{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,12]],"date-time":"2026-06-12T01:04:14Z","timestamp":1781226254522,"version":"3.54.1"},"reference-count":39,"publisher":"Springer Science and Business Media LLC","issue":"1","license":[{"start":{"date-parts":[[2026,4,24]],"date-time":"2026-04-24T00:00:00Z","timestamp":1776988800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0"},{"start":{"date-parts":[[2026,6,12]],"date-time":"2026-06-12T00:00:00Z","timestamp":1781222400000},"content-version":"vor","delay-in-days":49,"URL":"https:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0"}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["BMC Gastroenterol"],"DOI":"10.1186\/s12876-026-04843-0","type":"journal-article","created":{"date-parts":[[2026,4,24]],"date-time":"2026-04-24T04:25:30Z","timestamp":1777004730000},"update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Prophylactic hyperthermic intraperitoneal chemotherapy in patients with high-risk colorectal cancer with abdominal metastasis: a systematic review and meta-analysis"],"prefix":"10.1186","volume":"26","author":[{"given":"Zifeng","family":"Zhang","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tao","family":"Luo","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hua","family":"Tang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2026,4,24]]},"reference":[{"key":"4843_CR1","doi-asserted-by":"publisher","first-page":"209","DOI":"10.3322\/caac.21660","volume":"71","author":"H Sung","year":"2021","unstructured":"Sung H, Ferlay J, Siegel RL, Laversanne M, Soerjomataram I, Jemal A, et al. Global Cancer Statistics 2020: GLOBOCAN Estimates of Incidence and Mortality Worldwide for 36 Cancers in 185 Countries. CA Cancer J Clin. 2021;71:209\u201349. https:\/\/doi.org\/10.3322\/caac.21660.","journal-title":"CA Cancer J Clin"},{"key":"4843_CR2","doi-asserted-by":"publisher","first-page":"29765","DOI":"10.1038\/srep29765","volume":"6","author":"M Riihim\u00e4ki","year":"2016","unstructured":"Riihim\u00e4ki M, Hemminki A, Sundquist J, Hemminki K. Patterns of metastasis in colon and rectal cancer. Sci Rep. 2016;6:29765. https:\/\/doi.org\/10.1038\/srep29765.","journal-title":"Sci Rep"},{"key":"4843_CR3","doi-asserted-by":"publisher","first-page":"100637","DOI":"10.1016\/j.currproblcancer.2020.100637","volume":"45","author":"T Prasanna","year":"2021","unstructured":"Prasanna T, Wong R, Price T, Shapiro J, Tie J, Wong H-L, et al. Metastasectomy and BRAF mutation; an analysis of survival outcome in metastatic colorectal cancer. Curr Probl Cancer. 2021;45:100637. https:\/\/doi.org\/10.1016\/j.currproblcancer.2020.100637.","journal-title":"Curr Probl Cancer"},{"key":"4843_CR4","doi-asserted-by":"publisher","first-page":"1709","DOI":"10.1016\/S1470-2045(16)30500-9","volume":"17","author":"J Franko","year":"2016","unstructured":"Franko J, Shi Q, Meyers JP, Maughan TS, Adams RA, Seymour MT, et al. Prognosis of patients with peritoneal metastatic colorectal cancer given systemic therapy: an analysis of individual patient data from prospective randomised trials from the Analysis and Research in Cancers of the Digestive System (ARCAD) database. Lancet Oncol. 2016;17:1709\u201319. https:\/\/doi.org\/10.1016\/S1470-2045(16)30500-9.","journal-title":"Lancet Oncol"},{"key":"4843_CR5","doi-asserted-by":"publisher","first-page":"256","DOI":"10.1016\/S1470-2045(20)30599-4","volume":"22","author":"F Qu\u00e9net","year":"2021","unstructured":"Qu\u00e9net F, Elias D, Roca L, Go\u00e9r\u00e9 D, Ghouti L, Pocard M, et al. Cytoreductive surgery plus hyperthermic intraperitoneal chemotherapy versus cytoreductive surgery alone for colorectal peritoneal metastases (PRODIGE 7): a multicentre, randomised, open-label, phase 3 trial. Lancet Oncol. 2021;22:256\u201366. https:\/\/doi.org\/10.1016\/S1470-2045(20)30599-4.","journal-title":"Lancet Oncol"},{"key":"4843_CR6","doi-asserted-by":"publisher","first-page":"12","DOI":"10.3322\/caac.21820","volume":"74","author":"RL Siegel","year":"2024","unstructured":"Siegel RL, Giaquinto AN, Jemal A. Cancer statistics, 2024. CA Cancer J Clin. 2024;74:12\u201349. https:\/\/doi.org\/10.3322\/caac.21820.","journal-title":"CA Cancer J Clin"},{"key":"4843_CR7","doi-asserted-by":"publisher","first-page":"2717","DOI":"10.1002\/ijc.25596","volume":"128","author":"VE Lemmens","year":"2011","unstructured":"Lemmens VE, Klaver YL, Verwaal VJ, Rutten HJ, Coebergh JWW, de Hingh IH. Predictors and survival of synchronous peritoneal carcinomatosis of colorectal origin: a population-based study. Int J Cancer. 2011;128:2717\u201325. https:\/\/doi.org\/10.1002\/ijc.25596.","journal-title":"Int J Cancer"},{"key":"4843_CR8","doi-asserted-by":"publisher","first-page":"699","DOI":"10.1002\/bjs.8679","volume":"99","author":"J Segelman","year":"2012","unstructured":"Segelman J, Granath F, Holm T, Machado M, Mahteme H, Martling A. Incidence, prevalence and risk factors for peritoneal carcinomatosis from colorectal cancer. Br J Surg. 2012;99:699\u2013705. https:\/\/doi.org\/10.1002\/bjs.8679.","journal-title":"Br J Surg"},{"key":"4843_CR9","doi-asserted-by":"publisher","first-page":"963","DOI":"10.1016\/j.ejso.2013.10.001","volume":"40","author":"YRBM van Gestel","year":"2014","unstructured":"van Gestel YRBM, Thomassen I, Lemmens VEPP, Pruijt JFM, van Herk-Sukel MPP, Rutten HJT, et al. Metachronous peritoneal carcinomatosis after curative treatment of colorectal cancer. Eur J Surg Oncol. 2014;40:963\u20139. https:\/\/doi.org\/10.1016\/j.ejso.2013.10.001.","journal-title":"Eur J Surg Oncol"},{"key":"4843_CR10","doi-asserted-by":"publisher","first-page":"396","DOI":"10.1245\/s10434-010-1319-2","volume":"18","author":"S Noura","year":"2011","unstructured":"Noura S, Ohue M, Shingai T, Kano S, Ohigashi H, Yano M, et al. Effects of intraperitoneal chemotherapy with mitomycin C on the prevention of peritoneal recurrence in colorectal cancer patients with positive peritoneal lavage cytology findings. Ann Surg Oncol. 2011;18:396\u2013404. https:\/\/doi.org\/10.1245\/s10434-010-1319-2.","journal-title":"Ann Surg Oncol"},{"key":"4843_CR11","doi-asserted-by":"publisher","first-page":"428","DOI":"10.1186\/s12885-015-1430-7","volume":"15","author":"CEL Klaver","year":"2015","unstructured":"Klaver CEL, Musters GD, Bemelman WA, Punt CJA, Verwaal VJ, Dijkgraaf MGW, et al. Adjuvant hyperthermic intraperitoneal chemotherapy (HIPEC) in patients with colon cancer at high risk of peritoneal carcinomatosis; the COLOPEC randomized multicentre trial. BMC Cancer. 2015;15:428. https:\/\/doi.org\/10.1186\/s12885-015-1430-7.","journal-title":"BMC Cancer"},{"key":"4843_CR12","doi-asserted-by":"publisher","first-page":"230","DOI":"10.1056\/NEJMoa1708618","volume":"378","author":"WJ van Driel","year":"2018","unstructured":"van Driel WJ, Koole SN, Sikorska K, van Schagen JH, Schreuder HWR, Hermans RHM, et al. Hyperthermic Intraperitoneal Chemotherapy in Ovarian Cancer. N Engl J Med. 2018;378:230\u201340. https:\/\/doi.org\/10.1056\/NEJMoa1708618.","journal-title":"N Engl J Med"},{"key":"4843_CR13","doi-asserted-by":"publisher","first-page":"216","DOI":"10.1097\/PPO.0b013e3181a58d95","volume":"15","author":"K Van der Speeten","year":"2009","unstructured":"Van der Speeten K, Stuart OA, Sugarbaker PH. Pharmacokinetics and pharmacodynamics of perioperative cancer chemotherapy in peritoneal surface malignancy. Cancer J. 2009;15:216\u201324. https:\/\/doi.org\/10.1097\/PPO.0b013e3181a58d95.","journal-title":"Cancer J"},{"key":"4843_CR14","doi-asserted-by":"publisher","first-page":"63","DOI":"10.1200\/JCO.2009.23.9285","volume":"28","author":"D Elias","year":"2010","unstructured":"Elias D, Gilly F, Boutitie F, Quenet F, Bereder J-M, Mansvelt B, et al. Peritoneal colorectal carcinomatosis treated with surgery and perioperative intraperitoneal chemotherapy: retrospective analysis of 523 patients from a multicentric French study. J Clin Oncol. 2010;28:63\u20138. https:\/\/doi.org\/10.1200\/JCO.2009.23.9285.","journal-title":"J Clin Oncol"},{"key":"4843_CR15","doi-asserted-by":"publisher","first-page":"3737","DOI":"10.1200\/JCO.2003.04.187","volume":"21","author":"VJ Verwaal","year":"2003","unstructured":"Verwaal VJ, van Ruth S, de Bree E, van Sloothen GW, van Tinteren H, Boot H, et al. Randomized trial of cytoreduction and hyperthermic intraperitoneal chemotherapy versus systemic chemotherapy and palliative surgery in patients with peritoneal carcinomatosis of colorectal cancer. J Clin Oncol. 2003;21:3737\u201343. https:\/\/doi.org\/10.1200\/JCO.2003.04.187.","journal-title":"J Clin Oncol"},{"key":"4843_CR16","doi-asserted-by":"publisher","first-page":"804","DOI":"10.3760\/cma.j.cn441530-20241220-00414","volume":"28","author":"B Lan","year":"2025","unstructured":"Lan B, Qin XS, Wang H. [Value and controversy of prophylactic hyperthermic intraperitoneal chemotherapy in locally advanced colorectal cancer]. Zhonghua Wei Chang Wai Ke Za Zhi. 2025;28:804\u20139. https:\/\/doi.org\/10.3760\/cma.j.cn441530-20241220-00414.","journal-title":"Zhonghua Wei Chang Wai Ke Za Zhi"},{"key":"4843_CR17","doi-asserted-by":"publisher","first-page":"761","DOI":"10.1016\/S2468-1253(19)30239-0","volume":"4","author":"CEL Klaver","year":"2019","unstructured":"Klaver CEL, Wisselink DD, Punt CJA, Snaebjornsson P, Crezee J, Aalbers AGJ, et al. Adjuvant hyperthermic intraperitoneal chemotherapy in patients with locally advanced colon cancer (COLOPEC): a multicentre, open-label, randomised trial. Lancet Gastroenterol Hepatol. 2019;4:761\u201370. https:\/\/doi.org\/10.1016\/S2468-1253(19)30239-0.","journal-title":"Lancet Gastroenterol Hepatol"},{"key":"4843_CR18","doi-asserted-by":"publisher","first-page":"683","DOI":"10.1001\/jamasurg.2023.0662","volume":"158","author":"A Arjona-S\u00e1nchez","year":"2023","unstructured":"Arjona-S\u00e1nchez A, Espinosa-Redondo E, Guti\u00e9rrez-Calvo A, Segura-Sampedro JJ, P\u00e9rez-Viejo E, Concepci\u00f3n-Mart\u00edn V, et al. Efficacy and Safety of Intraoperative Hyperthermic Intraperitoneal Chemotherapy for Locally Advanced Colon Cancer: A Phase 3 Randomized Clinical Trial. JAMA Surg. 2023;158:683\u201391. https:\/\/doi.org\/10.1001\/jamasurg.2023.0662.","journal-title":"JAMA Surg"},{"key":"4843_CR19","doi-asserted-by":"publisher","first-page":"125","DOI":"10.1136\/ebmed-2016-110401","volume":"21","author":"MH Murad","year":"2016","unstructured":"Murad MH, Asi N, Alsawas M, Alahdab F. New evidence pyramid. Evid Based Med. 2016;21:125\u20137. https:\/\/doi.org\/10.1136\/ebmed-2016-110401.","journal-title":"Evid Based Med"},{"key":"4843_CR20","doi-asserted-by":"publisher","first-page":"n71","DOI":"10.1136\/bmj.n71","volume":"372","author":"MJ Page","year":"2021","unstructured":"Page MJ, McKenzie JE, Bossuyt PM, Boutron I, Hoffmann TC, Mulrow CD, et al. The PRISMA 2020 statement: an updated guideline for reporting systematic reviews. BMJ. 2021;372:n71. https:\/\/doi.org\/10.1136\/bmj.n71.","journal-title":"BMJ"},{"key":"4843_CR21","unstructured":"Wells GA, Shea B, O\u2019Connell D et al. The Newcastle-Ottawa Scale (NOS) for assessing the quality of nonrandomised studies in meta-analyses. 2000. Available at: http:\/\/www.ohri.ca\/programs\/clinical_epidemiology\/oxford.asp"},{"key":"4843_CR22","doi-asserted-by":"publisher","first-page":"l4898","DOI":"10.1136\/bmj.l4898","volume":"366","author":"JAC Sterne","year":"2019","unstructured":"Sterne JAC, Savovi\u0107 J, Page MJ, Elbers RG, Blencowe NS, Boutron I, et al. RoB 2: a revised tool for assessing risk of bias in randomised trials. BMJ. 2019;366:l4898. https:\/\/doi.org\/10.1136\/bmj.l4898.","journal-title":"BMJ"},{"key":"4843_CR23","doi-asserted-by":"publisher","first-page":"603","DOI":"10.1007\/s10654-010-9491-z","volume":"25","author":"A Stang","year":"2010","unstructured":"Stang A. Critical evaluation of the Newcastle-Ottawa scale for the assessment of the quality of nonrandomized studies in meta-analyses. Eur J Epidemiol. 2010;25:603\u20135. https:\/\/doi.org\/10.1007\/s10654-010-9491-z.","journal-title":"Eur J Epidemiol"},{"key":"4843_CR24","doi-asserted-by":"publisher","first-page":"140","DOI":"10.1200\/JCO.22.02644","volume":"42","author":"ES Zwanenburg","year":"2024","unstructured":"Zwanenburg ES, El Klaver C, Wisselink DD, Punt CJA, Snaebjornsson P, Crezee J, et al. Adjuvant Hyperthermic Intraperitoneal Chemotherapy in Patients With Locally Advanced Colon Cancer (COLOPEC): 5-Year Results of a Randomized Multicenter Trial. J Clin Oncol. 2024;42:140\u20135. https:\/\/doi.org\/10.1200\/JCO.22.02644.","journal-title":"J Clin Oncol"},{"key":"4843_CR25","doi-asserted-by":"publisher","first-page":"1145","DOI":"10.3390\/jcm12031145","volume":"12","author":"X Guo","year":"2023","unstructured":"Guo X, Lin Y, Shen C, Li Y, Zeng X, Lv J, et al. Comparative Study of Short-Term Efficacy and Safety of Radical Surgery with or without Hyperthermic Intraperitoneal Chemotherapy in Colorectal Cancer with T4 Stage: A Propensity Score Matching Analysis. J Clin Med. 2023;12:1145. https:\/\/doi.org\/10.3390\/jcm12031145.","journal-title":"J Clin Med"},{"key":"4843_CR26","doi-asserted-by":"publisher","first-page":"197","DOI":"10.1007\/s00384-024-04774-w","volume":"39","author":"H Zhou","year":"2024","unstructured":"Zhou H, Wang H, Yi S, Yu S. Effectiveness of hyperthermic intraperitoneal chemotherapy during primary curative resection for colorectal carcinoma. Int J Colorectal Dis. 2024;39:197. https:\/\/doi.org\/10.1007\/s00384-024-04774-w.","journal-title":"Int J Colorectal Dis"},{"key":"4843_CR27","doi-asserted-by":"publisher","first-page":"1081","DOI":"10.1007\/s00384-014-1929-4","volume":"29","author":"P Sammartino","year":"2014","unstructured":"Sammartino P, Sibio S, Biacchi D, Cardi M, Mingazzini P, Rosati MS, et al. Long-term results after proactive management for locoregional control in patients with colonic cancer at high risk of peritoneal metastases. Int J Colorectal Dis. 2014;29:1081\u20139. https:\/\/doi.org\/10.1007\/s00384-014-1929-4.","journal-title":"Int J Colorectal Dis"},{"key":"4843_CR28","doi-asserted-by":"publisher","first-page":"683","DOI":"10.1007\/s10151-020-02270-1","volume":"25","author":"T Li","year":"2021","unstructured":"Li T, Yu J, Chen Y, Liu R, Li Y, Wang YX, et al. Preventive intraperitoneal hyperthermic perfusion chemotherapy for patients with T4 stage colon adenocarcinoma. Tech Coloproctol. 2021;25:683\u201391. https:\/\/doi.org\/10.1007\/s10151-020-02270-1.","journal-title":"Tech Coloproctol"},{"key":"4843_CR29","doi-asserted-by":"publisher","first-page":"107958","DOI":"10.1016\/j.ejso.2024.107958","volume":"50","author":"Y Zheng","year":"2024","unstructured":"Zheng Y, Zhang J, Chen C, Gong Z, Wang Z, Deng Q, et al. Prophylactic hyperthermic intraperitoneal chemotherapy in T4 colorectal cancer: Can it improve the oncologic prognosis? - A propensity score matching study. Eur J Surg Oncol. 2024;50:107958. https:\/\/doi.org\/10.1016\/j.ejso.2024.107958.","journal-title":"Eur J Surg Oncol"},{"key":"4843_CR30","doi-asserted-by":"publisher","first-page":"4717","DOI":"10.1016\/j.asjsur.2024.03.143","volume":"47","author":"T Mo","year":"2024","unstructured":"Mo T, Wen X, Hu T, Zhang Z, Shi Y, Chen Y, et al. The safety and effectiveness of prophylactic hyperthermic intraperitoneal chemotherapy in patients with pathological T3-4 locally advanced colon cancer. Asian J Surg. 2024;47:4717\u201324. https:\/\/doi.org\/10.1016\/j.asjsur.2024.03.143.","journal-title":"Asian J Surg"},{"key":"4843_CR31","doi-asserted-by":"publisher","first-page":"1328","DOI":"10.17179\/excli2021-4108","volume":"20","author":"JL Dominic","year":"2021","unstructured":"Dominic JL, Kannan A, Tara A, Hakim Mohammed AR, Win M, Khorochkov A, Sultan W, Ahmed A, Kantamaneni K, Syzmanski MW, Singh R, Marquez RA, Asarian A, Thirunavukarasu P, Keckeisen G. Prophylactic hyperthermic intraperitoneal chemotherapy (HIPEC) for the prevention and control of peritoneal metastasis in patients with gastrointestinal malignancies: a systematic review of randomized controlled trials. EXCLI J. 2021;20:1328\u201345. https:\/\/doi.org\/10.17179\/excli2021-4108.","journal-title":"EXCLI J"},{"issue":"6","key":"4843_CR32","doi-asserted-by":"publisher","first-page":"1112","DOI":"10.1038\/bjc.2014.369","volume":"111","author":"DA Sloothaak","year":"2014","unstructured":"Sloothaak DA, Mirck B, Punt CJ, Bemelman WA, van der Bilt JD, D\u2019Hoore A, Tanis PJ. Intraperitoneal chemotherapy as adjuvant treatment to prevent peritoneal carcinomatosis of colorectal cancer origin: a systematic review. Br J Cancer. 2014;111(6):1112\u201321. https:\/\/doi.org\/10.1038\/bjc.2014.369. Epub 2014 Jul 15.","journal-title":"Br J Cancer"},{"key":"4843_CR33","doi-asserted-by":"publisher","first-page":"znaf076","DOI":"10.1093\/bjs\/znaf076","volume":"112","author":"JJM Hamm","year":"2025","unstructured":"Hamm JJM, van den Berg R, Andrinopoulou E-R, Zwanenburg ES, Musters GD, Tanis PJ, et al. Adjuvant hyperthermic intraperitoneal chemotherapy in patients with colon cancer at high risk of peritoneal metastases: individual patient data meta-analysis. Br J Surg. 2025;112:znaf076. https:\/\/doi.org\/10.1093\/bjs\/znaf076.","journal-title":"Br J Surg"},{"key":"4843_CR34","doi-asserted-by":"publisher","first-page":"590452","DOI":"10.3389\/fsurg.2020.590452","volume":"7","author":"PY Zhao","year":"2020","unstructured":"Zhao PY, Hu SD, Li YX, Yao RQ, Ren C, He CZ, Li SY, Wang YF, Yao YM, Huang XH, Du XH. Clinical Efficacy and Safety of Hyperthermic Intraperitoneal Chemotherapy in Colorectal Cancer Patients at High Risk of Peritoneal Carcinomatosis: A Systematic Review and Meta-Analysis. Front Surg. 2020;7:590452. https:\/\/doi.org\/10.3389\/fsurg.2020.590452.","journal-title":"Front Surg"},{"key":"4843_CR35","doi-asserted-by":"publisher","first-page":"68","DOI":"10.4251\/wjgo.v2.i2.68","volume":"2","author":"S Gonz\u00e1lez-Moreno","year":"2010","unstructured":"Gonz\u00e1lez-Moreno S, Gonz\u00e1lez-Bay\u00f3n LA, Ortega-P\u00e9rez G. Hyperthermic intraperitoneal chemotherapy: Rationale and technique. World J Gastrointest Oncol. 2010;2:68\u201375. https:\/\/doi.org\/10.4251\/wjgo.v2.i2.68.","journal-title":"World J Gastrointest Oncol"},{"key":"4843_CR36","doi-asserted-by":"publisher","first-page":"689","DOI":"10.1016\/s1055-3207(03)00029-2","volume":"12","author":"RP Sticca","year":"2003","unstructured":"Sticca RP, Dach BW. Rationale for hyperthermia with intraoperative intraperitoneal chemotherapy agents. Surg Oncol Clin N Am. 2003;12:689\u2013701. https:\/\/doi.org\/10.1016\/s1055-3207(03)00029-2.","journal-title":"Surg Oncol Clin N Am"},{"key":"4843_CR37","doi-asserted-by":"publisher","first-page":"247","DOI":"10.1002\/jso.21051","volume":"98","author":"S Kusamura","year":"2008","unstructured":"Kusamura S, Dominique E, Baratti D, Younan R, Deraco M. Drugs, carrier solutions and temperature in hyperthermic intraperitoneal chemotherapy. J Surg Oncol. 2008;98:247\u201352. https:\/\/doi.org\/10.1002\/jso.21051.","journal-title":"J Surg Oncol"},{"key":"4843_CR38","doi-asserted-by":"publisher","first-page":"91","DOI":"10.1038\/s41572-021-00326-6","volume":"7","author":"D Cort\u00e9s-Guiral","year":"2021","unstructured":"Cort\u00e9s-Guiral D, H\u00fcbner M, Alyami M, Bhatt A, Ceelen W, Glehen O, et al. Primary and metastatic peritoneal surface malignancies. Nat Rev Dis Primers. 2021;7:91. https:\/\/doi.org\/10.1038\/s41572-021-00326-6.","journal-title":"Nat Rev Dis Primers"},{"key":"4843_CR39","doi-asserted-by":"publisher","first-page":"10","DOI":"10.1016\/j.annonc.2022.10.003","volume":"34","author":"A Cervantes","year":"2023","unstructured":"Cervantes A, Adam R, Rosell\u00f3 S, Arnold D, Normanno N, Ta\u00efeb J, et al. Metastatic colorectal cancer: ESMO Clinical Practice Guideline for diagnosis, treatment and follow-up. Ann Oncol. 2023;34:10\u201332. https:\/\/doi.org\/10.1016\/j.annonc.2022.10.003.","journal-title":"Ann Oncol"}],"container-title":["BMC Gastroenterology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/link.springer.com\/article\/10.1186\/s12876-026-04843-0","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1186\/s12876-026-04843-0.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1186\/s12876-026-04843-0.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,6,12]],"date-time":"2026-06-12T00:52:50Z","timestamp":1781225570000},"score":1,"resource":{"primary":{"URL":"https:\/\/link.springer.com\/10.1186\/s12876-026-04843-0"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,4,24]]},"references-count":39,"journal-issue":{"issue":"1","published-online":{"date-parts":[[2026,12]]}},"alternative-id":["4843"],"URL":"https:\/\/doi.org\/10.1186\/s12876-026-04843-0","relation":{},"ISSN":["1471-230X"],"issn-type":[{"value":"1471-230X","type":"electronic"}],"subject":[],"published":{"date-parts":[[2026,4,24]]},"assertion":[{"value":"26 December 2025","order":1,"name":"received","label":"Received","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"14 April 2026","order":2,"name":"accepted","label":"Accepted","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"24 April 2026","order":3,"name":"first_online","label":"First Online","group":{"name":"ArticleHistory","label":"Article History"}},{"order":1,"name":"Ethics","group":{"name":"EthicsHeading","label":"Declarations"}},{"value":"Not applicable.","order":2,"name":"Ethics","group":{"name":"EthicsHeading","label":"Ethics approval and consent to participate"}},{"value":"Not applicable.","order":3,"name":"Ethics","group":{"name":"EthicsHeading","label":"Consent for publication"}},{"value":"The authors declare no competing interests.","order":4,"name":"Ethics","group":{"name":"EthicsHeading","label":"Competing interests"}}],"article-number":"352"}}