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This study investigated clinical differences, treatment responses, and predictors of response in familial and sporadic IBD patients.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>This case\u2012control study was conducted on ninety IBD patients (30 familial, 60 sporadic). Clinical history, inflammatory markers, endoscopic findings, and treatment outcomes were analysed over a one-year period. Predictors of response and mucosal healing were assessed via logistic regression.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>\n                      Mucosal healing was achieved in a greater percentage of patients in the familial group (73.3%) compared to those in the sporadic group (55%), but the difference did not reach statistical significance (\n                      <jats:italic>P<\/jats:italic>\n                      \u2009=\u20090.093). The percentages of patients with mucosal healing, clinical response, clinical remission and normalization of C-reactive protein (CRP) levels at one year were significantly greater in ulcerative patients in the familial group [17 (85%), 18 (90%), 18 (90%) and 18 (90%), respectively] than in ulcerative patients in the sporadic group [21 (53.8%), 19 (48.7%), 19 (48.7%) and 20 (51.3%), respectively], with p values of 0.018, 0.002, 0.002 and 0.003, respectively. However, there was no statistically significant difference between Crohn\u2019s disease patients of both groups regarding the outcome of the studied patients. A lower platelet count (\u2264\u2009324\u2009\u00d7\u200910\u00b3\/\u00b5L) and faecal calprotectin concentration (\u2264\u2009679\u00a0\u00b5g\/g) were significant predictors of mucosal healing in familial cases (\n                      <jats:italic>P<\/jats:italic>\n                      \u2009=\u20090.012,\n                      <jats:italic>P<\/jats:italic>\n                      \u2009=\u20090.008, respectively).\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion<\/jats:title>\n                    <jats:p>Familial IBD patients may present with a more severe initial inflammatory response but have better long-term treatment outcomes. These findings suggest that genetic and environmental influences play a role in IBD, highlighting the need for region-specific studies.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1186\/s12876-025-04492-9","type":"journal-article","created":{"date-parts":[[2025,12,15]],"date-time":"2025-12-15T11:27:27Z","timestamp":1765798047000},"update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Clinical characteristics of familial and sporadic inflammatory bowel disease in Egyptian patients"],"prefix":"10.1186","volume":"26","author":[{"given":"Abobakr K. 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Inflamm Bowel Dis. 2015;21(12):2825\u201332.","journal-title":"Inflamm Bowel Dis"}],"container-title":["BMC Gastroenterology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1186\/s12876-025-04492-9.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/article\/10.1186\/s12876-025-04492-9","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1186\/s12876-025-04492-9.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,1,20]],"date-time":"2026-01-20T13:00:47Z","timestamp":1768914047000},"score":1,"resource":{"primary":{"URL":"https:\/\/link.springer.com\/10.1186\/s12876-025-04492-9"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2025,12,15]]},"references-count":44,"journal-issue":{"issue":"1","published-online":{"date-parts":[[2026,12]]}},"alternative-id":["4492"],"URL":"https:\/\/doi.org\/10.1186\/s12876-025-04492-9","relation":{},"ISSN":["1471-230X"],"issn-type":[{"value":"1471-230X","type":"electronic"}],"subject":[],"published":{"date-parts":[[2025,12,15]]},"assertion":[{"value":"22 July 2025","order":1,"name":"received","label":"Received","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"18 November 2025","order":2,"name":"accepted","label":"Accepted","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"15 December 2025","order":3,"name":"first_online","label":"First Online","group":{"name":"ArticleHistory","label":"Article History"}},{"order":1,"name":"Ethics","group":{"name":"EthicsHeading","label":"Declarations"}},{"value":"Our study was approved by the Faculty of Medicine, Ain Shams University Research Ethics Committee, ensuring the preservation of patients\u2019 rights and privacy of their data. All patients signed an informed consent for participation in our study.","order":2,"name":"Ethics","group":{"name":"EthicsHeading","label":"Ethics approval and consent to participate"}},{"value":"Not applicable (no identifiable patient data\/images).","order":3,"name":"Ethics","group":{"name":"EthicsHeading","label":"Consent for publication"}},{"value":"The authors declare no competing interests.","order":4,"name":"Ethics","group":{"name":"EthicsHeading","label":"Competing interests"}}],"article-number":"43"}}