{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,16]],"date-time":"2026-09-16T00:28:19Z","timestamp":1789518499643,"version":"build-2803163510"},"reference-count":46,"publisher":"Springer Science and Business Media LLC","issue":"1","license":[{"start":{"date-parts":[[2026,2,26]],"date-time":"2026-02-26T00:00:00Z","timestamp":1772064000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0"},{"start":{"date-parts":[[2026,3,31]],"date-time":"2026-03-31T00:00:00Z","timestamp":1774915200000},"content-version":"vor","delay-in-days":33,"URL":"https:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0"}],"funder":[{"name":"Grant-in-Aid for Scientific Research from the Ministry of Education, Culture, Sports, Science and Technology of Japan","award":["Nos. 25K10147"],"award-info":[{"award-number":["Nos. 25K10147"]}]}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["BMC Gastroenterol"],"DOI":"10.1186\/s12876-025-04553-z","type":"journal-article","created":{"date-parts":[[2026,2,26]],"date-time":"2026-02-26T05:46:20Z","timestamp":1772084780000},"update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":3,"title":["Intrapancreatic fat deposition in the elderly: a retrospective cadaveric study with histopathological characterization"],"prefix":"10.1186","volume":"26","author":[{"given":"Ting","family":"Yang","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ke","family":"Ren","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xiangquan","family":"Chen","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Taku","family":"Toriumi","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Rujia","family":"Li","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jun","family":"Li","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yutaro","family":"Natsuyama","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Aoi","family":"Sukeda","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Toshitaka","family":"Nagao","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shuang-Qin","family":"Yi","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2026,2,26]]},"reference":[{"key":"4553_CR1","doi-asserted-by":"publisher","DOI":"10.1038\/nrgastro.2011.4","author":"MM Smits","year":"2011","unstructured":"Smits MM, van Geenen EJM. The clinical significance of pancreatic steatosis. Nat Rev Gastroenterol Hepatol. 2011. https:\/\/doi.org\/10.1038\/nrgastro.2011.4. 8:169\u2009\u2013\u200977.","journal-title":"Nat Rev Gastroenterol Hepatol"},{"key":"4553_CR2","doi-asserted-by":"publisher","first-page":"547","DOI":"10.1002\/path.1700920232","volume":"92","author":"MN Walters","year":"1966","unstructured":"Walters MN. Adipose atrophy of the exocrine pancreas. J Pathol. 1966;92:547\u201357. https:\/\/doi.org\/10.1002\/path.1700920232.","journal-title":"J Pathol"},{"key":"4553_CR3","doi-asserted-by":"publisher","first-page":"367","DOI":"10.1111\/j.1699-0463.1978.tb02058.x","volume":"86","author":"TS Olsen","year":"1978","unstructured":"Olsen TS. Lipomatosis of the pancreas in autopsy material and its relation to age and overweight. Acta Pathol Microbiol Scand A. 1978;86:367\u201373. https:\/\/doi.org\/10.1111\/j.1699-0463.1978.tb02058.x.","journal-title":"Acta Pathol Microbiol Scand A"},{"key":"4553_CR4","doi-asserted-by":"publisher","first-page":"45","DOI":"10.1016\/S0344-0338(81)80006-4","volume":"173","author":"P Schmitz-Moormann","year":"1981","unstructured":"Schmitz-Moormann P, Pittner PM, Heinze W. Lipomatosis of the pancreas. A morphometrical investigation. Pathol Res Pract. 1981;173:45\u201353. https:\/\/doi.org\/10.1016\/S0344-0338(81)80006-4.","journal-title":"Pathol Res Pract"},{"key":"4553_CR5","doi-asserted-by":"publisher","first-page":"677","DOI":"10.1016\/s0046-8177(84)80294-4","volume":"15","author":"BH Stamm","year":"1984","unstructured":"Stamm BH. Incidence and diagnostic significance of minor pathologic changes in the adult pancreas at autopsy: a systematic study of 112 autopsies in patients without known pancreatic disease. Hum Pathol. 1984;15:677\u201383. https:\/\/doi.org\/10.1016\/s0046-8177(84)80294-4.","journal-title":"Hum Pathol"},{"key":"4553_CR6","doi-asserted-by":"publisher","first-page":"671","DOI":"10.1016\/S2468-1253(23)00064-X","volume":"8","author":"MS Petrov","year":"2023","unstructured":"Petrov MS. Fatty change of the pancreas: the pandora\u2019s box of pancreatology. Lancet Gastroenterol Hepatol. 2023;8:671\u201382. https:\/\/doi.org\/10.1016\/S2468-1253(23)00064-X.","journal-title":"Lancet Gastroenterol Hepatol"},{"key":"4553_CR7","first-page":"584","volume":"37","author":"SA Wallace","year":"1942","unstructured":"Wallace SA, Ashworth CT. Early degenerative lesions of pancreas. Tex St J Med. 1942;37:584\u20137.","journal-title":"Tex St J Med"},{"key":"4553_CR8","doi-asserted-by":"publisher","first-page":"843","DOI":"10.2214\/ajr.135.4.843","volume":"135","author":"S Patel","year":"1980","unstructured":"Patel S, Bellon EM, Haaga J, Park CH. Fat replacement of the exocrine pancreas. AJR Am J Roentgenol. 1980;135:843\u20135. https:\/\/doi.org\/10.2214\/ajr.135.4.843.","journal-title":"AJR Am J Roentgenol"},{"key":"4553_CR9","first-page":"1243","volume":"99","author":"L Molnar","year":"1958","unstructured":"Molnar L, Kerekes E, Meszaros A. Significance of the fatty infiltration of the pancreas. Orv Hetil. 1958;99:1243\u20136.","journal-title":"Orv Hetil"},{"key":"4553_CR10","doi-asserted-by":"publisher","first-page":"444","DOI":"10.2337\/db06-0859","volume":"56","author":"H Raeder","year":"2007","unstructured":"Raeder H, Haldorsen IS, Ersland L, Gr\u00fcner R, Taxt T, S\u00f8vik O, et al. Pancreatic lipomatosis is a structural marker in nondiabetic children with mutations in carboxyl-ester lipase. Diabetes. 2007;56:444\u20139. https:\/\/doi.org\/10.2337\/db06-0859.","journal-title":"Diabetes"},{"key":"4553_CR11","doi-asserted-by":"publisher","DOI":"10.3389\/fmed.2023.1227188","volume":"10","author":"MA Mahyoub","year":"2023","unstructured":"Mahyoub MA, Elhoumed M, Maqul AH, Almezgagi M, Abbas M, Jiao Y, et al. Fatty infiltration of the pancreas: a systematic concept analysis. Front Med. 2023;10:1227188. https:\/\/doi.org\/10.3389\/fmed.2023.1227188.","journal-title":"Front Med"},{"key":"4553_CR12","doi-asserted-by":"publisher","first-page":"153","DOI":"10.1038\/s41575-021-00551-0","volume":"19","author":"MS Petrov","year":"2022","unstructured":"Petrov MS, Taylor R. Intra-pancreatic fat deposition: bringing hidden fat to the fore. Nat Rev Gastroenterol Hepatol. 2022;19:153\u201368. https:\/\/doi.org\/10.1038\/s41575-021-00551-0.","journal-title":"Nat Rev Gastroenterol Hepatol"},{"key":"4553_CR13","doi-asserted-by":"publisher","first-page":"117","DOI":"10.1111\/j.1530-0277.1982.tb05389.x","volume":"6","author":"JS Wilson","year":"1982","unstructured":"Wilson JS, Colley PW, Sosula L, Pirola RC, Chapman BA, Somer JB. Alcohol causes a fatty pancreas. A rat model of ethanol-induced pancreatic steatosis. Alcohol Clin Exp Res. 1982;6:117\u201321. https:\/\/doi.org\/10.1111\/j.1530-0277.1982.tb05389.x.","journal-title":"Alcohol Clin Exp Res"},{"key":"4553_CR14","doi-asserted-by":"publisher","DOI":"10.1590\/s0004-2803.202000000-27","volume":"57","author":"J Paul","year":"2020","unstructured":"Paul J, Shihaz AVH. Pancreatic steatosis: a new diagnosis and therapeutic challenge in gastroenterology. Arq Gastroenterol. 2020;57:216\u2009\u2212\u200920. https:\/\/doi.org\/10.1590\/s0004-2803.202000000-27.","journal-title":"Arq Gastroenterol"},{"key":"4553_CR15","doi-asserted-by":"publisher","first-page":"312","DOI":"10.1080\/13651820701504157","volume":"9","author":"A Mathur","year":"2007","unstructured":"Mathur A, Marine M, Lu D, Swartz-Basile DA, Saxena R, Zyromski NJ, et al. Nonalcoholic fatty pancreas disease. HPB (Oxford). 2007;9:312\u20138. https:\/\/doi.org\/10.1080\/13651820701504157.","journal-title":"HPB (Oxford)"},{"key":"4553_CR16","doi-asserted-by":"publisher","first-page":"392","DOI":"10.1097\/MPA.0b013e3181bd2923","volume":"39","author":"D Altinel","year":"2010","unstructured":"Altinel D, Basturk O, Sarmiento JM, Martin D, Jacobs MJ, Kooby DA, et al. Lipomatous pseudohypertrophy of the pancreas: a clinicopathologically distinct entity. Pancreas. 2010;39:392\u20137. https:\/\/doi.org\/10.1097\/MPA.0b013e3181bd2923.","journal-title":"Pancreas"},{"key":"4553_CR17","doi-asserted-by":"publisher","first-page":"1185","DOI":"10.1097\/MPA.0b013e3181f6fce2","volume":"39","author":"EJM van Geenen","year":"2010","unstructured":"van Geenen EJM, Smits MM, Schreuder TCMA, van der Peet DL, Bloemena E, Mulder CJ. Nonalcoholic fatty liver disease is related to nonalcoholic fatty pancreas disease. Pancreas. 2010;39:1185\u201390. https:\/\/doi.org\/10.1097\/MPA.0b013e3181f6fce2.","journal-title":"Pancreas"},{"key":"4553_CR18","doi-asserted-by":"publisher","DOI":"10.1038\/ctg.2014.5","volume":"5","author":"M Hori","year":"2014","unstructured":"Hori M, Takahashi M, Hiraoka N, Yamaji T, Mutoh M, Ishigamori R, et al. Association of pancreatic fatty infiltration with pancreatic ductal adenocarcinoma. Clin Transl Gastroenterol. 2014;5:e53. https:\/\/doi.org\/10.1038\/ctg.2014.5.","journal-title":"Clin Transl Gastroenterol"},{"key":"4553_CR19","doi-asserted-by":"publisher","first-page":"3013","DOI":"10.1111\/cas.13766","volume":"109","author":"M Takahashi","year":"2018","unstructured":"Takahashi M, Hori M, Ishigamori R, Mutoh M, Imai T, Nakagama H. Fatty pancreas: a possible risk factor for pancreatic cancer in animals and humans. Cancer Sci. 2018;109:3013\u201323. https:\/\/doi.org\/10.1111\/cas.13766.","journal-title":"Cancer Sci"},{"key":"4553_CR20","doi-asserted-by":"publisher","first-page":"987","DOI":"10.1016\/j.gie.2011.01.015","volume":"73","author":"PS Sepe","year":"2011","unstructured":"Sepe PS, Ohri A, Sanaka S, Berzin TM, Sekhon S, Bennett G, et al. A prospective evaluation of fatty pancreas by using EUS. Gastrointest Endosc. 2011;73:987\u201393. https:\/\/doi.org\/10.1016\/j.gie.2011.01.015.","journal-title":"Gastrointest Endosc"},{"key":"4553_CR21","doi-asserted-by":"publisher","first-page":"140","DOI":"10.1148\/radiol.2015142254","volume":"279","author":"JH Yoon","year":"2016","unstructured":"Yoon JH, Lee JM, Lee KB, Kim SW, Kang MJ, Jang JY, et al. Pancreatic steatosis and fibrosis: quantitative assessment with preoperative multiparametric MR imaging. Radiology. 2016;279:140\u201350. https:\/\/doi.org\/10.1148\/radiol.2015142254.","journal-title":"Radiology"},{"key":"4553_CR22","doi-asserted-by":"publisher","first-page":"1","DOI":"10.1016\/j.metabol.2016.12.012","volume":"69","author":"RG Singh","year":"2017","unstructured":"Singh RG, Yoon HD, Wu LM, Lu J, Plank LD, Petrov MS. Ectopic fat accumulation in the pancreas and its clinical relevance: a systematic review, meta-analysis, and meta-regression. Metabolism. 2017;69:1\u201313. https:\/\/doi.org\/10.1016\/j.metabol.2016.12.012.","journal-title":"Metabolism"},{"key":"4553_CR23","doi-asserted-by":"publisher","DOI":"10.1097\/MD.0000000000027487","volume":"100","author":"K Okada","year":"2021","unstructured":"Okada K, Watahiki T, Horie K, Takayama T, Aida Y, To K, et al. The prevalence and clinical implications of pancreatic fat accumulation identified during a medical check-up. Medicine (Baltimore). 2021;100:e27487. https:\/\/doi.org\/10.1097\/MD.0000000000027487.","journal-title":"Medicine (Baltimore)"},{"key":"4553_CR24","doi-asserted-by":"publisher","first-page":"362","DOI":"10.1016\/j.jped.2024.09.007","volume":"101","author":"G Alberti","year":"2025","unstructured":"Alberti G, Cantillo T, Pereira A, De Barbieri F, Garc\u00eda C, Villarroel L, et al. Prevalence of fatty pancreas and its relation with anthropometric values on the Growth and Obesity Cohort Study. J Pediatr (Rio J). 2025;101:362\u20139. https:\/\/doi.org\/10.1016\/j.jped.2024.09.007.","journal-title":"J Pediatr (Rio J)"},{"issue":"1","key":"4553_CR25","doi-asserted-by":"publisher","first-page":"74","DOI":"10.1186\/s12902-025-01900-9","volume":"25","author":"W Mi","year":"2025","unstructured":"Mi W, Zhang Y, Wang Q, Ding W, Mao X, Sun Y, Li X, Liu C, Xu S. Triglyceride-glucose index is independently associated with fatty pancreas disease in Chinese elderly. BMC Endocr Disord. 2025;25(1):74. https:\/\/doi.org\/10.1186\/s12902-025-01900-9.","journal-title":"BMC Endocr Disord"},{"key":"4553_CR26","doi-asserted-by":"publisher","first-page":"3251","DOI":"10.1210\/jc.2017-00828","volume":"102","author":"R Murakami","year":"2017","unstructured":"Murakami R, Saisho Y, Watanabe Y, Inaishi J, Tsuchiya T, Kou K, et al. Pancreas fat and \u03b2 cell mass in humans with and without diabetes: an analysis in the Japanese population. J Clin Endocrinol Metab. 2017;102:3251\u201360. https:\/\/doi.org\/10.1210\/jc.2017-00828.","journal-title":"J Clin Endocrinol Metab"},{"key":"4553_CR27","doi-asserted-by":"publisher","DOI":"10.1016\/j.aanat.2020.151481","volume":"229","author":"Y Dai","year":"2020","unstructured":"Dai Y, Kurosawa K, Ren K, Miwa Y, Sato I, Liu T, et al. Morphogenesis of the ventralpancreas anlagen is influenced by the SMA branching pattern. Annals of Anatomy - Anatomischer Anzeiger. 2020;229:151481. https:\/\/doi.org\/10.1016\/j.aanat.2020.151481.","journal-title":"Annals of Anatomy - Anatomischer Anzeiger"},{"key":"4553_CR28","doi-asserted-by":"publisher","first-page":"1039","DOI":"10.1016\/j.dld.2023.11.031","volume":"56","author":"R Li","year":"2024","unstructured":"Li R, Yang T, Zhang M, Ren K, Li J, Sato I, et al. A new histopathological phenomenon: pancreatic islet cell loss in the elderly population. Dig Liver Dis. 2024;56:1039\u201345. https:\/\/doi.org\/10.1016\/j.dld.2023.11.031.","journal-title":"Dig Liver Dis"},{"key":"4553_CR29","doi-asserted-by":"publisher","first-page":"450","DOI":"10.1111\/pin.12837","volume":"69","author":"Y Matsuda","year":"2019","unstructured":"Matsuda Y. Age-related morphological changes in the pancreas and their association with pancreatic carcinogenesis. Pathol Int. 2019;69:450\u201362. https:\/\/doi.org\/10.1111\/pin.12837.","journal-title":"Pathol Int"},{"key":"4553_CR30","doi-asserted-by":"publisher","first-page":"686","DOI":"10.1016\/S0016-5085(62)80120-6","volume":"42","author":"DA Dreiling","year":"1962","unstructured":"Dreiling DA, Elsbach P, Schaffner F, Schwartz IL. The effect of restriction of protein and total calories on pancreatic function in obese patients. Gastroenterology. 1962;42:686\u201390. https:\/\/doi.org\/10.1016\/S0016-5085(62)80120-6.","journal-title":"Gastroenterology"},{"key":"4553_CR31","doi-asserted-by":"publisher","first-page":"522","DOI":"10.1038\/oby.2007.110","volume":"16","author":"KE Pinnick","year":"2008","unstructured":"Pinnick KE, Collins SC, Londos C, Gauguier D, Clark A, Fielding B. Pancreatic ectopic fat is characterized by adipocyte infiltration and altered lipid composition. Obesity. 2008;16:522\u201330. https:\/\/doi.org\/10.1038\/oby.2007.110.","journal-title":"Obesity"},{"key":"4553_CR32","doi-asserted-by":"publisher","first-page":"3522","DOI":"10.1158\/1078-0432.CCR-14-2385","volume":"21","author":"V Rebours","year":"2015","unstructured":"Rebours V, Gaujoux S, d\u2019Assignies G, Sauvanet A, Ruszniewski P, L\u00e9vy P, et al. Obesity and fatty pancreatic infiltration are risk factors for pancreatic precancerous lesions (PanIN). Clin Cancer Res. 2015;21:3522\u20138. https:\/\/doi.org\/10.1158\/1078-0432.CCR-14-2385.","journal-title":"Clin Cancer Res"},{"key":"4553_CR33","doi-asserted-by":"publisher","first-page":"313","DOI":"10.1002\/jmri.21010","volume":"26","author":"JK Kim","year":"2007","unstructured":"Kim JK, Altun E, Elias J Jr, Pamuklar E, Rivero H, et al. Focal pancreatic mass: distinction of pancreatic cancer from chronic pancreatitis using gadolinium-enhanced 3D-gradient-echo MRI. J Magn Reson Imaging. 2007;26:313\u201322. https:\/\/doi.org\/10.1002\/jmri.21010.","journal-title":"J Magn Reson Imaging"},{"key":"4553_CR34","doi-asserted-by":"publisher","first-page":"7215","DOI":"10.1007\/s00330-023-09630-z","volume":"33","author":"A Meloni","year":"2023","unstructured":"Meloni A, Nobile M, Keilberg P, Positano V, Santarelli MF, Pistoia L, et al. Pancreatic fatty replacement as risk marker for altered glucose metabolism and cardiac iron and complications in thalassemia major. Eur Radiol. 2023;33:7215\u201325. https:\/\/doi.org\/10.1007\/s00330-023-09630-z.","journal-title":"Eur Radiol"},{"key":"4553_CR35","doi-asserted-by":"publisher","DOI":"10.6061\/clinics\/2021\/e2439","volume":"76","author":"LLSE Silva","year":"2021","unstructured":"Silva LLSE, Fernandes MSS, Lima EA, Stefano JT, Oliveira CP, Jukemura J. Fatty pancreas: disease or finding? Clinics (Sao Paulo). 2021;76:e2439. https:\/\/doi.org\/10.6061\/clinics\/2021\/e2439.","journal-title":"Clinics (Sao Paulo)"},{"key":"4553_CR36","doi-asserted-by":"publisher","DOI":"10.5334\/jbr-btr.1014","volume":"100","author":"B Coulier","year":"2016","unstructured":"Coulier B. Pancreatic lipomatosis: an extensive pictorial review. J Belg Soc Radiol. 2016;100:39. https:\/\/doi.org\/10.5334\/jbr-btr.1014.","journal-title":"J Belg Soc Radiol"},{"key":"4553_CR37","doi-asserted-by":"publisher","first-page":"453","DOI":"10.1148\/radiology.194.2.7824726","volume":"194","author":"S Matsumoto","year":"1995","unstructured":"Matsumoto S, Mori H, Miyake H, Takaki H, Maeda T, Yamada Y, et al. Uneven fatty replacement of the pancreas: evaluation with CT. Radiology. 1995;194:453\u20138. https:\/\/doi.org\/10.1148\/radiology.194.2.7824726.","journal-title":"Radiology"},{"key":"4553_CR38","doi-asserted-by":"publisher","first-page":"583","DOI":"10.1111\/j.1440-1827.1981.tb02755.x","volume":"31","author":"K Suda","year":"1981","unstructured":"Suda K, Mizuguchi K, Hoshino A. Differences of the ventral and dorsal anlagen of pancreas after fusion. Acta Pathol Jpn. 1981;31:583\u20139. https:\/\/doi.org\/10.1111\/j.1440-1827.1981.tb02755.x.","journal-title":"Acta Pathol Jpn"},{"key":"4553_CR39","doi-asserted-by":"publisher","first-page":"45","DOI":"10.1002\/jcu.20632","volume":"38","author":"DM Yang","year":"2010","unstructured":"Yang DM, Kim HY, Ryu JK, Joo KR, Ahn KJ. Sonographic appearance of focal fatty infiltration of the pancreas. J Clin Ultrasound. 2010;38:45\u20137. https:\/\/doi.org\/10.1002\/jcu.20632.","journal-title":"J Clin Ultrasound"},{"key":"4553_CR40","doi-asserted-by":"publisher","first-page":"1095","DOI":"10.2214\/ajr.139.6.1095","volume":"139","author":"NJ Worthen","year":"1982","unstructured":"Worthen NJ, Beabeau D. Normal pancreatic echogenicity: relation to age and body fat. AJR Am J Roentgenol. 1982;139:1095\u20138. https:\/\/doi.org\/10.2214\/ajr.139.6.1095.","journal-title":"AJR Am J Roentgenol"},{"key":"4553_CR41","doi-asserted-by":"publisher","first-page":"93","DOI":"10.1159\/000022141","volume":"46","author":"J Glaser","year":"2000","unstructured":"Glaser J, Stienecker K. Pancreas and aging: a study using ultrasonography. Gerontology. 2000;46:93\u20136. https:\/\/doi.org\/10.1159\/000022141.","journal-title":"Gerontology"},{"key":"4553_CR42","doi-asserted-by":"publisher","first-page":"2093","DOI":"10.1016\/j.ejrad.2011.07.014","volume":"81","author":"T Sato","year":"2012","unstructured":"Sato T, Ito K, Tamada T, Sone T, Noda Y, Higaki A, et al. Age-related changes in normal adult pancreas: MR imaging evaluation. Eur J Radiol. 2012;81:2093\u20138. https:\/\/doi.org\/10.1016\/j.ejrad.2011.07.014.","journal-title":"Eur J Radiol"},{"issue":"28","key":"4553_CR43","doi-asserted-by":"publisher","DOI":"10.1097\/MD.0000000000003858","volume":"95","author":"Z Dong","year":"2016","unstructured":"Dong Z, Luo Y, Cai H, Zhang Z, Peng Z, Jiang M, et al. Noninvasive fat quantification of the liver and pancreas may provide potential biomarkers of impaired glucose tolerance and type 2 diabetes. Medicine (Baltimore). 2016;95(28):e0916. https:\/\/doi.org\/10.1097\/MD.0000000000003858.","journal-title":"Medicine (Baltimore)"},{"issue":"1","key":"4553_CR44","doi-asserted-by":"publisher","DOI":"10.1038\/s41598-024-57294-6","volume":"14","author":"S Frendi","year":"2024","unstructured":"Frendi S, Martineau C, Cazier H, Nicolle R, Chassac A, Albuquerque M, et al. Role of the fatty pancreatic infiltration in pancreatic oncogenesis. Sci Rep. 2024;14(1):6582. https:\/\/doi.org\/10.1038\/s41598-024-57294-6.","journal-title":"Sci Rep"},{"key":"4553_CR45","doi-asserted-by":"publisher","first-page":"3369","DOI":"10.1158\/1078-0432.CCR-15-0718","volume":"21","author":"H Wang","year":"2015","unstructured":"Wang H, Maitra A, Wang H. Obesity, intrapancreatic fatty infiltration, and pancreatic cancer. Clin Cancer Res. 2015;21:3369\u201371. https:\/\/doi.org\/10.1158\/1078-0432.CCR-15-0718.","journal-title":"Clin Cancer Res"},{"key":"4553_CR46","doi-asserted-by":"publisher","first-page":"1243983","DOI":"10.3389\/fphys.2023.1243983","volume":"14","author":"N Otsuka","year":"2023","unstructured":"Otsuka N, Shimizu K, Taniai M, Tokushige K. Risk factors for fatty pancreas and effects of fatty infiltration on pancreatic cancer. Front Physiol. 2023;14:1243983. https:\/\/doi.org\/10.3389\/fphys.2023.1243983.","journal-title":"Front Physiol"}],"container-title":["BMC Gastroenterology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/link.springer.com\/article\/10.1186\/s12876-025-04553-z","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1186\/s12876-025-04553-z.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1186\/s12876-025-04553-z.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,3,31]],"date-time":"2026-03-31T16:00:59Z","timestamp":1774972859000},"score":1,"resource":{"primary":{"URL":"https:\/\/link.springer.com\/10.1186\/s12876-025-04553-z"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,2,26]]},"references-count":46,"journal-issue":{"issue":"1","published-online":{"date-parts":[[2026,12]]}},"alternative-id":["4553"],"URL":"https:\/\/doi.org\/10.1186\/s12876-025-04553-z","relation":{},"ISSN":["1471-230X"],"issn-type":[{"value":"1471-230X","type":"electronic"}],"subject":[],"published":{"date-parts":[[2026,2,26]]},"assertion":[{"value":"30 August 2025","order":1,"name":"received","label":"Received","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"5 December 2025","order":2,"name":"accepted","label":"Accepted","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"26 February 2026","order":3,"name":"first_online","label":"First Online","group":{"name":"ArticleHistory","label":"Article History"}},{"order":1,"name":"Ethics","group":{"name":"EthicsHeading","label":"Declarations"}},{"value":"All procedures were approved by the study security ethics committees of Tokyo Metropolitan University (No.18051), Nippon Dental University in Tokyo (NDU-T-2016-29), and Niigata (No. 23823). This study was performed in accordance with the institutional guidelines.","order":2,"name":"Ethics","group":{"name":"EthicsHeading","label":"Consent for publication"}},{"value":"The authors declare no competing interests.","order":3,"name":"Ethics","group":{"name":"EthicsHeading","label":"Competing interests"}}],"article-number":"201"}}