{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,17]],"date-time":"2026-08-17T10:55:56Z","timestamp":1786964156721,"version":"build-2736575974"},"reference-count":36,"publisher":"Springer Science and Business Media LLC","issue":"1","license":[{"start":{"date-parts":[[2025,11,12]],"date-time":"2025-11-12T00:00:00Z","timestamp":1762905600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0"},{"start":{"date-parts":[[2025,11,12]],"date-time":"2025-11-12T00:00:00Z","timestamp":1762905600000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0"}],"funder":[{"name":"Clinical Technology Innovation Project of Shanghai Hospital Development Center of China","award":["SHDC22021304"],"award-info":[{"award-number":["SHDC22021304"]}]},{"DOI":"10.13039\/501100003399","name":"Science and Technology Commission of Shanghai Municipality","doi-asserted-by":"publisher","award":["23015830500"],"award-info":[{"award-number":["23015830500"]}],"id":[{"id":"10.13039\/501100003399","id-type":"DOI","asserted-by":"publisher"}]},{"name":"Health Commission and Department of Science and Technology of Tibet Autonomous Region","award":["XZ2024ZR-ZY052(Z)"],"award-info":[{"award-number":["XZ2024ZR-ZY052(Z)"]}]}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["BMC Gastroenterol"],"DOI":"10.1186\/s12876-025-04404-x","type":"journal-article","created":{"date-parts":[[2025,11,13]],"date-time":"2025-11-13T15:28:44Z","timestamp":1763047724000},"update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":2,"title":["Anticoagulation therapy for intra-abdominal hypertension in patients with acute pancreatitis"],"prefix":"10.1186","volume":"25","author":[{"given":"Yan","family":"Ge","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Li","family":"Ma","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Wenwu","family":"Sun","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Bing","family":"Zhao","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ying","family":"Chen","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zhitao","family":"Yang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Erzhen","family":"Chen","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Weisong","family":"Jiang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Enqiang","family":"Mao","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tongtian","family":"Ni","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2025,11,12]]},"reference":[{"key":"4404_CR1","doi-asserted-by":"publisher","DOI":"10.3390\/medicina58060785","author":"C Mancilla Asencio","year":"2022","unstructured":"Mancilla Asencio C, Berger Fleiszig Z. Intra-abdominal hypertension: a systemic complication of severe acute pancreatitis. Medicina (Kaunas). 2022. https:\/\/doi.org\/10.3390\/medicina58060785.","journal-title":"Medicina (Kaunas)"},{"issue":"5","key":"4404_CR2","doi-asserted-by":"publisher","first-page":"411","DOI":"10.1016\/j.jviscsurg.2021.01.001","volume":"158","author":"M Siebert","year":"2021","unstructured":"Siebert M, Le Fouler A, Sitbon N, Cohen J, Abba J, Poupardin E. Management of abdominal compartment syndrome in acute pancreatitis. J Visc Surg. 2021;158(5):411\u20139.","journal-title":"J Visc Surg"},{"key":"4404_CR3","doi-asserted-by":"crossref","unstructured":"Dumnicka P, Maduzia D, Ceranowicz P, Olszanecki R, Drozdz R, Kusnierz-Cabala B. The interplay between Inflammation, coagulation and endothelial injury in the early phase of acute pancreatitis: clinical implications. Int J Mol Sci. 2017;18(2).","DOI":"10.3390\/ijms18020354"},{"issue":"4","key":"4404_CR4","volume":"69","author":"D Chen","year":"2021","unstructured":"Chen D. Heparin beyond anti-coagulation. Curr Res Transl Med. 2021;69(4):103300.","journal-title":"Curr Res Transl Med"},{"key":"4404_CR5","doi-asserted-by":"publisher","DOI":"10.1155\/2018\/4721357","volume":"2018","author":"R Garg","year":"2018","unstructured":"Garg R, Rustagi T. Management of hypertriglyceridemia induced acute pancreatitis. BioMed Res Int. 2018;2018:4721357.","journal-title":"BioMed Res Int"},{"issue":"147","key":"4404_CR6","first-page":"101","volume":"27","author":"YY Guo","year":"2019","unstructured":"Guo YY, Li HX, Zhang Y, He WH. Hypertriglyceridemia-induced acute pancreatitis: progress on disease mechanisms and treatment modalities. Discov Med. 2019;27(147):101\u20139.","journal-title":"Discov Med"},{"issue":"1","key":"4404_CR7","doi-asserted-by":"publisher","first-page":"102","DOI":"10.1136\/gutjnl-2012-302779","volume":"62","author":"PA Banks","year":"2013","unstructured":"Banks PA, Bollen TL, Dervenis C, Gooszen HG, Johnson CD, Sarr MG, et al. Classification of acute pancreatitis\u20132012: revision of the Atlanta classification and definitions by international consensus. Gut. 2013;62(1):102\u201311.","journal-title":"Gut"},{"issue":"22","key":"4404_CR8","doi-asserted-by":"publisher","DOI":"10.21037\/atm.2019.10.58","volume":"7","author":"E Mao","year":"2019","unstructured":"Mao E. Intensive management of severe acute pancreatitis. Ann Transl Med. 2019;7(22):687.","journal-title":"Ann Transl Med"},{"issue":"7","key":"4404_CR9","first-page":"578","volume":"59","author":"Chinese Pancreatic Surgery Association CSoSCMA","year":"2021","unstructured":"Chinese Pancreatic Surgery Association CSoSCMA. [Guidelines for diagnosis and treatment of acute pancreatitis in China (2021)]. Zhonghua Wai Ke Za Zhi. 2021;59(7):578\u201387.","journal-title":"Zhonghua Wai Ke Za Zhi"},{"issue":"7","key":"4404_CR10","doi-asserted-by":"publisher","first-page":"1190","DOI":"10.1007\/s00134-013-2906-z","volume":"39","author":"AW Kirkpatrick","year":"2013","unstructured":"Kirkpatrick AW, Roberts DJ, De Waele J, Jaeschke R, Malbrain ML, De Keulenaer B, et al. Intra-abdominal hypertension and the abdominal compartment syndrome: updated consensus definitions and clinical practice guidelines from the world society of the abdominal compartment syndrome. Intensive Care Med. 2013;39(7):1190\u2013206.","journal-title":"Intensive Care Med"},{"issue":"5","key":"4404_CR11","doi-asserted-by":"publisher","first-page":"1261","DOI":"10.2214\/ajr.183.5.1831261","volume":"183","author":"KJ Mortele","year":"2004","unstructured":"Mortele KJ, Wiesner W, Intriere L, Shankar S, Zou KH, Kalantari BN, et al. A modified CT severity index for evaluating acute pancreatitis: improved correlation with patient outcome. AJR Am J Roentgenol. 2004;183(5):1261\u20135.","journal-title":"AJR Am J Roentgenol"},{"key":"4404_CR12","doi-asserted-by":"publisher","DOI":"10.1155\/2022\/3771610","volume":"2022","author":"H Wu","year":"2022","unstructured":"Wu H, Ma K, Liao B, Ji T, Zhang S, Cao T. Comparative analysis of early clinical features and complications of different types of acute pancreatitis. Oxid Med Cell Longev. 2022;2022:3771610.","journal-title":"Oxid Med Cell Longev"},{"issue":"5","key":"4404_CR13","doi-asserted-by":"publisher","DOI":"10.1186\/cc13075","volume":"17","author":"JK Holodinsky","year":"2013","unstructured":"Holodinsky JK, Roberts DJ, Ball CG, Blaser AR, Starkopf J, Zygun DA, et al. Risk factors for intra-abdominal hypertension and abdominal compartment syndrome among adult intensive care unit patients: a systematic review and meta-analysis. Crit Care. 2013;17(5):R249.","journal-title":"Crit Care"},{"issue":"8","key":"4404_CR14","volume":"12","author":"A Amini","year":"2020","unstructured":"Amini A, Vaezi Z, Koury E, Zafar S, Chahla E. Portal vein thrombosis and intra-abdominal hypertension presenting as complications of hypertriglyceridemia-induced severe acute pancreatitis. Cureus. 2020;12(8):e9889.","journal-title":"Cureus"},{"issue":"5","key":"4404_CR15","doi-asserted-by":"publisher","first-page":"663","DOI":"10.1097\/MPA.0000000000001544","volume":"49","author":"MK Goenka","year":"2020","unstructured":"Goenka MK, Goenka U, Afzalpurkar S, Tiwari SC, Agarwal R, Tiwary IK. Role of static and dynamic intra-abdominal pressure monitoring in acute pancreatitis: a prospective study on its impact. Pancreas. 2020;49(5):663\u20137.","journal-title":"Pancreas"},{"issue":"3","key":"4404_CR16","volume":"41","author":"S Jaber","year":"2022","unstructured":"Jaber S, Garnier M, Asehnoune K, Bounes F, Buscail L, Chevaux JB, et al. Guidelines for the management of patients with severe acute pancreatitis, 2021. Anaesth Crit Care Pain Med. 2022;41(3):101060.","journal-title":"Anaesth Crit Care Pain Med"},{"issue":"8","key":"4404_CR17","doi-asserted-by":"publisher","first-page":"1428","DOI":"10.1016\/j.pan.2021.09.003","volume":"21","author":"PT Kroner","year":"2021","unstructured":"Kroner PT, Wallace MB, Raimondo M, Antwi SO, Ma Y, Li Z, et al. Systemic anticoagulation is associated with decreased mortality and morbidity in acute pancreatitis. Pancreatology. 2021;21(8):1428\u201333.","journal-title":"Pancreatology"},{"issue":"1","key":"4404_CR18","doi-asserted-by":"publisher","first-page":"81","DOI":"10.5152\/tjg.2018.18583","volume":"30","author":"M Tozlu","year":"2019","unstructured":"Tozlu M, Kayar Y, Ince AT, Baysal B, Senturk H. Low molecular weight heparin treatment of acute moderate and severe pancreatitis: a randomized, controlled, open-label study. Turk J Gastroenterol. 2019;30(1):81\u20137.","journal-title":"Turk J Gastroenterol"},{"key":"4404_CR19","doi-asserted-by":"publisher","DOI":"10.1177\/10760296211010260","volume":"27","author":"L Nawacki","year":"2021","unstructured":"Nawacki L, Matykiewicz J, Stochmal E, Gluszek S. Splanchnic vein thrombosis in acute pancreatitis and its consequences. Clin Appl Thromb Hemost. 2021;27:10760296211010260.","journal-title":"Clin Appl Thromb Hemost"},{"issue":"5","key":"4404_CR20","doi-asserted-by":"publisher","first-page":"415","DOI":"10.1097\/MPA.0000000000002044","volume":"51","author":"R Antkowiak","year":"2022","unstructured":"Antkowiak R, Bialecki J, Chabowski M, Domoslawski P. Treatment of microcirculatory disturbances in acute pancreatitis. Where are we now? Pancreas. 2022;51(5):415\u201321.","journal-title":"Pancreas"},{"issue":"Suppl 4","key":"4404_CR21","first-page":"103","volume":"59","author":"P Ceranowicz","year":"2008","unstructured":"Ceranowicz P, Dembinski A, Warzecha Z, Dembinski M, Cieszkowski J, Rembisz K, et al. Protective and therapeutic effect of heparin in acute pancreatitis. J Physiol Pharmacol. 2008;59(Suppl 4):103\u201325.","journal-title":"J Physiol Pharmacol"},{"key":"4404_CR22","doi-asserted-by":"publisher","DOI":"10.3390\/polym14122470","author":"J Yang","year":"2022","unstructured":"Yang J, Tang X, Wu Q, Ren P, Yan Y, Liu W, et al. Heparin protects severe acute pancreatitis by inhibiting HMGB-1 active secretion from macrophages. Polymers. 2022. https:\/\/doi.org\/10.3390\/polym14122470.","journal-title":"Polymers"},{"issue":"2","key":"4404_CR23","doi-asserted-by":"publisher","first-page":"11978","DOI":"10.1080\/21655979.2021.2011018","volume":"12","author":"L Zhou","year":"2021","unstructured":"Zhou L, Chen J, Mu G, Lu Z, Li W, Deng Y. Heparin-binding protein (HBP) worsens the severity of pancreatic necrosis via up-regulated M1 macrophages activation in acute pancreatitis mouse models. Bioengineered. 2021;12(2):11978\u201386.","journal-title":"Bioengineered"},{"issue":"1","key":"4404_CR24","doi-asserted-by":"publisher","DOI":"10.1186\/s12876-021-01910-6","volume":"21","author":"M Sjobeck","year":"2021","unstructured":"Sjobeck M, Sternby H, Herwald H, Thorlacius H, Regner S. Heparin-binding protein is significantly increased in acute pancreatitis. BMC Gastroenterol. 2021;21(1):337.","journal-title":"BMC Gastroenterol"},{"key":"4404_CR25","doi-asserted-by":"publisher","first-page":"702764","DOI":"10.3389\/fimmu.2021.702764","volume":"12","author":"Z Balla","year":"2021","unstructured":"Balla Z, Kormanyos ES, Kui B, Balint ER, Fur G, Orjan EM, et al. Kynurenic acid and its analogue SZR-72 ameliorate the severity of experimental acute necrotizing pancreatitis. Front Immunol. 2021;12:702764.","journal-title":"Front Immunol"},{"issue":"10","key":"4404_CR26","doi-asserted-by":"publisher","first-page":"1345","DOI":"10.1177\/0960327120919469","volume":"39","author":"S Li","year":"2020","unstructured":"Li S, Zhang S, Li R, Chen S, Chang S, Chen X, et al. Prophylactic low-molecular-weight heparin administration protected against severe acute pancreatitis partially by VEGF\/Flt-1 signaling in a rat model. Hum Exp Toxicol. 2020;39(10):1345\u201354.","journal-title":"Hum Exp Toxicol"},{"key":"4404_CR27","doi-asserted-by":"crossref","unstructured":"Maduzia D, Ceranowicz P, Cieszkowski J, Galazka K, Kusnierz-Cabala B, Warzecha Z. Pretreatment with warfarin attenuates the development of Ischemia\/Reperfusion-Induced acute pancreatitis in rats. Molecules. 2020;25(11).","DOI":"10.3390\/molecules25112493"},{"key":"4404_CR28","doi-asserted-by":"crossref","unstructured":"Warzecha Z, Sendur P, Ceranowicz P, Cieszkowski J, Dembinski M, Sendur R et al. Therapeutic effect of low doses of acenocoumarol in the course of Ischemia\/Reperfusion-Induced acute pancreatitis in rats. Int J Mol Sci. 2017;18(4).","DOI":"10.3390\/ijms18040882"},{"key":"4404_CR29","doi-asserted-by":"publisher","DOI":"10.1016\/j.ijsu.2022.106621","volume":"101","author":"B Patil","year":"2022","unstructured":"Patil B, Meena LN, Sharma DC, Agarwal G, Dadhich Y, Gupta G. Impact of low-molecular-weight heparin in the treatment of moderately severe and severe acute pancreatitis; a randomized, single blind, phase 3 control trial. Int J Surg. 2022;101:106621.","journal-title":"Int J Surg"},{"issue":"10","key":"4404_CR30","doi-asserted-by":"publisher","first-page":"512","DOI":"10.1111\/1751-2980.12815","volume":"20","author":"Q Qiu","year":"2019","unstructured":"Qiu Q, Li GJ, Tang L, Guo Y, Wen LZ, Wang B, et al. The efficacy of low molecular weight heparin in severe acute pancreatitis: a systematic review and meta-analysis of randomized controlled trials. J Dig Dis. 2019;20(10):512\u201322.","journal-title":"J Dig Dis"},{"issue":"11","key":"4404_CR31","doi-asserted-by":"publisher","first-page":"11695","DOI":"10.21037\/apm-21-3058","volume":"10","author":"H Wang","year":"2021","unstructured":"Wang H, Xu Y, Yang M, Zheng D, Chen L. Systematic review and meta-analysis of the safety and effectiveness of low molecular heparin for severe acute pancreatitis. Ann Palliat Med. 2021;10(11):11695\u2013704.","journal-title":"Ann Palliat Med"},{"issue":"2","key":"4404_CR32","doi-asserted-by":"publisher","first-page":"235","DOI":"10.1016\/j.pan.2021.12.008","volume":"22","author":"NJ Sissingh","year":"2022","unstructured":"Sissingh NJ, Groen JV, Koole D, Klok FA, Boekestijn B, Bollen TL, et al. Therapeutic anticoagulation for splanchnic vein thrombosis in acute pancreatitis: a systematic review and meta-analysis. Pancreatology. 2022;22(2):235\u201343.","journal-title":"Pancreatology"},{"issue":"6","key":"4404_CR33","doi-asserted-by":"publisher","first-page":"1021","DOI":"10.1007\/s11739-019-02271-5","volume":"15","author":"D Pagliari","year":"2020","unstructured":"Pagliari D, Cianci R, Brizi MG, Mancarella FA, Musso M, Cintoni M, et al. Anticoagulant therapy in the treatment of splanchnic vein thrombosis associated to acute pancreatitis: a 3-year single-centre experience. Intern Emerg Med. 2020;15(6):1021\u20139.","journal-title":"Intern Emerg Med"},{"issue":"3","key":"4404_CR34","doi-asserted-by":"publisher","first-page":"446","DOI":"10.1111\/jgh.15711","volume":"37","author":"FS Anis","year":"2022","unstructured":"Anis FS, Adiamah A, Lobo DN, Sanyal S. Incidence and treatment of splanchnic vein thrombosis in patients with acute pancreatitis: a systematic review and meta-analysis. J Gastroenterol Hepatol. 2022;37(3):446\u201354.","journal-title":"J Gastroenterol Hepatol"},{"issue":"3","key":"4404_CR35","doi-asserted-by":"publisher","first-page":"464","DOI":"10.1016\/j.pan.2017.03.010","volume":"17","author":"D Hashimoto","year":"2017","unstructured":"Hashimoto D, Nakagawa S, Umezaki N, Yamao T, Kitano Y, Yamamura K, et al. Efficacy and safety of postoperative anticoagulation prophylaxis with Enoxaparin in patients undergoing pancreatic surgery: a prospective trial and literature review. Pancreatology. 2017;17(3):464\u201370.","journal-title":"Pancreatology"},{"issue":"11","key":"4404_CR36","volume":"13","author":"RS Vadlamudi","year":"2021","unstructured":"Vadlamudi RS, Matli VVK, Thoguluva Chandrasekar V, Kalakonda A, Rawlins SR. Chemoprophylaxis to prevent deep venous thrombosis in patients hospitalized for pancreatitis: beneficial or harmful? Cureus. 2021;13(11):e19645.","journal-title":"Cureus"}],"container-title":["BMC Gastroenterology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1186\/s12876-025-04404-x.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/article\/10.1186\/s12876-025-04404-x\/fulltext.html","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1186\/s12876-025-04404-x.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,11,17]],"date-time":"2025-11-17T18:27:38Z","timestamp":1763404058000},"score":1,"resource":{"primary":{"URL":"https:\/\/bmcgastroenterol.biomedcentral.com\/articles\/10.1186\/s12876-025-04404-x"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2025,11,12]]},"references-count":36,"journal-issue":{"issue":"1","published-online":{"date-parts":[[2025,12]]}},"alternative-id":["4404"],"URL":"https:\/\/doi.org\/10.1186\/s12876-025-04404-x","relation":{},"ISSN":["1471-230X"],"issn-type":[{"value":"1471-230X","type":"electronic"}],"subject":[],"published":{"date-parts":[[2025,11,12]]},"assertion":[{"value":"7 December 2023","order":1,"name":"received","label":"Received","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"15 October 2025","order":2,"name":"accepted","label":"Accepted","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"12 November 2025","order":3,"name":"first_online","label":"First Online","group":{"name":"ArticleHistory","label":"Article History"}},{"order":1,"name":"Ethics","group":{"name":"EthicsHeading","label":"Declarations"}},{"value":"The study was approved by the Ethics committee of Ruijin Hospital affiliated to Shanghai Jiao Tong University School of Medicine and granted waiver of informed consent (2023235). The study strictly adheres to the ethical standards outlined in the Declaration of Helsinki and its later amendments.","order":2,"name":"Ethics","group":{"name":"EthicsHeading","label":"Ethics approval and consent to participate"}},{"value":"Not applicable in our study.","order":3,"name":"Ethics","group":{"name":"EthicsHeading","label":"Consent for publication"}},{"value":"The authors declare no competing interests.","order":4,"name":"Ethics","group":{"name":"EthicsHeading","label":"Competing interests"}}],"article-number":"804"}}