{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,4,28]],"date-time":"2026-04-28T00:40:57Z","timestamp":1777336857762,"version":"3.51.4"},"reference-count":45,"publisher":"Springer Science and Business Media LLC","issue":"1","license":[{"start":{"date-parts":[[2026,3,19]],"date-time":"2026-03-19T00:00:00Z","timestamp":1773878400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0"},{"start":{"date-parts":[[2026,4,28]],"date-time":"2026-04-28T00:00:00Z","timestamp":1777334400000},"content-version":"vor","delay-in-days":40,"URL":"https:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0"}],"funder":[{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"crossref","award":["82303446"],"award-info":[{"award-number":["82303446"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"crossref"}]},{"name":"Shenzhen High-level Hospital Construction Fund, Peking University Shenzhen Hospital Scientific Research Fund","award":["KYQD2023303"],"award-info":[{"award-number":["KYQD2023303"]}]},{"DOI":"10.13039\/501100021171","name":"Basic and Applied Basic Research Foundation of Guangdong Province","doi-asserted-by":"crossref","award":["2023A1515220200"],"award-info":[{"award-number":["2023A1515220200"]}],"id":[{"id":"10.13039\/501100021171","id-type":"DOI","asserted-by":"crossref"}]},{"DOI":"10.13039\/501100003785","name":"Medical Scientific Research Foundation of Guangdong Province of China","doi-asserted-by":"crossref","award":["A2024351"],"award-info":[{"award-number":["A2024351"]}],"id":[{"id":"10.13039\/501100003785","id-type":"DOI","asserted-by":"crossref"}]},{"name":"Shenzhen Science and Technology Program","award":["JCYJ20240813115900001"],"award-info":[{"award-number":["JCYJ20240813115900001"]}]}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["BMC Gastroenterol"],"DOI":"10.1186\/s12876-026-04756-y","type":"journal-article","created":{"date-parts":[[2026,3,19]],"date-time":"2026-03-19T04:01:58Z","timestamp":1773892918000},"update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Multi-omics analysis and experimental validation uncovers prognosis significance of IKBIP in patients with hepatocellular carcinoma: a multicenter cohort study"],"prefix":"10.1186","volume":"26","author":[{"given":"Yuanjun","family":"Jiao","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Lingling","family":"Guo","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yubin","family":"Lu","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Mengqing","family":"Li","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yanfeng","family":"Zhong","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Bo","family":"Wu","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Hanxing","family":"Dong","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ting","family":"Wang","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Erbao","family":"Chen","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"297","published-online":{"date-parts":[[2026,3,19]]},"reference":[{"issue":"3","key":"4756_CR1","first-page":"229","volume":"74","author":"F Bray","year":"2024","unstructured":"Bray F, Laversanne M, Sung H, et al. Global cancer statistics 2022: GLOBOCAN estimates of incidence and mortality worldwide for 36 cancers in 185 countries. CA Cancer J Clin. 2024;74(3):229\u201363.","journal-title":"CA Cancer J Clin"},{"issue":"6","key":"4756_CR2","doi-asserted-by":"publisher","first-page":"995","DOI":"10.1016\/j.jhep.2024.06.018","volume":"81","author":"C Fuster-Anglada","year":"2024","unstructured":"Fuster-Anglada C, Mauro E, Ferrer-F\u00e0brega J, et al. Histological predictors of aggressive recurrence of hepatocellular carcinoma after liver resection. J Hepatol. 2024;81(6):995\u20131004.","journal-title":"J Hepatol"},{"key":"4756_CR3","doi-asserted-by":"publisher","first-page":"182","DOI":"10.1016\/j.jhep.2018.03.019","volume":"69","author":"PR Galle","year":"2018","unstructured":"Galle PR, Forner A, Llovet JM, et al. EASL Clinical Practice Guidelines: Management of hepatocellular carcinoma. J Hepatol. 2018;69:182\u2013236.","journal-title":"J Hepatol"},{"issue":"15","key":"4756_CR4","doi-asserted-by":"publisher","first-page":"1450","DOI":"10.1056\/NEJMra1713263","volume":"380","author":"A Villanueva","year":"2019","unstructured":"Villanueva A. Hepatocellular Carcinoma. N Engl J Med. 2019;380(15):1450\u201362.","journal-title":"N Engl J Med"},{"issue":"11","key":"4756_CR5","doi-asserted-by":"publisher","first-page":"8212","DOI":"10.1097\/JS9.0000000000003045","volume":"111","author":"L Ma","year":"2025","unstructured":"Ma L, Liao S, Yuan S, et al. Refining Risk Stratification in Hepatocellular Carcinoma by Integrating Tertiary Lymphoid Structures and Microvascular Invasion: a Multicenter Retrospective Study. Int J Surg. 2025;111(11):8212\u201325. https:\/\/doi.org\/10.1097\/JS9.0000000000003045.","journal-title":"Int J Surg"},{"key":"4756_CR6","doi-asserted-by":"publisher","first-page":"iv238","DOI":"10.1093\/annonc\/mdy308","volume":"29","author":"A Vogel","year":"2018","unstructured":"Vogel A, Cervantes A, Chau I, et al. Hepatocellular carcinoma: ESMO Clinical Practice Guidelines for diagnosis, treatment and follow-up. Ann Oncol. 2018;29:iv238\u201355.","journal-title":"Ann Oncol"},{"issue":"2","key":"4756_CR7","doi-asserted-by":"publisher","first-page":"366","DOI":"10.3390\/cancers15020366","volume":"15","author":"R Stulpinas","year":"2023","unstructured":"Stulpinas R, Zilenaite-Petrulaitiene D, Rasmusson A, et al. Prognostic Value of CD8\u2009+\u2009Lymphocytes in Hepatocellular Carcinoma and Perineoplastic Parenchyma Assessed by Interface Density Profiles in Liver Resection Samples. Cancers. 2023;15(2):366.","journal-title":"Cancers"},{"issue":"4","key":"4756_CR8","doi-asserted-by":"publisher","first-page":"290","DOI":"10.2174\/0109298665301698240404061300","volume":"31","author":"M Sotoudeheian","year":"2024","unstructured":"Sotoudeheian M. Galectin-3 and Severity of Liver Fibrosis in Metabolic Dysfunction-Associated Fatty Liver Disease. Protein Pept Lett. 2024;31(4):290\u2013304. https:\/\/doi.org\/10.2174\/0109298665301698240404061300.","journal-title":"Protein Pept Lett"},{"key":"4756_CR9","doi-asserted-by":"publisher","first-page":"e18761429358008","DOI":"10.2174\/0118761429358008250305070518","volume":"17","author":"W Xu","year":"2024","unstructured":"Xu W, Liao S, Hu Y, Huang Y, Zhou J. Upregulation of miR-3130-5p Enhances Hepatocellular Carcinoma Growth by Suppressing Ferredoxin 1: miR-3130-5p Enhances HCC Growth via Inhibiting FDX1. Curr Mol Pharmacol. 2024;17:e18761429358008. https:\/\/doi.org\/10.2174\/0118761429358008250305070518.","journal-title":"Curr Mol Pharmacol"},{"issue":"4","key":"4756_CR10","doi-asserted-by":"publisher","first-page":"532","DOI":"10.2174\/0115665232308821240826075513","volume":"25","author":"L Qi","year":"2025","unstructured":"Qi L, Tan Y, Zhou Y, et al. Proteogenomic Identification and Analysis of KIF5B as a Prognostic Signature for Hepatocellular Carcinoma. Curr Gene Ther. 2025;25(4):532\u201345. https:\/\/doi.org\/10.2174\/0115665232308821240826075513.","journal-title":"Curr Gene Ther"},{"issue":"5","key":"4756_CR11","doi-asserted-by":"publisher","first-page":"453","DOI":"10.2174\/1566523222666220825110147","volume":"24","author":"C Liu","year":"2024","unstructured":"Liu C, Shi J, Lin B, et al. SHR6390 Combined with Cabozantinib Inhibits Tumor Progression in the Hepatocellular Carcinoma Mouse Model. Curr Gene Ther. 2024;24(5):453\u201364. https:\/\/doi.org\/10.2174\/1566523222666220825110147.","journal-title":"Curr Gene Ther"},{"issue":"9","key":"4756_CR12","doi-asserted-by":"publisher","first-page":"706","DOI":"10.2174\/0109298665330781240830042601","volume":"31","author":"W Ye","year":"2024","unstructured":"Ye W, Wang J, Zheng J, Jiang M, Zhou Y, Wu Z. Association between Higher Expression of Vav1 in Hepatocellular Carcinoma and Unfavourable Clinicopathological Features and Prognosis. Protein Pept Lett. 2024;31(9):706\u201313. https:\/\/doi.org\/10.2174\/0109298665330781240830042601.","journal-title":"Protein Pept Lett"},{"issue":"1","key":"4756_CR13","doi-asserted-by":"publisher","first-page":"48","DOI":"10.2174\/0113892029308243240709073945","volume":"26","author":"IP Gudivada","year":"2025","unstructured":"Gudivada IP, Amajala KC. Integrative Bioinformatics Analysis for Targeting Hub Genes in Hepatocellular Carcinoma Treatment. Curr Genomics. 2025;26(1):48\u201380. https:\/\/doi.org\/10.2174\/0113892029308243240709073945.","journal-title":"Curr Genomics"},{"issue":"12","key":"4756_CR14","doi-asserted-by":"publisher","first-page":"1317","DOI":"10.1038\/sj.cdd.4401502","volume":"11","author":"R Hofer-Warbinek","year":"2004","unstructured":"Hofer-Warbinek R, Schmid JA, Mayer H, et al. A highly conserved proapoptotic gene, IKIP, located next to the APAF1 gene locus, is regulated by p53. Cell Death Differ. 2004;11(12):1317\u201325.","journal-title":"Cell Death Differ"},{"issue":"2","key":"4756_CR15","doi-asserted-by":"publisher","first-page":"418","DOI":"10.4049\/jimmunol.1900626","volume":"204","author":"H Wu","year":"2020","unstructured":"Wu H, Liu H, Zhao X, et al. IKIP negatively regulates NF-\u03baB activation and inflammation through inhibition of IKK\u03b1\/\u03b2 phosphorylation. J Immunol. 2020;204(2):418\u201327.","journal-title":"J Immunol"},{"issue":"1","key":"4756_CR16","doi-asserted-by":"publisher","first-page":"121","DOI":"10.1186\/s12894-023-01290-x","volume":"23","author":"H Zhang","year":"2023","unstructured":"Zhang H, Tang R, Wen X, et al. Prognostic value of IKBIP in papillary renal cell carcinoma. BMC Urol. 2023;23(1):121.","journal-title":"BMC Urol"},{"issue":"1","key":"4756_CR17","doi-asserted-by":"publisher","first-page":"759","DOI":"10.1186\/s12885-024-12510-4","volume":"24","author":"J Hu","year":"2024","unstructured":"Hu J, Dai C, Ding Z, et al. IKBIP promotes tumor development via the akt signaling pathway in esophageal squamous cell carcinoma. BMC Cancer. 2024;24(1):759.","journal-title":"BMC Cancer"},{"issue":"6","key":"4756_CR18","doi-asserted-by":"publisher","first-page":"743","DOI":"10.1093\/carcin\/bgz194","volume":"41","author":"TY Chen","year":"2020","unstructured":"Chen TY, Liu Y, Chen L, Luo J, Zhang C, Shen XF. Identification of the potential biomarkers in patients with glioma: a weighted gene co-expression network analysis. Carcinogenesis. 2020;41(6):743\u201350.","journal-title":"Carcinogenesis"},{"issue":"1","key":"4756_CR19","doi-asserted-by":"publisher","first-page":"9","DOI":"10.1515\/tnsci-2021-0002","volume":"12","author":"Y Yang","year":"2021","unstructured":"Yang Y, Wang J, Xu S, Lv W, Shi F, Shan A. IKBIP is a novel EMT-related biomarker and predicts poor survival in glioma. Transl Neurosci. 2021;12(1):9\u201319.","journal-title":"Transl Neurosci"},{"issue":"1","key":"4756_CR20","doi-asserted-by":"publisher","first-page":"166571","DOI":"10.1016\/j.bbadis.2022.166571","volume":"1869","author":"K Li","year":"2023","unstructured":"Li K, Huang G, Wang Z, et al. IKBIP, a novel glioblastoma biomarker, maintains abnormal proliferation of tumor cells by inhibiting the ubiquitination and degradation of CDK4. Biochim Biophys Acta Mol Basis Dis. 2023;1869(1):166571.","journal-title":"Biochim Biophys Acta Mol Basis Dis"},{"key":"4756_CR21","doi-asserted-by":"publisher","first-page":"110030","DOI":"10.1016\/j.intimp.2023.110030","volume":"118","author":"H Chen","year":"2023","unstructured":"Chen H, Liang B, Luo X, et al. IKBIP might be a potential prognostic biomarker for glioblastoma multiforme. Int Immunopharmacol. 2023;118:110030.","journal-title":"Int Immunopharmacol"},{"key":"4756_CR22","doi-asserted-by":"publisher","first-page":"1138137","DOI":"10.3389\/fgene.2023.1138137","volume":"14","author":"C Bi","year":"2023","unstructured":"Bi C, Wang Z, Xiao Y, et al. I kappa B kinase interacting protein as a promising biomarker in pan-cancer: A multi-omics analysis. Front Genet. 2023;14:1138137.","journal-title":"Front Genet"},{"issue":"174","key":"4756_CR23","doi-asserted-by":"publisher","first-page":"57","DOI":"10.24976\/Discov.Med.202335174.7","volume":"35","author":"Q Li","year":"2023","unstructured":"Li Q, Zhao Z, Pei F, Kang C, Duan F. IKBIP is a Predictive Biomarker Related to Immunosuppressive Microenvironment in Digestive System Malignancies. Discov Med. 2023;35(174):57\u201372.","journal-title":"Discov Med"},{"issue":"1","key":"4756_CR24","doi-asserted-by":"publisher","first-page":"9","DOI":"10.1186\/s40164-022-00366-y","volume":"12","author":"E Chen","year":"2023","unstructured":"Chen E, He Y, Jiang J, et al. CDCA8 induced by NF-YA promotes hepatocellular carcinoma progression by regulating the MEK\/ERK pathway. Exp Hematol Oncol. 2023;12(1):9.","journal-title":"Exp Hematol Oncol"},{"key":"4756_CR25","doi-asserted-by":"publisher","first-page":"e15701808359324","DOI":"10.2174\/0115701808359324241221182323","volume":"21","author":"J Hong","year":"2024","unstructured":"Hong J, Ding J, Wang P, et al. Predicting the Potential Mechanism of Radix Sophorae Flavescentis Treating Hepatocellular Carcinoma Based on the Strategies of Network Pharmacology, Molecular Docking, and Molecular Dynamics Simulation. Lett Drug Des Discov. 2024;21:e15701808359324. https:\/\/doi.org\/10.2174\/0115701808359324241221182323.","journal-title":"Lett Drug Des Discov"},{"key":"4756_CR26","doi-asserted-by":"publisher","unstructured":"Fernando Martinez-Esquivias, Luz Andrea Mart\u00ednez-Perez, Laura Elena Iniguez-Munoz, et al. Bioinformatic Analysis and Molecular Docking to Elucidate the Anticancer Effect of Silver Nanoparticles in Hepatocellular Carcinoma. Lett Drug Des Discov. 2024;21:e15701808352454. https:\/\/doi.org\/10.2174\/0115701808352454241115065851","DOI":"10.2174\/0115701808352454241115065851"},{"issue":"4","key":"4756_CR27","doi-asserted-by":"publisher","first-page":"798","DOI":"10.1016\/j.jhep.2016.05.007","volume":"65","author":"G Giannelli","year":"2016","unstructured":"Giannelli G, Koudelkova P, Dituri F, Mikulits W. Role of epithelial to mesenchymal transition in hepatocellular carcinoma. J Hepatol. 2016;65(4):798\u2013808.","journal-title":"J Hepatol"},{"issue":"1","key":"4756_CR28","doi-asserted-by":"publisher","first-page":"203","DOI":"10.1186\/s13046-018-0887-z","volume":"37","author":"L Yan","year":"2018","unstructured":"Yan L, Xu F, Dai CL. Relationship between epithelial-to-mesenchymal transition and the inflammatory microenvironment of hepatocellular carcinoma. J Exp Clin Cancer Res. 2018;37(1):203. https:\/\/doi.org\/10.1186\/s13046-018-0887-z.","journal-title":"J Exp Clin Cancer Res"},{"issue":"11","key":"4756_CR29","doi-asserted-by":"publisher","first-page":"3184","DOI":"10.1002\/1878-0261.12980","volume":"15","author":"Q Xie","year":"2021","unstructured":"Xie Q, Guo H, He P, et al. Tspan5 promotes epithelial-mesenchymal transition and tumour metastasis of hepatocellular carcinoma by activating Notch signalling. Mol Oncol. 2021;15(11):3184\u2013202.","journal-title":"Mol Oncol"},{"issue":"3","key":"4756_CR30","doi-asserted-by":"publisher","first-page":"249","DOI":"10.2174\/0115665232274223231017052707","volume":"24","author":"J Wang","year":"2024","unstructured":"Wang J, Sun L, Liu Y, Zhang Y. FIGNL1 Promotes Hepatocellular Carcinoma Formation via Remodeling ECM-receptor Interaction Pathway Mediated by HMMR. Curr Gene Ther. 2024;24(3):249\u201363. https:\/\/doi.org\/10.2174\/0115665232274223231017052707.","journal-title":"Curr Gene Ther"},{"issue":"6","key":"4756_CR31","doi-asserted-by":"publisher","first-page":"214","DOI":"10.31083\/j.fbl2906214","volume":"29","author":"S Zheng","year":"2024","unstructured":"Zheng S, Mo Z, Lv Z, Zhuang Y, Zhou S. SMP30 Interacts with ROCK1 to Inhibit HCC Invasiveness by Effecting the Epithelial-Mesenchymal Transition. Front Biosci (Landmark Ed). 2024;29(6):214.","journal-title":"Front Biosci (Landmark Ed)"},{"issue":"1","key":"4756_CR32","doi-asserted-by":"publisher","first-page":"136","DOI":"10.4149\/neo_2023_220816N835","volume":"70","author":"Z Mao","year":"2023","unstructured":"Mao Z, Wu Y, Yao P, Xing C. GOLM1 facilitates human colorectal cancer progression and metastasis via activating the AKT\/GSK3\u03b2\/EMT axis. Neoplasma. 2023;70(1):136\u201344.","journal-title":"Neoplasma"},{"key":"4756_CR33","doi-asserted-by":"publisher","unstructured":"Han H, Wang S, Ma L, Yin H, Cheng X, Wang Y, et al. ASH2L-K312-Lac Stimulates Angiogenesis in Tumors to Expedite the Malignant Progression of Hepatocellular Carcinoma. Adv Sci (Weinh). 2025:e09477. https:\/\/doi.org\/10.1002\/advs.202509477.","DOI":"10.1002\/advs.202509477"},{"issue":"1","key":"4756_CR34","doi-asserted-by":"publisher","first-page":"333","DOI":"10.1186\/s40425-019-0824-5","volume":"7","author":"M Hilmi","year":"2019","unstructured":"Hilmi M, Neuzillet C, Calderaro J, Lafdil F, Pawlotsky JM, Rousseau B. Angiogenesis and immune checkpoint inhibitors as therapies for hepatocellular carcinoma: current knowledge and future research directions. J Immunother Cancer. 2019;7(1):333.","journal-title":"J Immunother Cancer"},{"issue":"1","key":"4756_CR35","doi-asserted-by":"publisher","first-page":"82","DOI":"10.1016\/j.jhep.2023.10.006","volume":"80","author":"L Zhang","year":"2024","unstructured":"Zhang L, Xu J, Zhou S, et al. Endothelial DGKG promotes tumor angiogenesis and immune evasion in hepatocellular carcinoma. J Hepatol. 2024;80(1):82\u201398.","journal-title":"J Hepatol"},{"issue":"1","key":"4756_CR36","doi-asserted-by":"publisher","first-page":"160","DOI":"10.1186\/s13046-024-03082-z","volume":"43","author":"K Zhang","year":"2024","unstructured":"Zhang K, Zhu Z, Jia R, et al. CD151-enriched migrasomes mediate hepatocellular carcinoma invasion by conditioning cancer cells and promoting angiogenesis. J Exp Clin Cancer Res. 2024;43(1):160. https:\/\/doi.org\/10.1186\/s13046-024-03082-z.","journal-title":"J Exp Clin Cancer Res"},{"issue":"1","key":"4756_CR37","doi-asserted-by":"publisher","first-page":"597","DOI":"10.1038\/s41419-025-07905-5","volume":"16","author":"W Zhang","year":"2025","unstructured":"Zhang W, Ren W, Guo S, et al. ULBP2 CAR-T cells enhance gastric cancer immunotherapy by inhibiting CAF activation. Cell Death Dis. 2025;16(1):597.","journal-title":"Cell Death Dis"},{"issue":"1","key":"4756_CR38","doi-asserted-by":"publisher","first-page":"227","DOI":"10.1038\/s41392-025-02280-1","volume":"10","author":"M Tufail","year":"2025","unstructured":"Tufail M, Jiang CH, Li N. Immune evasion in cancer: mechanisms and cutting-edge therapeutic approaches. Signal Transduct Target Ther. 2025;10(1):227.","journal-title":"Signal Transduct Target Ther"},{"key":"4756_CR39","doi-asserted-by":"publisher","first-page":"1244392","DOI":"10.3389\/fimmu.2024.1244392","volume":"15","author":"E Chen","year":"2024","unstructured":"Chen E, Zou Z, Wang R, et al. Predictive value of a stemness-based classifier for prognosis and immunotherapy response of hepatocellular carcinoma based on bioinformatics and machine-learning strategies. Front Immunol. 2024;15:1244392.","journal-title":"Front Immunol"},{"key":"4756_CR40","doi-asserted-by":"publisher","first-page":"216594","DOI":"10.1016\/j.canlet.2023.216594","volume":"582","author":"W Hong","year":"2024","unstructured":"Hong W, Zhang Y, Wang S, et al. Deciphering the immune modulation through deep transcriptomic profiling and therapeutic implications of DNA damage repair pattern in hepatocellular carcinoma. Cancer Lett. 2024;582:216594.","journal-title":"Cancer Lett"},{"issue":"1","key":"4756_CR41","doi-asserted-by":"publisher","first-page":"202","DOI":"10.1186\/s12967-024-06051-4","volume":"23","author":"X Chen","year":"2025","unstructured":"Chen X, Wu S, He H, et al. G2M-checkpoint related immune barrier structure and signature for prognosis and immunotherapy response in hepatocellular carcinoma: insights from spatial transcriptome and machine learning. J Transl Med. 2025;23(1):202.","journal-title":"J Transl Med"},{"key":"4756_CR42","doi-asserted-by":"publisher","first-page":"1","DOI":"10.1016\/j.canlet.2021.04.026","volume":"512","author":"Z Zhao","year":"2021","unstructured":"Zhao Z, He K, Zhang Y, et al. XRCC2 repairs mitochondrial DNA damage and fuels malignant behavior in hepatocellular carcinoma. Cancer Lett. 2021;512:1\u201314.","journal-title":"Cancer Lett"},{"issue":"2","key":"4756_CR43","doi-asserted-by":"publisher","first-page":"307","DOI":"10.1016\/j.surg.2023.04.030","volume":"174","author":"K Chida","year":"2023","unstructured":"Chida K, Oshi M, Roy AM, et al. E2F target score is associated with cell proliferation and survival of patients with hepatocellular carcinoma. Surgery. 2023;174(2):307\u201314.","journal-title":"Surgery"},{"issue":"1","key":"4756_CR44","doi-asserted-by":"publisher","first-page":"828","DOI":"10.1186\/s12967-023-04365-3","volume":"21","author":"H Liao","year":"2023","unstructured":"Liao H, Chang X, Gao L, et al. IL-17A promotes tumorigenesis and upregulates PD-L1 expression in non-small cell lung cancer. J Transl Med. 2023;21(1):828. https:\/\/doi.org\/10.1186\/s12967-023-04365-3.","journal-title":"J Transl Med"},{"key":"4756_CR45","doi-asserted-by":"publisher","first-page":"853165","DOI":"10.3389\/fimmu.2022.853165","volume":"13","author":"H Xu","year":"2022","unstructured":"Xu H, Liu T, Li J, et al. Roburic Acid Targets TNF to Inhibit the NF-\u03baB Signaling Pathway and Suppress Human Colorectal Cancer Cell Growth. Front Immunol. 2022;13:853165. https:\/\/doi.org\/10.3389\/fimmu.2022.853165.","journal-title":"Front Immunol"}],"container-title":["BMC Gastroenterology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/link.springer.com\/article\/10.1186\/s12876-026-04756-y","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1186\/s12876-026-04756-y.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1186\/s12876-026-04756-y.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,4,27]],"date-time":"2026-04-27T23:47:30Z","timestamp":1777333650000},"score":1,"resource":{"primary":{"URL":"https:\/\/link.springer.com\/10.1186\/s12876-026-04756-y"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,3,19]]},"references-count":45,"journal-issue":{"issue":"1","published-online":{"date-parts":[[2026,12]]}},"alternative-id":["4756"],"URL":"https:\/\/doi.org\/10.1186\/s12876-026-04756-y","relation":{},"ISSN":["1471-230X"],"issn-type":[{"value":"1471-230X","type":"electronic"}],"subject":[],"published":{"date-parts":[[2026,3,19]]},"assertion":[{"value":"17 October 2025","order":1,"name":"received","label":"Received","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"17 March 2026","order":2,"name":"accepted","label":"Accepted","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"19 March 2026","order":3,"name":"first_online","label":"First Online","group":{"name":"ArticleHistory","label":"Article History"}},{"order":1,"name":"Ethics","group":{"name":"EthicsHeading","label":"Declarations"}},{"value":"The study was conducted in accordance with the Declaration of Helsinki and approved by the Ethics Committees of Peking University Shenzhen Hospital (approval number: 2022\u2009\u2212\u2009164) and Shanghai Outdo Biotech Company (approval number: SHYJS-CP-1804007). Informed Consent was waived by the Ethics Committee of Peking University Shenzhen Hospital and Shanghai Outdo Biotech Company for this retrospective study.","order":2,"name":"Ethics","group":{"name":"EthicsHeading","label":"Ethics approval and consent to participate"}},{"value":"Not applicable.","order":3,"name":"Ethics","group":{"name":"EthicsHeading","label":"Consent for publication"}},{"value":"The authors declare no competing interests.","order":4,"name":"Ethics","group":{"name":"EthicsHeading","label":"Competing interests"}}],"article-number":"256"}}