{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,11,12]],"date-time":"2026-11-12T01:28:59Z","timestamp":1794446939901,"version":"4.9.1"},"reference-count":28,"publisher":"Springer Science and Business Media LLC","issue":"1","license":[{"start":{"date-parts":[[2025,12,30]],"date-time":"2025-12-30T00:00:00Z","timestamp":1767052800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0"},{"start":{"date-parts":[[2026,1,30]],"date-time":"2026-01-30T00:00:00Z","timestamp":1769731200000},"content-version":"vor","delay-in-days":31,"URL":"https:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0"}],"funder":[{"DOI":"10.13039\/501100007129","name":"Natural Science Foundation of Shandong Province","doi-asserted-by":"publisher","award":["ZR2024QC313"],"award-info":[{"award-number":["ZR2024QC313"]}],"id":[{"id":"10.13039\/501100007129","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["BMC Gastroenterol"],"DOI":"10.1186\/s12876-025-04573-9","type":"journal-article","created":{"date-parts":[[2025,12,30]],"date-time":"2025-12-30T08:15:34Z","timestamp":1767082534000},"update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":2,"title":["Elevated serum lipoprotein(a) as a prognostic marker for reduced survival in pancreatic cancer"],"prefix":"10.1186","volume":"26","author":[{"given":"Jinyue","family":"Liu","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yueping","family":"Jiang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yueyi","family":"Xing","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shijin","family":"Wang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Beibei","family":"Ma","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mengdi","family":"Guo","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xue","family":"Jing","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Libin","family":"Liu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2025,12,30]]},"reference":[{"issue":"10485","key":"4573_CR1","doi-asserted-by":"publisher","first-page":"1182","DOI":"10.1016\/S0140-6736(25)00261-2","volume":"405","author":"TF Stoop","year":"2025","unstructured":"Stoop TF, Javed AA, Oba A, Koerkamp BG, Seufferlein T, Wilmink JW, Besselink MG. Pancreatic cancer. Lancet. 2025;405(10485):1182\u2013202.","journal-title":"Lancet"},{"issue":"1","key":"4573_CR2","first-page":"17","volume":"73","author":"RL Siegel","year":"2023","unstructured":"Siegel RL, Miller KD, Wagle NS, Jemal A. Cancer statistics, 2023. CA Cancer J Clin. 2023;73(1):17\u201348.","journal-title":"CA Cancer J Clin"},{"issue":"7","key":"4573_CR3","doi-asserted-by":"publisher","first-page":"493","DOI":"10.1038\/s41575-021-00457-x","volume":"18","author":"AP Klein","year":"2021","unstructured":"Klein AP. Pancreatic cancer epidemiology: Understanding the role of lifestyle and inherited risk factors. Nat Rev Gastroenterol Hepatol. 2021;18(7):493\u2013502.","journal-title":"Nat Rev Gastroenterol Hepatol"},{"issue":"20","key":"4573_CR4","doi-asserted-by":"publisher","first-page":"1553","DOI":"10.1093\/eurheartj\/ehx033","volume":"38","author":"B Gencer","year":"2017","unstructured":"Gencer B, Kronenberg F, Stroes ES, Mach F. Lipoprotein(a): the revenant. Eur Heart J. 2017;38(20):1553\u201360.","journal-title":"Eur Heart J"},{"issue":"1","key":"4573_CR5","doi-asserted-by":"publisher","first-page":"154","DOI":"10.1093\/clinchem\/hvaa247","volume":"67","author":"PR Kamstrup","year":"2021","unstructured":"Kamstrup PR. Lipoprotein(a) and cardiovascular disease. Clin Chem. 2021;67(1):154\u201366.","journal-title":"Clin Chem"},{"key":"4573_CR6","doi-asserted-by":"publisher","first-page":"4","DOI":"10.1186\/1476-511X-5-4","volume":"5","author":"J Jiang","year":"2006","unstructured":"Jiang J, Nilsson-Ehle P, Xu N. Influence of liver cancer on lipid and lipoprotein metabolism. Lipids Health Dis. 2006;5:4.","journal-title":"Lipids Health Dis"},{"issue":"1","key":"4573_CR7","doi-asserted-by":"publisher","first-page":"1049","DOI":"10.1186\/s12885-022-10120-6","volume":"22","author":"E Wong Chong","year":"2022","unstructured":"Wong Chong E, Joncas FH, Seidah NG, Calon F, Diorio C, Gangloff A. Circulating levels of PCSK9, ANGPTL3 and Lp(a) in stage III breast cancers. BMC Cancer. 2022;22(1):1049.","journal-title":"BMC Cancer"},{"issue":"4","key":"4573_CR8","doi-asserted-by":"publisher","first-page":"452","DOI":"10.1515\/CCLM.2009.094","volume":"47","author":"HH Yang","year":"2009","unstructured":"Yang HH, Chen XF, Hu W, Lv DQ, Ding WJ, Tang LJ, Jiang JJ, Ye MH. Lipoprotein(a) level and its association with tumor stage in male patients with primary lung cancer. Clin Chem Lab Med. 2009;47(4):452\u20137.","journal-title":"Clin Chem Lab Med"},{"key":"4573_CR9","doi-asserted-by":"publisher","first-page":"9483935","DOI":"10.1155\/2019\/9483935","volume":"2019","author":"FM Wang","year":"2019","unstructured":"Wang FM, Zhang Y. High Lipoprotein(a) level is independently associated with adverse clinicopathological features in patients with prostate cancer. Dis Markers. 2019;2019:9483935.","journal-title":"Dis Markers"},{"key":"4573_CR10","doi-asserted-by":"publisher","first-page":"1181508","DOI":"10.3389\/fonc.2023.1181508","volume":"13","author":"H Wang","year":"2023","unstructured":"Wang H, Zheng H, Meng P, Cao X, Liu J, Zhang T, Zuo H, Wang Z. Relationship between lipoprotein(a) and colorectal cancer among inpatients: a retrospective study. Front Oncol. 2023;13:1181508.","journal-title":"Front Oncol"},{"key":"4573_CR11","doi-asserted-by":"publisher","first-page":"104858","DOI":"10.1016\/j.phrs.2020.104858","volume":"158","author":"V Kalaivani","year":"2020","unstructured":"Kalaivani V, Jaleel A. Apolipoprotein(a), an enigmatic anti-angiogenic glycoprotein in human plasma: A curse or cure? Pharmacol Res. 2020;158:104858.","journal-title":"Pharmacol Res"},{"issue":"30","key":"4573_CR12","doi-asserted-by":"publisher","first-page":"30251","DOI":"10.18632\/oncotarget.4943","volume":"6","author":"G Yao","year":"2015","unstructured":"Yao G, Zhang Q, Doeppner TR, Niu F, Li Q, Yang Y, Kuckelkorn U, Hagemann N, Li W, Hermann DM, Dai Y, Zhou W, Jin F. LDL suppresses angiogenesis through disruption of the HIF pathway via NF-\u03baB Inhibition which is reversed by the proteasome inhibitor BSc2118. Oncotarget. 2015;6(30):30251\u201362.","journal-title":"Oncotarget"},{"issue":"5","key":"4573_CR13","doi-asserted-by":"publisher","first-page":"427","DOI":"10.1016\/j.ctrv.2007.02.006","volume":"33","author":"G Lippi","year":"2007","unstructured":"Lippi G, Franchini M, Salvagno GL, Guidi GC. Lipoprotein[a] and cancer: anti-neoplastic effect besides its cardiovascular potency. Cancer Treat Rev. 2007;33(5):427\u201336.","journal-title":"Cancer Treat Rev"},{"issue":"21","key":"4573_CR14","doi-asserted-by":"publisher","first-page":"7252","DOI":"10.1158\/1078-0432.CCR-04-0713","volume":"10","author":"RL Camp","year":"2004","unstructured":"Camp RL, Dolled-Filhart M, Rimm DL. X-tile: a new bio-informatics tool for biomarker assessment and outcome-based cut-point optimization. Clin Cancer Res. 2004;10(21):7252\u20139.","journal-title":"Clin Cancer Res"},{"issue":"1","key":"4573_CR15","doi-asserted-by":"publisher","first-page":"e20201606","DOI":"10.1084\/jem.20201606","volume":"218","author":"X Bian","year":"2021","unstructured":"Bian X, Liu R, Meng Y, Xing D, Xu D, Lu Z. Lipid metabolism and cancer. J Exp Med. 2021;218(1):e20201606.","journal-title":"J Exp Med"},{"issue":"8","key":"4573_CR16","doi-asserted-by":"publisher","first-page":"1339","DOI":"10.1194\/jlr.R067314","volume":"57","author":"K Schmidt","year":"2016","unstructured":"Schmidt K, Noureen A, Kronenberg F, Utermann G. Structure, function, and genetics of lipoprotein (a). J Lipid Res. 2016;57(8):1339\u201359.","journal-title":"J Lipid Res"},{"issue":"6144","key":"4573_CR17","doi-asserted-by":"publisher","first-page":"132","DOI":"10.1038\/330132a0","volume":"330","author":"JW McLean","year":"1987","unstructured":"McLean JW, Tomlinson JE, Kuang WJ, Eaton DL, Chen EY, Fless GM, Scanu AM, Lawn RM. cDNA sequence of human apolipoprotein(a) is homologous to plasminogen. Nature. 1987;330(6144):132\u20137.","journal-title":"Nature"},{"issue":"26","key":"4573_CR18","doi-asserted-by":"publisher","first-page":"23260","DOI":"10.1074\/jbc.M302780200","volume":"278","author":"MA Hancock","year":"2003","unstructured":"Hancock MA, Boffa MB, Marcovina SM, Nesheim ME, Koschinsky ML. Inhibition of plasminogen activation by lipoprotein(a): critical domains in apolipoprotein(a) and mechanism of Inhibition on fibrin and degraded fibrin surfaces. J Biol Chem. 2003;278(26):23260\u20139.","journal-title":"J Biol Chem"},{"key":"4573_CR19","doi-asserted-by":"publisher","first-page":"105689","DOI":"10.1016\/j.phrs.2021.105689","volume":"169","author":"G Reyes-Soffer","year":"2021","unstructured":"Reyes-Soffer G, Westerterp M. Beyond Lipoprotein(a) plasma measurements: Lipoprotein(a) and inflammation. Pharmacol Res. 2021;169:105689.","journal-title":"Pharmacol Res"},{"issue":"22","key":"4573_CR20","doi-asserted-by":"publisher","first-page":"3698","DOI":"10.3390\/cells11223698","volume":"11","author":"M Ra\u0161kov\u00e1","year":"2022","unstructured":"Ra\u0161kov\u00e1 M, Lacina L, Kej\u00edk Z, Venhauerov\u00e1 A, Skali\u010dkov\u00e1 M, Kol\u00e1\u0159 M, Jakubek M, Rosel D, Smetana K Jr. The role of IL-6 in cancer cell invasiveness and Metastasis-Overview and therapeutic opportunities. Cells. 2022;11(22):3698.","journal-title":"Cells"},{"issue":"9","key":"4573_CR21","first-page":"1614","volume":"61","author":"P Peker","year":"2025","unstructured":"Peker P, Ge\u00e7gel A, \u00d6zkan O, G\u00f6kmen I, Menekse S, Du\u015fgun A, Duman BB, \u00c7il T. Systemic Immune-Inflammation index as a prognostic marker in gastric and gastroesophageal junction cancers receiving perioperative FLOT therapy. Med (Kaunas). 2025;61(9):1614.","journal-title":"Med (Kaunas)"},{"issue":"2","key":"4573_CR22","first-page":"133","volume":"14","author":"E K\u00f6ko\u011flu","year":"1994","unstructured":"K\u00f6ko\u011flu E, Karaarslan I, Karaarslan HM, Balo\u011flu H. Elevated serum Lp(a) levels in the early and advanced stages of breast cancer. Cancer Biochem Biophys. 1994;14(2):133\u20136.","journal-title":"Cancer Biochem Biophys"},{"issue":"1","key":"4573_CR23","doi-asserted-by":"publisher","first-page":"e1003859","DOI":"10.1371\/journal.pmed.1003859","volume":"19","author":"A Ioannidou","year":"2022","unstructured":"Ioannidou A, Watts EL, Perez-Cornago A, Platz EA, Mills IG, Key TJ, Travis RC, PRACTICAL consortium CRUK, BPC3, Tsilidis CAPSPEGASUS, Zuber KK. The relationship between lipoprotein A and other lipids with prostate cancer risk: A multivariable Mendelian randomisation study. PLoS Med. 2022;19(1):e1003859.","journal-title":"PLoS Med"},{"issue":"1","key":"4573_CR24","doi-asserted-by":"publisher","first-page":"218","DOI":"10.1186\/s12916-017-0976-4","volume":"15","author":"VA Katzke","year":"2017","unstructured":"Katzke VA, Sookthai D, Johnson T, K\u00fchn T, Kaaks R. Blood lipids and lipoproteins in relation to incidence and mortality risks for CVD and cancer in the prospective EPIC-Heidelberg cohort. BMC Med. 2017;15(1):218.","journal-title":"BMC Med"},{"key":"4573_CR25","doi-asserted-by":"publisher","first-page":"1","DOI":"10.2147\/CLEP.S437456","volume":"16","author":"Y Zhang","year":"2024","unstructured":"Zhang Y, Wang W, Xu L, Lian Z, Huang J, Chang Y, Guo J, Wang Y, Song K, Ji H. Inflammation-Dependent association of lipoprotein (a) with cardiovascular and cancer mortality. Clin Epidemiol. 2024;16:1\u20134.","journal-title":"Clin Epidemiol"},{"issue":"4","key":"4573_CR26","doi-asserted-by":"publisher","first-page":"e31954","DOI":"10.1371\/journal.pone.0031954","volume":"7","author":"M Sawabe","year":"2012","unstructured":"Sawabe M, Tanaka N, Mieno MN, Ishikawa S, Kayaba K, Nakahara K, Matsushita S, JMS Cohort Study Group. Low lipoprotein(a) concentration is associated with cancer and all-cause deaths: a population-based cohort study (the JMS cohort study). PLoS ONE. 2012;7(4):e31954.","journal-title":"PLoS ONE"},{"issue":"11","key":"4573_CR27","doi-asserted-by":"publisher","first-page":"e7331","DOI":"10.1002\/cam4.7331","volume":"13","author":"S Fan","year":"2024","unstructured":"Fan S, Mao Y, Ge Y, Liang Z. Association of preoperative elevated lipoprotein (a) with poor survival in patients with biliary tract cancers. Cancer Med. 2024;13(11):e7331.","journal-title":"Cancer Med"},{"key":"4573_CR28","doi-asserted-by":"crossref","unstructured":"Liu C, Xiao Z, Liu Z, Huang X. Correlation between Lipoprotein(a) and endometrial cancer prognosis: a retrospective cohort study. Clin Lab. 2025;71(10):10.7754.","DOI":"10.7754\/Clin.Lab.2025.250239"}],"container-title":["BMC Gastroenterology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/link.springer.com\/article\/10.1186\/s12876-025-04573-9","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1186\/s12876-025-04573-9.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1186\/s12876-025-04573-9.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,1,30]],"date-time":"2026-01-30T14:31:25Z","timestamp":1769783485000},"score":1,"resource":{"primary":{"URL":"https:\/\/link.springer.com\/10.1186\/s12876-025-04573-9"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2025,12,30]]},"references-count":28,"journal-issue":{"issue":"1","published-online":{"date-parts":[[2026,12]]}},"alternative-id":["4573"],"URL":"https:\/\/doi.org\/10.1186\/s12876-025-04573-9","relation":{},"ISSN":["1471-230X"],"issn-type":[{"value":"1471-230X","type":"electronic"}],"subject":[],"published":{"date-parts":[[2025,12,30]]},"assertion":[{"value":"11 September 2025","order":1,"name":"received","label":"Received","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"19 December 2025","order":2,"name":"accepted","label":"Accepted","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"30 December 2025","order":3,"name":"first_online","label":"First Online","group":{"name":"ArticleHistory","label":"Article History"}},{"order":1,"name":"Ethics","group":{"name":"EthicsHeading","label":"Declarations"}},{"value":"The ethical standards and regulations outlined in the Declaration of Helsinki guided the research. The study received approval from the Ethics Committee of the Affiliated Hospital of Qingdao University (QYFY WZLL 28521). All enrolled patients provided informed consent for the procedure. The need for additional informed consent specifically for this study was waived due to the general consent for retrospective studies on participating hospital in-patient consent forms.","order":2,"name":"Ethics","group":{"name":"EthicsHeading","label":"Ethics approval and consent to participate"}},{"value":"Not applicable.","order":3,"name":"Ethics","group":{"name":"EthicsHeading","label":"Consent for publication"}},{"value":"The authors declare no competing interests.","order":4,"name":"Ethics","group":{"name":"EthicsHeading","label":"Competing interests"}}],"article-number":"81"}}