{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,18]],"date-time":"2026-09-18T23:20:18Z","timestamp":1789773618123,"version":"4.0.1"},"reference-count":50,"publisher":"Springer Science and Business Media LLC","issue":"1","license":[{"start":{"date-parts":[[2025,10,9]],"date-time":"2025-10-09T00:00:00Z","timestamp":1759968000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0"},{"start":{"date-parts":[[2025,10,9]],"date-time":"2025-10-09T00:00:00Z","timestamp":1759968000000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0"}],"funder":[{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"crossref","award":["Grant no. 82273245"],"award-info":[{"award-number":["Grant no. 82273245"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"crossref"}]},{"name":"Capital's Funds for Health Improvement and Research","award":["Grant no. 2022-1-5082"],"award-info":[{"award-number":["Grant no. 2022-1-5082"]}]},{"name":"Beijing Natural Science Foundation","award":["Grant no. 7212107"],"award-info":[{"award-number":["Grant no. 7212107"]}]},{"DOI":"10.13039\/501100009592","name":"Beijing Municipal Science and Technology Commission","doi-asserted-by":"crossref","award":["No. Z171100001017145"],"award-info":[{"award-number":["No. Z171100001017145"]}],"id":[{"id":"10.13039\/501100009592","id-type":"DOI","asserted-by":"crossref"}]}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["BMC Gastroenterol"],"DOI":"10.1186\/s12876-025-04312-0","type":"journal-article","created":{"date-parts":[[2025,10,9]],"date-time":"2025-10-09T12:29:55Z","timestamp":1760012995000},"update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":1,"title":["Elucidating the role of IgA plasma cells and PECAM1-CD38 interaction in intestinal fibrosis: a single-cell RNA sequencing analysis in Crohn's disease"],"prefix":"10.1186","volume":"25","author":[{"given":"Shuyang","family":"Sun","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jiheng","family":"Wang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kai","family":"Li","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hua","family":"Jin","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shuwen","family":"Du","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jingyan","family":"Feng","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Limin","family":"Zhang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lei","family":"Li","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yuqi","family":"He","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2025,10,9]]},"reference":[{"issue":"1","key":"4312_CR1","doi-asserted-by":"publisher","first-page":"211","DOI":"10.1111\/imr.12974","volume":"302","author":"J Wang","year":"2021","unstructured":"Wang J, Lin S, Brown JM, van Wagoner D, Fiocchi C, Rieder F. Novel mechanisms and clinical trial endpoints in intestinal fibrosis. Immunol Rev. 2021;302(1):211\u201327.","journal-title":"Immunol Rev"},{"issue":"10114","key":"4312_CR2","doi-asserted-by":"publisher","first-page":"2769","DOI":"10.1016\/S0140-6736(17)32448-0","volume":"390","author":"SC Ng","year":"2017","unstructured":"Ng SC, Shi HY, Hamidi N, Underwood FE, Tang W, Benchimol EI, et al. Worldwide incidence and prevalence of inflammatory bowel disease in the 21st century: a systematic review of population-based studies. Lancet. 2017;390(10114):2769\u201378.","journal-title":"Lancet"},{"issue":"8","key":"4312_CR3","doi-asserted-by":"publisher","first-page":"970","DOI":"10.1038\/s41590-019-0415-0","volume":"20","author":"MF Neurath","year":"2019","unstructured":"Neurath MF. Targeting immune cell circuits and trafficking in inflammatory bowel disease. Nat Immunol. 2019;20(8):970\u20139.","journal-title":"Nat Immunol"},{"issue":"4","key":"4312_CR4","doi-asserted-by":"publisher","first-page":"378","DOI":"10.1097\/MOG.0000000000000078","volume":"30","author":"H Sokol","year":"2014","unstructured":"Sokol H, Seksik P, Cosnes J. Complications and surgery in the inflammatory bowel diseases biological era. Curr Opin Gastroenterol. 2014;30(4):378\u201384.","journal-title":"Curr Opin Gastroenterol"},{"key":"4312_CR5","doi-asserted-by":"publisher","first-page":"39","DOI":"10.1016\/j.trsl.2019.03.005","volume":"209","author":"J Li","year":"2019","unstructured":"Li J, Mao R, Kurada S, Wang J, Lin S, Chandra J, et al. Pathogenesis of fibrostenosing Crohn\u2019s disease. Transl Res. 2019;209:39\u201354.","journal-title":"Transl Res"},{"issue":"4","key":"4312_CR6","doi-asserted-by":"publisher","first-page":"279","DOI":"10.1016\/j.crohns.2008.05.009","volume":"2","author":"F Rieder","year":"2008","unstructured":"Rieder F, Fiocchi C. Intestinal fibrosis in inflammatory bowel disease - current knowledge and future perspectives. J Crohns Colitis. 2008;2(4):279\u201390.","journal-title":"J Crohns Colitis"},{"issue":"2","key":"4312_CR7","doi-asserted-by":"publisher","first-page":"335","DOI":"10.1111\/j.1572-0241.2004.04044.x","volume":"99","author":"SN Leeb","year":"2004","unstructured":"Leeb SN, Vogl D, Grossmann J, Falk W, Scholmerich J, Rogler G, et al. Autocrine fibronectin-induced migration of human colonic fibroblasts. Am J Gastroenterol. 2004;99(2):335\u201340.","journal-title":"Am J Gastroenterol"},{"issue":"10","key":"4312_CR8","doi-asserted-by":"publisher","first-page":"834","DOI":"10.1016\/j.tcb.2023.03.007","volume":"33","author":"MD Brugger","year":"2023","unstructured":"Brugger MD, Basler K. The diverse nature of intestinal fibroblasts in development, homeostasis, and disease. Trends Cell Biol. 2023;33(10):834\u201349.","journal-title":"Trends Cell Biol"},{"issue":"8","key":"4312_CR9","doi-asserted-by":"publisher","first-page":"484","DOI":"10.1038\/nrcardio.2017.57","volume":"14","author":"MD Tallquist","year":"2017","unstructured":"Tallquist MD, Molkentin JD. Redefining the identity of cardiac fibroblasts. Nat Rev Cardiol. 2017;14(8):484\u201391.","journal-title":"Nat Rev Cardiol"},{"issue":"13","key":"4312_CR10","doi-asserted-by":"publisher","first-page":"3625","DOI":"10.1016\/j.celrep.2018.03.010","volume":"22","author":"T Xie","year":"2018","unstructured":"Xie T, Wang Y, Deng N, Huang G, Taghavifar F, Geng Y, et al. Single-cell deconvolution of fibroblast heterogeneity in mouse pulmonary fibrosis. Cell Rep. 2018;22(13):3625\u201340.","journal-title":"Cell Rep"},{"issue":"4","key":"4312_CR11","doi-asserted-by":"publisher","first-page":"485","DOI":"10.1046\/j.1365-2222.2000.00737.x","volume":"30","author":"A Berton","year":"2000","unstructured":"Berton A, Levi-Schaffer F, Emonard H, Garbuzenko E, Gillery P, Maquart FX. Activation of fibroblasts in collagen lattices by mast cell extract: a model of fibrosis. Clin Exp Allergy. 2000;30(4):485\u201392.","journal-title":"Clin Exp Allergy"},{"issue":"1","key":"4312_CR12","doi-asserted-by":"publisher","first-page":"63","DOI":"10.1053\/j.gastro.2003.10.046","volume":"126","author":"JD Vogel","year":"2004","unstructured":"Vogel JD, West GA, Danese S, De La Motte C, Phillips MH, Strong SA, et al. CD40-mediated immune-nonimmune cell interactions induce mucosal fibroblast chemokines leading to T-cell transmigration. Gastroenterology. 2004;126(1):63\u201380.","journal-title":"Gastroenterology"},{"issue":"3","key":"4312_CR13","doi-asserted-by":"publisher","first-page":"546","DOI":"10.1016\/S0016-5085(99)70447-6","volume":"117","author":"A Musso","year":"1999","unstructured":"Musso A, Condon TP, West GA, De La Motte C, Strong SA, Levine AD, et al. Regulation of ICAM-1-mediated fibroblast-T cell reciprocal interaction: implications for modulation of gut inflammation. Gastroenterology. 1999;117(3):546\u201356.","journal-title":"Gastroenterology"},{"issue":"1","key":"4312_CR14","doi-asserted-by":"publisher","first-page":"89","DOI":"10.1053\/j.gastro.2022.09.006","volume":"164","author":"X Zhao","year":"2023","unstructured":"Zhao X, Yang W, Yu T, Yu Y, Cui X, Zhou Z, et al. Th17 cell-derived amphiregulin promotes colitis-associated intestinal fibrosis through activation of mTOR and MEK in intestinal myofibroblasts. Gastroenterology. 2023;164(1):89\u2013102.","journal-title":"Gastroenterology"},{"issue":"3","key":"4312_CR15","doi-asserted-by":"publisher","first-page":"800","DOI":"10.1002\/art.30171","volume":"63","author":"J Avouac","year":"2011","unstructured":"Avouac J, Furnrohr BG, Tomcik M, Palumbo K, Zerr P, Horn A, et al. Inactivation of the transcription factor STAT-4 prevents inflammation-driven fibrosis in animal models of systemic sclerosis. Arthritis Rheum. 2011;63(3):800\u20139.","journal-title":"Arthritis Rheum"},{"key":"4312_CR16","doi-asserted-by":"crossref","unstructured":"Santacroce G, Lenti MV, Di Sabatino A. Therapeutic targeting of intestinal fibrosis in Crohn\u2019s disease. Cells. 2022;11(3):429.","DOI":"10.3390\/cells11030429"},{"key":"4312_CR17","doi-asserted-by":"publisher","first-page":"101251","DOI":"10.1016\/j.mam.2024.101251","volume":"96","author":"MV Lenti","year":"2024","unstructured":"Lenti MV, Santacroce G, Broglio G, Rossi CM, Di Sabatino A. Recent advances in intestinal fibrosis. Mol Aspects Med. 2024;96:101251.","journal-title":"Mol Aspects Med"},{"issue":"7","key":"4312_CR18","doi-asserted-by":"publisher","first-page":"922","DOI":"10.1111\/apt.14526","volume":"47","author":"IO Gordon","year":"2018","unstructured":"Gordon IO, Agrawal N, Willis E, Goldblum JR, Lopez R, Allende D, et al. Fibrosis in ulcerative colitis is directly linked to severity and chronicity of mucosal inflammation. Aliment Pharmacol Ther. 2018;47(7):922\u201339.","journal-title":"Aliment Pharmacol Ther"},{"key":"4312_CR19","doi-asserted-by":"publisher","first-page":"71","DOI":"10.1016\/j.coph.2019.09.004","volume":"49","author":"R Dobie","year":"2019","unstructured":"Dobie R, Henderson NC. Unravelling fibrosis using single-cell transcriptomics. Curr Opin Pharmacol. 2019;49:71\u20135.","journal-title":"Curr Opin Pharmacol"},{"issue":"1","key":"4312_CR20","doi-asserted-by":"publisher","first-page":"1921","DOI":"10.1038\/s41467-021-22164-6","volume":"12","author":"N Jaeger","year":"2021","unstructured":"Jaeger N, Gamini R, Cella M, Schettini JL, Bugatti M, Zhao S, et al. Single-cell analyses of Crohn\u2019s disease tissues reveal intestinal intraepithelial T cells heterogeneity and altered subset distributions. Nat Commun. 2021;12(1):1921.","journal-title":"Nat Commun"},{"issue":"6","key":"4312_CR21","doi-asserted-by":"publisher","first-page":"1493","DOI":"10.1016\/j.cell.2019.08.008","volume":"178","author":"JC Martin","year":"2019","unstructured":"Martin JC, Chang C, Boschetti G, Ungaro R, Giri M, Grout JA, Gettler K, Chuang LS, Nayar S, Greenstein AJ, et al. Single-cell analysis of Crohn\u2019s disease lesions identifies a pathogenic cellular module associated with resistance to anti-TNF therapy. Cell. 2019;178(6):1493-1508 e1420.","journal-title":"Cell"},{"issue":"8","key":"4312_CR22","doi-asserted-by":"publisher","first-page":"1728","DOI":"10.1016\/j.immuni.2021.07.004","volume":"54","author":"LJ Huang","year":"2021","unstructured":"Huang LJ, Mao XT, Li YY, Liu DD, Fan KQ, Liu RB, Wu TT, Wang HL, Zhang Y, Yang B et al: Multiomics analyses reveal a critical role of selenium in controlling T cell differentiation in Crohn's disease. Immunity 2021, 54(8):1728\u20131744 e1727.","journal-title":"Immunity"},{"issue":"5","key":"4312_CR23","doi-asserted-by":"publisher","first-page":"411","DOI":"10.1038\/nbt.4096","volume":"36","author":"A Butler","year":"2018","unstructured":"Butler A, Hoffman P, Smibert P, Papalexi E, Satija R. Integrating single-cell transcriptomic data across different conditions, technologies, and species. Nat Biotechnol. 2018;36(5):411\u201320.","journal-title":"Nat Biotechnol"},{"issue":"4","key":"4312_CR24","doi-asserted-by":"publisher","first-page":"381","DOI":"10.1038\/nbt.2859","volume":"32","author":"C Trapnell","year":"2014","unstructured":"Trapnell C, Cacchiarelli D, Grimsby J, Pokharel P, Li S, Morse M, et al. The dynamics and regulators of cell fate decisions are revealed by pseudotemporal ordering of single cells. Nat Biotechnol. 2014;32(4):381\u20136.","journal-title":"Nat Biotechnol"},{"issue":"7731","key":"4312_CR25","doi-asserted-by":"publisher","first-page":"347","DOI":"10.1038\/s41586-018-0698-6","volume":"563","author":"R Vento-Tormo","year":"2018","unstructured":"Vento-Tormo R, Efremova M, Botting RA, Turco MY, Vento-Tormo M, Meyer KB, et al. Single-cell reconstruction of the early maternal\u2013fetal interface in humans. Nature. 2018;563(7731):347\u201353.","journal-title":"Nature"},{"issue":"Database issue","key":"4312_CR26","first-page":"480","volume":"36","author":"M AM Kanehisa","year":"2008","unstructured":"Kanehisa M AM, Goto S, Hattori M, Hirakawa M, Itoh M, Katayama T, Kawashima S, Okuda S, Tokimatsu T, Yamanishi Y.: Kegg for linking genomes to life and source nucleic acids. Nucleic Acids Res 2008, 36(Database issue):480\u2013484.","journal-title":"Nucleic Acids Res"},{"issue":"43","key":"4312_CR27","doi-asserted-by":"publisher","first-page":"15545","DOI":"10.1073\/pnas.0506580102","volume":"102","author":"A Subramanian","year":"2005","unstructured":"Subramanian A, Tamayo P, Mootha VK, Mukherjee S, Ebert BL, Gillette MA, et al. Gene set enrichment analysis: a knowledge-based approach for interpreting genome-wide expression profiles. Proc Natl Acad Sci U S A. 2005;102(43):15545\u201350.","journal-title":"Proc Natl Acad Sci U S A"},{"issue":"14","key":"4312_CR28","doi-asserted-by":"publisher","first-page":"7","DOI":"10.1186\/1471-2105-14-7","volume":"16","author":"SCR H\u00e4nzelmann","year":"2013","unstructured":"H\u00e4nzelmann SCR, Guinney J. GSVA gene set variation analysis fo Source BMC Bioinformatics. BMC Bioinformatics. 2013;16(14):7.","journal-title":"BMC Bioinformatics"},{"issue":"3","key":"4312_CR29","doi-asserted-by":"publisher","first-page":"309","DOI":"10.1038\/nmeth.4150","volume":"14","author":"X Qiu","year":"2017","unstructured":"Qiu X, Hill A, Packer J, Lin D, Ma YA, Trapnell C. Single-cell mRNA quantification and differential analysis with census. Nat Methods. 2017;14(3):309\u201315.","journal-title":"Nat Methods"},{"issue":"1","key":"4312_CR30","doi-asserted-by":"publisher","first-page":"232","DOI":"10.1186\/s12931-019-1195-7","volume":"20","author":"P Heukels","year":"2019","unstructured":"Heukels P, van Hulst JAC, van Nimwegen M, Boorsma CE, Melgert BN, von der Thusen JH, et al. Enhanced Bruton\u2019s tyrosine kinase in B-cells and autoreactive IgA in patients with idiopathic pulmonary fibrosis. Respir Res. 2019;20(1):232.","journal-title":"Respir Res"},{"issue":"6","key":"4312_CR31","doi-asserted-by":"publisher","first-page":"722","DOI":"10.1165\/rcmb.2020-0387OC","volume":"64","author":"MF Ali","year":"2021","unstructured":"Ali MF, Egan AM, Shaughnessy GF, Anderson DK, Kottom TJ, Dasari H, et al. Antifibrotics modify B-cell-induced fibroblast migration and activation in patients with idiopathic pulmonary fibrosis. Am J Respir Cell Mol Biol. 2021;64(6):722\u201333.","journal-title":"Am J Respir Cell Mol Biol"},{"issue":"12","key":"4312_CR32","doi-asserted-by":"publisher","first-page":"800","DOI":"10.1016\/j.prp.2010.08.002","volume":"206","author":"DF Brandao","year":"2010","unstructured":"Brandao DF, Ramalho FS, Martinelli AL, Zucoloto S, Ramalho LN. Relationship between plasma cells and hepatic stellate cells in autoimmune hepatitis. Pathol Res Pract. 2010;206(12):800\u20134.","journal-title":"Pathol Res Pract"},{"issue":"1","key":"4312_CR33","first-page":"7","volume":"10","author":"YM Bai","year":"2023","unstructured":"Bai YM, Yang F, Luo P, Xie LL, Chen JH, Guan YD, et al. Single-cell transcriptomic dissection of the cellular and molecular events underlying the triclosan-induced liver fibrosis in mice. Mil Med Res. 2023;10(1):7.","journal-title":"Mil Med Res"},{"issue":"7","key":"4312_CR34","doi-asserted-by":"publisher","first-page":"429","DOI":"10.1038\/s41577-021-00639-3","volume":"22","author":"T Huby","year":"2022","unstructured":"Huby T, Gautier EL. Immune cell-mediated features of non-alcoholic steatohepatitis. Nat Rev Immunol. 2022;22(7):429\u201343.","journal-title":"Nat Rev Immunol"},{"issue":"9","key":"4312_CR35","doi-asserted-by":"publisher","first-page":"e18344","DOI":"10.1111\/jcmm.18344","volume":"28","author":"DT Humphreys","year":"2024","unstructured":"Humphreys DT, Lewis A, Pan-Castillo B, Berti G, Mein C, Wozniak E, et al. Single cell sequencing data identify distinct B cell and fibroblast populations in stricturing Crohn\u2019s disease. J Cell Mol Med. 2024;28(9):e18344.","journal-title":"J Cell Mol Med"},{"key":"4312_CR36","first-page":"6085678","volume":"2020","author":"J Torle","year":"2020","unstructured":"Torle J, Dabir PD, Korsgaard U, Christiansen J, Qvist N, El-Hussuna A. Levels of Intestinal Inflammation and Fibrosis in Resection Specimens after Preoperative Anti-Tumor Necrosis Factor Alpha Treatment in Patients with Crohn\u2019s Disease: A Comparative Pilot Study. Surg Res Pract. 2020;2020:6085678.","journal-title":"Surg Res Pract"},{"issue":"6","key":"4312_CR37","doi-asserted-by":"publisher","first-page":"1750","DOI":"10.1053\/j.gastro.2003.08.027","volume":"125","author":"IC Lawrance","year":"2003","unstructured":"Lawrance IC, Wu F, Leite AZ, Willis J, West GA, Fiocchi C, et al. A murine model of chronic inflammation-induced intestinal fibrosis down-regulated by antisense NF-kappa B. Gastroenterology. 2003;125(6):1750\u201361.","journal-title":"Gastroenterology"},{"issue":"1","key":"4312_CR38","doi-asserted-by":"publisher","first-page":"178","DOI":"10.1038\/s41385-018-0087-3","volume":"12","author":"DC Macias-Ceja","year":"2019","unstructured":"Macias-Ceja DC, Ortiz-Masia D, Salvador P, Gisbert-Ferrandiz L, Hernandez C, Hausmann M, et al. Succinate receptor mediates intestinal inflammation and fibrosis. Mucosal Immunol. 2019;12(1):178\u201387.","journal-title":"Mucosal Immunol"},{"issue":"Pt 2","key":"4312_CR39","first-page":"136","volume":"86","author":"JH Lee","year":"2022","unstructured":"Lee JH, Massague J. TGF-beta in developmental and fibrogenic EMTs. Semin Cancer Biol. 2022;86(Pt 2):136\u201345.","journal-title":"Semin Cancer Biol"},{"issue":"10","key":"4312_CR40","doi-asserted-by":"publisher","first-page":"605","DOI":"10.1093\/intimm\/dxs056","volume":"24","author":"Y Liu","year":"2012","unstructured":"Liu Y, Zhu H, Su Z, Sun C, Yin J, Yuan H, et al. IL-17 contributes to cardiac fibrosis following experimental autoimmune myocarditis by a PKCbeta\/Erk1\/2\/NF-kappaB-dependent signaling pathway. Int Immunol. 2012;24(10):605\u201312.","journal-title":"Int Immunol"},{"key":"4312_CR41","doi-asserted-by":"publisher","first-page":"101479","DOI":"10.1016\/j.smim.2021.101479","volume":"52","author":"S Shalapour","year":"2021","unstructured":"Shalapour S, Karin M. The neglected brothers come of age: B cells and cancer. Semin Immunol. 2021;52:101479.","journal-title":"Semin Immunol"},{"issue":"6","key":"4312_CR42","doi-asserted-by":"publisher","first-page":"850","DOI":"10.1093\/ibd\/izac266","volume":"29","author":"W Shu","year":"2023","unstructured":"Shu W, Wang Y, Li C, Zhang L, Zhuoma D, Yang P, et al. Single-cell expression atlas reveals cell heterogeneity in the creeping fat of Crohn\u2019s disease. Inflamm Bowel Dis. 2023;29(6):850\u201365.","journal-title":"Inflamm Bowel Dis"},{"key":"4312_CR43","doi-asserted-by":"publisher","first-page":"1","DOI":"10.1186\/1472-6793-8-1","volume":"8","author":"V Miragliotta","year":"2008","unstructured":"Miragliotta V, Ipina Z, Lefebvre-Lavoie J, Lussier JG, Theoret CL. Equine CTNNB1 and PECAM1 nucleotide structure and expression analyses in an experimental model of normal and pathological wound repair. BMC Physiol. 2008;8:1.","journal-title":"BMC Physiol"},{"key":"4312_CR44","doi-asserted-by":"publisher","first-page":"1","DOI":"10.1016\/j.ijcard.2016.06.137","volume":"220","author":"PS Yang","year":"2016","unstructured":"Yang PS, Lee SH, Park J, Kim TH, Uhm JS, Joung B, et al. Atrial tissue expression of receptor for advanced glycation end-products (RAGE) and atrial fibrosis in patients with mitral valve disease. Int J Cardiol. 2016;220:1\u20136.","journal-title":"Int J Cardiol"},{"key":"4312_CR45","doi-asserted-by":"publisher","first-page":"712893","DOI":"10.1155\/2014\/712893","volume":"2014","author":"E Raskopf","year":"2014","unstructured":"Raskopf E, Gonzalez Carmona MA, Van Cayzeele CJ, Strassburg C, Sauerbruch T, Schmitz V. Toxic damage increases angiogenesis and metastasis in fibrotic livers via PECAM-1. Biomed Res Int. 2014;2014:712893.","journal-title":"Biomed Res Int"},{"issue":"1","key":"4312_CR46","doi-asserted-by":"publisher","first-page":"101902","DOI":"10.1016\/j.isci.2020.101902","volume":"24","author":"B Shi","year":"2021","unstructured":"Shi B, Wang W, Korman B, Kai L, Wang Q, Wei J, et al. Targeting CD38-dependent NAD(+) metabolism to mitigate multiple organ fibrosis. iScience. 2021;24(1):101902.","journal-title":"iScience"},{"issue":"4","key":"4312_CR47","doi-asserted-by":"publisher","first-page":"459","DOI":"10.1164\/rccm.202109-2151OC","volume":"206","author":"H Cui","year":"2022","unstructured":"Cui H, Xie N, Banerjee S, Dey T, Liu RM, Antony VB, et al. CD38 mediates lung fibrosis by promoting alveolar epithelial cell aging. Am J Respir Crit Care Med. 2022;206(4):459\u201375.","journal-title":"Am J Respir Crit Care Med"},{"key":"4312_CR48","doi-asserted-by":"crossref","unstructured":"Massimino L, Parigi TL, Riva M, Nicolo S, Errico C, Spano S, Mino S, Bugatti M, Frontali A, Scarfo F et al: Spatiotemporal analysis of Crohn's disease reveals PECAM2 signaling at the basis of inflammation-to-fibrosis transition. J Crohns Colitis 2025. Epub ahead of print. PMID: 40680170.","DOI":"10.1093\/ecco-jcc\/jjaf130"},{"key":"4312_CR49","doi-asserted-by":"publisher","first-page":"145","DOI":"10.1186\/1742-2094-8-145","volume":"8","author":"MK Mamik","year":"2011","unstructured":"Mamik MK, Banerjee S, Walseth TF, Hirte R, Tang L, Borgmann K, et al. HIV-1 and IL-1beta regulate astrocytic CD38 through mitogen-activated protein kinases and nuclear factor-kappaB signaling mechanisms. J Neuroinflammation. 2011;8:145.","journal-title":"J Neuroinflammation"},{"issue":"7","key":"4312_CR50","doi-asserted-by":"publisher","first-page":"1072","DOI":"10.1136\/gutjnl-2012-304353","volume":"62","author":"F Rieder","year":"2013","unstructured":"Rieder F, Zimmermann EM, Remzi FH, Sandborn WJ. Crohn\u2019s disease complicated by strictures: a systematic review. Gut. 2013;62(7):1072\u201384.","journal-title":"Gut"}],"container-title":["BMC Gastroenterology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1186\/s12876-025-04312-0.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/article\/10.1186\/s12876-025-04312-0\/fulltext.html","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1186\/s12876-025-04312-0.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,10,9]],"date-time":"2025-10-09T14:04:10Z","timestamp":1760018650000},"score":1,"resource":{"primary":{"URL":"https:\/\/bmcgastroenterol.biomedcentral.com\/articles\/10.1186\/s12876-025-04312-0"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2025,10,9]]},"references-count":50,"journal-issue":{"issue":"1","published-online":{"date-parts":[[2025,12]]}},"alternative-id":["4312"],"URL":"https:\/\/doi.org\/10.1186\/s12876-025-04312-0","relation":{},"ISSN":["1471-230X"],"issn-type":[{"value":"1471-230X","type":"electronic"}],"subject":[],"published":{"date-parts":[[2025,10,9]]},"assertion":[{"value":"19 February 2025","order":1,"name":"received","label":"Received","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"8 September 2025","order":2,"name":"accepted","label":"Accepted","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"9 October 2025","order":3,"name":"first_online","label":"First Online","group":{"name":"ArticleHistory","label":"Article History"}},{"order":1,"name":"Ethics","group":{"name":"EthicsHeading","label":"Declarations"}},{"value":"All research activities were approved by the Medical Ethics Committee of the Seventh Medical Center of Chinese PLA General Hospital and in accordance with the declaration of Helsinki (ID: 2017\u201346). This study was in accordance with the declaration of Helsinki. Written informed consent was obtained from all participants before the colonoscopy and secured at the Seventh Medical Center of Chinese PLA General Hospital.","order":2,"name":"Ethics","group":{"name":"EthicsHeading","label":"Ethics approval and consent to participate"}},{"value":"Not applicable.","order":3,"name":"Ethics","group":{"name":"EthicsHeading","label":"Consent for publication"}},{"value":"The authors declare no competing interests.","order":4,"name":"Ethics","group":{"name":"EthicsHeading","label":"Competing interests"}}],"article-number":"712"}}