao LP, Yu XP, et al. Soluble intercellular adhesion molecule-1, D-lactate and diamine oxidase in patients with inflammatory bowel disease. World J Gastroenterol. 2009;15(31):3916\u20139.","journal-title":"World J Gastroenterol"},{"issue":"6","key":"4273_CR27","doi-asserted-by":"publisher","first-page":"900","DOI":"10.1093\/ecco-jcc\/jjab186","volume":"16","author":"M Walshe","year":"2022","unstructured":"Walshe M, Nayeri S, Ji J, Hernandez-Rocha C, Sabic K, Hu L, et al. A role for CXCR3 ligands as biomarkers of Post-Operative crohn\u2019s disease recurrence. J Crohns Colitis. 2022;16(6):900\u201310.","journal-title":"J Crohns Colitis"},{"issue":"12","key":"4273_CR28","doi-asserted-by":"publisher","first-page":"1797","DOI":"10.1093\/ecco-jcc\/jjac076","volume":"16","author":"AL Hamilton","year":"2022","unstructured":"Hamilton AL, Cruz P, De, Wright EK, Dervieux T, Jain A, Kamm MA. Non-invasive serological monitoring for crohn\u2019s disease postoperative recurrence. J Crohn Colitis. 2022;16(12):1797\u2013807.","journal-title":"J Crohn Colitis"},{"issue":"1","key":"4273_CR29","doi-asserted-by":"publisher","first-page":"9031","DOI":"10.1038\/s41598-025-93831-7","volume":"15","author":"T Tashiro","year":"2025","unstructured":"Tashiro T, Shinzaki S, Yoshihara T, Tsujii Y, Asakura A, Amano T, et al. Leucine-rich alpha-2 glycoprotein could be clinically useful in active and postoperative crohn\u2019s disease. Sci Rep. 2025;15(1):9031.","journal-title":"Sci Rep"},{"issue":"6","key":"4273_CR30","doi-asserted-by":"publisher","first-page":"911","DOI":"10.1016\/j.jada.2010.03.018","volume":"110","author":"J Uribarri","year":"2010","unstructured":"Uribarri J, Woodruff S, Goodman S, Cai W, Chen X, Pyzik R, et al. Advanced glycation end products in foods and a practical guide to their reduction in the diet. J Am Diet Assoc. 2010;110(6):911\u2013e1612.","journal-title":"J Am Diet Assoc"},{"issue":"17","key":"4273_CR31","doi-asserted-by":"publisher","DOI":"10.3390\/ijms22179562","volume":"22","author":"C Erlanson-Albertsson","year":"2021","unstructured":"Erlanson-Albertsson C, Stenkula KG. The importance of food for endotoxemia and an inflammatory response. Int J Mol Sci. 2021;22(17):9562.","journal-title":"Int J Mol Sci"}],"container-title":["BMC Gastroenterology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1186\/s12876-025-04273-4.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/article\/10.1186\/s12876-025-04273-4\/fulltext.html","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1186\/s12876-025-04273-4.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,9,29]],"date-time":"2025-09-29T13:14:56Z","timestamp":1759151696000},"score":1,"resource":{"primary":{"URL":"https:\/\/bmcgastroenterol.biomedcentral.com\/articles\/10.1186\/s12876-025-04273-4"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2025,9,29]]},"references-count":31,"journal-issue":{"issue":"1","published-online":{"date-parts":[[2025,12]]}},"alternative-id":["4273"],"URL":"https:\/\/doi.org\/10.1186\/s12876-025-04273-4","relation":{},"ISSN":["1471-230X"],"issn-type":[{"value":"1471-230X","type":"electronic"}],"subject":[],"published":{"date-parts":[[2025,9,29]]},"assertion":[{"value":"20 May 2025","order":1,"name":"received","label":"Received","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"26 August 2025","order":2,"name":"accepted","label":"Accepted","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"29 September 2025","order":3,"name":"first_online","label":"First Online","group":{"name":"ArticleHistory","label":"Article History"}},{"order":1,"name":"Ethics","group":{"name":"EthicsHeading","label":"Declarations"}},{"value":"This study was approved by the institutional review board of the Second Hospital of Nanjing (Approval No. 2024-LS-ky042). The study was conducted in accordance with the Declaration of Helsinki. Written informed consents were obtained from all the subjects.","order":2,"name":"Ethics","group":{"name":"EthicsHeading","label":"Ethics approval and consent to participate"}},{"value":"Not Applicable.","order":3,"name":"Ethics","group":{"name":"EthicsHeading","label":"Consent for publication"}},{"value":"The authors declare no competing interests.","order":4,"name":"Ethics","group":{"name":"EthicsHeading","label":"Competing interests"}}],"article-number":"668"}}