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The association of HLA-DQB1 and HLA-DRB1with the disease was tested using a control group of 50 non-CD healthy individuals.<\/jats:p>\n                    <jats:p>Genotyping was performed by PCR-SSP and next-generation sequencing (NGS).<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>Genotyping of the studied population revealed that the most frequent alleles of DQB1\/DRB1gens among CD patients were DQB1*02(70%) and DQB1*03(9%), DRB1*03 (52%) was the largest group followed by DRB1*07 (12%).<\/jats:p>\n                    <jats:p>The major allelic combination was DRB1*03\u2013DQB1*02, with a frequency of 47%.<\/jats:p>\n                    <jats:p>\n                      Analysis of allele frequency in patients and controls revealed a significant association between CD and the two key HLA alleles here respectively DQB1*02(\u03c7\n                      <jats:sup>2<\/jats:sup>\n                      = 44.46;\n                      <jats:italic>p<\/jats:italic>\n                      = 2.59 \u00d7 10\u207b\n                      <jats:sup>11<\/jats:sup>\n                      ) and DRB1*03 (\u03c7\n                      <jats:sup>2<\/jats:sup>\n                      = 8.32;\n                      <jats:italic>p<\/jats:italic>\n                      = 3.9 \u00d7 10\u207b\n                      <jats:sup>3<\/jats:sup>\n                      ). Significant association was also found with DQB1*02-DRB1*03 (\u03c7\n                      <jats:sup>2<\/jats:sup>\n                      = 31.47;\n                      <jats:italic>p<\/jats:italic>\n                      = 2.0 \u00d7 10\u207b\u2078). However, no considerable risk of the disease was conferred by any of the other haplotypes tested here.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion<\/jats:title>\n                    <jats:p>These preliminary results, consistent with previous literature on CD genetic susceptibility, support the predominant role of DQB1*02 and DRB1*03 alleles and haplotypes in celiac onset in our population. The availability of NGS typing for celiac disease maybe an additive tool to exclude symptoms ambiguity during CD diagnosis in our medical facilities.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1186\/s12876-026-05086-9","type":"journal-article","created":{"date-parts":[[2026,7,15]],"date-time":"2026-07-15T23:23:32Z","timestamp":1784157812000},"update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["HLA-DQB1*02, HLA-DRB1*03 alleles and HLA-DQB1*02-HLA-DRB1*03 haplotype confer a significant risk of celiac disease in the Mauritanian population"],"prefix":"10.1186","volume":"26","author":[{"given":"Saleck Mahfoudh","family":"Ebebecar","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Malak","family":"Salame","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"family":"MohamedHameyin","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tijani","family":"Hamed","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Fatimetou","family":"Vetten","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tetou","family":"Soumbara","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mohamed lemine","family":"Hmeity","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Abdallahi Sidi","family":"Mohmed","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Houria","family":"Abdelghaffar","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ahmed","family":"Houmeida","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2026,7,16]]},"reference":[{"key":"5086_CR1","doi-asserted-by":"publisher","first-page":"100240","DOI":"10.1016\/j.jtauto.2024.100240","volume":"8","author":"M Laezza","year":"2024","unstructured":"Laezza M, Pisapia L, Toro B, Mercadante V, Rispo A, Gianfrani C, et al. 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