{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,9]],"date-time":"2026-06-09T01:02:16Z","timestamp":1780966936112,"version":"3.54.1"},"reference-count":21,"publisher":"Springer Science and Business Media LLC","issue":"1","license":[{"start":{"date-parts":[[2026,4,25]],"date-time":"2026-04-25T00:00:00Z","timestamp":1777075200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0"},{"start":{"date-parts":[[2026,6,9]],"date-time":"2026-06-09T00:00:00Z","timestamp":1780963200000},"content-version":"vor","delay-in-days":45,"URL":"https:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0"}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["BMC Gastroenterol"],"DOI":"10.1186\/s12876-026-04794-6","type":"journal-article","created":{"date-parts":[[2026,4,25]],"date-time":"2026-04-25T10:16:12Z","timestamp":1777112172000},"update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Expression characteristics of ferroptosis-related immune genes in chronic pancreatitis and screening and validation of key genes"],"prefix":"10.1186","volume":"26","author":[{"given":"Xianrong","family":"Du","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xiaoyu","family":"Cai","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lin","family":"Zhong","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2026,4,25]]},"reference":[{"issue":"1","key":"4794_CR1","doi-asserted-by":"publisher","first-page":"57","DOI":"10.1016\/j.mpsur.2024.10.007","volume":"43","author":"J Lucocq","year":"2025","unstructured":"Lucocq J, Hughes M. Chronic pancreatitis. Surg (Oxford). 2025;43(1):57\u201363.","journal-title":"Surg (Oxford)"},{"key":"4794_CR2","doi-asserted-by":"publisher","first-page":"1622845","DOI":"10.3389\/fphys.2025.1622845","volume":"16","author":"Z Lin","year":"2025","unstructured":"Lin Z, et al. Navigating chronic pancreatitis pain: a pathophysiological and therapeutic overview. Front Physiol. 2025;16:1622845.","journal-title":"Front Physiol"},{"issue":"1","key":"4794_CR3","doi-asserted-by":"publisher","first-page":"398","DOI":"10.1186\/s12876-024-03481-8","volume":"24","author":"T Li","year":"2024","unstructured":"Li T, et al. Global and regional burden of pancreatitis: epidemiological trends, risk factors, and projections to 2050 from the global burden of disease study 2021. BMC Gastroenterol. 2024;24(1):398.","journal-title":"BMC Gastroenterol"},{"key":"4794_CR4","doi-asserted-by":"publisher","first-page":"1151103","DOI":"10.3389\/fonc.2023.1151103","volume":"13","author":"Y Zhang","year":"2023","unstructured":"Zhang Y, et al. Immune cells and immune cell-targeted therapy in chronic pancreatitis. Front Oncol. 2023;13:1151103.","journal-title":"Front Oncol"},{"key":"4794_CR5","doi-asserted-by":"publisher","first-page":"214677","DOI":"10.1016\/j.bioadv.2025.214677","volume":"182","author":"A Sabu","year":"2025","unstructured":"Sabu A, et al. Targeted nanotheranostics mitigates radiation-induced fibrosis to promote immune infiltration and enhance radio-chemotherapy in pancreatic ductal adenocarcinoma. Biomater Adv. 2025;182:214677.","journal-title":"Biomater Adv"},{"issue":"1","key":"4794_CR6","doi-asserted-by":"publisher","first-page":"2602216","DOI":"10.1080\/2162402X.2025.2602216","volume":"14","author":"N Li","year":"2025","unstructured":"Li N, et al. Mild microwave hyperthermia promotes mitotic catastrophe, induces time-delayed cGAS-STING activation and restores sensitivity to anti-PDL1 therapy in Pan02 pancreatic cancer model. Oncoimmunology. 2025;14(1):2602216.","journal-title":"Oncoimmunology"},{"issue":"5","key":"4794_CR7","doi-asserted-by":"publisher","first-page":"1060","DOI":"10.1016\/j.cell.2012.03.042","volume":"149","author":"SJ Dixon","year":"2012","unstructured":"Dixon SJ, et al. Ferroptosis: an iron-dependent form of nonapoptotic cell death. Cell. 2012;149(5):1060\u201372.","journal-title":"Cell"},{"issue":"1","key":"4794_CR8","doi-asserted-by":"publisher","first-page":"26","DOI":"10.1007\/s11064-025-04628-z","volume":"51","author":"G Dong","year":"2025","unstructured":"Dong G, et al. Schisanhenol Inhibits MPTP\/MPP(+)-Induced Ferroptosis in Dopaminergic Neurons Via Nrf2\/TrxR1\/GPX4 Pathway against Parkinson\u2019s Disease. Neurochem Res. 2025;51(1):26.","journal-title":"Neurochem Res"},{"key":"4794_CR9","doi-asserted-by":"crossref","unstructured":"Huang CS, et al. Synergistic Induction of Ferroptosis by GPX4 Inhibitor and GSH-Depleted Nanoparticles Effectively Reverses Gemcitabine Resistance in Pancreatic Ductal Adenocarcinoma PDX Model. Adv Healthc Mater. 2025;15(11):e03694.","DOI":"10.1002\/adhm.202503694"},{"issue":"6","key":"4794_CR10","doi-asserted-by":"publisher","first-page":"1000","DOI":"10.21147\/j.issn.1000-9604.2025.06.11","volume":"37","author":"P Zhang","year":"2025","unstructured":"Zhang P, et al. Metabolic reprogramming signature predicts immunotherapy efficacy in lung adenocarcinoma: Targeting SLC25A1 to overcome immune resistance. Chin J Cancer Res. 2025;37(6):1000\u201319.","journal-title":"Chin J Cancer Res"},{"issue":"1","key":"4794_CR11","doi-asserted-by":"publisher","first-page":"230","DOI":"10.1007\/s11033-025-11385-3","volume":"53","author":"W Gharbi","year":"2025","unstructured":"Gharbi W, et al. Functional genetic variants in immune-checkpoint molecules and susceptibility to Nasopharyngeal carcinoma in a Tunisian case-control study. Mol Biol Rep. 2025;53(1):230.","journal-title":"Mol Biol Rep"},{"key":"4794_CR12","doi-asserted-by":"publisher","first-page":"123939","DOI":"10.1016\/j.biomaterials.2025.123939","volume":"329","author":"N Liu","year":"2025","unstructured":"Liu N, et al. Glycolysis inhibition-based breakdown of ferroptosis defenses to achieve ferroptosis and immune cascades for antitumor therapy. Biomaterials. 2025;329:123939.","journal-title":"Biomaterials"},{"key":"4794_CR13","doi-asserted-by":"publisher","first-page":"18009","DOI":"10.2147\/JIR.S555252","volume":"18","author":"Z Yan","year":"2025","unstructured":"Yan Z, et al. The Effects of Da-Chai-Hu Decoction Alleviating Pancreatic Exocrine Dysfunction by Inhibiting Endoplasmic Reticulum Stress of Acinar Cell in Mice with Chronic Pancreatitis. J Inflamm Res. 2025;18:18009\u201324.","journal-title":"J Inflamm Res"},{"issue":"2","key":"4794_CR14","doi-asserted-by":"publisher","first-page":"273","DOI":"10.1016\/j.cell.2017.09.021","volume":"171","author":"BR Stockwell","year":"2017","unstructured":"Stockwell BR, et al. Ferroptosis: A Regulated Cell Death Nexus Linking Metabolism, Redox Biology, and Disease. Cell. 2017;171(2):273\u201385.","journal-title":"Cell"},{"issue":"1","key":"4794_CR15","doi-asserted-by":"publisher","first-page":"10","DOI":"10.1007\/s10735-025-10661-7","volume":"57","author":"H Youssef","year":"2025","unstructured":"Youssef H, et al. Neurotoxic and neurobehavioral impacts of silica nanoparticles on brain tissue of albino rats with the potential ameliorative efficacy of liposomal curcumin. J Mol Histol. 2025;57(1):10.","journal-title":"J Mol Histol"},{"key":"4794_CR16","doi-asserted-by":"publisher","first-page":"1611637","DOI":"10.3389\/fphar.2025.1611637","volume":"16","author":"J Amer","year":"2025","unstructured":"Amer J, et al. Antagonizing IL-6 receptor restores pancreatic tissue resident NK cells activation and ameliorates pancreatic injury in the mouse model of MASH. Front Pharmacol. 2025;16:1611637.","journal-title":"Front Pharmacol"},{"key":"4794_CR17","doi-asserted-by":"publisher","first-page":"6375","DOI":"10.1016\/j.csbj.2021.11.031","volume":"19","author":"C Hu","year":"2021","unstructured":"Hu C, et al. The unique pancreatic stellate cell gene expression signatures are associated with the progression from acute to chronic pancreatitis. Comput Struct Biotechnol J. 2021;19:6375\u201385.","journal-title":"Comput Struct Biotechnol J"},{"issue":"Pt 1","key":"4794_CR18","first-page":"149698","volume":"338","author":"W Xie","year":"2025","unstructured":"Xie W, et al. From stem cells to nanomedicine: A multimodal approach targeting pancreatic fibrosis via MFGE8-dependent ANXA1-SMAD2\/3 axis. Int J Biol Macromol. 2025;338(Pt 1):149698.","journal-title":"Int J Biol Macromol"},{"key":"4794_CR19","doi-asserted-by":"publisher","first-page":"121001","DOI":"10.1016\/j.jep.2025.121001","volume":"358","author":"C Li","year":"2026","unstructured":"Li C, et al. Chaihu Guizhi Ganjiang decoction attenuates chronic pancreatitis by suppressing acinar cell ferroptosis via regulating p53\/SLC7A11\/GPX4 pathway. J Ethnopharmacol. 2026;358:121001.","journal-title":"J Ethnopharmacol"},{"key":"4794_CR20","doi-asserted-by":"publisher","first-page":"123939","DOI":"10.1016\/j.biomaterials.2025.123939","volume":"329","author":"N Liu","year":"2026","unstructured":"Liu N, et al. Glycolysis inhibition-based breakdown of ferroptosis defenses to achieve ferroptosis and immune cascades for antitumor therapy. Biomaterials. 2026;329:123939.","journal-title":"Biomaterials"},{"key":"4794_CR21","doi-asserted-by":"publisher","first-page":"800650","DOI":"10.3389\/fcell.2022.800650","volume":"10","author":"X Wei","year":"2022","unstructured":"Wei X, et al. Identification of Subtypes and a Delayed Graft Function Predictive Signature Based on Ferroptosis in Renal Ischemia-Reperfusion Injury. Front Cell Dev Biol. 2022;10:800650.","journal-title":"Front Cell Dev Biol"}],"container-title":["BMC Gastroenterology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/link.springer.com\/article\/10.1186\/s12876-026-04794-6","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1186\/s12876-026-04794-6.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1186\/s12876-026-04794-6.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,6,9]],"date-time":"2026-06-09T00:53:32Z","timestamp":1780966412000},"score":1,"resource":{"primary":{"URL":"https:\/\/link.springer.com\/10.1186\/s12876-026-04794-6"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,4,25]]},"references-count":21,"journal-issue":{"issue":"1","published-online":{"date-parts":[[2026,12]]}},"alternative-id":["4794"],"URL":"https:\/\/doi.org\/10.1186\/s12876-026-04794-6","relation":{},"ISSN":["1471-230X"],"issn-type":[{"value":"1471-230X","type":"electronic"}],"subject":[],"published":{"date-parts":[[2026,4,25]]},"assertion":[{"value":"19 January 2026","order":1,"name":"received","label":"Received","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"30 March 2026","order":2,"name":"accepted","label":"Accepted","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"25 April 2026","order":3,"name":"first_online","label":"First Online","group":{"name":"ArticleHistory","label":"Article History"}},{"order":1,"name":"Ethics","group":{"name":"EthicsHeading","label":"Declarations"}},{"value":"The study was approved by the Animal Ethics Committee of Guangdong Medical Laboratory Animal Center (Approval No.D202601-8). The study was conducted in compliance with the ARRIVE guidelines.","order":2,"name":"Ethics","group":{"name":"EthicsHeading","label":"Ethics approval and consent to participate"}},{"value":"Not applicable.","order":3,"name":"Ethics","group":{"name":"EthicsHeading","label":"Consent for publication"}},{"value":"The authors declare no competing interests.","order":4,"name":"Ethics","group":{"name":"EthicsHeading","label":"Competing interests"}}],"article-number":"351"}}