{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,23]],"date-time":"2026-10-23T20:38:07Z","timestamp":1792787887409,"version":"4.5.0"},"reference-count":50,"publisher":"Springer Science and Business Media LLC","issue":"1","license":[{"start":{"date-parts":[[2026,7,8]],"date-time":"2026-07-08T00:00:00Z","timestamp":1783468800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0"},{"start":{"date-parts":[[2026,10,1]],"date-time":"2026-10-01T00:00:00Z","timestamp":1790812800000},"content-version":"vor","delay-in-days":85,"URL":"https:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0"}],"funder":[{"name":"Sel\u00e7uk University Research Foundation","award":["22212019"],"award-info":[{"award-number":["22212019"]}],"id":[{"id":"https:\/\/ror.org\/045hgzm75","id-type":"ROR","asserted-by":"crossref"}]}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["BMC Gastroenterol"],"DOI":"10.1186\/s12876-026-05083-y","type":"journal-article","created":{"date-parts":[[2026,7,8]],"date-time":"2026-07-08T08:05:51Z","timestamp":1783497951000},"update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["FMT from Turkish patients with celiac disease is associated with celiac-like enteropathy features in a rat model"],"prefix":"10.1186","volume":"26","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-7079-8500","authenticated-orcid":false,"given":"Rugiyya","family":"Samadzade","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Salih","family":"Macin","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Babek","family":"Alibayov","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zeynep","family":"Celik","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mehmet Burak","family":"Ates","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Muslu Kaz\u0131m","family":"Korez","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Huseyin","family":"Korkmaz","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Duygu","family":"Findik","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2026,7,8]]},"reference":[{"key":"5083_CR1","doi-asserted-by":"publisher","first-page":"70","DOI":"10.1016\/S0140-6736(17)31796-8","volume":"391","author":"B Lebwohl","year":"2018","unstructured":"Lebwohl B, Sanders DS, Green PHR. Coeliac disease. Lancet. 2018;391:70\u201381.","journal-title":"Lancet"},{"key":"5083_CR2","doi-asserted-by":"publisher","first-page":"1421","DOI":"10.1056\/NEJMcp2415548","volume":"394","author":"JA Murray","year":"2026","unstructured":"Murray JA, Husby S. Celiac disease. N Engl J Med. 2026;394:1421\u20139.","journal-title":"N Engl J Med"},{"key":"5083_CR3","doi-asserted-by":"publisher","unstructured":"Wall E, Semrad CE. Celiac disease, gluten sensitivity, and diet management. Curr Gastroenterol Rep. 2024;26:191\u20139. https:\/\/doi.org\/10.1007\/s11894-024-00931-x.","DOI":"10.1007\/s11894-024-00931-x"},{"key":"5083_CR4","doi-asserted-by":"publisher","DOI":"10.3390\/nu10111796","volume":"10","author":"A Itzlinger","year":"2018","unstructured":"Itzlinger A, Branchi F, Elli L, et al. Gluten-free diet in celiac disease forever and for all? Nutrients. 2018;10:1796.","journal-title":"Nutrients"},{"key":"5083_CR5","doi-asserted-by":"publisher","first-page":"2387","DOI":"10.1038\/s41467-025-57564-5","volume":"16","author":"R Iversen","year":"2025","unstructured":"Iversen R, Heggelund JE, Das S, et al. Enzyme-activating B-cell receptors boost antigen presentation to pathogenic T cells. Nat Commun. 2025;16:2387.","journal-title":"Nat Commun"},{"key":"5083_CR6","doi-asserted-by":"publisher","first-page":"142","DOI":"10.1186\/s12916-019-1380-z","volume":"17","author":"G Caio","year":"2019","unstructured":"Caio G, Volta U, Sapone A, et al. Celiac disease: a comprehensive review. BMC Med. 2019;17:142.","journal-title":"BMC Med"},{"key":"5083_CR7","doi-asserted-by":"publisher","first-page":"1374","DOI":"10.3389\/fimmu.2020.01374","volume":"11","author":"MR Dunne","year":"2020","unstructured":"Dunne MR, Byrne G, Chirdo FG, et al. Coeliac disease pathogenesis Front Immunol. 2020;11:1374.","journal-title":"Coeliac disease pathogenesis Front Immunol"},{"key":"5083_CR8","doi-asserted-by":"publisher","first-page":"223","DOI":"10.1016\/j.trsl.2014.02.006","volume":"164","author":"T Rauhavirta","year":"2014","unstructured":"Rauhavirta T, Lindfors K, Koskinen O, et al. Impaired epithelial integrity in the duodenal mucosa in early stages of celiac disease. Transl Res. 2014;164:223\u201331.","journal-title":"Transl Res"},{"issue":"15","key":"5083_CR9","doi-asserted-by":"publisher","first-page":"2124","DOI":"10.1016\/j.yexcr.2011.05.022","volume":"317","author":"Y Reinke","year":"2011","unstructured":"Reinke Y, Behrendt M, Schmidt S, et al. Impairment of protein trafficking by direct interaction of gliadin peptides with actin. Exp Cell Res. 2011;317(15):2124\u201335.","journal-title":"Exp Cell Res"},{"key":"5083_CR10","first-page":"559","volume":"17","author":"V Bul","year":"2016","unstructured":"Bul V, Sleesman B, Boulay B. Celiac crisis Am J Case Rep. 2016;17:559\u201361.","journal-title":"Celiac crisis Am J Case Rep"},{"key":"5083_CR11","doi-asserted-by":"publisher","first-page":"20","DOI":"10.1097\/01.NPR.0000000000000232","volume":"49","author":"J Olmstead","year":"2024","unstructured":"Olmstead J. Guideline update overview. Nurse Pract. 2024;49:20\u20138.","journal-title":"Nurse Pract"},{"key":"5083_CR12","first-page":"583","volume":"7","author":"A Al-Toma","year":"2019","unstructured":"Al-Toma A, Volta U, Auricchio R, et al. ESsCD guideline. United Eur. Gastroenterol J. 2019;7:583\u2013613.","journal-title":"Gastroenterol J"},{"key":"5083_CR13","doi-asserted-by":"publisher","first-page":"141","DOI":"10.1097\/MPG.0000000000002497","volume":"70","author":"S Husby","year":"2020","unstructured":"Husby S, Koletzko S, Korponay-Szabo I, et al. Diagnostic guidelines. J Pediatr Gastroenterol Nutr. 2020;70:141\u201356.","journal-title":"J Pediatr Gastroenterol Nutr"},{"key":"5083_CR14","doi-asserted-by":"publisher","first-page":"689","DOI":"10.1053\/j.gastro.2017.05.015","volume":"153","author":"JA Silvester","year":"2017","unstructured":"Silvester JA, Kurada S, Szwajcer A, et al. Antibody testing limitations. Gastroenterology. 2017;153:689-701.e1.","journal-title":"Gastroenterology"},{"key":"5083_CR15","first-page":"132","volume":"167","author":"G Malamut","year":"2024","unstructured":"Malamut G, Soderquist CG, Bhagat G, et al. Refractory celiac disease. Gastroenterology. 2024;167:132\u201347.","journal-title":"Gastroenterology"},{"key":"5083_CR16","first-page":"36","volume":"6","author":"M Olivares","year":"2018","unstructured":"Olivares M, Walker AW, Capilla A, et al. Gut microbiota trajectory Microbiome. 2018;6:36.","journal-title":"Gut microbiota trajectory Microbiome"},{"key":"5083_CR17","first-page":"2039","volume":"13","author":"O Belei","year":"2023","unstructured":"Belei O, Jug\u0103naru I, Basaca DG, et al. Microbiota role. Life (Basel). 2023;13:2039.","journal-title":"Life (Basel)"},{"key":"5083_CR18","doi-asserted-by":"publisher","first-page":"2848","DOI":"10.3390\/microorganisms11122848","volume":"11","author":"O Zolnikova","year":"2023","unstructured":"Zolnikova O, Dzhakhaya N, Bueverova E, et al. Microbiota contribution Microorganisms. 2023;11:2848.","journal-title":"Microbiota contribution Microorganisms"},{"key":"5083_CR19","doi-asserted-by":"publisher","first-page":"1099","DOI":"10.1016\/j.jaci.2015.01.044","volume":"135","author":"PH Green","year":"2015","unstructured":"Green PH, Lebwohl B, Greywoode R. Celiac disease. J Allergy Clin Immunol. 2015;135:1099\u2013106.","journal-title":"J Allergy Clin Immunol"},{"key":"5083_CR20","doi-asserted-by":"publisher","first-page":"619","DOI":"10.3390\/molecules28020619","volume":"28","author":"RS Aleman","year":"2023","unstructured":"Aleman RS, Moncada M, Aryana KJ. Leaky gut review. Molecules. 2023;28:619.","journal-title":"Molecules"},{"key":"5083_CR21","doi-asserted-by":"publisher","first-page":"S23","DOI":"10.1016\/j.jfma.2018.08.011","volume":"118","author":"JW Wang","year":"2019","unstructured":"Wang JW, Kuo CH, Kuo FH, et al. FMT review. J Formos Med Assoc. 2019;118:S23\u201331.","journal-title":"J Formos Med Assoc"},{"key":"5083_CR22","doi-asserted-by":"publisher","DOI":"10.1002\/advs.202413197","volume":"12","author":"S Hou","year":"2025","unstructured":"Hou S, Yu J, Li Y, et al. FMT advances. Adv Sci. 2025;12:e2413197.","journal-title":"Adv Sci"},{"key":"5083_CR23","doi-asserted-by":"publisher","first-page":"571","DOI":"10.1016\/j.amjmed.2024.03.024","volume":"137","author":"M Cymbal","year":"2024","unstructured":"Cymbal M, Chatterjee A, Baggott B, et al. C. difficile management. Am J Med. 2024;137:571\u20136.","journal-title":"Am J Med"},{"key":"5083_CR24","first-page":"30","volume":"44","author":"K Matsuoka","year":"2021","unstructured":"Matsuoka K. FMT in colitis Immunol Med. 2021;44:30\u20134.","journal-title":"FMT in colitis Immunol Med"},{"key":"5083_CR25","doi-asserted-by":"publisher","first-page":"1461","DOI":"10.1007\/s10620-015-4020-2","volume":"61","author":"G Marasco","year":"2016","unstructured":"Marasco G, Di Biase AR, Schiumerini R, et al. Microbiota and CD. Dig Dis Sci. 2016;61:1461\u201372.","journal-title":"Dig Dis Sci"},{"key":"5083_CR26","doi-asserted-by":"crossref","first-page":"125","DOI":"10.1016\/j.ijfoodmicro.2016.07.025","volume":"237","author":"M De Angelis","year":"2016","unstructured":"De Angelis M, Vannini L, Di Cagno R, et al. Microbiota in children. Int J Food Microbiol. 2016;237:125\u201332.","journal-title":"Int J Food Microbiol"},{"key":"5083_CR27","doi-asserted-by":"publisher","DOI":"10.3389\/fcimb.2021.711055","volume":"11","author":"SC Bokoliya","year":"2021","unstructured":"Bokoliya SC, Dorsett Y, Panier H, et al. Murine FMT Front Cell Infect Microbiol. 2021;11:711055.","journal-title":"Murine FMT Front Cell Infect Microbiol"},{"key":"5083_CR28","doi-asserted-by":"publisher","first-page":"712","DOI":"10.1016\/j.chom.2023.03.020","volume":"31","author":"S Porcari","year":"2023","unstructured":"Porcari S, Benech N, Valles-Colomer M, et al. FMT success. Cell Host Microbe. 2023;31:712\u201333.","journal-title":"Cell Host Microbe"},{"key":"5083_CR29","doi-asserted-by":"publisher","first-page":"173","DOI":"10.1016\/j.chom.2020.01.018","volume":"27","author":"PE Carlson","year":"2020","unstructured":"Carlson PE. Regulatory considerations. Cell Host Microbe. 2020;27:173\u20135.","journal-title":"Cell Host Microbe"},{"key":"5083_CR30","doi-asserted-by":"publisher","first-page":"1185","DOI":"10.1097\/00042737-199910000-00019","volume":"11","author":"G Oberhuber","year":"1999","unstructured":"Oberhuber G, Granditsch G, Vogelsang H. Histopathology scheme. Eur J Gastroenterol Hepatol. 1999;11:1185\u201394.","journal-title":"Eur J Gastroenterol Hepatol"},{"key":"5083_CR31","first-page":"111","volume":"31","author":"MN Marsh","year":"1990","unstructured":"Marsh MN. Grains of truth Gut. 1990;31:111\u20134.","journal-title":"Grains of truth Gut"},{"key":"5083_CR32","doi-asserted-by":"crossref","first-page":"385","DOI":"10.15403\/jgld.2014.1121.253.cel","volume":"25","author":"YHV Beurden","year":"2016","unstructured":"Beurden YHV, Gils TV, Gils NAV, et al. Recovery after FMT. J Gastrointestin Liver Dis. 2016;25:385\u20138.","journal-title":"J Gastrointestin Liver Dis"},{"key":"5083_CR33","doi-asserted-by":"publisher","first-page":"350","DOI":"10.3389\/fped.2018.00350","volume":"6","author":"JA Tye-Din","year":"2018","unstructured":"Tye-Din JA, Galipeau HJ, Agardh D. CD review Front Pediatr. 2018;6:350.","journal-title":"CD review Front Pediatr"},{"key":"5083_CR34","doi-asserted-by":"publisher","first-page":"2211","DOI":"10.4049\/jimmunol.0901919","volume":"184","author":"I Monteleone","year":"2010","unstructured":"Monteleone I, Massimiliano S, Del Vecchio BG, et al. IL-17A cells. J Immunol. 2010;184:2211\u20138.","journal-title":"J Immunol"},{"key":"5083_CR35","doi-asserted-by":"publisher","first-page":"134","DOI":"10.1038\/ajg.2015.390","volume":"111","author":"M Borrelli","year":"2016","unstructured":"Borrelli M, Gianfrani C, Lania G, et al. IL-21 expression. Am J Gastroenterol. 2016;111:134\u201344.","journal-title":"Am J Gastroenterol"},{"key":"5083_CR36","first-page":"6179243","volume":"2019","author":"T Vorobjova","year":"2019","unstructured":"Vorobjova T, Tagoma A, Oras A, et al. Cytokine balance. J. Immunol Res. 2019;2019:6179243.","journal-title":"Immunol Res"},{"key":"5083_CR37","doi-asserted-by":"crossref","first-page":"469","DOI":"10.1136\/gut.2005.068684","volume":"55","author":"A Di Sabatino","year":"2006","unstructured":"Di Sabatino A, Ciccocioppo R, Cupelli F, et al. IL-15 role. Gut. 2006;55:469\u201377.","journal-title":"Gut"},{"key":"5083_CR38","doi-asserted-by":"publisher","first-page":"493","DOI":"10.1146\/annurev-immunol-040210-092915","volume":"29","author":"V Abadie","year":"2011","unstructured":"Abadie V, Sollid LM, Barreiro LB, et al. Genetic and immun integration. Annu Rev Immunol. 2011;29:493\u2013525.","journal-title":"Annu Rev Immunol"},{"key":"5083_CR39","doi-asserted-by":"publisher","unstructured":"Velikova T, Shahid M, Ivanova-Todorova E, et al. Autoantibodies and IL-17A. J Immunol Res. 2019.Velikova T, Shahid M, Ivanova-Todorova E, et al. Celiac-related autoantibodies and IL-17A in Bulgarian patients with dermatitis herpetiformis: A cross-sectional study. Medicina (Kaunas). 2019;55(5):136. https:\/\/doi.org\/10.3390\/medicina55050136.","DOI":"10.3390\/medicina55050136"},{"key":"5083_CR40","doi-asserted-by":"crossref","first-page":"745","DOI":"10.1016\/j.dld.2016.03.024","volume":"48","author":"A Di Sabatino","year":"2016","unstructured":"Di Sabatino A, Giuffrida P, Fornasa G, et al. Immunity comparison. Dig Liver Dis. 2016;48:745\u201352.","journal-title":"Dig Liver Dis"},{"key":"5083_CR41","doi-asserted-by":"publisher","first-page":"455","DOI":"10.1016\/j.cytogfr.2013.05.004","volume":"24","author":"D Pagliari","year":"2013","unstructured":"Pagliari D, Cianci R, Frosali S, et al. IL-15 GI diseases. Cytokine Growth Factor Rev. 2013;24:455\u201366.","journal-title":"Cytokine Growth Factor Rev"},{"key":"5083_CR42","doi-asserted-by":"publisher","first-page":"50","DOI":"10.1016\/j.humimm.2009.09.351","volume":"71","author":"JS Manavalan","year":"2010","unstructured":"Manavalan JS, Hernandez L, Shah JG, et al. Serum cytokines. Hum Immunol. 2010;71:50\u20137.","journal-title":"Hum Immunol"},{"key":"5083_CR43","doi-asserted-by":"publisher","first-page":"7849","DOI":"10.3748\/wjg.v23.i44.7849","volume":"23","author":"A Piatek-Guziewicz","year":"2017","unstructured":"Piatek-Guziewicz A, Ptak-Belowska A, Przybylska-Felus M, et al. Oxidative imbalance in CD. World J Gastroenterol. 2017;23:7849.","journal-title":"World J Gastroenterol"},{"key":"5083_CR44","first-page":"9","volume":"11","author":"K Girdhar","year":"2023","unstructured":"Girdhar K, Dogru YD, Huang Q, et al. Gut microbiome dynamics Microbiome. 2023;11:9.","journal-title":"Gut microbiome dynamics Microbiome"},{"key":"5083_CR45","doi-asserted-by":"publisher","DOI":"10.1016\/j.bpg.2024.101951","volume":"72","author":"G Catassi","year":"2024","unstructured":"Catassi G, Lener E, Grattagliano MM, et al. Microbiome in gluten disorders. Best Pract Res Clin Gastroenterol. 2024;72:101951.","journal-title":"Best Pract Res Clin Gastroenterol"},{"key":"5083_CR46","doi-asserted-by":"publisher","DOI":"10.3389\/fimmu.2021.578386","volume":"12","author":"F Cristofori","year":"2021","unstructured":"Cristofori F, Dargenio VN, Dargenio C, et al. Probiotics and inflammation Front Immunol. 2021;12:578386.","journal-title":"Probiotics and inflammation Front Immunol"},{"key":"5083_CR47","doi-asserted-by":"crossref","first-page":"2645","DOI":"10.3390\/ijms221810177","volume":"22","author":"L Costantini","year":"2021","unstructured":"Costantini L, Molinari R, Farinon B, et al. Omega-3 and microbiota. Int J Mol Sci. 2021;22:2645.","journal-title":"Int J Mol Sci"},{"key":"5083_CR48","volume":"2015","author":"D Pagliari","year":"2015","unstructured":"Pagliari D, Urgesi R, Frosali S, et al. Microbiota interaction. J. Immunol Res. 2015;2015:123653.","journal-title":"Immunol Res"},{"key":"5083_CR49","doi-asserted-by":"publisher","first-page":"593","DOI":"10.1007\/s00431-018-3103-4","volume":"177","author":"M Van Kalleveen","year":"2018","unstructured":"Van Kalleveen M, de Meij T, Pl\u00f6tz FB. Clinical spectrum of paediatric coeliac disease. Eur J Pediatr. 2018;177:593\u2013602.","journal-title":"Eur J Pediatr"},{"key":"5083_CR50","doi-asserted-by":"publisher","first-page":"148","DOI":"10.1097\/MCG.0000000000000688","volume":"50","author":"MC Cenit","year":"2016","unstructured":"Cenit MC, Codo\u00f1er-Franch P, Sanz Y. Gut microbiota risk. J Clin Gastroenterol. 2016;50:148\u201352.","journal-title":"J Clin Gastroenterol"}],"container-title":["BMC Gastroenterology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/link.springer.com\/article\/10.1186\/s12876-026-05083-y","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1186\/s12876-026-05083-y.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1186\/s12876-026-05083-y.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,10,1]],"date-time":"2026-10-01T10:02:34Z","timestamp":1790848954000},"score":1,"resource":{"primary":{"URL":"https:\/\/link.springer.com\/10.1186\/s12876-026-05083-y"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,7,8]]},"references-count":50,"journal-issue":{"issue":"1","published-online":{"date-parts":[[2026,12]]}},"alternative-id":["5083"],"URL":"https:\/\/doi.org\/10.1186\/s12876-026-05083-y","relation":{},"ISSN":["1471-230X"],"issn-type":[{"value":"1471-230X","type":"electronic"}],"subject":[],"published":{"date-parts":[[2026,7,8]]},"assertion":[{"value":"12 January 2026","order":1,"name":"received","label":"Received","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"29 June 2026","order":2,"name":"accepted","label":"Accepted","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"8 July 2026","order":3,"name":"first_online","label":"First Online","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"The study involving human participants was approved by the Ethics Committee of the Faculty of Medicine, Sel\u00e7uk University (Approval No: 2022\/10) and was conducted in accordance with the Declaration of Helsinki.All animal procedures were approved by the Animal Experiments Ethics Committee of Sel\u00e7uk University (Approval No: 2022\/12) and were conducted in accordance with institutional guidelines and the ARRIVE guidelines.All participants provided written informed consent prior to participation.","order":1,"name":"Ethics","label":"Ethics approval and consent to participate","group":{"name":"EthicsHeading","label":"Declarations"}},{"value":"Not Applicable.","order":2,"name":"Ethics","label":"Consent for publication","group":{"name":"EthicsHeading","label":"Declarations"}},{"value":"The authors declare no competing interests.","order":3,"name":"Ethics","label":"Competing interests","group":{"name":"EthicsHeading","label":"Declarations"}}],"article-number":"599"}}