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Following this approval, the University of Calgary was added as a participating site in the ARISE system. The study has also received approval from the Ottawa Health Science Network Research Ethics Board (OHSN-REB) at the University of Ottawa. Provisional approval has been obtained from the Hamilton Integrated Research Ethics Board (HiREB) at McMaster University. ARISE stands for Alberta Research Information Services. It is the online platform used for research ethics submissions and review in Alberta, primarily through the University of Alberta\u2019s Health Research Ethics Board and related committees. In Alberta, there is a harmonized, province-wide approach to research ethics, which allows multi-site studies to be managed efficiently across institutions. 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