{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,23]],"date-time":"2026-10-23T20:38:50Z","timestamp":1792787930392,"version":"4.5.0"},"reference-count":27,"publisher":"Springer Science and Business Media LLC","issue":"1","license":[{"start":{"date-parts":[[2026,7,3]],"date-time":"2026-07-03T00:00:00Z","timestamp":1783036800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0"},{"start":{"date-parts":[[2026,9,28]],"date-time":"2026-09-28T00:00:00Z","timestamp":1790553600000},"content-version":"vor","delay-in-days":87,"URL":"https:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0"}],"funder":[{"name":"Health research project of Anhui Province","award":["AHWJ2023A30148"],"award-info":[{"award-number":["AHWJ2023A30148"]}]},{"name":"Bethune Charity Foundation","award":["BFC-QYWL-QL-20240905-09"],"award-info":[{"award-number":["BFC-QYWL-QL-20240905-09"]}]},{"name":"The 2023 \"Hengrui \u00b7 Tianqing Medical Education Fund\" horizontal project of the Second Affiliated Hospital of Wannan Medical College","award":["HXKT2022024"],"award-info":[{"award-number":["HXKT2022024"]}],"id":[{"id":"https:\/\/ror.org\/037ejjy86","id-type":"ROR","asserted-by":"crossref"}]},{"name":"2025 Key Natural Science Research Projects of Anhui Provincial Higher Education Institutions","award":["2025AHGXZK31067"],"award-info":[{"award-number":["2025AHGXZK31067"]}]}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["BMC Gastroenterol"],"DOI":"10.1186\/s12876-026-05031-w","type":"journal-article","created":{"date-parts":[[2026,7,3]],"date-time":"2026-07-03T12:19:50Z","timestamp":1783081190000},"update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Uncommon initial presentation of a gastric mass in a patient with primary plasma cell leukemia: a case report"],"prefix":"10.1186","volume":"26","author":[{"given":"Shao-juan","family":"Cui","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hang","family":"Yin","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Chun-li","family":"Xu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yu","family":"Chen","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zhao-ying","family":"Wu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Dong-ping","family":"Huang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2026,7,3]]},"reference":[{"issue":"S1","key":"5031_CR1","doi-asserted-by":"publisher","first-page":"62","DOI":"10.5045\/br.2022.2022033","volume":"57","author":"SH Jung","year":"2022","unstructured":"Jung SH, Lee JJ. Update on primary plasma cell leukemia [J]. Blood Res. 2022;57(S1):62\u20136. https:\/\/doi.org\/10.5045\/br.2022.2022033.","journal-title":"Blood Res"},{"issue":"6","key":"5031_CR2","doi-asserted-by":"publisher","first-page":"907","DOI":"10.1182\/blood-2014-03-565051","volume":"124","author":"WI Gonsalves","year":"2014","unstructured":"Gonsalves WI, Rajkumar SV, Go RS, Dispenzieri A, Gupta V, Singh PP, et al. Trends in survival of patients with primary plasma cell leukemia: a population-based analysis [J]. Blood. 2014;124(6):907\u201312. https:\/\/doi.org\/10.1182\/blood-2014-03-565051.","journal-title":"Blood"},{"issue":"17","key":"5031_CR3","doi-asserted-by":"publisher","first-page":"e70192","DOI":"10.1002\/cam4.70192","volume":"13","author":"C Tessier","year":"2024","unstructured":"Tessier C, Leblanc R, Roy J, Trudel S, C\u00f4t\u00e9 J, Lalancette M, et al. Poor outcome despite modern treatments: a retrospective study of 99 patients with primary and secondary plasma cell leukemia [J]. Cancer Med. 2024;13(17):e70192. https:\/\/doi.org\/10.1002\/cam4.70192.","journal-title":"Cancer Med"},{"issue":"12","key":"5031_CR4","doi-asserted-by":"publisher","first-page":"192","DOI":"10.1038\/s41408-021-00587-0","volume":"11","author":"C Fern\u00e1ndez de Larrea","year":"2021","unstructured":"Fern\u00e1ndez de Larrea C, Kyle R, Rosi\u00f1ol L, Paiva B, Engelhardt M, Usmani S, et al. Primary plasma cell leukemia: consensus definition by the International Myeloma Working Group according to peripheral blood plasma cell percentage [J]. Blood Cancer J. 2021;11(12):192. https:\/\/doi.org\/10.1038\/s41408-021-00587-0.","journal-title":"Blood Cancer J"},{"issue":"12","key":"5031_CR5","doi-asserted-by":"publisher","first-page":"2376","DOI":"10.1182\/blood-2012-05-408682","volume":"120","author":"NW Van de Donk","year":"2012","unstructured":"Van de Donk NW, Lokhorst HM, Anderson KC, Richardson PG. How I treat plasma cell leukemia [J]. Blood. 2012;120(12):2376\u201389. https:\/\/doi.org\/10.1182\/blood-2012-05-408682.","journal-title":"Blood"},{"issue":"11","key":"5031_CR6","doi-asserted-by":"publisher","first-page":"1048","DOI":"10.1684\/bdc.2014.2048","volume":"101","author":"A Ravinet","year":"2014","unstructured":"Ravinet A, Bay JO, Tournilhac O. Plasma cell leukemia] [J. Bull Cancer. 2014;101(11):1048\u201358. https:\/\/doi.org\/10.1684\/bdc.2014.2048.","journal-title":"Bull Cancer"},{"issue":"1","key":"5031_CR7","doi-asserted-by":"publisher","first-page":"158","DOI":"10.1038\/leu.2011.176","volume":"26","author":"H Avet-Loiseau","year":"2012","unstructured":"Avet-Loiseau H, Roussel M, Campion L, Leleu X, Marit G, Jardel H, et al. Cytogenetic and therapeutic characterization of primary plasma cell leukemia: the IFM experience [J]. Leukemia. 2012;26(1):158\u20139. https:\/\/doi.org\/10.1038\/leu.2011.176.","journal-title":"Leukemia"},{"issue":"7","key":"5031_CR8","first-page":"514","volume":"36","author":"HL Pang","year":"2023","unstructured":"Pang HL, Zhang DF, Fan WJ, Guo RQ, Jiang J. Clinical features and prognostic analysis of 27 cases of primary plasma cell leukemia. J Clin Hematol. 2023;36(7):514\u20139.","journal-title":"J Clin Hematol"},{"key":"5031_CR9","doi-asserted-by":"publisher","unstructured":"Di Gregorio F, Polici M, Pilozzi E, Giallorenzi MA, Ciolina M, Oedegaard PEK, Zerunian M, Caruso D, Iannicelli E, Laghi A. Staging of Gastric Cancer: CT Patterns and Correlation with Pathologic Findings. Radiographics : a review publication of the Radiological Society of North America, Inc. 2025;45(8):e240186. https:\/\/doi.org\/10.1148\/rg.240186.","DOI":"10.1148\/rg.240186"},{"issue":"7","key":"5031_CR10","first-page":"694","volume":"33","author":"E Zucca","year":"2022","unstructured":"Zucca E, et al. Gastric lymphoma: ESMO Clinical Practice Guidelines for diagnosis, treatment and follow-up. Ann Oncol. 2022;33(7):694\u2013707.","journal-title":"Ann Oncol"},{"issue":"11","key":"5031_CR11","doi-asserted-by":"publisher","first-page":"1618","DOI":"10.3324\/haematol.2012.078519","volume":"97","author":"J Blad\u00e9","year":"2012","unstructured":"Blad\u00e9 J, de Larrea CF, Rosi\u00f1ol L. Extramedullary involvement in multiple myeloma [J]. Haematologica. 2012;97(11):1618\u20139. https:\/\/doi.org\/10.3324\/haematol.2012.078519.","journal-title":"Haematologica"},{"issue":"4","key":"5031_CR12","doi-asserted-by":"publisher","first-page":"780","DOI":"10.1038\/leu.2012.336","volume":"27","author":"C Fern\u00e1ndez de Larrea","year":"2013","unstructured":"Fern\u00e1ndez de Larrea C, Kyle RA, Durie BG, Ludwig H, Usmani S, Vesole DH, et al. Plasma cell leukemia: consensus statement on diagnostic requirements, response criteria and treatment recommendations by the International Myeloma Working Group [J]. Leukemia. 2013;27(4):780\u201391. https:\/\/doi.org\/10.1038\/leu.2012.336.","journal-title":"Leukemia"},{"key":"5031_CR13","doi-asserted-by":"publisher","unstructured":"Hanamura I, Karnan S, Ota A, Takami A. Primary plasma cell leukemia: recent advances in molecular understanding and treatment approaches [J]. Int J Mol Sci. 2025;26(13). https:\/\/doi.org\/10.3390\/ijms26136166.","DOI":"10.3390\/ijms26136166"},{"issue":"3","key":"5031_CR14","doi-asserted-by":"publisher","first-page":"299","DOI":"10.1046\/j.1365-2141.2003.04783.x","volume":"124","author":"JE Guikema","year":"2004","unstructured":"Guikema JE, Vellenga E, Abdulahad WH, Hovenga S, Bos NA. CD27-triggering on primary plasma cell leukaemia cells has anti-apoptotic effects involving mitogen activated protein kinases [J]. Br J Haematol. 2004;124(3):299\u2013308. https:\/\/doi.org\/10.1046\/j.1365-2141.2003.04783.x.","journal-title":"Br J Haematol"},{"issue":"6","key":"5031_CR15","doi-asserted-by":"publisher","first-page":"698","DOI":"10.1684\/abc.2013.0888","volume":"71","author":"H Eddou","year":"2013","unstructured":"Eddou H, Mahtat ELM, Zahid H, Maaroufi HE, Jennane S, Messaoudi N, et al. Plasma cell leukemia: three case-reports and review of literature. Ann Biol Clin (Paris). 2013;71(6):698\u2013702. https:\/\/doi.org\/10.1684\/abc.2013.0888.","journal-title":"Ann Biol Clin (Paris)"},{"issue":"12","key":"5031_CR16","doi-asserted-by":"publisher","first-page":"1256","DOI":"10.1038\/s41417-020-00291-4","volume":"28","author":"D Chen","year":"2021","unstructured":"Chen D, Yang X, Liu M, Zhang Z, Xing E. Roles of miRNA dysregulation in the pathogenesis of multiple myeloma. Cancer Gene Ther. 2021;28(12):1256\u201368. https:\/\/doi.org\/10.1038\/s41417-020-00291-4.","journal-title":"Cancer Gene Ther"},{"issue":"16","key":"5031_CR17","doi-asserted-by":"publisher","first-page":"1181","DOI":"10.2217\/bmm-2022-0349","volume":"16","author":"S Leng","year":"2022","unstructured":"Leng S, Qu H, Lv X, Liu X. Role of Ncrna in multiple myeloma. Biomark Med. 2022;16(16):1181\u201391. https:\/\/doi.org\/10.2217\/bmm-2022-0349.","journal-title":"Biomark Med"},{"issue":"1","key":"5031_CR18","doi-asserted-by":"publisher","first-page":"637","DOI":"10.1186\/s13018-021-02793-9","volume":"16","author":"X Gao","year":"2021","unstructured":"Gao X, Zhou J, Wang J, Dong X, Chang Y, Jin Y. Mechanism of exosomal miR-155 derived from bone marrow mesenchymal stem cells on stemness maintenance and drug resistance in myeloma cells. J Orthop Surg Res. 2021;16(1):637. https:\/\/doi.org\/10.1186\/s13018-021-02793-9.","journal-title":"J Orthop Surg Res"},{"key":"5031_CR19","doi-asserted-by":"publisher","unstructured":"Musto P, Simeon V, Martorelli MC, Petrucci MT, Cascavilla N, DI Raimondo F, Caravita T, Morabito F, Offidani M, Olivieri A, Benevolo G, Mina R, Guariglia R, D'Arena G, Mansueto G, Filardi N, Nobile F, Levi A, Falcone A, Cavalli M, Pietrantuono G, Villani O, Bringhen S, Omed\u00e8 P, Lerose R, Agnelli L, Todoerti K, Neri A, Boccadoro M, Palumbo A. Lenalidomide and low-dose dexamethasone for newly diagnosed primary plasma cell leukemia [J]. Leukemia. 2014;28(1):222-5. https:\/\/doi.org\/10.1038\/leu.2013.241.","DOI":"10.1038\/leu.2013.241"},{"issue":"27","key":"5031_CR20","doi-asserted-by":"publisher","first-page":"3151","DOI":"10.1200\/jco.21.01365","volume":"40","author":"JJ Garc\u00e9s","year":"2022","unstructured":"Garc\u00e9s JJ, Cedena MT, Puig N, Burgos L, Perez JJ, Cordon L, et al. Circulating tumor cells for the staging of patients with newly diagnosed transplant-eligible multiple myeloma. J Clin Oncol. 2022;40(27):3151\u201361. https:\/\/doi.org\/10.1200\/jco.21.01365.","journal-title":"J Clin Oncol"},{"issue":"3","key":"5031_CR21","doi-asserted-by":"publisher","first-page":"31","DOI":"10.1038\/s41408-018-0059-6","volume":"8","author":"E Katodritou","year":"2018","unstructured":"Katodritou E, Terpos E, Delimpasi S, Kotsopoulou M, Michalis E, Vadikolia C, et al. Real-world data on prognosis and outcome of primary plasma cell leukemia in the era of novel agents: a multicenter national study by the Greek Myeloma Study Group. Blood Cancer J. 2018;8(3):31. https:\/\/doi.org\/10.1038\/s41408-018-0059-6.","journal-title":"Blood Cancer J"},{"issue":"7","key":"5031_CR22","doi-asserted-by":"publisher","first-page":"499","DOI":"10.3760\/cma.j.cn112137-20231005-00634","volume":"104","author":"XL Dou","year":"2024","unstructured":"Dou XL, Liu RX, Liu Y, Peng N, Wen L, Wu Y, et al. Efficacy and safety of first-line treatment with anti-CD38 monoclonal antibody-based regimen for primary plasma cell leukemia] [J. Zhonghua Yi Xue Za Zhi. 2024;104(7):499\u2013506. https:\/\/doi.org\/10.3760\/cma.j.cn112137-20231005-00634.","journal-title":"Zhonghua Yi Xue Za Zhi"},{"key":"5031_CR23","doi-asserted-by":"publisher","unstructured":"Elmaleh H, Li H, Raza S, Mazzoni S, Samaras C J, Faiman B M, Khouri J, Valent J, Anwer F, Williams LSJB. Impact of T-cell redirecting therapies on survival outcomes in ultra-high-risk multiple myeloma and plasma cell leukemia [J]. 2024;144(Supplement 1):7092. https:\/\/doi.org\/10.1182\/blood-2024-208780.","DOI":"10.1182\/blood-2024-208780"},{"key":"5031_CR24","doi-asserted-by":"publisher","unstructured":"Moreau P, Chanan-Khan AA, Roberts AW, et al. Venetoclax Combined with Bortezomib and Dexamethasone for Patients with Relapsed\/Refractory Multiple Myeloma [J]. Blood. 2016;128(22):975. https:\/\/doi.org\/10.1182\/blood.V128.22.975.975.","DOI":"10.1182\/blood.V128.22.975.975"},{"issue":"6","key":"5031_CR25","doi-asserted-by":"publisher","first-page":"1837","DOI":"10.7534\/j.issn.1009-2137.2017.06.048","volume":"25","author":"H Wang","year":"2017","unstructured":"Wang H, Li JY, Sun C, Zhou X. Advances in the diagnosis and therapy of primary plasma cell leukemia -review] [J. Zhongguo Shi Yan Xue Ye Xue Za Zhi. 2017;25(6):1837\u201341. https:\/\/doi.org\/10.7534\/j.issn.1009-2137.2017.06.048.","journal-title":"Zhongguo Shi Yan Xue Ye Xue Za Zhi"},{"issue":"4","key":"5031_CR26","first-page":"553","volume":"54","author":"Y Chen","year":"2024","unstructured":"Chen Y, Zhang FH, Zhou M, Hou CX, Xu CL, Wang Q, et al. Effective treatment with venetoclax and hypomethylating agents for the coexistence of multiple myeloma and acute myeloid leukemia: a case report and literature review [J]. Ann Clin Lab Sci. 2024;54(4):553\u20137.","journal-title":"Ann Clin Lab Sci"},{"issue":"3","key":"5031_CR27","doi-asserted-by":"publisher","first-page":"626","DOI":"10.4103\/ijpm.ijpm_990_23","volume":"68","author":"F Zhang","year":"2025","unstructured":"Zhang F, Chen Y, Huang D, Chen S. A rare case of concurrent JAK2V617F-positive essential thrombocythemia, multiple myeloma, and colorectal adenocarcinoma [J]. Indian J Pathol Microbiol. 2025;68(3):626\u20139. https:\/\/doi.org\/10.4103\/ijpm.ijpm_990_23.","journal-title":"Indian J Pathol Microbiol"}],"container-title":["BMC Gastroenterology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/link.springer.com\/article\/10.1186\/s12876-026-05031-w","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1186\/s12876-026-05031-w.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1186\/s12876-026-05031-w.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,9,28]],"date-time":"2026-09-28T01:19:00Z","timestamp":1790558340000},"score":1,"resource":{"primary":{"URL":"https:\/\/link.springer.com\/10.1186\/s12876-026-05031-w"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,7,3]]},"references-count":27,"journal-issue":{"issue":"1","published-online":{"date-parts":[[2026,12]]}},"alternative-id":["5031"],"URL":"https:\/\/doi.org\/10.1186\/s12876-026-05031-w","relation":{},"ISSN":["1471-230X"],"issn-type":[{"value":"1471-230X","type":"electronic"}],"subject":[],"published":{"date-parts":[[2026,7,3]]},"assertion":[{"value":"25 February 2026","order":1,"name":"received","label":"Received","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"16 June 2026","order":2,"name":"accepted","label":"Accepted","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"3 July 2026","order":3,"name":"first_online","label":"First Online","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"This study protocol was reviewed and approved by the ethics committee of the Second Affiliated Hospital of Wannan Medical College (approval number WYEFYLS2023019). Written informed consent was obtained from the patient for publication of clinical details and accompanying images. The patient\u2019s data were anonymized and de-identified prior to analysis. All case information presented in this study was collected with written informed consent obtained from the patients.","order":1,"name":"Ethics","label":"Ethics approval and consent to participate","group":{"name":"EthicsHeading","label":"Declarations"}},{"value":"Each author has approved the final version of the manuscript for publication.The case information involved in this article has been approved for publication.","order":2,"name":"Ethics","label":"Consent for publication","group":{"name":"EthicsHeading","label":"Declarations"}},{"value":"The authors declare no competing interests.","order":3,"name":"Ethics","label":"Competing interests","group":{"name":"EthicsHeading","label":"Declarations"}}],"article-number":"585"}}