{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,19]],"date-time":"2026-06-19T14:52:25Z","timestamp":1781880745385,"version":"3.54.5"},"reference-count":13,"publisher":"Springer Science and Business Media LLC","issue":"1","license":[{"start":{"date-parts":[[2026,5,2]],"date-time":"2026-05-02T00:00:00Z","timestamp":1777680000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0"},{"start":{"date-parts":[[2026,6,19]],"date-time":"2026-06-19T00:00:00Z","timestamp":1781827200000},"content-version":"vor","delay-in-days":48,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0"}],"funder":[{"DOI":"10.13039\/501100003996","name":"Kunming Medical University","doi-asserted-by":"publisher","award":["202401AY070001-090"],"award-info":[{"award-number":["202401AY070001-090"]}],"id":[{"id":"10.13039\/501100003996","id-type":"DOI","asserted-by":"publisher"}]},{"name":"Yunnan Provincial Health and Health Commission","award":["2024YNLCYXZX0525"],"award-info":[{"award-number":["2024YNLCYXZX0525"]}]}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["BMC Gastroenterol"],"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Introduction<\/jats:title>\n                    <jats:p>Perivascular epithelioid cell tumors (PEComas) are rare mesenchymal tumors composed of cells exhibiting an epithelioid morphology. These cells typically arrange around small blood vessels (perivascular spaces) and display dual differentiation characteristics of smooth muscle cells and melanocytes. Diagnosis is challenging due to the absence of specific symptoms or tumor markers. This case features a young male patient with a large hepatic PEComa, whose imaging findings resemble those of hepatocellular carcinoma. We have detailed the entire process from diagnosis to treatment to aid in differential diagnosis and surgical planning.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Case<\/jats:title>\n                    <jats:p>A 31-year-old male patient with no prior medical history underwent a routine health examination 20\u00a0days prior to presentation. Although the patient was asymptomatic, ultrasound revealed an incidental hepatic lesion measuring 58\u2009\u00d7\u200950\u2009\u00d7\u200945\u00a0mm (maximum diameter 58\u00a0mm, or 5.8\u00a0cm). The screening center suspected a hemangioma. Subsequently, he presented to our hospital. Comprehensive imaging studies, including ultrasound, computed tomography (CT), and magnetic resonance imaging (MRI), revealed a 58\u00a0mm-diameter space-occupying lesion in segments V and VIII of the right hepatic lobe. Imaging findings initially raised suspicion for hepatocellular carcinoma. To minimize surgical trauma and preserve liver function, our team discussed surgical approaches and ultimately decided on a laparoscopic partial hepatectomy. During the procedure, we obtained a specimen for pathological examination. The final histopathological analysis confirmed the diagnosis of a PEComa with undetermined malignant potential. The patient recovered smoothly postoperatively and was successfully discharged.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion<\/jats:title>\n                    <jats:p>PEComa has an insidious onset and is rare. Early diagnosis is often challenging, and imaging studies typically show no highly specific findings. Clinical diagnosis frequently relies on biopsy. In terms of treatment, radical resection (R0 resection, i.e., negative margins) represents the definitive therapeutic approach.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1186\/s12876-026-04884-5","type":"journal-article","created":{"date-parts":[[2026,5,2]],"date-time":"2026-05-02T11:45:48Z","timestamp":1777722348000},"update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Laparoscopic partial hepatectomy for primary hepatic PEComa: a case report"],"prefix":"10.1186","volume":"26","author":[{"given":"Bing","family":"Liang","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hongjin","family":"Shi","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Qingbin","family":"Zeng","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xin","family":"Tie","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kui","family":"Long","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2026,5,2]]},"reference":[{"key":"4884_CR1","doi-asserted-by":"crossref","unstructured":"Czarnecka A M, Skoczylas J, Bartnik E, et al. Management strategies for adults with locally advanced, unresectable or metastatic malignant perivascular epithelioid cell tumor (PEComa): challenges and solutions. Cancer Manag Res. 2023:615-623.","DOI":"10.2147\/CMAR.S351284"},{"issue":"25","key":"4884_CR2","doi-asserted-by":"publisher","first-page":"e29506","DOI":"10.1097\/MD.0000000000029506","volume":"101","author":"X Yang","year":"2022","unstructured":"Yang X, Wang Q, Zhou X, et al. Retrospective analysis of hepatic perivascular epithelioid cell tumour (PEComa) in a single centre for clinical diagnosis and treatment clinical diagnosis and treatment of hepatic PEComa[J]. Medicine. 2022;101(25):e29506.","journal-title":"Medicine"},{"issue":"1","key":"4884_CR3","first-page":"541626","volume":"2012","author":"JS Bleeker","year":"2012","unstructured":"Bleeker JS, Quevedo JF, Folpe AL. \u201cMalignant\u201d perivascular epithelioid cell neoplasm: Risk stratification and treatment strategies. Sarcoma. 2012;2012(1):541626.","journal-title":"Sarcoma"},{"issue":"12","key":"4884_CR4","doi-asserted-by":"publisher","first-page":"1558","DOI":"10.1097\/01.pas.0000173232.22117.37","volume":"29","author":"AL Folpe","year":"2005","unstructured":"Folpe AL, Mentzel T, Lehr HA, et al. Perivascular epithelioid cell neoplasms of soft tissue and gynecologic origin: a clinicopathologic study of 26 cases and review of the literature[J]. Am J Surg Pathol. 2005;29(12):1558\u201375.","journal-title":"Am J Surg Pathol"},{"issue":"14","key":"4884_CR5","doi-asserted-by":"publisher","first-page":"2276","DOI":"10.3390\/cancers17142276","volume":"17","author":"K Papantoniou","year":"2025","unstructured":"Papantoniou K, Aggeletopoulou I, Kalafateli M, et al. Characteristics and treatment of primary hepatic perivascular epithelioid cell tumor (PEComa) in adults: a systematic review. Cancers Basel. 2025;17(14):2276.","journal-title":"Cancers Basel"},{"issue":"1","key":"4884_CR6","doi-asserted-by":"publisher","first-page":"72","DOI":"10.14218\/JCTH.2020.00170","volume":"10","author":"J Jia","year":"2021","unstructured":"Jia J, Luo J, Pan CG, et al. Single-center experience in the diagnosis and treatment of hepatic perivascular epithelioid cell neoplasm. J Clin Transl Hepatol. 2021;10(1):72.","journal-title":"J Clin Transl Hepatol"},{"key":"4884_CR7","doi-asserted-by":"publisher","first-page":"1416254","DOI":"10.3389\/fonc.2024.1416254","volume":"14","author":"M Ji","year":"2024","unstructured":"Ji M, Zhang Y, Liu S, et al. Hepatic perivascular epithelioid cell tumor: a retrospective analysis of 36 cases. Front Oncol. 2024;14:1416254.","journal-title":"Front Oncol"},{"key":"4884_CR8","doi-asserted-by":"publisher","first-page":"1616755","DOI":"10.3389\/fonc.2025.1616755","volume":"15","author":"N Li","year":"2025","unstructured":"Li N, Liu H, Chen J, et al. Imaging features of CT and MR in hepatic perivascular epithelioid cell tumor: Case series and literature review. Front Oncol. 2025;15:1616755.","journal-title":"Front Oncol"},{"issue":"1","key":"4884_CR9","doi-asserted-by":"publisher","first-page":"80","DOI":"10.3350\/cmh.2016.0034","volume":"23","author":"HJ Son","year":"2017","unstructured":"Son HJ, Kang DW, Kim JH, et al. Hepatic perivascular epithelioid cell tumor (PEComa): a case report with a review of literatures. Clin Mol Hepatol. 2017;23(1):80.","journal-title":"Clin Mol Hepatol"},{"issue":"1","key":"4884_CR10","doi-asserted-by":"publisher","first-page":"e1","DOI":"10.1097\/PAS.0000000000001552","volume":"45","author":"ME Kallen","year":"2021","unstructured":"Kallen ME, Hornick JL. The 2020 WHO classification: What\u2019s new in soft tissue tumor pathology? Am J Surg Pathol. 2021;45(1):e1\u201323.","journal-title":"Am J Surg Pathol"},{"issue":"10","key":"4884_CR11","doi-asserted-by":"publisher","first-page":"1395","DOI":"10.1097\/PAS.0b013e3181f17ac0","volume":"34","author":"P Argani","year":"2010","unstructured":"Argani P, Aulmann S, Illei PB, et al. A distinctive subset of PEComas harbors TFE3 gene fusions. Am J Surg Pathol. 2010;34(10):1395\u2013406.","journal-title":"Am J Surg Pathol"},{"issue":"1","key":"4884_CR12","doi-asserted-by":"publisher","first-page":"46","DOI":"10.1186\/1477-7819-12-46","volume":"12","author":"F Bergamo","year":"2014","unstructured":"Bergamo F, Maruzzo M, Basso U, et al. Neoadjuvant sirolimus for a large hepatic perivascular epithelioid cell tumor (PEComa). World J Surg Oncol. 2014;12(1):46.","journal-title":"World J Surg Oncol"},{"issue":"13","key":"4884_CR13","doi-asserted-by":"publisher","first-page":"1472","DOI":"10.1200\/JCO.23.02266","volume":"42","author":"AJ Wagner","year":"2024","unstructured":"Wagner AJ, Ravi V, Riedel RF, et al. Phase II trial of nab-sirolimus in patients with advanced malignant perivascular epithelioid cell tumors (AMPECT): long-term efficacy and safety update. J Clin Oncol. 2024;42(13):1472\u20136.","journal-title":"J Clin Oncol"}],"container-title":["BMC Gastroenterology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/link.springer.com\/article\/10.1186\/s12876-026-04884-5","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1186\/s12876-026-04884-5.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1186\/s12876-026-04884-5.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,6,19]],"date-time":"2026-06-19T14:04:25Z","timestamp":1781877865000},"score":1,"resource":{"primary":{"URL":"https:\/\/link.springer.com\/10.1186\/s12876-026-04884-5"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,5,2]]},"references-count":13,"journal-issue":{"issue":"1","published-online":{"date-parts":[[2026,12]]}},"alternative-id":["4884"],"URL":"https:\/\/doi.org\/10.1186\/s12876-026-04884-5","relation":{},"ISSN":["1471-230X"],"issn-type":[{"value":"1471-230X","type":"electronic"}],"subject":[],"published":{"date-parts":[[2026,5,2]]},"assertion":[{"value":"16 March 2026","order":1,"name":"received","label":"Received","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"27 April 2026","order":2,"name":"accepted","label":"Accepted","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"2 May 2026","order":3,"name":"first_online","label":"First Online","group":{"name":"ArticleHistory","label":"Article History"}},{"order":1,"name":"Ethics","group":{"name":"EthicsHeading","label":"Declarations"}},{"value":"The participants provided their written informed consent to participate in this study. All images are de\u2011identified.","order":2,"name":"Ethics","group":{"name":"EthicsHeading","label":"Ethics approval and consent to participate"}},{"value":"Written informed consent was obtained from the individual(s) for the publication of any potentially identifiable images or data included in this article.","order":3,"name":"Ethics","group":{"name":"EthicsHeading","label":"Consent for publication"}},{"value":"The authors declare no competing interests.","order":4,"name":"Ethics","group":{"name":"EthicsHeading","label":"Competing interests"}}],"article-number":"377"}}